Immune responses and HIV: A little order from the chaos

Journal of Experimental Medicine

Volumn 203, Issue 3, 2006, Pages 501-503

  O'Connor, David H ^a   Burton, Dennis R ^b  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; ANTIRETROVIRUS AGENT; HLA ANTIGEN CLASS 1; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; NEUTRALIZING ANTIBODY;

ALLELE; ANTIBODY PRODUCTION; ANTIGEN RECOGNITION; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CYTOTOXIC T LYMPHOCYTE; DISEASE COURSE; DRUG ACTIVITY; DRUG DESIGN; HOST PATHOGEN INTERACTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; IMMUNOGENICITY; MUTATION; PRIORITY JOURNAL; REVIEW; TWINS; VIRUS REPLICATION;

AMINO ACID SUBSTITUTION; ANTIBODIES, VIRAL; CD4 LYMPHOCYTE COUNT; CD8-POSITIVE T-LYMPHOCYTES; EPITOPES, T-LYMPHOCYTE; EVOLUTION, MOLECULAR; FEMALE; FOLLOW-UP STUDIES; GENE PRODUCTS, ENV; HIV SEROPOSITIVITY; HIV-1; HUMANS; IMMUNITY, CELLULAR; MALE; POINT MUTATION;

EID: 33645047178     PISSN: 00221007     EISSN: 00221007     Source Type: Journal    
DOI: 10.1084/jem.20060216     Document Type: Review

References (11)

1. Draenert, R., T.M. Allen, Y. Liu, T. Wrin, C. Chappey, C. Verrill, G. Sirera, R.L. Eldridge, M.P. Lahaie, L. Ruiz, B. Clotet, C.J. Petropoulos, B.D. Walker, and J. Martinez-Picado. Constraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virus. J. Exp. Med. 203:529-539.
2. Yang, O.O., J. Church, C.M. Kitchen, R. Kilpatrick, A. Ali, Y. Geng, M.S. Killian, R.L. Sabado, H. Ng, J. Suen, et al. 2005. Genetic and stochastic influences on the interaction of human immunodeficiency virus type 1 and cytotoxic T lymphocytes in identical twins. J. Virol. 79:15368-15375.
3. Meyer-Olson, D., K.W. Brady, M.T. Bartman, K.M. O'Sullivan, B.C. Simons, J.A. Conrad, C.B. Duncan, S. Lorey, A. Siddique, R.A. Draenert, et al. 2005. Fluctuations of functionally distinct CD8+ T cell clonotypes demonstrate flexibility of the HIV-specific TCR repertoire. Blood. 10.1182/blood-2005-04- 1636.
4. Richman, D.D., T. Wrin, S.J. Little, and C.J. Petropoulos. 2003. Rapid evolution of the neutralizing antibody response to HIV type 1 infection. Proc. Natl. Acad. Sci. USA. 100:4144-4149.
5. Wei, X., J.M. Decker, S. Wang, H. Hui, J.C. Kappes, X. Wu, J.F. Salazar-Gonzalez, M.G. Salazar, J.M. Kilby, M.S. Saag, et al. 2003. Antibody neutralization and escape by HIV- 1. Nature. 422:307-312.
6. Price, D.A., P.J. Goulder, P. Klenerman, A.K. Sewell, P.J. Easterbrook, M. Troop, C.R. Bangham, and R.E. Phillips. 1997. Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection. Proc. Natl. Acad. Sci. USA. 94:1890-1895.
7. Koibuchi, T., T.M. Allen, M. Lichterfeld, S.K. Mui, K.M. O'Sullivan, A. Trocha, S.A. Kalams, R.P. Johnson, and B.D. Walker. 2005. Limited sequence evolution within persistently targeted CD8 epitopes in chronic human immunodeficiency virus type 1 infection. J. Virol. 79:8171-8181.
8. Allen, T.M., M. Altfeld, S.C. Geer, E.T. Kalife, C. Moore, K.M. O'sullivan, I. Desouza, M.E. Feeney, R.L. Eldridge, E.L. Maier, et al. 2005. Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution. J. Virol. 79:13239-13249.
9. Allen, T.M., X.G. Yu, E.T. Kalife, L.L. Reyor, M. Lichterfeld, M. John, M. Cheng, R.L. Allgaier, S. Mui, N. Frahm, et al. 2005. De novo generation of escape variant-specific CD8+ T-cell responses following cytotoxic T-lymphocyte escape in chronic human immunodeficiency virus type 1 infection. J. Virol. 79:12952-12960.
10. Feeney, M.E., Y. Tang, K. Pfafferott, K.A. Roosevelt, R. Draenert, A. Trocha, X.G. Yu, C. Verrill, T. Allen, C. Moore, et al. 2005. HIV-1 viral escape in infancy followed by emergence of a variant-specific CTL response. J. Immunol. 174:7524-7530.
11. Korber, B., B. Gaschen, K. Yusim, R. Thakallapally, C. Kesmir, and V. Detours. 2001. Evolutionary and immunological implications of contemporary HIV-1 variation. Br. Med. Bull. 58:19-42.