메뉴 건너뛰기




Volumn , Issue , 2005, Pages 293-326

Multistability and Multicellularity: Cell Fates as High-Dimensional Attractors of Gene Regulatory Networks

Author keywords

[No Author keywords available]

Indexed keywords


EID: 33645097368     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012088786-6/50033-2     Document Type: Chapter
Times cited : (5)

References (114)
  • 1
    • 0037438387 scopus 로고    scopus 로고
    • Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis
    • K. Akashi, X. He, J. Chen, H. Iwasaki, C. Niu, B. Steenhard, J. Zhang, J. Haug and L. Li (2003) Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis. Blood 101 383-389.
    • (2003) Blood , vol.101 , pp. 383-389
    • Akashi, K.1    He, X.2    Chen, J.3    Iwasaki, H.4    Niu, C.5    Steenhard, B.6    Zhang, J.7    Haug, J.8    Li, L.9
  • 2
    • 0032616683 scopus 로고    scopus 로고
    • Identification of genetic networks from a small number of gene expression patterns under the Boolean network model
    • T. Akutsu, S. Miyano and S. Kuhara (1999) Identification of genetic networks from a small number of gene expression patterns under the Boolean network model. Pac. Symp. Biocomput. 17-28.
    • (1999) Pac. Symp. Biocomput. , pp. 17-28
    • Akutsu, T.1    Miyano, S.2    Kuhara, S.3
  • 4
    • 0042808605 scopus 로고    scopus 로고
    • A natural class of robust networks
    • M. Aldana and P. Cluzel (2003) A natural class of robust networks. Proc. Natl. Acad. Sci. USA 100 8710-8714.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 8710-8714
    • Aldana, M.1    Cluzel, P.2
  • 6
    • 1242274449 scopus 로고    scopus 로고
    • Detection of multistability, bifurcations, and hysteresis in a large class of biological positive-feedback systems
    • D. Angeli, J.E. Ferrell Jr. and E.D. Sontag (2004) Detection of multistability, bifurcations, and hysteresis in a large class of biological positive-feedback systems. Proc. Natl. Acad. Sci. USA 101 1822-1827.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 1822-1827
    • Angeli, D.1    Ferrell, J.E.2    Sontag, E.D.3
  • 7
    • 5444263735 scopus 로고    scopus 로고
    • Epigenetic aspects of differentiation
    • K.L. Arney and A.G. Fisher (2004) Epigenetic aspects of differentiation. J. Cell Sci. 117 4355-4363.
    • (2004) J. Cell Sci. , vol.117 , pp. 4355-4363
    • Arney, K.L.1    Fisher, A.G.2
  • 8
    • 0030574422 scopus 로고    scopus 로고
    • Counting and classifying attractors in high dimensional dynamical systems
    • R.J. Bagley and L. Glass (1996) Counting and classifying attractors in high dimensional dynamical systems. J. Theo. Biol. 183 269-284.
    • (1996) J. Theo. Biol. , vol.183 , pp. 269-284
    • Bagley, R.J.1    Glass, L.2
  • 9
    • 0038483826 scopus 로고    scopus 로고
    • Emergence of scaling in random networks
    • A.L. Barabasi and R. Albert (1999) Emergence of scaling in random networks. Science 286 509-512.
    • (1999) Science , vol.286 , pp. 509-512
    • Barabasi, A.L.1    Albert, R.2
  • 11
    • 17144456808 scopus 로고    scopus 로고
    • Positive feedback in eukaryotic gene networks: Cell differentiation by graded to binary response conversion
    • A. Becksei, B. Seraphin and L. Serrano (2001) Positive feedback in eukaryotic gene networks: Cell differentiation by graded to binary response conversion. EMBO J. 20 2528-2535.
    • (2001) EMBO J. , vol.20 , pp. 2528-2535
    • Becksei, A.1    Seraphin, B.2    Serrano, L.3
  • 12
    • 12444301754 scopus 로고    scopus 로고
    • Structure and evolution of protein interaction networks: A statistical model for link dynamics and gene duplications
    • J. Berg, M. Lassig and A. Wagner (2004) Structure and evolution of protein interaction networks: A statistical model for link dynamics and gene duplications. BMC Evol. Biol. 4 51.
