Laboratory-observed behavioral disinhibition in the young offspring of parents with bipolar disorder: A high-risk pilot study

American Journal of Psychiatry

Volumn 163, Issue 2, 2006, Pages 265-271

  Hirshfeld Becker, Dina R ^a   Biederman, Joseph ^b   Henin, Aude ^b   Faraone, Stephen V ^b   Cayton, Gabrielle A ^b   Rosenbaum, Jerrold F ^b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; ATTENTION DEFICIT DISORDER; BEHAVIOR DISORDER; BEHAVIORAL DISINHIBITION; BEHAVIORAL RESEARCH; BIPOLAR DISORDER; CHILD BEHAVIOR; CLINICAL ARTICLE; CONDUCT DISORDER; CONTROLLED STUDY; DEPRESSION; FEMALE; HIGH RISK POPULATION; HUMAN; INHIBITION (PSYCHOLOGY); LABORATORY; MAJOR DEPRESSION; MALE; OBSERVATION; PANIC; PILOT STUDY; PRESCHOOL CHILD; PREVALENCE; PRIORITY JOURNAL; PROGENY; PSYCHOPATHY; SUBSTANCE ABUSE; AGE; CHILD; COMPARATIVE STUDY; EPIDEMIOLOGY; GENETIC PREDISPOSITION; GENETICS; MENTAL DISEASE; PSYCHOLOGICAL ASPECT; RISK FACTOR; STATISTICAL MODEL; STATISTICS;

AGE FACTORS; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; BIPOLAR DISORDER; CAUSALITY; CHILD; CHILD BEHAVIOR; CHILD OF IMPAIRED PARENTS; CHILD, PRESCHOOL; DEPRESSIVE DISORDER, MAJOR; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INHIBITION (PSYCHOLOGY); LOGISTIC MODELS; MALE; MENTAL DISORDERS; PANIC DISORDER; PILOT PROJECTS; RISK FACTORS;

EID: 33645007809     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/appi.ajp.163.2.265     Document Type: Article

References (43)

