Cost-effectiveness analysis of antifungal treatment for patients on chemotherapy

European Journal of Cancer Care

Volumn 15, Issue 1, 2006, Pages 44-50

  Nomura, K ^a   Kawasugi, K ^a   Morimoto, T ^b  

^a TEIKYO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

Amphotericin B; Antifungal prophylaxis; Chemotherapy; Cost effectiveness analysis; Fluconazole; Fungal infection

Indexed keywords

AMPHOTERICIN B; ANTIFUNGAL AGENT; ANTINEOPLASTIC AGENT; CYCLOPEPTIDE; FLUCONAZOLE; LIPOPROTEIN; MICAFUNGIN;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; COHORT ANALYSIS; CONFERENCE PAPER; COST BENEFIT ANALYSIS; ECONOMICS; HUMAN; MYCOSIS; OPPORTUNISTIC INFECTION;

ADULT; AMPHOTERICIN B; ANTIFUNGAL AGENTS; ANTINEOPLASTIC AGENTS; COHORT STUDIES; COST-BENEFIT ANALYSIS; FLUCONAZOLE; HUMANS; LEUKEMIA, MYELOCYTIC, ACUTE; LIPOPROTEINS; MYCOSES; OPPORTUNISTIC INFECTIONS; PEPTIDES, CYCLIC;

EID: 33645065900     PISSN: 09615423     EISSN: 13652354     Source Type: Journal    
DOI: 10.1111/j.1365-2354.2005.00618.x     Document Type: Conference Paper

References (35)