    • (2004) BMC Evol. Biol. , vol.4 , pp. 51
    • Berg, J.1    Lassig, M.2    Wagner, A.3
  • 13
    • 0037047611 scopus 로고    scopus 로고
    • MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network
    • U.S. Bhalla, P.T. Ram and R. Iyengar (2002) MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Science 297 1018-1023.
    • (2002) Science , vol.297 , pp. 1018-1023
    • Bhalla, U.S.1    Ram, P.T.2    Iyengar, R.3
  • 14
    • 0025182223 scopus 로고
    • Cross-talk between second messengers
    • M. Bouvier (1990) Cross-talk between second messengers. Ann. NY Acad. Sci. 594 120-129.
    • (1990) Ann. NY Acad. Sci. , vol.594 , pp. 120-129
    • Bouvier, M.1
  • 15
    • 0141596113 scopus 로고    scopus 로고
    • Molecular networks: The top-down view
    • D. Bray (2003) Molecular networks: The top-down view. Science 301 1864-1865.
    • (2003) Science , vol.301 , pp. 1864-1865
    • Bray, D.1
  • 16
  • 20
    • 0034696445 scopus 로고    scopus 로고
    • How to make a biological switch
    • J.L. Cherry and F.R. Adler (2000) How to make a biological switch. J. Theo. Biol. 203 117-133.
    • (2000) J. Theo. Biol. , vol.203 , pp. 117-133
    • Cherry, J.L.1    Adler, F.R.2
  • 22
    • 0036306859 scopus 로고    scopus 로고
    • Positive and negative feedback: striking a balance between necessary antagonists
    • O. Cinquin and J. Demongeot (2002) Positive and negative feedback: striking a balance between necessary antagonists. J. Theo. Biol. 216 229-241.
    • (2002) J. Theo. Biol. , vol.216 , pp. 229-241
    • Cinquin, O.1    Demongeot, J.2
  • 23
    • 0023605430 scopus 로고
    • The HL-60 promyelocytic leukemia cell line: Proliferation, differentiation, and cellular oncogene expression
    • S.J. Collins (1987) The HL-60 promyelocytic leukemia cell line: Proliferation, differentiation, and cellular oncogene expression. Blood 70 1233-1244.
    • (1987) Blood , vol.70 , pp. 1233-1244
    • Collins, S.J.1
  • 25
    • 0034574602 scopus 로고    scopus 로고
    • The establishment of Spemann's organizer and patterning of the vertebrate embryo
    • E.M. De Robertis, J. Larrain, M. Oelgeschlager and O. Wessely (2000) The establishment of Spemann's organizer and patterning of the vertebrate embryo. Nat. Rev. Genet. 1 171-181.
    • (2000) Nat. Rev. Genet. , vol.1 , pp. 171-181
    • De Robertis, E.M.1    Larrain, J.2    Oelgeschlager, M.3    Wessely, O.4
  • 26
    • 84956252965 scopus 로고
    • Random networks of automata: A simple annealed approximation
    • B. Derrida and Y. Pomeau (1986) Random networks of automata: A simple annealed approximation. Europhys. Lett. 1 45-49.
    • (1986) Europhys. Lett. , vol.1 , pp. 45-49
    • Derrida, B.1    Pomeau, Y.2
  • 27
    • 0033736476 scopus 로고    scopus 로고
    • Genetic network inference: From co-expression clustering to reverse engineering
    • P. D'Haeseleer, S. Liang and R. Somogyi (2000) Genetic network inference: From co-expression clustering to reverse engineering. Bioinformatics 16 707-726.
    • (2000) Bioinformatics , vol.16 , pp. 707-726
    • D'Haeseleer, P.1    Liang, S.2    Somogyi, R.3
  • 29
    • 0038692119 scopus 로고    scopus 로고
    • Human housekeeping genes are compact
    • E. Eisenberg and E.Y. Levanon (2003) Human housekeeping genes are compact. Trends Genet. 19 362-365.
    • (2003) Trends Genet. , vol.19 , pp. 362-365
    • Eisenberg, E.1    Levanon, E.Y.2
  • 30
    • 0035905782 scopus 로고    scopus 로고
    • Modelling cellular behaviour
    • D. Endy and R. Brent (2001) Modelling cellular behaviour. Nature 409 391-395.
