Investigation of degradation products in a topical gel containing erythromycin and benzoyl peroxide by liquid chromatography-mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis

Volumn 41, Issue 1, 2006, Pages 165-175

  Haghedooren, Erik ^a   Raju V S , Kiran Kumar Raju Bhupathi ^a   Dehouck, Pieter ^a   Govaerts, Cindy ^a   Schepdael, Ann Van ^a   Hoogmartens, Jos ^a   Adams, Erwin ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Benzoyl peroxide; Degradation products; Erythromycin; LC MS

Indexed keywords

BENZAMYCIN; BENZOYL PEROXIDE; BERYTHROMYCIN; ERYTHROMYCIN; ERYTHROMYCIN A N OXIDE; ERYTHROMYCIN C; ERYTHROMYCIN C N OXIDE; ERYTHROMYCIN D; ERYTHROMYCIN DERIVATIVE; ERYTHROMYCIN E; ERYTHROMYCIN E N OXIDE; ERYTHROMYCIN F; ERYTHROMYCIN F N OXIDE; MONOBENZOYLERYTHROMYCIN A N OXIDE; MONOBENZOYLERYTHROMYCIN B N OXIDE; MONOBENZOYLERYTHROMYCIN E N OXIDE; MONOBENZOYLERYTHROMYCIN F N OXIDE; NORERYTHROMYCIN A; TOPICAL AGENT; UNCLASSIFIED DRUG; VOLATILE AGENT;

ARTICLE; CHEMICAL MODIFICATION; CHEMICAL REACTION; DEGRADATION; DRUG DECOMPOSITION; DRUG DEGRADATION; DRUG STABILITY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; OXIDATION; PRIORITY JOURNAL;

BENZOYL PEROXIDE; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; ERYTHROMYCIN; GELS; MASS SPECTROMETRY; MODELS, CHEMICAL; TECHNOLOGY, PHARMACEUTICAL;

EID: 33645101866     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2005.11.019     Document Type: Article

References (22)

1. G.E. Piérard Rev. Med. Liège 52 1997 120 122
2. J.J. Leyden J. Am. Acad. Dermatol. 49 2003 200 210
3. J. Nyirady, C. Lucas, M. Yusuf, P. Mignone, and S. Wisniewski Cutis 70 2002 295 298
4. European Pharmacopoeia, fifth ed., Council of Europe, Strasbourg, 2005, p. 1518-1520.
5. United States Pharmacopeia, 28th ed., United States Pharmacopeial Convention, Rockville, MD, 2005, pp. 757-758.
6. J. Paesen, E. Roets, and J. Hoogmartens Chromatographia 32 1991 162 166
7. J. Paesen, D.H. Calam, J.H.McB. Miller, G. Raiola, A. Rozanski, B. Silver, and J. Hoogmartens J. Liq. Chromatogr. 16 1993 1529 1544
8. C. Govaerts, H.K. Chepkwony, A. Van Schepdael, E. Roets, and J. Hoogmartens Rapid Commun. Mass Spectrom. 14 2000 878 884
9. H.K. Chepkwony, P. Dehouck, E. Roets, and J. Hoogmartens Chromatographia 53 2001 159 165
10. S.K. Chitneni, C. Govaerts, E. Adams, A. Van Schepdael, and J. Hoogmartens J. Chromatogr. A 1056 2004 111 120
11. United States Pharmacopeia, 28th ed., United States Pharmacopeial Convention, Rockville, MD, 2005, pp. 236-237.
12. B. Vermeulen, J.P. Remon, and H. Nelis Int. J. Pharm. 178 1999 137 141
13. P. Dehouck, E. Van Looy, E. Haghedooren, K. Deckers, Y. Vander Heyden, E. Adams, E. Roets, and J. Hoogmartens J. Chromatogr. B 794 2003 293 302
14. J.R. Martin, R.S. Egan, A.W. Goldstein, and P. Collum Tetrahedron 31 1975 1985 1989
15. P.J. Atkins, T.O. Herbert, and N.B. Jones Int. J. Pharm. 30 1986 199 207
16. E.H. Flynn, E.H. Sigal, P.F. Wiley, and K. Gerzon J. Am. Chem. Soc. 76 1954 3121 3131
17. L.A. Freiberg, US Pat. 1972. 3, p. 725, 385, CA 1996.
18. H.A. Kirst, J.A. Wind, and J.W. Paschal J. Org. Chem. 52 1987 4359 4362
19. C. Vinckier, R. Hauchecorne, T. Cachet, G. Van den Mooter, and J. Hoogmartens Int. J. Pharm. 55 1989 67 76
20. P. Kurath, P.H. Jones, R.S. Egan, and T.J. Perun Experientia 27 1971 362 363
21. I.O. Kibwage, E. Roets, and J. Hoogmartens J. Chromatogr. 256 1983 164 171
22. P.J. Gates, G.C. Kearney, R. Jones, P.F. Leadley, and J. Staunton Rapid Commun. Mass Spectrom. 13 1999 242 246