Protease variants, LDL, and coronary heart disease

New England Journal of Medicine

Volumn 354, Issue 12, 2006, Pages 1310-1312

  Tall, Alan R ^a  

^a NewYork Presbyterian Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; KEXIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; MESSENGER RNA; PCSK9 ENZYME; PROTEINASE; STEROL REGULATORY ELEMENT BINDING PROTEIN; SUBTILISIN; UNCLASSIFIED DRUG;

ATHEROSCLEROSIS; CARDIOVASCULAR RISK; CELL MEMBRANE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; EDITORIAL; FAMILIAL HYPERCHOLESTEROLEMIA; GENE MUTATION; HUMAN; ISCHEMIC HEART DISEASE; MISSENSE MUTATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

ANIMALS; CHOLESTEROL, LDL; CODON, NONSENSE; CORONARY DISEASE; GENE EXPRESSION REGULATION; HUMANS; HYPERLIPOPROTEINEMIA TYPE II; HYPOLIPOPROTEINEMIAS; MICE; MUTATION, MISSENSE; RECEPTORS, LDL; SERINE ENDOPEPTIDASES; VARIATION (GENETICS);

EID: 33645098219     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMe068026     Document Type: Editorial

References (5)

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2. Rashid S, Curtis DE, Garuti R, et al. Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9. Proc Natl Acad Sci U S A 2005;102:5374-9.
3. Maxwell KN, Fisher EA, Breslow JL. Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment. Proc Natl Acad Sci U S A 2005;102:2069-74.
4. Cohen JC, Boerwinkle E, Mosley TH Jr, Hobbs HH. Sequence variation in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med 2006;354:1264-72.
5. Carroll MD, Lacher DA, Sorlie PD, et al. Trends in serum lipids and lipoproteins of adults, 1960-2002. JAMA 2005;294:1773-81.