Fatal HHV-8-associated hemophagocytic syndrome in an HIV-negative immunocompetent patient with plasmablastic variant of multicentric castleman disease (plasmablastic microlymphoma)

American Journal of Surgical Pathology

Volumn 30, Issue 1, 2006, Pages 123-127

  Li, Chien Feng ^a   Ye, Hongtao ^c   Liu, Hongxiang ^c   Du, Ming Qing ^c   Chuang, Shih Sung ^a,b,d  

^a CHI MEI MEDICAL CENTER   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d CHI MEI FOUNDATION HOSPITAL   (Taiwan)

Author keywords

Castleman disease; HHV 8; Plasmablastic microlymphoma; Virus associated hemophagocytic syndrome

Indexed keywords

ADULT; ANGIOFOLLICULAR LYMPH NODE HYPERPLASIA; ARTICLE; CASE REPORT; FATALITY; HEMOPHAGOCYTIC SYNDROME; HIGH RISK PATIENT; HUMAN; HUMAN HERPESVIRUS 8; IMMUNOCOMPETENCE; INGUINAL LYMPH NODE; LYMPHADENOPATHY; LYMPHOMA; MALE; POLYMERASE CHAIN REACTION; T CELL LYMPHOMA; VIRUS ASSOCIATED HEMOPHAGOCYTIC SYNDROME; VIRUS REACTIVATION; B LYMPHOCYTE; BIOSYNTHESIS; BLOOD; BONE MARROW CELL; HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; HERPES VIRUS INFECTION; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PATHOLOGY; PLASMA CELL; SERODIAGNOSIS; VIROLOGY;

IMMUNOGLOBULIN LAMBDA CHAIN; IMMUNOGLOBULIN M; INTERFERON REGULATORY FACTOR; INTERFERON REGULATORY FACTOR 4; INTERFERON REGULATORY FACTOR-4; INTERLEUKIN 6; LATENCY ASSOCIATED NUCLEAR ANTIGEN; LATENCY-ASSOCIATED NUCLEAR ANTIGEN; NUCLEAR PROTEIN; VIRUS ANTIGEN;

ANTIGENS, VIRAL; B-LYMPHOCYTES; BONE MARROW CELLS; FATAL OUTCOME; GIANT LYMPH NODE HYPERPLASIA; HERPESVIRIDAE INFECTIONS; HERPESVIRUS 8, HUMAN; HIV SERONEGATIVITY; HUMANS; IMMUNOGLOBULIN LAMBDA-CHAINS; IMMUNOGLOBULIN M; IMMUNOHISTOCHEMISTRY; INTERFERON REGULATORY FACTORS; INTERLEUKIN-6; LYMPHOHISTIOCYTOSIS, HEMOPHAGOCYTIC; MALE; MIDDLE AGED; NUCLEAR PROTEINS; PLASMA CELLS;

EID: 33645067966     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.pas.0000172293.59785.b4     Document Type: Article

References (34)

