Structure of the neuronal protein calexcitin suggests a mode of interaction in signalling pathways of learning and memory

Journal of Molecular Biology

Volumn 357, Issue 5, 2006, Pages 1536-1547

  Erskine, P T ^a   Beaven, G D E ^a   Hagan, R ^a   Findlow, I S ^a   Werner, J M ^a   Wood, S P ^a   Vernon, J ^b   Giese, K P ^b   Fox, G ^c   Cooper, J B ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c EUROPEAN SYNCHROTRON RADIATION FACILITY   (France)

Author keywords

Calcium sensing; GTPase; Learning and memory; Signal transduction; X ray structure

Indexed keywords

AMINO ACID DERIVATIVE; CALCIUM BINDING PROTEIN; CALCIUM ION; CALMODULIN; FISH PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; POTASSIUM CHANNEL; PROTEIN CALEXCITIN; RYANODINE RECEPTOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CALCIUM BINDING; CONDITIONING; CRYSTAL STRUCTURE; HYDROPHOBICITY; LEARNING; MEMORY; MUTAGENESIS; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; PROTEIN TARGETING; SARCOPLASMIC RETICULUM; UPREGULATION; X RAY ANALYSIS;

BRANCHIOSTOMA LANCEOLATUM; LOLIGO PEALEI;

EID: 33645088176     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2006.01.083     Document Type: Article

References (36)