    • (2001) Nature , vol.409 , pp. 391-395
    • Endy, D.1    Brent, R.2
  • 31
    • 0032504051 scopus 로고    scopus 로고
    • Loops, lineage, and leukemia
    • T. Enver and M. Greaves (1998) Loops, lineage, and leukemia. Cell 94 9-12.
    • (1998) Cell , vol.94 , pp. 9-12
    • Enver, T.1    Greaves, M.2
  • 34
    • 0033001953 scopus 로고    scopus 로고
    • Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes
    • D. Fambrough, K. McClure, A. Kazlauskas and E.S. Lander (1999) Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes. Cell 97 727-741.
    • (1999) Cell , vol.97 , pp. 727-741
    • Fambrough, D.1    McClure, K.2    Kazlauskas, A.3    Lander, E.S.4
  • 35
    • 0035650176 scopus 로고    scopus 로고
    • From topology to dynamics in biochemical networks
    • J.J. Fox and C.C. Hill (2001) From topology to dynamics in biochemical networks. Chaos 11 809-815.
    • (2001) Chaos , vol.11 , pp. 809-815
    • Fox, J.J.1    Hill, C.C.2
  • 37
    • 11244264337 scopus 로고    scopus 로고
    • Loss of gata1 but not gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos
    • J.L. Galloway, R.A. Wingert, C. Thisse, B. Thisse and L.I. Zon (2005) Loss of gata1 but not gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos. Dev. Cell 8 109-116.
    • (2005) Dev. Cell , vol.8 , pp. 109-116
    • Galloway, J.L.1    Wingert, R.A.2    Thisse, C.3    Thisse, B.4    Zon, L.I.5
  • 38
    • 36949041214 scopus 로고
    • Connectance of large dynamic (cybernetic) systems: Critical values for stability
    • M.R. Gardner and W.R. Ashby (1970) Connectance of large dynamic (cybernetic) systems: Critical values for stability. Nature 228 784.
    • (1970) Nature , vol.228 , pp. 784
    • Gardner, M.R.1    Ashby, W.R.2
  • 39
    • 0034688174 scopus 로고    scopus 로고
    • Construction of a genetic toggle switch in Escherichia coli
    • T.S. Gardner, C.R. Cantor and J.J. Collins (2000) Construction of a genetic toggle switch in Escherichia coli. Nature 403 339-342.
    • (2000) Nature , vol.403 , pp. 339-342
    • Gardner, T.S.1    Cantor, C.R.2    Collins, J.J.3
  • 40
    • 0038048325 scopus 로고    scopus 로고
    • Inferring genetic networks and identifying compound mode of action via expression profiling
    • T.S. Gardner, D. di Bernardo, D. Lorenz and J.J. Collins (2003) Inferring genetic networks and identifying compound mode of action via expression profiling. Science 301 102-105.
    • (2003) Science , vol.301 , pp. 102-105
    • Gardner, T.S.1    di Bernardo, D.2    Lorenz, D.3    Collins, J.J.4
  • 41
    • 0036519296 scopus 로고    scopus 로고
    • Haematopoietic cell-fate decisions, chromatin regulation and ikaros
    • K. Georgopoulos (2002) Haematopoietic cell-fate decisions, chromatin regulation and ikaros. Nat. Rev. Immunol. 2 162-174.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 162-174
    • Georgopoulos, K.1
  • 42
    • 4444258534 scopus 로고    scopus 로고
    • Chromatin architecture of the human genome: Gene-rich domains are enriched in open chromatin fibers
    • N. Gilbert, S. Boyle, H. Fiegler, K. Woodfine, N.P. Carter and W.A. Bickmore (2004) Chromatin architecture of the human genome: Gene-rich domains are enriched in open chromatin fibers. Cell 118 555-566.
    • (2004) Cell , vol.118 , pp. 555-566
    • Gilbert, N.1    Boyle, S.2    Fiegler, H.3    Woodfine, K.4    Carter, N.P.5    Bickmore, W.A.6
  • 44
    • 0015609281 scopus 로고
    • The logical analysis of continuous, non-linear biochemical control networks
    • L. Glass and S.A. Kauffman (1973) The logical analysis of continuous, non-linear biochemical control networks. J. Theo. Biol. 39 103-129.
    • (1973) J. Theo. Biol. , vol.39 , pp. 103-129
    • Glass, L.1    Kauffman, S.A.2
  • 45
    • 0003343268 scopus 로고
    • The strategy of growth
    • H. Teir, T. Rytaumaa (Eds), London: Academic Press
    • R.J. Goss (1967) The strategy of growth. H. Teir, T. Rytaumaa (Eds) Control of Cellular Growth in the Adult Organism London: Academic Press 3-27.