1. Anaissie EJ. Darouiche RO. Abi-Said D. Uzun O. Mera J. Gentry LO. Williams T. Kontoyiannis DP. Karl CL. Bodey GP. 1996 Management of invasive candidal infections: results of a prospective, randomized, Multicenter study of Fluconazole versus Amphotericin B and review of the literature Clinical Infection and Disease 23 964 972
2. Ascioglu S. Rex JH. de Pauw B. Bennett JE. Bille J. Crokaert F. Denning DW. Donnelly JP. Edwards JE. Erjavec Z. Fiere D. Lortholary O. Maertens J. Meis JF. Patterson TF. Ritter J. Selleslag D. Shah PM. Stevens DA. Walsh TJ. 2002 Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus Clinical Infection and Disease 34 7 14
3. Beck JR. Pauker SG. Gottlieb JE. Klein K. Kassirer JP. 1982 A convenient approximation of life expectancy (the 'DEALE'). II. Use in medical decision-making American Journal of Medicine 73 889 897
4. Berman E. Little C. Teschendorf B. Jones M. Heller G. 2002 Financial analysis of patients with newly diagnosed acute myelogenous leukemia on protocol or standard therapy Cancer 95 1064 1070
5. Bodey GP. Anaissie EJ. Elting LS. Estey E. O'Brien S. Kantarjian H. 1994 Antifungal prophylaxis during remission induction therapy for acute leukemia Fluconazole versus Intravenous Amphotericin B Cancer 73 2099 2106
6. Cassileth PA. Harrington DP. Appelbaum FR. Lazarus HM. Rowe JM. Paietta E. Willman C. Hurd DD. Bennett JM. Blume KG. Head DR. Wiernik PH. 1998 Chemotherapy compared with autologous or allogeneic bone marrow transplantation in the management of acute myeloid leukemia in first remission New England Journal of Medicine 339 1649 1656
7. Chandrasekar PH. Gatny CM. 1994 Effect of fluconazole prophylaxis on fever and use of amphotericin in Neutropenia cancer patients Chemotherapy 40 136 143
8. Cheson BD. Cassileth PA. Head DR. Schiffer CA. Bennett JM. Bloomfield CD. Brunning R. Gale RP. Grever MR. Keating MJ. Sawitsky A. Stass S. Weinstein H. Woods WG. 1990 Report of the National Cancer Institute-sponsored workshop on definitions of diagnosis and response in acute myeloid leukemia Journal of Clinical Oncology 8 813 819
9. Egger T. Gratwohl A. Tichelli A. Uhr M. Stebler Gysi C. Passweg J. Pless M. Wernli M. Buser U. Wuhrmann J. Frei R. Nissen C. Speck B. 1995 Comparison of fluconazole with oral polyenes in the prevention of fungal infections in neutropenic patients. A prospective, randomized, single-center study Support Care Cancer 3 139 146
10. EORTC International Antimicrobial Therapy Cooperative Group 1989 Empiric antifungal therapy in febrile granulocytopenic patients American Journal of Medicine 86 668 672
11. Fromtling RA. 2002 Micafungin sodium (FK-463) Drugs Today (Barc) 38 245 257
12. Gotzsche PC. Johansen HK. 1997 Meta-analysis of prophylactic or empirical antifungal treatment versus placebo or no treatment in patients with cancer complicated by neutropenia British Medical Journal 314 1238 1244
13. Hughes WT. Armstrong D. Bodey GP. Bow EJ. Brown AE. Calandra T. Feld R. Pizzo PA. Rolston KV. Shenep JL. Young LS. 2002 2002 guidelines for the use of antimicrobial agents in neutropenic patients with cancer Clinical Infection and Disease 34 730 751
14. Malik IA. Moid I. Aziz Z. Khan S. Suleman M. 1998 A randomized comparison of fluconazole with amphotericin B as empiric anti-fungal agents in cancer patients with prolonged fever and neutropenia American Journal of Medicine 105 478
15. Menichetti F. Del Favero A. Martino P. Bucaneve G. Micozzi A. D'Antonio D. Ricci P. Carotenuto M. Liso V. Nosari AM. 1994 Preventing fungal infection in neutropenic patients with acute leukemia Annals of Internal Medicine 120 913 918
16. Meunier F. Aoun M. Janssens M. Dekoster C. Paesmans M. 1991 Chemoprophylaxis of fungal infections in granulocytopenis patients using fluconazole vs oral amphotericin B Drug Investigations 3 258 265
17. Miyawaki S. Tanimoto M. Kobayashi T. Minami S. Tamura J. Omoto E. Kuriyama K. Hatake K. Saito K. Kanamaru A. Oh H. Ohtake S. Asou N. Sakamaki H. Yamada O. Jinnai I. Tsubaki K. Takeyama K. Hiraoka A. Matsuda S. Takahashi M. Shimazaki C. Adachi K. Kageyama S. Ohno R. for the Japan Adult Leukaemia Study Group (JALSG) 1999 No beneficial effect from addition of etoposide to daunorubicin, cytarabine, and 6-mercaptopurine in individualized induction therapy of adult acute myeloid leukemia: the JALSG-AML92 study. Japan Adult Leukemia Study Group International Journal of Hematology 70 97 104
