Testosterone levels and histological features of reproductive glands in adult male rats treated neonatally with tamoxifen

Neuroendocrinology Letters

Volumn 26, Issue 6, 2005, Pages 729-732

  Morales Otal, Adriana ^a   Retana Márquez, Socorro ^a   Ferreira Nuño, Armando ^a   Velázquez Moctezuma, Javier ^a  

^a DEPARTAMENTO DE QUÍMICA   (Mexico)

Author keywords

Rats; Sexual differentiation; Tamoxifen; Testis; Testosterone

Indexed keywords

TAMOXIFEN; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DEMASCULINIZATION; DOSE RESPONSE; GONADAL DISEASE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; MALE; MALE GENITAL SYSTEM; MICROSCOPY; NONHUMAN; ORGAN WEIGHT; RAT; SEMINAL VESICLE; SEMINIFEROUS TUBULE; SEXUAL BEHAVIOR; TESTIS WEIGHT; TESTOSTERONE BLOOD LEVEL; TESTOSTERONE RELEASE;

EID: 33645005940     PISSN: 0172780X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Gorski RA. Sexual dimorphisms of the brain. J Anim Sci. 1985; 61 Suppl 3:38-61.
2. Dorner G. Sex hormone dependent brain diferentiation and sexual behavior. Exp Brain Res. 1981; Suppl 3:238-245.
3. Weisz J, Ward IL. Plasma testosterone and progesterone titers of pregnant rats, their male and female fetuses, and neonatal offspring. Endocrinol. 106(1):306-316.
4. Döhler KD, Wuttke W. Changes with age in levels of serum gonadotropins, prolactin and gonadal steroids in prepubertal male and female rats, Endocrinol 1975; 97(4):898-907.
5. Gorski RA, Gordon JH, Shryne JE, Southam AM. Evidence for a morphological sex difference within the medial preoptic area of the rat brain, Brain Res 1978; 148(2):333-346.
6. Jacobson CD, Csernus VJ, Shryne JE, Gorski RA. The influence of gonadectomy, androgen exposure, or a gonadal graft in the neonatal rat on the volume of the sexually dimorphic nucleus of the preoptic area, J Neurosci 1981; 1(10):1142-1147.
7. Döhler, K. D., Coquelin, A., Davis, F., Hines, M., Shryne, J. E. and Gorski, R. A., Differentiation of the sexually nucleus in the preoptic area of the rat brain is determined by the perinatal hormone environment, Neurosci Lett 1982; 33(3):295-298
8. Döhler KD. The pre- and postnatal influence of hormones and neurotransmitters on sexual differentiation of the mammalian hypothalamus, Int Rev Citol 1991; 131: 1-55.
9. Csaba G, Karabélyos C. The effect of a single neonatal treatment (hormonal imprinting) with tha antihormones, tamoxifen and mifepristone on the sexual behaviour of adult rats, Pharmacol Res 2001; 43(6): 531-534.
10. Morales-Otal A, Ferreira-Nuño A. Velázquez-Moctezuma J. Monoaminergic and cholinergic stimulation of masculine sexual behavior in neonatally demasculinized male rats, Pharmacol Res 2002; 46(1):61-66.
11. Donaldson MD, Saez JM, Forest MG. Effects of the aromatase inhibitor 1,4,6-androstatriene-3,17-dione and the anti-oestrogen tamoxifen on rat testicular function, J Steroid 1981; 14:823-828.
12. Cigorraga SB, Sorrell S, Bator J, Catt J, Dufau ML. Estrogen dependence of a gonadotropin-induced steroidogenic lesion in rat testicular Leydig cells. J Clin Invest 1980; 65:699-705.
13. Hodgson YM, Urquhart G. Kretser DM. Effect of oestradiol and tamoxifen on the testosterone response in male rats to a single injection of hCG. J Reprod Fert 1983; 68:295-304.
14. Lin T, Murono EP, Osterman J, Nankin HR. Direct inhibition of rat Leydig cell function by tamoxifen, Metabolism 1981; 31:543-547.
15. Bartke A, Mason M, Dalterio S, Bex F. 1978. Effects of tamoxifen on plasma concentrations of testosterone and gonadotrophins in the male rat. J Endocrinol 1978; 79: 239-240.
16. Woodward JH, Emery PW. Determination of plasma corticosterone using high-performance liquid chromatography. J. Chromatogr. 1987; 419:280-284.
17. Vergouwen RPFA, Huiskamp R, Bas RJ, Roepers-Gajadien HL, Davids JAG, de Rooij DG. Postnatal development of testicular cell populations in mice. J Reprod Fert 1993; 99:479-485.
18. Vandekerckhove P, Lilford R, Vail A, Hughes E. Clomiphene or tamoxifen for idiophatic oligo/asthenospermia. Cochrane Database Syst Rev. 2000; (2): CD000151.
19. Huhtaniemi I, Pelliniemi LJ. Fetal Leydig cells: cellular origin, morphology, life span, and special functional features Proc Soc Exp Biol Med. 1992; 201(2):125-40.
20. Kuopio T, Tapanainen J, Pelliniemi LJ, Huhtaniemi I. Developmental stages of fetal-type Leydig cells in prepubertal rats. Development. 1989; 107(2):213-20.