    • (1967) Control of Cellular Growth in the Adult Organism , pp. 3-27
    • Goss, R.J.1
  • 46
    • 0036566226 scopus 로고    scopus 로고
    • Differentiation plasticity of hematopoietic cells
    • T. Graf (2002) Differentiation plasticity of hematopoietic cells. Blood 99 3089-3101.
    • (2002) Blood , vol.99 , pp. 3089-3101
    • Graf, T.1
  • 47
    • 0041806587 scopus 로고    scopus 로고
    • GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling
    • J.A. Grass, M.E. Boyer, S. Pal, J. Wu, M.J. Weiss and E.H. Bresnick (2003) GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling. Proc. Natl. Acad. Sci. USA 100 8811-8816.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 8811-8816
    • Grass, J.A.1    Boyer, M.E.2    Pal, S.3    Wu, J.4    Weiss, M.J.5    Bresnick, E.H.6
  • 48
    • 85040473565 scopus 로고    scopus 로고
    • A model of transcriptional regulatory networks based on biases in the observed regulation rules
    • S.E. Harris, B.K. Sawhill, A. Wuensche and S.A. Kauffman (2002) A model of transcriptional regulatory networks based on biases in the observed regulation rules. Complexity 7 23-40.
    • (2002) Complexity , vol.7 , pp. 23-40
    • Harris, S.E.1    Sawhill, B.K.2    Wuensche, A.3    Kauffman, S.A.4
  • 51
    • 0032809387 scopus 로고    scopus 로고
    • Gene expression profiling, genetic networks, and cellular states: An integrating concept for tumorigenesis and drug discovery
    • S. Huang (1999) Gene expression profiling, genetic networks, and cellular states: An integrating concept for tumorigenesis and drug discovery. J. Mol. Med. 77 469-480.
    • (1999) J. Mol. Med. , vol.77 , pp. 469-480
    • Huang, S.1
  • 52
    • 0034850921 scopus 로고    scopus 로고
    • Genomics, complexity and drug discovery: Insights from Boolean network models of cellular regulation
    • S. Huang (2001) Genomics, complexity and drug discovery: Insights from Boolean network models of cellular regulation. Pharmacogenomics 2 203-222.
    • (2001) Pharmacogenomics , vol.2 , pp. 203-222
    • Huang, S.1
  • 53
    • 2442583455 scopus 로고    scopus 로고
    • Regulation of cellular states in mammalian cells from a genome-wide view
    • J. Collado-Vides, R.C. Hofestadt (Eds), Cambridge, MA: MIT Press
    • S. Huang (2002) Regulation of cellular states in mammalian cells from a genome-wide view. J. Collado-Vides, R.C. Hofestadt (Eds) Gene Regulation and Metabolism: Post-Genomic Computational Approach Cambridge, MA: MIT Press 181-220.
    • (2002) Gene Regulation and Metabolism: Post-Genomic Computational Approach , pp. 181-220
    • Huang, S.1
  • 54
    • 3042721988 scopus 로고    scopus 로고
    • Back to the biology in systems biology: What can we learn from biomolecular networks
    • S. Huang (2004) Back to the biology in systems biology: What can we learn from biomolecular networks. Brief Funct. Genomics Proteomics 2 279-297.
    • (2004) Brief Funct. Genomics Proteomics , vol.2 , pp. 279-297
    • Huang, S.1
  • 55
    • 0034715919 scopus 로고    scopus 로고
    • Shape-dependent control of cell growth, differentiation, and apoptosis: Switching between attractors in cell regulatory networks
    • S. Huang and D.E. Ingber (2000) Shape-dependent control of cell growth, differentiation, and apoptosis: Switching between attractors in cell regulatory networks. Exp. Cell Res. 261 91-103.
    • (2000) Exp. Cell Res. , vol.261 , pp. 91-103
    • Huang, S.1    Ingber, D.E.2
  • 56
    • 18144408736 scopus 로고    scopus 로고
    • Cell fate as high-dimensional attractor of a complex gene regulatory network
    • S. Huang, G.S. Eichler, Y. Bar-Yam and D.E. Ingber (2005) Cell fate as high-dimensional attractor of a complex gene regulatory network. Phys. Rev. Lett. (in press)
    • (2005) Phys. Rev. Lett.