1. Hirshfeld-Becker DR, Biederman J, Calltharp S, Rosenbaum ED, Rosenbaum JF: Behavioral inhibition and disinhibition as hypothesized precursors to psychopathology: implications for pediatric bipolar disorder. Biol Psychiatry 2003; 53:985-999
2. Kagan J, Reznick J, Gibbons J: Inhibited and uninhibited types of children. Child Dev 1989; 60:838-845
3. Derryberry D, Reed MA: Temperament and the self-organization of personality. Dev Psychopathol 1994; 6:653-676
4. Goldsmith HH, Lemery KS: Linking temperamental tearfulness and anxiety symptoms: a behavior-genetic perspective. Biol Psychiatry 2000; 48:1199-1209
5. Hirshfeld DR, Rosenbaum JF, Biederman J, Bolduc EA, Faraone SV, Snidman N, Reznick JS, Kagan J: Stable behavioral inhibition and its association with anxiety disorder. J Am Acad Child Adolesc Psychiatry 1992; 31:103-111
6. Rothbart MK, Ahadi SA, Hershey KL: Temperament and social behavior in childhood. Merrill Palmer Q 1994; 40:21-39
7. Tremblay RE, Pihl RO, Vitaro F, Dobkin PL: Predicting early onset of male antisocial behavior from preschool behavior. Arch Gen Psychiatry 1994; 51:732-739
8. Raine A, Reynolds C, Venables PH, Mednick SA, Farrington DP: Fearlessness, stimulation-seeking and large body size at age 3 years as early predispositions to childhood aggression at age 11 years. Arch Gen Psychiatry 1998; 55:745-751
9. Caspi A, Henry B, McGee RO, Moffitt TE, Silva PA: Temperamental origins of child and adolescent behavior problems: from age three to age fifteen. Child Dev 1995; 66:55-68
10. Caspi A, Moffitt TE, Newman DL, Silva PA: Behavioral observations at age 3 years predict adult psychiatric disorders. Arch Gen Psychiatry 1996; 53:1033-1039
11. Hirshfeld-Becker DR, Biederman J, Faraone S, Violette H, Wrightsman J, Rosenbaum JF: Temperamental correlates of disruptive behavior disorders in young children: preliminary findings. Biol Psychiatry 2002; 50:563-574
12. Chang KD, Steiner H, Ketter TA: Psychiatric phenomenology of child and adolescent bipolar offspring. J Am Acad Child Adolesc Psychiatry 2000; 39:453-460
13. Wozniak J, Biederman J, Faraone SV, Blier H, Monuteaux MC: Heterogeneity of childhood conduct disorder: further evidence of a subtype of conduct disorder linked to bipolar disorder. J Affect Disord 2001; 64:121-131
14. Biederman J, Faraone SV, Chu MP, Wozniak J: Further evidence of a bidirectional overlap between juvenile mania and conduct disorder in children. J Am Acad Child Adolesc Psychiatry 1999; 38:468-476
15. Geller B, Zimerman B, Williams M, DelBello M, Bolhofner K, Craney J, Frazier J, Beringer L, Nickelsburg M: DSM-IV mania symptoms in a prepubertal and early adolescent bipolar disorder phenotype compared to attention-deficit hyperactive and normal controls. J Child Adolesc Psychopharmacol 2002; 12:11-25
16. Duffy A, Grof P, Kutcher S, Robertson C, Alda M: Measures of attention and hyperactivity symptoms in a high-risk sample of children of bipolar parents. J Affect Disord 2001; 67:159-165
17. Grigoroiu-Serbanescu M, Christodorescu D, Jipescu I, Totoescu A, Marinescu E, Ardelean V: Psychopathology in children aged 10-17 of bipolar parents: psychopathology rate and correlates of the severity of the psychopathology. J Affect Disord 1989; 16:167-179
18. Carlson GA, Weintraub S: Childhood behavior problems and bipolar disorder: relationship or coincidence? J Affect Disord 1993; 28:143-153
19. Egeland J, Shaw J, Endicott J, Pauls D, Allen C, Hosteller A, Sussex J: Prospective study of prodromal features for bipolarity in well Amish children. J Am Acad Child Adolesc Psychiatry 2003; 42:786-796
20. Akiskal HS, Mallya G: Criteria for the "soft" bipolar spectrum: treatment implications. Psychopharmacol Bull 1987; 23:68-73
21. Cassano GB, Akiskal HS, Perugi G, Musetti L, Savino M: The importance of measures of affective temperaments in genetic studies of mood disorders. J Psychiatr Res 1992; 26:257-268
22. Janowsky DS, Morter S, Hong L, Howe L: Myers Briggs type indicator and Tridimensional Personality Questionnaire differences between bipolar patients and unipolar depressed patients. Bipolar Disord 1999; 2:98-108
23. Young LT, Bagby MR, Cooke RG, Parker JDA, Levitt AJ, Joffe RT: A comparison of Tridimensional Personality Questionnaire dimensions in bipolar disorder and unipolar depression. Psychiatry Res 1995; 58:139-143
24. Sauer H, Richter P, Czernik A, Ludwig-Mayerhofer W, Schochlin C, Greil W, von Zerssen D: Personality differences between patients with major depression and bipolar disorder - the impact of minor symptoms on self-ratings of personality. J Affect Disord 1997; 42:169-177
25. Chang KD, Blasey CM, Ketter TA, Steiner H: Temperament characteristics of child and adolescent bipolar offspring. J Affect Disorder 2003; 77:11-19
26. Graham P, Stevenson J: Temperament and psychiatric disorder: the genetic contribution to behavior in childhood. Aust NZ J Psychiatry 1987; 21:267-274
27. Lewinsohn PM, Klein DN, Seeley JR: Bipolar disorders in a community sample of older adolescents: prevalence, phenomenology, comorbidity, and course. J Am Acad Child Adolesc Psychiatry 1995; 34:454-463
28. Nigg JT: On inhibition/disinhibition in developmental psychopathology: views from cognitive and personality psychology and a working inhibition taxonomy. Psychol Bull 2000; 126:220-246
29. Iacono WG, Carlson SR, Taylor J, Elkins IJ, McGue M: Behavioral disinhibition and the development of substance-use disorders: findings from the Minnesota Twin Family Study. Dev Psychopathol 1999; 11:869-900
30. Depue R, Iacono W: Neurobehavioral aspects of affective disorders. Ann Rev Psychol 1989; 40:457-492
31. Faraone SV, Tsuang D, Tsuang MT: Genetics and Mental Disorders: A Guide for Students, Clinicians, and Researchers. New York, Guilford, 1999
32. Rosenbaum JF, Biederman J, Hirshfeld-Becker DR, Kagan J, Snidman N, Friedman D, Nineberg A, Gallery DJ, Faraone SV: A controlled study of behavioral inhibition in children of parents with panic disorder and depression. Am J Psychiatry 2000; 157:2002-2010
33. Spitzer RL, Williams JBW, Gibbon M, First MB: Structured Clinical Interview for DSM-III-R - Non-Patient Edition (SCID-NP, Version 1.0). Washington, DC, American Psychiatric Press, 1990
34. Hollingshead AB: Four-Factor Index of Social Status. New Haven, Conn, Yale University, Department of Sociology, 1975
35. Fleiss JL: Statistical Methods for Rates and Proportions. New York, John Wiley & Sons, 1981
36. Kagan J: Galen's Prophecy: Temperament in Human Nature. New York, Basic Books, 1994
37. Kagan J: Matching Familiar Figures Test. Cambridge, Mass, Harvard University, 1964
38. McGraw KO, Wong SP: Forming inferences about some intraclass correlations. Psychol Methods 1996; 1:30-46
39. Stata Reference Manual: Release 5.0. College Station, Tex, Stata Corp, 1997
40. Greenland S: Modeling and variable selection in epidemiologic analysis. Am J Public Health 1989; 79:340-349
41. Rosenbaum JF, Biederman J, Gersten M, Hirshfeld DR, Meminger SR, Herman JB, Kagan J, Reznick JS, Snidman N: Behavioral inhibition in children of parents with panic disorder and agoraphobia: a controlled study. Arch Gen Psychiatry 1988; 45:463-470
42. Rosenbaum JF, Biederman J, Hirshfeld DR, Faraone SV, Bolduc EA, Kagan J, Snidman N, Reznick JS: Further evidence of an association between behavioral inhibition and anxiety disorders: results from a family study of children from a non-clinical sample. J Psychiat Res 1991; 25:49-65
43. Biederman J, Hirshfeld-Becker DR, Rosenbaum JF, Perenick SG, Wood J, Faraone SV: Lack of association between parental alcohol or drug addiction and behavioral inhibition in children. Am J Psychiatry 2001; 158:1731-1733