1. T.J. Nelson, C. Collin, and D.L. Alkon Isolation of a G protein that is modified by learning and reduces potassium currents in Hermissenda Science 247 1990 1479 1483
2. D.L. Alkon, and T.J. Nelson Specificity of molecular changes in neurons involved in memory storage FASEB J. 4 1990 1567 1576
3. T.J. Nelson, S. Cavallaro, C.-L. Yi, D. McPhie, B.G. Schreurs, and P.A. Gusev Calexcitin: a signaling protein that binds calcium and GTP, inhibits potassium channels, and enhances membrane excitability Proc. Natl Acad. Sci. USA 93 1996 13808 13813
4. T.J. Nelson, T. Yoshioka, S. Toyoshima, Y.-F. Fan, and D.L. Alkon Characterisation of a GTP-binding protein implicated in both memory storage and inter-organelle vesicle transport Proc. Natl Acad. Sci. USA 91 1994 9287 9291
5. T.J. Nelson, and D. Alkon Phosphorylation of the conditioning-associated GTP-binding protein cp20 by protein kinase C J. Neurochem. 65 1995 2350 2357
6. Z. Gombos, A. Jeromin, T.K. Mal, A. Chakrabartty, and M. Ikura Calexcitin B is a new member of the sarcoplasmic calcium-binding protein family J. Biol. Chem. 276 2001 22529 22536
7. S. Cavallaro, N. Meiri, C.-L. Yi, S. Musco, W. Ma, J. Goldberg, and D.L. Alkon Late memory-related genes in the hippocampus revealed by RNA fingerprinting Proc. Natl Acad. Sci. USA 94 1997 9669 9673
8. T.J. Nelson, W.-Q. Zhao, S. Yuan, A. Favit, L. Pozzo-Miller, and D.H. Alkon Calexcitin interaction with neuronal ryanodine receptors Biochem. J. 341 1999 423 433
9. W.J. Cook, L.C. Jeffrey, J.A. Cox, and S. Vijay-Kumar Structure of a sarcoplasmic calcium-binding protein from Amphioxus refined at 2.4 Å resolution J. Mol. Biol. 229 1993 461 471
10. S. Vijay-Kumar, and W.J. Cook Structure of a sarcoplasmic calcium-binding protein from Nereis diversicolor refined at 2.0 Å resolution J. Mol. Biol. 224 1992 413 426
11. 2+-induced conformational change of calexcitin, a learning-associated protein J. Biol. Chem. 272 1997 24771 24779
12. T.J. Nelson, A. Quattrone, J. Kim, A. Pacini, V. Cesati, and D.L. Alkon Calcium-regulated GTPase activity in the calcium-binding protein calexcitin Comp. Biochem. Physiol. ser. B 135 2003 627 638
13. R.A. Maxwell, W.H. Welch, and D.A. Schooley Juvenile hormone diol kinase I. Purification, characterization and substrate specificity of juvenile hormone-selective diol kinase from Manduca sexta J. Biol. Chem. 277 2002 21874 21881
14. R.A. Maxwell, W.H. Welch, F.M. Horodyski, K.M. Schegg, and D.A. Schooley Juvenile hormone diol kinase II. Sequencing, cloning and molecular modeling of juvenile hormone-selective diol kinase from Manduca sexta J. Biol. Chem. 277 2002 21882 21890
15. S. Li, Q.-R. Zhang, W.-H. Xu, and D.A. Schooley Juvenile hormone diol kinase, a calcium-binding protein with kinase activity, from the silkworm, Bombyx mori Insect Biochem. Mol. Biol. 35 2005 1235 1248
16. R.A. Laskowski, M.W. MacArthur, D.S. Moss, and J.M. Thornton PROCHECK: a program to check the stereochemical quality of protein structures J. Appl. Crystallog. 26 1993 283 291
17. A.R. Rhoads, and F. Friedberg Sequence motifs for calmodulin recognition FASEB J. 11 1997 331 340
18. K.L. Yap, J.B. Ames, M.B. Swindells, and M. Ikura Diversity of conformational states and changes within the EF-hand superfamily Proteins: Struct. Funct. Genet. 37 1999 499 507
19. K.L. Yap, J.B. Ames, M.B. Swindells, and M. Ikura Vector geometry mapping: a method to characterise the conformation of helix-loop-helix calcium binding proteins Methods Mol. Biol. 173 2001 317 324
20. S. Mirzoeva, S. Weigand, T.J. Lukas, L. Shuvalova, W.F. Anderson, and D.M. Watterson Analysis of the functional coupling between calmodulin's calcium binding and peptide recognition properties Biochemistry 38 1999 3936 3947
21. R. Minakami, N. Jinnai, and H. Sugiyama Phosphorylation and calmodulin binding of the metabotropic glutamate receptor subtype 5 (mGluR5) are antagonistic in vitro J. Biol. Chem. 272 1997 20291 20298
22. Y. Nakajima, T. Yamamoto, T. Nakayama, and S. Nakanishi A relationship between protein kinase C phosphorylation and calmodulin binding to the metabotropic glutamate receptor subtype 7 J. Biol. Chem. 274 1999 27573 27577
23. A. Nicholls, K. Sharp, and B. Honig Protein folding and association-insights from the interfacial and thermodynamic properties of hydrocarbons Proteins: Struct. Funct. Genet. 11 1991 281 296
24. E.J.M. Helmreich Structural versatility of small GTPases. Can it explain their functional versatility? Biol. Chem. 385 2004 1121 1136
25. M. Bahler, and A. Rhoads Calmodulin signaling via the IQ motif FEBS Letters 513 2002 107 113
26. 2+-calmodulin Nature Struct. Biol. 1 1994 795 801
27. G.D.E. Beaven, P.T. Erskine, J.N. Wright, F. Mohammed, R. Gill, and S.P. Wood Crystallisation and preliminary X-ray diffraction analysis of calexcitin from Loligo pealei-a neuronal protein implicated in learning and memory Acta Crystallog. sect. F 61 2005 879 881
28. A.G.W. Leslie The integration of macromolecular diffraction data Acta Crystallog. sect. D 62 2006 48 57
29. Collaborative Computing Project Number 4 The CCP4 suite: programs for protein crystallography Acta Crystallog. sect. D 50 1994 760 763
30. T.C. Terwilliger, and J. Berendzen Automated MAD and MIR structure solution Acta Crystallog. sect. D 55 1999 849 861
31. K. Cowtan DM: an automated procedure for phase improvement by density modification Joint CCP4 and ESF-EACBM Newsletter on Protein Crystallography vol. 31 1994 Daresbury Laboratory Warrington, UK 34 38
32. D.G. Levitt A new software routine that automates the fitting of protein X-ray crystallographic electron density maps Acta Crystallog. sect. D 57 2001 1013 1019
33. G.M. Sheldrick, and T.R. Schneider SHELXL: high-resolution refinement Methods Enzymol. 277 1997 319 343
34. A.T. Brunger, P.D. Adams, G.M. Clore, W.L. DeLano, P. Gros, and R.W. Grosse-Kunstleve Crystallography & NMR system: a new software suite for macromolecular structure determination Acta Crystallog. sect. D 54 1998 905 921
35. M.S. Johnson, J.P. Overington, and T.L. Blundell Alignment and searching for common protein folds using a data bank of structural templates J. Mol. Biol. 231 1993 735 752
36. G.J. Barton ALSCRIPT-a tool to format multiple sequence alignments Protein Eng. 6 1993 37 40