Histologic characteristics of late cellular rejection, significance of centrilobular injury, and long-term outcome in pediatric liver transplant recipients

Liver Transplantation

Volumn 12, Issue 1, 2006, Pages 58-64

  Sundaram, Shikha S ^a,b   Melin Aldana, Hector ^a   Neighbors, Katie ^a   Alonso, Estella M ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b CHILDREN'S MEMORIAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN; PREDNISONE; TSUKUBAENOLIDE;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; GRAFT RECIPIENT; HEPATITIS; HISTOPATHOLOGY; HUMAN; LIVER BIOPSY; LIVER GRAFT REJECTION; LIVER INJURY; LIVER NECROSIS; LIVER TRANSPLANTATION; MORBIDITY; MORTALITY; OUTCOME ASSESSMENT; POSTOPERATIVE PERIOD; PRESCHOOL CHILD; PRIORITY JOURNAL; SCORING SYSTEM;

BIOPSY, NEEDLE; CHILD; CHILD, PRESCHOOL; CHOLESTASIS; FEMALE; GRAFT REJECTION; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; LIVER CIRRHOSIS; LIVER FUNCTION TESTS; LIVER TRANSPLANTATION; MALE; NECROSIS; PROGNOSIS; RETROSPECTIVE STUDIES; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; SURVIVAL RATE; TIME FACTORS; VASCULITIS;

EID: 33645099816     PISSN: 15276465     EISSN: 15276473     Source Type: Journal    
DOI: 10.1002/lt.20661     Document Type: Article

References (28)

1. Dhawan A, Muiesan P. Pediatric liver transplantation. Acta Paediatr Jpn 1998;40:525-529.
2. Anand AC, Hubscher SG, Gunson BK, McMaster P, Neuberger JM. Timing, significance, and prognosis of late acute liver allograft rejection. Transplantation 1995;60: 1098-1103.
3. Mor E, Gonwa TA, Husberg BS, Goldstein RM, Klintmalm GB. Late-onset acute rejection in orthotopic liver transplantation: associated risk factors and outcome. Transplantation 1992;54:821-824.
4. D'Antiga L, Dhawan A, Portmann B, Francavilla R, Rela M, Heaton N, Mieli-Vergani G. Late cellular rejection in paediatric liver transplantation: aetiology and outcome. Transplantation 2002;73:80-84.
5. Sellers M, Singer A, Maller E, Olthoff K, Jacobowski D, Shaked A. Incidence of late acute rejection and progression to chronic rejection in pediatric liver recipients. Transplant Proc 1997;29:428-429.
6. Hassoun Z, Shah V, Lohse CM, Pankratz VS, Petrovic LM. Centrilobular necrosis after orthotopic liver transplantation: association with acute cellular rejection and impact on outcome. Liver Transpl 2004;10:480-487.
7. Tsamandas AC, Jain AB, Felekouras ES, Fung JJ, Demetris AJ, Lee RG. Central venulitis in the allograft liver: a clinico-pathologic study. Transplantation 1997;64:252-257.
8. Krasinskas AM, Ruchelli ED, Rand EB, Chittams JL, Furth EE. Central venulitis in pediatric liver allografts. Hepatology 2001;33:1141-1147.
9. Demetris AJ. Central venulitis in liver allografts: considerations of differential diagnosis. Hepatology 2001;33: 1329-1330.
10. Nakazawa Y, Walker NI, Kerlin P, Steadman C, Lynch SV, Strong RW, Clouston AD. Clinicopathological analysis of liver allograft biopsies with late centrilobular necrosis: a comparative study in 54 patients. Transplantation 2000; 69:1599-1608.
11. Turlin B, Slapak GI, Hayllar KM, Heaton N, Williams R, Portmann B. Centrilobular necrosis after orthotopic liver transplantation: a longitudinal clinicopathologic study in 71 patients. Liver Transpl Surg 1995;1:285-289.
12. Lovell MO, Speeg KV, Halff GA, Molina DK, Sharkey FE. Acute hepatic allograft rejection: a comparison of patients with and without centrilobular alterations during first rejection episode. Liver Transpl 2004;10:369-373.
13. Demetris A, Adams D, Bellamy C, Blakolmer K, Clouston A, Dhillon AP, et al. Update of the International Banff Schema for Liver Allograft Rejection: working recommendations for the histopathologic staging and reporting of chronic rejection. An International Panel. Hepatology 2000;31:792-799.
14. Gouw AS, van den Heuvel MC, van den Berg AP, Slooff MJ, de Jong KP, Poppema S. The significance of parenchymal changes of acute cellular rejection in predicting chronic liver graft rejection. Transplantation 2002;73:243-247.
15. Banff schema for grading liver allograft rejection: an international consensus document. Hepatology 1997;25:658-663.
16. Kerkar N, Hadzic N, Davies ET, Portmann B, Donaldson PT, Rela M, et al. De-novo autoimmune hepatitis after liver transplantation. Lancet 1998;351:409-413.
17. Wiesner RH, Demetris AJ, Belle SH, Seaberg EC, Lake JR, Zetterman RK, et al. Acute hepatic allograft rejection: incidence, risk factors, and impact on outcome. Hepatology 1998;28:638-645.
18. Samuel D, Gugenheim J, Canon C, Saliba F, Bismuth H. Use of OKT3 for late acute rejection in liver transplantation. Transplant Proc 1990;22:1767-1768.
19. Khettry U, Backer A, Ayata G, Lewis WD, Jenkins RL, Gordon FD. Centrilobular histopathologic changes in liver transplant biopsies. Hum Pathol 2002;33:270-276.
20. Dousset B, Conti F, Cherruau B, Louvel A, Soubrane O, Houssin D, Calmus Y. Is acute rejection deleterious to long-term liver allograft function? J Hepatol 1998;29:660-668.
21. Conti F, Dousset B, Archambeau D, Louvel A, Houssin D, Calmus Y. Enhanced risk of steroid-resistant acute rejection following pretransplant steroid therapy in liver graft recipients. Transplantation 1995;60:1104-1108.
22. Allen KJ, Rand EB, Hart J, Whitington PF. Prognostic implications of centrilobular necrosis in pediatric liver transplant recipients. Transplantation 1998;65:692-698.
23. Martin SR, Russo P, Dubois J, Alvarez F. Centrilobular fibrosis in long-term follow-up of pediatric liver transplant recipients. Transplantation 2002;74:828-836.
24. Czaja AJ. Autoimmune liver disease. Curr Opin Gastroenterol 2005;21:293-299.
25. Te HS, Koukoulis G, Ganger DR. Autoimmune hepatitis: a histological variant associated with prominent centrilobular necrosis. Gut 1997;41:269-271.
26. Hytiroglou P, Lee R, Sharma K, Theise ND, Schwartz M, Miller C, Thung SN. FK506 versus cyclosporine as primary immunosuppressive agent for orthotopic liver allograft recipients. Histologic and immunopathologic observations. Transplantation 1993;56:1389-1394.
27. Hassoun Z, Shah V, Petrovic LM. The choice of calcineurin inhibitor does not influence centrilobular necrosis after orthotopic liver transplantation. Transplant Proc 2002;34: 1519-1520.
28. Wallot MA, Mathot M, Janssen M, Holter T, Paul K, Buts JP, Reding R, et al. Long-term survival and late graft loss in pediatric liver transplant recipients-a 15-year single-center experience. Liver Transpl 2002;8:615-622.