Current topics in pharmacological research on bone metabolism: Regulation of bone mass by the function of endogenous modulators of bone morphogenetic protein in adult stage

Journal of Pharmacological Sciences

Volumn 100, Issue 3, 2006, Pages 211-214

  Noda, Masaki ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Bone formation; Bone mass; Bone morphogenetic protein; Bone resorption; Tob

Indexed keywords

BINDING PROTEIN; BONE MORPHOGENETIC PROTEIN; CYTOKINE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN; FIBROBLAST GROWTH FACTOR; LUCIFERASE; MESSENGER RNA; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN TOB; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR ALPHA; UNCLASSIFIED DRUG;

BONE MASS; BONE METABOLISM; BONE REGENERATION; BONE REMODELING; CANCELLOUS BONE; CELL STRUCTURE; DRUG RESEARCH; MORPHOMETRICS; NONHUMAN; OSTEOLYSIS; OVARIECTOMY; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SHORT SURVEY;

EID: 33645094647     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.FMJ05004X6     Document Type: Short Survey

References (5)

1. Yoshida Y, Tanaka S, Umemori H, Minowa O, Usui M, Ikematsu N, et al. Negative regulation of BMP /Smad signaling by Tob in osteoblasts. Cell. 2000;103:1085-1097.
2. Usui M, Yoshida Y, Yamashita T, Tsuji K, Isao I, Yamamoto T, et al. Enhancing effect of Tob deficiency on bone formation is specific to bone morphogenetic protein-induced osteogenesis. J Bone Miner Res. 2002;17:1026-1033.
3. Morinobu M, Nakamoto T, Hino K, Tsuji K, Shen ZJ, Nakashima K, et al. The nucleocytoplasmic shuttling protein CIZ reduces adult bone mass by inhibiting bone morphogenetic protein-induced bone formation. J Exp Med. 2005;201:961-970.
4. Usui M, Yoshida Y, Tsuji K, Oikawa K, Miyazono K, Ishikawa I, et al. Tob deficiency superenhances osteoblastic activity after ovariectomy to block estrogen deficiency-induced osteoporosis. Proc Natl Acad Sci U S A. 2004;101:6653-6658.
5. Shen ZJ, Nakamoto T, Tsuji K, Nifuji A, Miyazono K, Komori T, et al. Negative regulation of bone morphogenetic protein /Smad signaling by Cas-interacting zinc finger protein in osteoblasts. J Biol Chem. 2002;277:29840-29846.