Levan (β-2, 6-fructan), a major fraction of fermented soybean mucilage, displays immunostimulating properties via Toll-like receptor 4 signalling: Induction of interleukin-12 production and suppression of T-helper type 2 response and immunoglobulin E production

Clinical and Experimental Allergy

Volumn 36, Issue 1, 2006, Pages 94-101

  Xu, Q ^a   Yajima, T ^b   Li, W ^b   Saito, K ^b   Ohshima, Y ^a   Yoshikai, Y ^b  

^a Mizkan Group Corporation   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

Allergy; Cytokines; IgE; Levan; Th1; Th2

Indexed keywords

GAMMA POLYGLUTAMIC ACID; IMMUNOGLOBULIN E; INTERLEUKIN 12P40; LEVAN; OVALBUMIN; POLYGLUTAMIC ACID; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALLERGIC DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACILLUS SUBTILIS; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; EMBRYO; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTATION; FERMENTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOGLOBULIN PRODUCTION; IMMUNOMODULATION; IMMUNOSTIMULATION; MACROPHAGE; MOLECULAR RECOGNITION; MOUSE; MUCILAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PURIFICATION; SIGNAL TRANSDUCTION; SOYBEAN; TH2 CELL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; BACILLUS SUBTILIS; CELL LINE; FERMENTATION; FRUCTANS; IMMUNOGLOBULIN E; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-4; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, INBRED C57BL; PLANT EXTRACTS; POLYGLUTAMIC ACID; SIGNAL TRANSDUCTION; SOYBEANS; TH2 CELLS; TOLL-LIKE RECEPTOR 4;

EID: 33645036149     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2006.02401.x     Document Type: Article

References (43)

