Synthesis and cytostatic activity of 4,7-dihydroxythioaurone derivatives. Effect of B ring substitution on the activity

Chemical and Pharmaceutical Bulletin

Volumn 54, Issue 3, 2006, Pages 350-353

  Konieczny, Marek Tadeusz ^a   Konieczny, Wojciech ^a   Okabe, Soko ^b   Tsujimoto, Hiroaki ^b   Suda, Yoshimitsu ^b   Wierzba, Konstanty ^b  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

^b TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Antitumor; Cytotoxicity; Thioaurone

Indexed keywords

2 (3' BROMO 3',5' DIMETHOXYBENZYLIDENE) 7 HYDROXY 4 METHOXY 2,3 DIHYDROBENZO[B]THIOPHEN 3 ONE; 2 (3' BROMO 4' HYDROXY 5' METHOXYBENZYLIDENE) 7 HYDROXY 4 METHOXY 2,3 DIHYDROBENZO[B]THIOPHEN 3 ONE; 2 (3' BROMO 4',5' DIMETHOXYBENZYLIDENE) 4,7 DIHYDROXY 2,3 DIHYDROBENZO[B]THIOPHEN 3 ONE; 2 (3' CHLOROBENZYLIDENE) 4,7 DIHYDROXY 2,3 DIHYDROBENZO[B]THIOPHEN 3 ONE; 2 (3' CHLOROBENZYLIDENE) 7 HYDROXY 4 METHOXY 2,3 DIHYDROBENZO[B]THIOPHEN 3 ONE; 2 (3',4' DIHYDROXYBENZYLIDENE) 4 HYDROXY 7 PIPERIDINOCARBONYLOXY 2,3 DIHYDROBENZO[B]THIOPHEN 3 ONE; 2 (3',4' DIHYDROXYBENZYLIDENE) 4,7 DIHYDROXY 2,3 DIHYDROBENZO[B]THIOPHEN 3 ONE; 2 (3',4' DIMETHOXYBENZYLIDENE) 4,7 DIHYDROXY 2,3 DIHYDROBENZO[B]THIOPHEN 3 ONE; 2 (3',4' DIMETHOXYBENZYLIDENE) 7 HYDROXY 4 METHOXY 2,3 DIHYDROBENZO[B]THIOPHEN 3 ONE; 2 (4' BROMO 3',5' DIMETHOXYBENZYLIDENE) 7 HYDROXY 4 METHOXY 2,3 DIHYDROBENZO[B]THIOPHEN 3 ONE; 2 (4' CHLOROBENZYLIDENE) 4,7 DIHYDROXY 2,3 DIHYDROBENZO[B]THIOPHEN 3 ONE; 2 BENZYLIDENE 4,7 DIHYDROXY 2,3 DIHYDROBENZO[B]THIOPHEN 3 ONE; 2 BENZYLIDENE 7 HYDROXY 4 METHOXY 2,3 DIHYDROBENZO[B]THIOPHEN 3 ONE; 4,7 DIHYDROXYTHIOAURONE DERIVATIVE; ANTINEOPLASTIC AGENT; FLAVONOID; HYDROQUINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOSTASIS; CYTOTOXICITY; DRUG ACTIVITY; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HETEROCYCLIC COMPOUNDS, 2-RING; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 33645236521     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.54.350     Document Type: Article

References (6)

1. Williams R. J., Spencer J. P. E., Rice-Evans C., Free Radic. Biol. Med., 36, 838-849 (2004).
2. Middleton E., Jr., Kandaswami C., Theoharides T. C., Pharmacol. Rev., 52, 673-751 (2000).
3. Boumendjel A., Curr. Med. Chem., 10, 2621-2630 (2003).
4. Konieczny M. T., Konieczny W., Heterocycles, 65, 451-464 (2005).
5. Konieczny M. T., Konieczny W., Wolniewicz S., Wierzba K., Suda Y., Sowinski P., Tetrahedron, 61, 8648-8655 (2005).
6. Konieczny M. T., Maciejewski G., Konieczny W., Synthesis, 2005, 1575-1577 (2005).