    • Huang, S.1    Eichler, G.S.2    Bar-Yam, Y.3    Ingber, D.E.4
  • 57
    • 0034307684 scopus 로고    scopus 로고
    • Probability in transcriptional regulation and its implications for leukocyte differentiation and inducible gene expression
    • D.A. Hume (2000) Probability in transcriptional regulation and its implications for leukocyte differentiation and inducible gene expression. Blood 96 2323-2328.
    • (2000) Blood , vol.96 , pp. 2323-2328
    • Hume, D.A.1
  • 58
    • 0036960243 scopus 로고    scopus 로고
    • The changing concept of epigenetics
    • E. Jablonka and M.J. Lamb (2002) The changing concept of epigenetics. Ann. N. Y Acad. Sci. 981 82-96.
    • (2002) Ann. N. Y Acad. Sci. , vol.981 , pp. 82-96
    • Jablonka, E.1    Lamb, M.J.2
  • 59
    • 4444311806 scopus 로고    scopus 로고
    • A proposal for using the ensemble approach to understand genetic regulatory networks
    • S. Kauffman (2004) A proposal for using the ensemble approach to understand genetic regulatory networks. J. Theo. Biol. 230 581-590.
    • (2004) J. Theo. Biol. , vol.230 , pp. 581-590
    • Kauffman, S.1
  • 61
    • 0014489272 scopus 로고
    • Metabolic stability and epigenesis in randomly constructed genetic nets
    • S.A. Kauffman (1969) Metabolic stability and epigenesis in randomly constructed genetic nets. J. Theo. Biol. 22 437-467.
    • (1969) J. Theo. Biol. , vol.22 , pp. 437-467
    • Kauffman, S.A.1
  • 63
    • 0842324785 scopus 로고    scopus 로고
    • The nucleosome: From genomic organization to genomic regulation
    • S. Khorasanizadeh (2004) The nucleosome: From genomic organization to genomic regulation. Cell 116 259-272.
    • (2004) Cell , vol.116 , pp. 259-272
    • Khorasanizadeh, S.1
  • 64
    • 0019996706 scopus 로고
    • Amplification and adaptation in regulatory and sensory systems
    • D.E. Koshland Jr., A. Goldbeter and J.B. Stock (1982) Amplification and adaptation in regulatory and sensory systems. Science 217 220-225.
    • (1982) Science , vol.217 , pp. 220-225
    • Koshland, D.E.1    Goldbeter, A.2    Stock, J.B.3
  • 65
    • 11144277879 scopus 로고    scopus 로고
    • A crack in histone lysine methylation
    • S. Kubicek and T. Jenuwein (2004) A crack in histone lysine methylation. Cell 119 903-906.
    • (2004) Cell , vol.119 , pp. 903-906
    • Kubicek, S.1    Jenuwein, T.2
  • 67
    • 0033230728 scopus 로고    scopus 로고
    • Multistability: A major means of differentiation and evolution in biological systems
    • M. Laurent and N. Kellershohn (1999) Multistability: A major means of differentiation and evolution in biological systems. Trends Biochem. Sci. 24 418-422.
    • (1999) Trends Biochem. Sci. , vol.24 , pp. 418-422
    • Laurent, M.1    Kellershohn, N.2
  • 69
    • 0037213715 scopus 로고    scopus 로고
    • Gene expression and the myth of the average cell
    • J.M. Levsky and R.H. Singer (2003) Gene expression and the myth of the average cell. Trends Cell Biol 13 4-6.
    • (2003) Trends Cell Biol , vol.13 , pp. 4-6
    • Levsky, J.M.1    Singer, R.H.2
  • 71
    • 0031616241 scopus 로고    scopus 로고
    • Reveal, a general reverse engineering algorithm for inference of genetic network architectures
    • S. Liang, S. Fuhrman and R. Somogyi (1998) Reveal, a general reverse engineering algorithm for inference of genetic network architectures. Pac. Symp. Biocomput. 18-29.
    • (1998) Pac. Symp. Biocomput. , pp. 18-29
    • Liang, S.1    Fuhrman, S.2    Somogyi, R.3
  • 73
    • 0035409444 scopus 로고    scopus 로고
    • The path not taken
    • E.M. Marcotte (2001) The path not taken. Nat. Biotechnol. 19 626-627.
