Changes in vascular flow after transdermal oestradiol therapy for prostate cancer: A mechanism for cardiovascular toxicity and benefit?

BJU International

Volumn 97, Issue 3, 2006, Pages 498-504

  Ockrim, Jeremy L ^a   Lalani, El Nasir ^a   Aslam, Mo ^a   Standfield, Nigel ^a   Abel, Paul D ^a,b  

^a IMPERIAL COLLEGE HEALTHCARE NHS TRUST   (United Kingdom)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

Oestradiol; Prostate cancer; Transdermal administration; Vascular capacitance; Vasculature

Indexed keywords

ESTRADIOL; ESTRADIOL VALERATE;

ADVANCED CANCER; AGED; ARTERY BLOOD FLOW; ARTERY COMPLIANCE; ARTICLE; BLOOD FLOW; CAPILLARY PERMEABILITY; CARDIOTOXICITY; CARDIOVASCULAR DISEASE; DOPPLER ECHOGRAPHY; DOPPLER FLOWMETRY; FLUID RETENTION; HUMAN; LIMB BLOOD FLOW; MALE; METASTASIS; PHOTOELECTRIC PLETHYSMOGRAPHY; PLETHYSMOGRAPHY; PRIORITY JOURNAL; PROSTATE CANCER; SIDE EFFECT; THROMBOEMBOLISM;

ADMINISTRATION, CUTANEOUS; AGED; AGED, 80 AND OVER; ARTERIES; BLOOD FLOW VELOCITY; CARDIOVASCULAR DISEASES; COMPLIANCE; ESTRADIOL; EXTREMITIES; HUMANS; MALE; PILOT PROJECTS; PROSTATIC NEOPLASMS; REGIONAL BLOOD FLOW;

EID: 33645002608     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2006.05937.x     Document Type: Article

References (27)

1. Huggins C Hodges C Studies on prostatic cancer I. effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate Cancer Res 1941 1 293 7
2. The Veterans Administration Co-operative Urological Research Group 1967. Treatment and survival of patients with cancer of the prostate Surg Gynecol Obstet 1967 124 1011 7
3. Mikkola AK Ruutu ML Aro JL Rannikko SA Salo JO Parenteral polyoestradiol phosphate vs orchidectomy in the treatment of advanced prostatic cancer. Efficacy and cardiovascular complications: a 2-year follow-up report of a national, prospective prostatic cancer study. Finnprostate Group Br J Urol 1998 82 63 8
4. Hedlund PO Henriksson P Parenteral estrogen versus total androgen ablation in the treatment of advanced prostate carcinoma: effects on overall survival and cardiovascular mortality. The Scandinavian Prostatic Cancer Group (SPCG)-5 Trial Study Urology 2000 55 328 33
5. Ockrim JL Lalani EN Laniado ME Carter SS Abel PD Transdermal estradiol therapy for advanced prostate cancer - forward to the past? J Urol 2003 169 1735 7
6. Ockrim JL Lalani EN Banks LM et al. Transdermal estradiol improves bone density when used as single agent therapy for prostate cancer J Urol 2004 172 2203 7
7. Hedlund PO Ala-Opas M Brekkan E et al. Parenteral estrogen versus combined androgen deprivation in the treatment of metastatic prostatic cancer - Scandinavian Prostatic Cancer Group (SPCG) Study No. 5 Scand J Urol Nephrol 2002 36 405 13
8. Henriksson P Blomback M Eriksson A Stege R Carlstrom K Effect of parenteral oestrogen on the coagulation system in patients with prostatic carcinoma Br J Urol 1990 65 282 5
9. Ockrim JL Lalani EN Kakkar AJ Abel PD Transdermal estradiol therapy for prostate cancer reduces thrombophilic activation and protects against thromboembolism J Urol 2005 174 527 33
10. Pannier BM Avolio AP Hoeks A Mancia G Takazawa K Methods and devices for measuring arterial compliance in humans Am J Hypertens 2002 15 743 53
11. Blacher J Asmar R Djane S London GM Safar ME Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients Hypertension 1999 33 1111 7
12. Laurent S Boutouyrie P Asmar R et al. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients Hypertension 2001 37 1236 41
13. de Voogt HJ Smith PH Pavone-Macaluso M de Pauw M Suciu S Cardiovascular side effects of diethylstilbestrol, cyproterone acetate, medroxyprogesterone acetate and estramustine phosphate used for the treatment of advanced prostatic cancer: results from European Organization for Research on Treatment of Cancer trials 30761 and 30762 J Urol 1986 135 303 7
14. Robinson MR Smith PH Richards B Newling DW de Pauw M Sylvester R The final analysis of the EORTC Genito-Urinary Tract Cancer Co-Operative Group phase III clinical trial (protocol 30805) comparing orchidectomy, orchidectomy plus cyproterone acetate and low dose stilboestrol in the management of metastatic carcinoma of the prostate Eur Urol 1995 28 273 83
15. Aro J Cardiovascular and all-cause mortality in prostatic cancer patients treated with estrogens or orchiectomy as compared to the standard population Prostate 1991 18 131 7
16. Volterrani M Rosano G Coats A Beale C Collins P Estrogen acutely increases peripheral blood flow in postmenopausal women Am J Med 1995 99 119 22
17. Collins P Vascular aspects of oestrogen Maturitas 1996 23 217 26
18. Jilma B Wolzt M Wagner OF et al. In vivo study of the effect of exogenous estradiol on alpha-adrenoceptor responsiveness of human veins J Cardiovasc Pharmacol 1994 23 859 63
19. Hodges YK Tung L Yan XD Graham JD Horwitz KB Horwitz LD Estrogen receptors alpha and beta: prevalence of estrogen receptor beta mRNA in human vascular smooth muscle and transcriptional effects Circulation 2000 101 1792 8
20. Pines A Averbuch M Fisman EZ Rosano GM The acute effects of sublingual 17beta-estradiol on the cardiovascular system Maturitas 1999 33 81 5
21. Leonardo F Medeirus C Rosano GM et al. Effect of acute administration of estradiol 17 beta on aortic blood flow in menopausal women Am J Cardiol 1997 80 791 3
22. Bishop MC Experience with low-dose oestrogen in the treatment of advanced prostate cancer: a personal view Br J Urol 1996 78 921 8
23. Rajkumar C Kingwell BA Cameron JD et al. Hormonal therapy increases arterial compliance in postmenopausal women J Am Coll Cardiol 1997 30 350 6
24. Mijatovic V Pines A The first clinical synthesis conference on hormone replacement therapy: new perspectives for HRT? Maturitas 1999 33 87 92
25. Hulley S Grady D Bush T et al. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart Estrogen/Progestin Replacement Study (HERS) Research Group JAMA 1998 280 605 13
26. Grodstein F Manson JE Stampfer MJ Postmenopausal hormone use and secondary prevention of coronary events in the nurses' health study. a prospective, observational study Ann Intern Med 2001 135 1 8
27. Bracamonte MP Miller VM Vascular effects of estrogens: arterial protection versus venous thrombotic risk Trends Endocrinol Metab 2001 12 204 9