The mitogen-activated protein kinase kinase (MEK) inhibitor PD98059 elevates primary cultured rat hepatocyte glutathione levels independent of inhibiting MEK

Drug Metabolism and Disposition

Volumn 34, Issue 4, 2006, Pages 683-689

  Kim, Sang K ^a,b   Abdelmegeed, Mohamed A ^a   Novak, Raymond F ^a  

^a WAYNE STATE UNIVERSITY   (United States)

^b Chungnam National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CYSTEINE; FLAVONE; GLUTATHIONE; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHEMOPROPHYLAXIS; CONCENTRATION RESPONSE; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HOMEOSTASIS; HORMONAL REGULATION; HORMONE DETERMINATION; HORMONE INHIBITION; HORMONE SYNTHESIS; LIVER CELL; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; CELL CULTURE TECHNIQUES; CELLS, CULTURED; CYSTEINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONOIDS; GLUTATHIONE; HEPATOCYTES; MALE; MAP KINASE KINASE 1; PROTEIN KINASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA;

EID: 33645100940     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.105.007666     Document Type: Article

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