    • (2001) Nat. Biotechnol. , vol.19 , pp. 626-627
    • Marcotte, E.M.1
  • 74
    • 0015514970 scopus 로고
    • Will a large complex system be stable?
    • R.M. May (1972) Will a large complex system be stable? Nature 238 413-414.
    • (1972) Nature , vol.238 , pp. 413-414
    • May, R.M.1
  • 75
    • 0027375186 scopus 로고
    • Lineage commitment in human hemopoiesis involves asymmetric cell division of multipotent progenitors and does not appear to be influenced by cytokines
    • H. Mayani, W. Dragowska and P.M. Lansdorp (1993) Lineage commitment in human hemopoiesis involves asymmetric cell division of multipotent progenitors and does not appear to be influenced by cytokines. J. Cell Physiol. 157 579-586.
    • (1993) J. Cell Physiol. , vol.157 , pp. 579-586
    • Mayani, H.1    Dragowska, W.2    Lansdorp, P.M.3
  • 76
    • 0037197962 scopus 로고    scopus 로고
    • Characterization of the c-MYC-regulated transcriptome by SAGE: Identification and analysis of c-MYC target genes
    • A. Menssen and H. Hermeking (2002) Characterization of the c-MYC-regulated transcriptome by SAGE: Identification and analysis of c-MYC target genes. Proc. Natl. Acad. Sci. USA 99 6274-6279.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 6274-6279
    • Menssen, A.1    Hermeking, H.2
  • 78
    • 0000702702 scopus 로고    scopus 로고
    • Statistical mechanics of voting
    • D.A. Meyer and T.A. Brown (1998) Statistical mechanics of voting. Phys. Rev. 81 1718-1721.
    • (1998) Phys. Rev. , vol.81 , pp. 1718-1721
    • Meyer, D.A.1    Brown, T.A.2
  • 81
    • 73049167504 scopus 로고
    • Teleonomic mechanisms in cellular metabolism, growth, and differentiation
    • J. Monod and F. Jacob (1961) Teleonomic mechanisms in cellular metabolism, growth, and differentiation. Cold Spring Harb. Symp. Quant. Biol. 26 389-401.
    • (1961) Cold Spring Harb. Symp. Quant. Biol. , vol.26 , pp. 389-401
    • Monod, J.1    Jacob, F.2
  • 82
    • 0030088078 scopus 로고    scopus 로고
    • Chromatin diminution in nematodes
    • F. Muller, V. Bernard and H. Tobler (1996) Chromatin diminution in nematodes. Bioessays 18 133-138.
    • (1996) Bioessays , vol.18 , pp. 133-138
    • Muller, F.1    Bernard, V.2    Tobler, H.3
  • 83
    • 85147616647 scopus 로고    scopus 로고
    • Personal Coummonication
    • Myer, J. (2001). Personal Coummonication.
    • (2001)
    • Myer, J.1
  • 84
    • 0034656393 scopus 로고    scopus 로고
    • GATA-1 interacts with the myeloid PU.1 transcription factor and represses PU.1-dependent transcription
    • C. Nerlov, E. Querfurth, H. Kulessa and T. Graf (2000) GATA-1 interacts with the myeloid PU.1 transcription factor and represses PU.1-dependent transcription. Blood 95 2543-2551.
    • (2000) Blood , vol.95 , pp. 2543-2551
    • Nerlov, C.1    Querfurth, E.2    Kulessa, H.3    Graf, T.4
  • 85
    • 0001389945 scopus 로고
    • Enzyme induction as an all-or-none phenomenon
    • A. Novick and M. Weiner (1957) Enzyme induction as an all-or-none phenomenon. Proc. Natl. Acad. Sci. USA 43 553-566.
    • (1957) Proc. Natl. Acad. Sci. USA , vol.43 , pp. 553-566
    • Novick, A.1    Weiner, M.2
  • 87
    • 0036435483 scopus 로고    scopus 로고
    • Roles of hematopoietic transcription factors GATA-1 and GATA-2 in the development of red blood cell lineage
    • K. Ohneda and M. Yamamoto (2002) Roles of hematopoietic transcription factors GATA-1 and GATA-2 in the development of red blood cell lineage. Acta Haematol. 108 237-245.