1. Aoki Y, Yarchoan R, Wyvill K, et al. Detection of viral interleukin-6 in Kaposi sarcoma-associated herpesvirus-linked disorders. Blood. 2001;97: 2173-2176.
2. Bacon CM, Miller RF, Noursadeghi M, et al. Pathology of bone marrow in human herpes virus-8 (HHV-8)-associated multicentric Castleman disease. Br J Haematol. 2004;127:585-591.
3. Billiau AD, Roskams T, Van Damme-Lombaerts R, et al. Macrophage activation syndrome: characteristic findings on liver biopsy illustrating the key role of activated, IFN-γ-producing lymphocytes and IL-6-and TNF-α-producing macrophages. Blood. 2005;105:1648-1651.
4. Chadburn A, Cesarman E, Nador RG, et al. Kaposi's sarcoma-associated herpesvirus sequences in benign lymphoid proliferations not associated with human immunodeficiency virus. Cancer. 1997;80:788-797.
5. Chen JS, Lin KH, Lin DT, et al. Longitudinal observation and outcome of nonfamilial childhood haemophagocytic syndrome receiving etoposide-containing regimens. Br J Haematol. 1998;103:756-762.
6. Corbellino M, Poire L, Aubin JT, et al. The role of human herpesvirus 8 and Epstein-Barr virus in the pathogenesis of giant lymph node hyperplasia (Castleman's disease). Clin Infect Dis. 1996;22:1120-1121.
7. Coupland SE, Charlotte F, Mansour G, et al. HHV-8-associated T-cell lymphoma in a lymph node with concurrent peritoneal effusion in an HIV-positive man. Am J Surg Pathol. 2005;29:647-652.
8. Craig FE, Clare CN, Sklar JL, et al. T-cell lymphoma and the virus-associated hemophagocytic syndrome. Am J Clin Pathol. 1992;97:189-194.
9. Daum GS, Sullivan JL, Ansell J, et al. Virus-associated hemophagocytic syndrome: identification of an immunoproliferative precursor lesion. Hum Pathol. 1987;18:1071-1074.
10. Du MQ, Liu H, Diss TC, et al. Kaposi sarcoma-associated herpesvrus infects monotypic (IgM) but polyclonal naïve B cells in Castleman disease and associated lymphoproliferative disorders. Blood. 2001;97:2130-2136.
11. Du MQ, Diss TC, Liu H, et al. KSHV- and EBV-associated germinotropic lymphoproliferative disorder. Blood. 2002;100:3415-3418.
12. Dupin N, Fisher C, Kellam P, et al. Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma. Proc Natl Acad Sci USA. 1999; 96:4546-4551.
13. Dupin N, Diss TL, Kellam P, et al. HHV-8 is associated with a plasmablastic variant of Castleman disease that is linked to HHV-8-positive plasmablastic lymphoma. Blood. 2000;95:1406-1412.
14. Fardet L, Blum L, Kerob D, et al. Human herpesvirus 8-associated hemophagocytic lymphohistiocytosis in human immunodeficiency virus-infected patients. Clin Infect Dis. 2003;37:285-291.
15. Friborg J Jr, Kong W, Hottiger MO, et al. p53 inhibition by the LANA protein of KSHV protects against cell death. Nature. 1999;402:889-894.
16. Frizzera G. Atypical lymphoproliferative disorders. In: Knowles DM, eds. Neoplastic Hematopathology, 2nd ed. Philadelphia: Lippincott Williams & Wilkins, 2001:595-607.
17. Fujiwara F, Hibi S, Imashuku S. Hypercytokinemia in hemophagocytic syndrome. Am J Pediatr Hematol Oncol. 1993;15:92-98.
18. Henter JI, Elinder G, Ost A. Diagnostic guidelines for hemophagocytic lymphohistiocytosis: the FHL Study Group of the Histiocyte Society. Semin Oncol. 1991;18:29-33.
19. Karras A, Thervet E, Legendre C, et al. Hemophagocytic syndrome in renal transplant recipients: report of 17 cases and review of literature. Transplantation. 2004;77:238-243.
20. Lanzafame M, Caretta G, Trevenzoli M, et al. Successful treatment of Castleman's disease with HAART in two HIV-infected patients. J Infect. 2000;40:90-91.
21. Low P, Neipel F, Rascu A, et al. Suppression of HHV-8 viremia by foscarnet in an HIV-infected patient with Kaposi's sarcoma and HHV-8 associated hemophagocytic syndrome. Eur J Med Res. 1998;3:461-464.
22. Luppi M, Barozzi P, Rasini V, et al. Severe pancytopenia and hemophagocytosis after HHV-8 primary infection in a renal transplant patient successfully treated with foscarnet. Transplantation. 2002;74:131-133.
23. Marrache F, Larroche C, Memain N, et al. Prolonged remission of HIV-asscoiated multicentric Castleman's disease with an anti-CD20 monoclonal antibody as primary therapy. AIDS. 2003;17:1409-1410.
24. Menke DM, Chadbum A, Cesarman E, et al. Analysis of the human herpesvirus 8 (HHV-8) genome and HHV-8 vIL-6 expression in archival cases of Castleman disease at low risk for HIV infection. Am J Clin Pathol. 2002;117:268-275.
25. Oksenhendler E, Duarte M, Soulier J, et al. Multicentric Castleman's disease in HIV infection: a clinical and pathological study of 20 patients. AIDS. 1996;10:61-67.
26. Oksenhendler E, Carcelain G, Aoki Y, et al. High levels of human herpesvirus 8 viral load, human interleukin-6, interleukin-10 and C reactive protein correlate with exacerbation of multicentric Castleman disease in HIV-infected patients. Blood. 2000;96:2069-2073.
27. Parravicini C, Chandran B, Corbellino M, et al. Differential viral protein expression in Kaposi's sarcoma-associated herpesvirus-infected diseases: Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. Am J Pathol. 2000;156:743-749.
28. Pastore RD, Chadburn A, Kripas C, et al. Novel association of haemophagocytic syndrome with Kaposi's sarcoma-associated herpesvirus-related primary effusion lymphoma. Br J Haematol. 2000;111:1112-1115.
29. Scott D, Cabral L, Harrington WJ Jr. Treatment of HIV-associated multicentric Castleman's disease with oral etoposide. Am J Hematol. 2001;66: 148-150.
30. Soulier J, Grollet L, Oksenhendler E, et al. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. Blood. 1995;86:1276-1280.
31. Su IJ, Hsu TH, Lin MT, et al. Epstein-Barr virus-containing T-cell lymphoma presents with hemophagocytic syndrome mimicking malignant histiocytosis. Cancer. 1993;72:2019-2027.
32. Su IJ, Wang CH, Cheng AL, et al. Hemophagocytic syndrome in Epstein-Barr virus-associated T-lymphoproliferative disorders: disease spectrum, pathogenesis, and management. Leuk Lymphoma. 1995;19:401-406.
33. Sullivan JL, Woda BA, Herrod HG, et al. Epstein-Barr virus-associated hemophagocytic syndrome: virological and immunopathological studies. Blood. 1985;65:1097-1104.
34. van Dongen JJ, Langerak AW, Bruggemann M, et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia. 2003;17:2257-2317.