Is the inverse association between Alzheimer's disease and cancer the result of a different propensity to methylate DNA? [9]

Medical Hypotheses

Volumn 66, Issue 6, 2006, Pages 1251-1252

  Tremolizzo, Lucio ^a   Rodriguez Menendez, Virginia ^a   Brighina, Laura ^a   Ferrarese, Carlo ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN;

ALZHEIMER DISEASE; CANCER; CANCER RESEARCH; CANCER RISK; CHROMATIN ASSEMBLY AND DISASSEMBLY; DISEASE ASSOCIATION; DNA METHYLATION; ENZYME SYNTHESIS; GENE MUTATION; GENETIC EPIGENESIS; GENETIC TRANSCRIPTION; HUMAN; LETTER; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ALZHEIMER DISEASE; CAUSALITY; COMORBIDITY; DNA METHYLATION; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; NEOPLASMS; REGRESSION ANALYSIS;

EID: 33645230794     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2005.12.022     Document Type: Letter

References (5)

1. C.M. Roe, M.I. Behrens, C. Xiong, J.P. Miller, and J.C. Morris Alzheimer disease and cancer Neurology 64 2005 895 898
2. R. Holliday DNA methylation and epigenotypes Biochemistry (Mosc) 70 2005 500 504
3. M. Menendez Pathological and clinical heterogeneity of presenilin 1 gene mutations J Alzheimers Dis 6 2004 475 482
4. A.L. Miller The methionine-homocysteine cycle and its effects on cognitive diseases Altern Med Rev 8 2003 7 19
5. A. Fuso, L. Seminara, R.A. Cavallaro, F. D'Anselmi, and S. Scarpa S-adenosylmethionine/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production Mol Cell Neurosci 28 2005 195 204