    • (2002) Acta Haematol. , vol.108 , pp. 237-245
    • Ohneda, K.1    Yamamoto, M.2
  • 88
  • 89
    • 0842285841 scopus 로고    scopus 로고
    • Summing up the noise in gene networks
    • J. Paulsson (2004) Summing up the noise in gene networks. Nature 427 415-418.
    • (2004) Nature , vol.427 , pp. 415-418
    • Paulsson, J.1
  • 90
    • 0034691214 scopus 로고    scopus 로고
    • Stochastic focusing: Fluctuationenhanced sensitivity of intracellular regulation
    • J. Paulsson, O.G. Berg and M. Ehrenberg (2000) Stochastic focusing: Fluctuationenhanced sensitivity of intracellular regulation. Proc. Natl. Acad. Sci. USA 97 7148-7153.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 7148-7153
    • Paulsson, J.1    Berg, O.G.2    Ehrenberg, M.3
  • 93
    • 0026504147 scopus 로고
    • Social controls on cell survival and cell death
    • M.C. Raff (1992) Social controls on cell survival and cell death. Nature 356 397-400.
    • (1992) Nature , vol.356 , pp. 397-400
    • Raff, M.C.1
  • 94
    • 0037199968 scopus 로고    scopus 로고
    • Hierarchical organization of modularity in metabolic networks
    • E. Ravasz, A.L. Somera, D.A. Mongru, Z.N. Oltvai and A.L. Barabasi (2002) Hierarchical organization of modularity in metabolic networks. Science 297 1551-1555.
    • (2002) Science , vol.297 , pp. 1551-1555
    • Ravasz, E.1    Somera, A.L.2    Mongru, D.A.3    Oltvai, Z.N.4    Barabasi, A.L.5
  • 95
    • 0025237515 scopus 로고
    • On the nature of enduring modifications induced in cells and organisms
    • H. Rubin (1990) On the nature of enduring modifications induced in cells and organisms. Am. J. Physiol. 258 L19-L24.
    • (1990) Am. J. Physiol. , vol.258 , pp. L19-L24
    • Rubin, H.1
  • 97
    • 0029134903 scopus 로고
    • Michaelis-Menten mechanism reconsidered: Implications of fractal kinetics
    • M.A. Savageau (1995) Michaelis-Menten mechanism reconsidered: Implications of fractal kinetics. J. Theo. Biol. 176 115-124.
    • (1995) J. Theo. Biol. , vol.176 , pp. 115-124
    • Savageau, M.A.1
  • 98
    • 0032720438 scopus 로고    scopus 로고
    • GM-CSF stimulates proliferation of clonal leukemic bone marrow cells in acute myeloid leukemia (AML) in vitro
    • H.M. Schmetzer, H.H. Gerhartz and W. Wilmanns (1999) GM-CSF stimulates proliferation of clonal leukemic bone marrow cells in acute myeloid leukemia (AML) in vitro. Ann. Hematol. 78 449-455.
    • (1999) Ann. Hematol. , vol.78 , pp. 449-455
    • Schmetzer, H.M.1    Gerhartz, H.H.2    Wilmanns, W.3
  • 100
    • 0036578795 scopus 로고    scopus 로고
    • Network motifs in the transcriptional regulation network of Escherichia coli
    • S.S. Shen-Orr, R. Milo, S. Mangan and U. Alon (2002) Network motifs in the transcriptional regulation network of Escherichia coli. Nat. Genet. 31 64-68.
    • (2002) Nat. Genet. , vol.31 , pp. 64-68
    • Shen-Orr, S.S.1    Milo, R.2    Mangan, S.3    Alon, U.4
  • 101
    • 85088493259 scopus 로고    scopus 로고
    • Activities and sensitivities in Boolean network models
    • I. Shmulevich and S.A. Kauffman (2004) Activities and sensitivities in Boolean network models. Phys. Rev. Lett. (in press)
    • (2004) Phys. Rev. Lett.
    • Shmulevich, I.1    Kauffman, S.A.2
  • 102
    • 2942617034 scopus 로고    scopus 로고
    • Has the yo-yo stopped? An assessment of human protein-coding gene number
    • C. Southan (2004) Has the yo-yo stopped? An assessment of human protein-coding gene number. Proteomics 4 1712-1726.