18. Morimoto T. Fukui T. Koyama H. Noguchi Y. Shimbo T. 2002 Optimal strategy for the first episode of primary spontaneous pneumothorax in young men. A decision analysis Journal of General Internal Medicine 17 193 202
19. Pizzo PA. Robichaud KJ. Gill FA. Witebsky FG. 1982 Empiric antibiotic and antifungal therapy for cancer patients with prolonged fever and granulocytopenia American Journal of Medicine 72 101 111
20. Rotstein C. Bow EJ. Laverdiere M. Ioannou S. Carr D. Moghaddam N. 1999 Randomized placebo-controlled trial of fluconazole prophylaxis for Neutropenic cancer patients: Benefit based on purpose and intensity of cytotoxic therapy Clinical Infection and Disease 28 331 340
21. Rozenberg-Arska M. Dekker AW. Branger J. Verhoef J. 1991 A randomized study to compare oral fluconazole to amphotericin B in the Journal of Antimicrobial Chemotherapy 27 369 376
22. Schaffner A. Schaffner M. 1995 Effect of prophylactic fluconazole on the frequency of fungal infections Journal of Infection and Disease 172 1035 1041
23. Scharfstein JA. Paltiel AD. Freedberg KA. 1997 The cost-effectiveness of fluconazole prophylaxis against primary systemic fungal infections in AIDS patients Medical Decision Making 17 373 381
24. Slavin MA. Osborne B. Adams R. Levenstein MJ. Schoch HG. Feldman AR. Meyers JD. Bowden RA. 1995 Efficacy and safety of fluconazole prophylaxis for fungal infections after Journal of Infection and Disease 171 1545 1552
25. Sox HC. Blatt MA. Higgins MC. Marton KI. 1988 Medical Deicision Making Butterworth-Heinemann Boston, MA, USA
26. Stein R. Kayser J. Flexner J. 1982 Clinical value of empirical amphotericin B in Patients with acute myelogenous leuckemia Cancer 50 2247 2251
27. UpToDate 2004 ) UpToDate. Available from: (cited 12 July 2004).
28. Uyl-de Groot CA. Lowenberg B. Vellenga E. Suciu S. Willemze R. Rutten FF. 1998 Cost-effectiveness and quality-of-life assessment of GM-CSF as an adjunct to intensive remission induction chemotherapy in elderly patients with acute myeloid leukemia British Journal of Haematology 100 629 636
29. Viscoli C. Castagnola E. Van Lint MT. Moroni C. Garaventa A. Rossi MR. Fanci R. Menichetti F. Caselli D. Giacchino M. Congiu M. 1996 Fluconazole versus amphotericin B as empirical antifungal therapy of unexplained fever in granulocytopenic cancer patients: a pragmatic, multicentre, prospective and randomised clinical trial European Journal of Cancer 32A 814 820
30. Walsh TJ. Finberg RW. Arndt C. Hiemenz J. Schwartz C. Bodensteiner D. Pappas P. Seibel N. Greenberg RN. Dummer S. Schuster M. Holcenberg JS. 1999 Liposomal amphotericin B for empirical therapy in patients with persistent fever and neutropenia. National Institute of Allergy and Infectious Diseases Mycoses Study Group New England Journal of Medicine 340 764 771
31. Walsh TJ. Lee J. Lecciones J. Rubin M. Butler K. Francis P. Weinberger M. Roilides E. Marshall D. Gress J. Pizzo PA. 1991 Empiric therapy with amphotericin B, in febrile granulocytopenic patients Review of Infection and Disease 13 496 503
32. Winston DJ. Chandrasekar PH. Lazarus HM. Goodman JL. Silber JL. Horowitz H. Shadduck RK. Rosenfeld CS. Ho WG. Islam MZ. 1993 Fluconazole prophylaxis of fungal infections in patients with acute leukemia. Results of a randomized placebo-controlled, double-blind, multicenter trial Annals of Internal Medicine 118 495 503
33. Winston DJ. Hathorn JW. Schuster MG. Schiller GJ. Territo MC. 2000 A multicenter, randomized trial of fluconazole versus amphotericin B for empiric antifungal therapy of febrile neutropenic patients with cancer American Journal of Medicine 108 282 289
34. Wolff SN. Fay J. Stevens D. Herzig RH. Pohlman B. Bolwell B. Lynch J. Ericson S. Freytes CO. LeMaistre F. Collins R. Pineiro L. Greer J. Stein R. Goodman SA. Dummer S. 2000 Fluconazole vs low-dose amphotericin B for the prevention of fungal infections in patients undergoing bone marrow transplantation: a study of the North American Marrow Transplant Group Bone Marrow Transplantation 25 853 859
35. Zittoun RA. Mandelli F. Willemze R. de Witte T. Labar B. Resegotti L. Leoni F. Damasio E. Visani G. Papa G. Caronia F. Hayat M. Stryckmans P. Rotoli B. Leoni P. Peetermans ME. Dardenne M. Vegna ML. Petti MC. Solbu G. Suciu S. 1995 Autologous or allogeneic bone marrow transplantation compared with intensive chemotherapy in acute myelogenous leukemia. European organization for research and treatment of cancer (EORTC) and the gruppo italiano malattie ematologiche maligne dell'Adulto (GIMEMA) Leukemia Cooperative Groups New England Journal of Medicine 332 217 223