1. Golbitz P. Traditional soyfoods processing and products J Nutr 1995 125 570S 2S
2. Cross HS Kallay E Lechner D Gerdenitsch W Adlercreutz H Armbrecht HJ. Phytoestrogens and vitamin D metabolism a new concept for the prevention and therapy of colorectal, prostate, and mammary carcinomas J Nutr 2004 134 1207S 12S
3. Kazi A Daniel KG Smith DM Kumar NB Dou QP. Inhibition of the proteasome activity, a novel mechanism associated with the tumor cell apoptosis-inducing ability of genistein Biochem Pharmacol 2003 66 965 76
4. Takahashi C Kikuchi N Katou N Miki T Yanagida F Umeda M. Possible anti-tumour-promoting activity of components in Japanese soybean fermented food, Natto effect on gap junctional intercellular communication Carcinogenesis 1995 16 471 6
5. Cohen LA Zhao Z Pittman B Scimeca J. Effect of soy protein isolate and conjugated linoleic acid on the growth of Dunning R-3327-AT-1 rat prostate tumors Prostate 2003 54 169 80
6. Hoa NT Baccigalupi L Huxham A et al Characterization of Bacillus species used for oral bacteriotherapy and bacterioprophylaxis of gastrointestinal disorders Appl Environ Microbiol 2000 66 5241 7
7. Hosoi T Ametani A Kiuchi K Kaminogawa S. Changes in fecal microflora induced by intubation of mice with Bacillus subtilis (natto) spores are dependent upon dietary components Can J Microbiol 1999 45 59 66
8. Chihara G Maeda Y Hamuro J Sasaki T Fukuoka F. Inhibition of mouse sarcoma 180 by polysaccharides from Lentinus edodes (Berk.) sing Nature 1969 222 687 8
9. Rau DC Parsegian VA. Direct measurement of forces between linear polysaccharides xanthan and schizophyllan Science 1990 249 1278 1
10. Mizutani Y Nio Y Yoshida O. Effect of PSK and its subfractions on peripheral blood lymphocytes mediated cytotoxicity against urinary bladder tumor cells J Urol 1992 148 1571 6
11. Rice PJ Kelley JL Kogan G et al Human monocyte scavenger receptors are pattern recognition receptors for (1→3)-beta- d -glucans J Leukoc Biol 2002 72 140 6
12. Han YW. Microbial levan Adv Appl Microbiol 1990 35 171 94
13. Leibovici J Susskind-Brudner G Wolman M. Direct antitumor effect of high-molecular-weight levan on Lewis lung carcinoma cells in mice J Natl Cancer Inst 1980 65 391 6
14. Stark Y Leibovici J. Different effects of the polysaccharide levan on the oncogenicity of cells of two variants of Lewis lung carcinoma Br J Exp Pathol 1986 67 141 7
15. Calazans GMT Lima RC de Franca FP Lopes CE. Molecular weight and antitumour activity of Zymomonas mobilis levans Int J Biol Macromol 2000 27 245 7
16. Yoo SH Yoon EJ Cha J Lee HG. Antitumor activity of levan polysaccharides from selected microorganisms Int J Biol Macromol 2004 34 37 41
17. Meng G Futterer K. Structural framework of fructosyl transfer in Bacillus subtilis levansucrase Nat Struct Biol 2003 10 935 41
18. Beutler B. Inferences, questions and possibilities in Toll-like receptor signalling Nature 2004 430 257 63
19. Nishiya T DeFranco AL. Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors J Biol Chem 2004 279 19008 17
20. Miyake K. Innate recognition of lipopolysaccharide by Toll-like receptor 4-MD-2 Trends Microbiol 2004 12 186 92
21. Takeda K Kaisho T Akira S. Toll-like receptors Annu Rev Immunol 2003 21 335 76
22. Brown GD Taylor PR Reid DM et al Dectin-1 is a major beta-glucan receptor on macrophages J Exp Med 2002 196 407 12
23. Vicente AM Guillen MI Alcaraz MJ. Modulation of haem oxygenase-1 expression by nitric oxide and leukotrienes in zymosan-activated macrophages Br J Pharmacol 2001 133 920 6
24. Underhill DM. Macrophage recognition of zymosan particles J Endotoxin Res 2003 9 176 80
25. Ozinsky A Underhill DM Fontenot JD et al The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors Proc Natl Acad Sci USA 2000 97 13766 71
26. Colvin JR Sowden LC Leppard GG. The structure of cellulose-producing bacteria, Acetobacter xylinum and Acetobacter acetigenus Can J Microbiol 1977 23 790 7
27. Saito K Yajima T Nishimura H et al Soluble branched beta-(1,4)glucans from Acetobacter species show strong activities to induce interleukin-12 in vitro and inhibit T-helper 2 cellular response with immunoglobulin E production in vivo J Biol Chem 2003 278 38571 8
28. Romagnani S. Immunologic influences on allergy and the Th1/Th2 balance J Allergy Clin Immunol 2004 113 395 400
29. Helmby H Grencis RK. IFN-gamma-independent effects of IL-12 during intestinal nematode infection J Immunol 2003 171 3691 6
30. Takeuchi O Hoshino K Kawai T et al Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components Immunity 1999 11 443 51
31. Tanimoto H Mori M Motoki M Torii K Kadowaki M Noguchi T. Natto mucilage containing poly-gamma-glutamic acid increases soluble calcium in the rat small intestine Biosci Biotechnol Biochem 2001 65 516 21
32. Tsukamoto Y Kasai M Kakuda H. Construction of a Bacillus subtilis (natto) with high productivity of vitamin K2 (menaquinone-7) by analog resistance Biosci Biotechnol Biochem 2001 65 2007 15
33. Ashiuchi M Soda K Misono H. A poly-gamma-glutamate synthetic system of Bacillus subtilis IFO 3336 gene cloning and biochemical analysis of poly-gamma-glutamate produced by Escherichia coli clone cells Biochem Biophys Res Commun 1999 263 6 12
34. Jansova E Schwarzova Z Chaloupka J. Sporulation and synthesis of extracellular proteinases in Bacillus subtilis are more temperature-sensitive than growth Folia Microbiol (Praha) 1993 38 22 4
35. Matsuguchi T Musikacharoen T Ogawa T Yoshikai Y. Gene expressions of Toll-like receptor 2, but not Toll-like receptor 4, is induced by LPS and inflammatory cytokines in mouse macrophages J Immunol 2000 165 5767 72
36. Iwasaki A Medzhitov R. Toll-like receptor control of the adaptive immune responses Nat Immunol 2004 5 987 95
37. Nishikubo K Murata Y Tamaki S et al A single administration of interleukin-4 antagonistic mutant DNA inhibits allergic airway inflammation in a mouse model of asthma Gene Ther 2003 10 2119 25
38. Lewkowich IP Rempel JD HayGlass KT. Antigen-specific vs. total immunoglobulin synthesis total IgE and IgG1, but not IgG2a levels predict murine antigen-specific responses Int Arch Allergy Immunol 2004 133 145 53
39. Bochner BS Busse WW. Advances in mechanisms of allergy J Allergy Clin Immunol 2004 113 868 75
40. Matsuse H Kong X Hu J Wolf SF Lockey RF Mohapatra SS. Intranasal IL-12 produces discreet pulmonary and systemic effects on allergic inflammation and airway reactivity Int Immunopharmacol 2003 3 457 68
41. King CL Hakimi J Shata MT Medhat A. IL-12 regulation of parasite antigen-driven IgE production in human helminth infections J Immunol 1995 155 454 61
42. Kips JC Brusselle GJ Joos GF et al Interleukin-12 inhibits antigen-induced airway hyperresponsiveness in mice Am J Respir Crit Care Med 1996 153 535 9
43. Pauwels RA Brusselle GJ Kips JC. Cytokine manipulation in animal models of asthma Am J Respir Crit Care Med 1997 156 S78 S