    • (2004) Proteomics , vol.4 , pp. 1712-1726
    • Southan, C.1
  • 103
    • 0035826155 scopus 로고    scopus 로고
    • Exploring complex networks
    • S.H. Strogatz (2001) Exploring complex networks. Nature 410 268-276.
    • (2001) Nature , vol.410 , pp. 268-276
    • Strogatz, S.H.1
  • 104
    • 0242285692 scopus 로고    scopus 로고
    • TGF-beta switches from tumor suppressor to prometastatic factor in a model of breast cancer progression
    • B. Tang, M. Vu, T. Booker, S.J. Santner, F.R. Miller, M.R. Anver and L.M. Wakefield (2003) TGF-beta switches from tumor suppressor to prometastatic factor in a model of breast cancer progression. J. Clin. Invest. 112 1116-1124.
    • (2003) J. Clin. Invest. , vol.112 , pp. 1116-1124
    • Tang, B.1    Vu, M.2    Booker, T.3    Santner, S.J.4    Miller, F.R.5    Anver, M.R.6    Wakefield, L.M.7
  • 105
    • 10944230777 scopus 로고    scopus 로고
    • Duplication and divergence: The evolution of new genes and old ideas
    • J.S. Taylor and J. Raes (2004) Duplication and divergence: The evolution of new genes and old ideas. Ann. Rev. Genet. 38 615-643.
    • (2004) Ann. Rev. Genet. , vol.38 , pp. 615-643
    • Taylor, J.S.1    Raes, J.2
  • 106
    • 0018080896 scopus 로고
    • Logical analysis of systems comprising feedback loops
    • R. Thomas (1978) Logical analysis of systems comprising feedback loops. J. Theo. Biol. 73 631-656.
    • (1978) J. Theo. Biol. , vol.73 , pp. 631-656
    • Thomas, R.1
  • 107
    • 0037376655 scopus 로고    scopus 로고
    • Sniffers, buzzers, toggles and blinkers: Dynamics of regulatory and signaling pathways in the cell
    • J.J. Tyson, K.C. Chen and B. Novak (2003) Sniffers, buzzers, toggles and blinkers: Dynamics of regulatory and signaling pathways in the cell. Curr. Opin. Cell Biol. 15 221-231.
    • (2003) Curr. Opin. Cell Biol. , vol.15 , pp. 221-231
    • Tyson, J.J.1    Chen, K.C.2    Novak, B.3
  • 109
    • 0032482432 scopus 로고    scopus 로고
    • Collective dynamics of “small-world” networks
    • D.J. Watts and S.H. Strogatz (1998) Collective dynamics of “small-world” networks. Nature 393 440-442.
    • (1998) Nature , vol.393 , pp. 440-442
    • Watts, D.J.1    Strogatz, S.H.2
  • 110
    • 0031630211 scopus 로고    scopus 로고
    • Genomic regulation modeled as a network with basins of attraction
    • A. Wuensche (1998) Genomic regulation modeled as a network with basins of attraction. Pac. Symp. Biocomput. 89-102.
    • (1998) Pac. Symp. Biocomput. , pp. 89-102
    • Wuensche, A.1
  • 111
    • 0345359924 scopus 로고    scopus 로고
    • A positive-feedback-based bistable “memory module’ that governs a cell fate decision
    • W. Xiong and J.E. Ferrell Jr. (2003) A positive-feedback-based bistable “memory module’ that governs a cell fate decision. Nature 426 460-465.
    • (2003) Nature , vol.426 , pp. 460-465
    • Xiong, W.1    Ferrell, J.E.2
  • 112
    • 0037197936 scopus 로고    scopus 로고
    • Reverse engineering gene networks using singular value decomposition and robust regression
    • M.K. Yeung, J. Tegner and J.J. Collins (2002) Reverse engineering gene networks using singular value decomposition and robust regression. Proc. Natl. Acad. Sci. USA 99 6163-6168.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 6163-6168
    • Yeung, M.K.1    Tegner, J.2    Collins, J.J.3
  • 114
    • 0028364906 scopus 로고
    • MyoD1 promoter autoregulation is mediated by two proximal E-boxes
    • J.M. Zingg, G. Pedraza-Alva and J.P. Jost (1994) MyoD1 promoter autoregulation is mediated by two proximal E-boxes. Nucleic Acids Res. 22 2234-2241.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 2234-2241
    • Zingg, J.M.1    Pedraza-Alva, G.2    Jost, J.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.