Sequential Ugi/Strecker reactions via microwave assisted organic synthesis: Novel 3-center-4-component and 3-center-5-component multi-component reactions

Tetrahedron Letters

Volumn 47, Issue 17, 2006, Pages 2989-2991

  Masquelin, Thierry ^a   Bui, Hai ^a   Brickley, Bob ^a   Stephenson, Gregory ^a   Schwerkoske, John ^b   Hulme, Christopher ^a  

^a ELI LILLY AND COMPANY   (United States)

^b Lilly Summer Intern Program

Author keywords

[No Author keywords available]

Indexed keywords

ACETONITRILE DERIVATIVE; ALDEHYDE; METHANOL; PYRIDINE DERIVATIVE; SCANDIUM; SCANDIUM TRIFLATE; TRIMETHYLSILYL DERIVATIVE; TRIMETHYLSILYLCYANIDE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL REACTION; MICROWAVE RADIATION; STOICHIOMETRY; STRECKER SYNTHESIS;

EID: 33645231449     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2006.01.160     Document Type: Article

References (20)

1. A. Strecker Ann. Chem. Pharm. 75 1850 27
2. R.O. Duthaler Tetrahedron 50 1994 1539
3. R.M. Williams, and J.A. Hendrix Chem. Rev. 92 1992 889
4. L. Yet Angew. Chem., Int. Ed. 40 2001 875
5. S. Kobayashi, and H. Ishitani Chem. Rev. 99 1999 1069
6. For recent reviews see: I. Ugi Angew. Chem., Int. Ed. Engl. 1 1962 8
7. I. Ugi, A. Domling, and W. Horl Endeavor 18 1994 115
8. A. Domling Comb. Chem. High Throughput Screening 1 1998 1
9. C. Hulme, and V. Gore Curr. Med. Chem. 10 2003 51 80
10. C. Blackburn, B. Guan, P. Fleming, K. Shiosaki, and S. Tsai Tetrahedron Lett. 39 1998 3635
11. H. Bienayme, and K. Bouzid Angew. Chem., Int. Ed. 37 1998 2234
12. K. Groebke, L. Weber, and F. Mehlin Synlett 1998 661 663
13. C. Zanchini Chem. Phys. 254 2000 187
14. C. Blackburn Tetrahedron Lett. 39 1998 5469 5472
15. C. Blackburn, and B. Guan Tetrahedron Lett. 41 2000 1495
16. J. Schwerkoske, T. Masquelin, T. Perrun, and C. Hulme Tetrahedron Lett. 46 2005 8355
17. 3, Solvent B-acetonitrile.
18. 3, 125 MHz) 158.96, 144.32, 137.24, 136.40, 131.08, 128.83, 128.78, 128.28, 128.18, 127.62, 125.11, 115.54, 113.97, 21.53.
19. A.K. Murthy, S. Sailaja, E. Rajanarendar, and C.J. Rao Synthesis 1983 839
20. 13C (DMSO, 125 MHz) 148.2, 144.4, 140.3, 126.8, 120.1, 116.4, 112.2, 58.3, 40.5, 36.0, 34.5, 30.1, 28.7, 26.2, 19.5.