A rabbit model for sublingual drug delivery: Comparison with human pharmacokinetic studies of propranolol, verapamil and captopril

Journal of Pharmaceutical Sciences

Volumn 95, Issue 1, 2006, Pages 37-44

  Dali, Manisha M ^a   Moench, Paul A ^a   Mathias, Neil R ^a   Stetsko, Paul I ^a   Heran, Christopher L ^a   Smith, Ronald L ^a  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

Author keywords

Absorption; Bioavailability; Buccal; Formulation; Rabbit model; Sublingual

Indexed keywords

CAPTOPRIL; PROPRANOLOL; VERAPAMIL;

AEROSOL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG INSTILLATION; HUMAN; NONHUMAN; RABBIT; ANIMAL; ANIMAL MODEL; BLOOD; COMPARATIVE STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PH; SUBLINGUAL DRUG ADMINISTRATION;

ADMINISTRATION, SUBLINGUAL; ANIMALS; CAPTOPRIL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; HYDROGEN-ION CONCENTRATION; MODELS, ANIMAL; PROPRANOLOL; RABBITS; VERAPAMIL;

EID: 33645237337     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20312     Document Type: Article

References (29)

1. Motwani JG, Lipworth BJ. 1991. Clinical pharmacokinetics of drug administered buccally and sublingually. Clin Pharmacokinet 21:83-94.
2. Squier CA, Wertz PW. 1996. Structure and function of the oral mucosa and implications for drug delivery. In: Rathbone MJ, editor. Oral mucosal drug delivery. New York: Marcel Dekker, Inc. pp 1-26.
3. Squier CA, Johnson NW. 1975. Permeability of oral mucosa. Br Med Bull 31:169-175.
4. Beckett AH, Triggs EJ. 1967. Buccal absorption of basic drugs and its application as an in vivo model of passive drug transfer through lipid membranes. J Pharm Pharmacol 19:418.
5. Beckett AH, Moffat AC. 1971. The buccal absorption of some barbiturates. J Pharm Pharmacol 23:15-18.
6. Audus KL, Tavakoli-Saberi MR, Zheng H, Boyce EN. 1992. Chlorhexidine effects on membrane lipid domains of human buccal epithelial cells. J Dent Res 71:1298-1303.
7. Audus KL. 1996. Buccal epithelial cell cultures as a model to study oral mucosal drug transport and metabolism. In: Rathbone MJ, editor. Oral mucosal drug delivery. New York: Marcel Dekker, Inc. pp 101-119.
8. MacCallum DK, Lillie JH, Jepsen A, Arenholt-Bindslev D. 1987. The culture of oral epithelium. Int Rev Cytol 109:313-330.
9. Tavakoli-Saberi MR, Audus KL. 1989. Cultured buccal epithelium: An in vitro model derived from the hamster pouch for studying drug transport and metabolism. Pharm Res 6:160-166.
10. Zhang H, Robinson JR. 1996. In vitro methods for measuring permeability of the oral mucosa. In: Rathbone MJ, editor. Oral mucosal drug delivery. New York: Marcel Dekker, Inc. pp 85-100.
11. Jepsen A. 1974. An in vitro model of an oral keratinizing squamous epithelium. Scand J Dent Res 82:144-146.
12. Garren KW, Topp EM, Repta AJ. 1989. Buccal absorption. III. Simultaneous diffusion and metabolism of an aminopeptidase substrate in the hamster cheek pouch. Pharm Res 6:966-970.
13. Garren KW, Repta AJ. 1989. Buccal drug absorption. II: In vitro diffusion across the hamster cheek pouch. J Pharm Sci 78:160-164.
14. Siegel IA, Izutsu KT, Watson E. 1981. Mechanisms of non-electrolyte penetration across dog and rabbit oral mucosa in vitro. Arch Oral Biol 26:357-361.
15. Lesch CA, Squier CA, Cruchley A, Williams DM, Speight P. 1989. The permeability of human oral mucosa and skin to water. J Dent Res 68:1345-1349.
16. Squier CA, Fejerskov O, Jepsen A. 1978. The permeability of a keratinizing squamous epithelium in culture. J Anat 126:103-109.
17. Rathbone MJ, Purves R, Ghazali FA, Ho PC. 1996. In vivo techniques for studying the oral mucosal absorption characteristics of drugs in animals and humans. In: Rathbone MJ, editor. Oral mucosal drug delivery. New York: Marcel Dekker, Inc. pp 121-156.
18. Chen SY. 1970. Comparison of the fine structure of the mucosa of cheek and hard palate in the rabbit. M.S. Thesis, University of Illinois Medical Center.
19. Alvares OF, Meyer J. 1971. Current concepts of the histology of the oral mucosa. In: Squier CA, Meyer J, editors. Current concepts of the histology of the oral mucosa. Springfield, IL: Charles C. Thomas. 97p.
20. Kates RE. 1977. Absorption kinetics of sublingually administered propranolol. J Med 8:393-402.
21. Berk SI, Beckman K, Hoon TJ, Hariman RJ, Hu D, Siegel FP, Bauman JL. 1992. Comparison of the pharmacokinetics and electrocardiographic effects of sublingual and intravenous verapamil. Pharmacotherapy 12:33-39.
22. McElnay JC, Al Furaih TA, Hughes CM, Scott MG, Nicholls DP. 1996. A pharmacokinetic and pharmacodynamic evaluation of buffered sublingual captopril in patients with congestive heart failure. Eur J Clin Pharmacol 49:471-476.
23. Al Furaih TA, McElnay JC, Elborn JS, Rusk R, Scott MG, McMahon J, Nicholls DP. 1991. Sublingual captopril-a pharmacokinetic and pharmacodynamic evaluation. Eur J Clin Pharmacol 40:393-398.
24. Maitani Y, Coutel-Egros A, Obata Y, Nagai T. 1993. Prediction of skin permeabilities of diclofenac and propranolol from theoretical partition coefficients determined from cohesion parameters. J Pharm Sci 82:416-420.
25. Schurmann W, Turner P. 1978. A membrane model of the human oral mucosa as derived from buccal absorption performance and physicochemical properties of the beta-blocking drugs atenolol and propranolol. J Pharm Pharmacol 30:137-147.
26. Achari R, Beckett AH. 1982. Buccal uptake, urinary excretion, and physicochemical properties of zipeprol and its N-dealkylated products. Biopharm Drug Dispos 3:203-209.
27. Coutel-Egros A, Maitani Y, Veillard M, Machida Y, Nagai T. 1992. Combined effects of pH, cosolvent and penetration enhancers on the in vitro buccal absorption of propranolol through excised hamster cheek pouch. Inter J Pharm 84:117-128.
28. McElnay JC, Al Furaih TA, Hughes CM, Scott MG, Elborn JS, Nicholls DP. 1995. The effect of pH on the buccal and sublingual absorption of captopril. Eur J Clin Pharmacol 48:373-379.
29. Moench PA, Heran CL, Stetsko PI, Mathias NR, Wall DA, Hussain MA, Smith RL. 2003. The effect of anesthesia on the pharmacokinetics of sublingually administered verapamil in rabbits. J Pharm Sci 92:1735-1738.