A promoter element of the CD-RAP gene is required for repression of gene expression in non-cartilage tissues in vitro and in vivo

Journal of Cellular Biochemistry

Volumn 97, Issue 4, 2006, Pages 857-868

  Okazaki, Ken ^a   Yu, Hua ^a   Davies, Sherri R ^a   Imamura, Toshihiro ^a   Sandell, Linda J ^a,b  

^a BARNES JEWISH HOSPITAL   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cartilage; CCAAT enhancer binding protein; CD RAP; Sox9; Transcription

Indexed keywords

CARTILAGE DERIVED RETINOIC ACID SENSITIVE PROTEIN; CCAAT ENHANCER BINDING PROTEIN; DNA; GENE PRODUCT; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SOX; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARTILAGE; CARTILAGE CELL; CD RAP GENE; CELL ACTIVATION; CELL TYPE; CONTROLLED STUDY; EMBRYO; FEMALE; GENE; GENE ACTIVATION; GENE REPRESSION; GENETIC TRANSCRIPTION; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; MYOBLAST; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN MOTIF; RAT; REPORTER GENE; TRANSGENIC MOUSE;

ANIMALS; BALB 3T3 CELLS; CARTILAGE; CCAAT-ENHANCER-BINDING PROTEINS; CELL LINE, TUMOR; ENHANCER ELEMENTS (GENETICS); EPITHELIAL CELLS; EXTRACELLULAR MATRIX PROTEINS; GENE EXPRESSION REGULATION; GENES, REPORTER; MICE; MICE, TRANSGENIC; MYOBLASTS; NEOPLASM PROTEINS; PROMOTER REGIONS (GENETICS); RATS; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS; TRANSFECTION;

ANIMALIA; MUS MUSCULUS;

EID: 33644998779     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.20648     Document Type: Article

References (39)

1. Akira S, Isshiki H, Sugita T, Tanabe O, Kinoshita S, Nishio Y, Nakajima T, Hirano T, Kishimoto T. 1990. A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J 9:1897-1906.
2. Barolo S, Posakony JW. 2002. Three habits of highly effective signaling pathways: Principles of transcriptional control by developmental cell signaling. Genes Dev 16:1167-1181.
3. Bi W, Deng JM, Zhang Z, Behringer RR, de Crombrugghe B. 1999. Sox9 is required for cartilage formation. Nat Genet 22:85-89.
4. Blesch A, Bosserhoff AK, Apfel R, Behl C, Hessdoerfer B, Schmitt A, Jachimczak P, Lottspeich F, Buettner R, Bogdahn U. 1994. Cloning of a novel malignant melanoma-derived growth-regulatory protein, MIA. Cancer Res 54:5695-5701.
5. Bosserhoff AK, Kondo S, Moser M, Dietz UH, Copeland NG, Gilbert DJ, Jenkins NA, Buettner R, Sandell LJ. 1997. Mouse CD-RAP/MIA gene: Structure, chromosomal localization, and expression in cartilage and chondrosarcoma. Dev Dyn 208:516-525.
6. Bosserhoff AK, Moser M, Hein R, Landthaler M, Buettner R. 1999. In situ expression patterns of melanoma-inhibiting activity (MIA) in melanomas and breast cancers. J Pathol 187:446-454.
7. Bridgewater LC, Lefebvre V, de Crombrugghe B. 1998. Chondrocyte-specific enhancer elements in the Col11a2 gene resemble the Col2a1 tissue-specific enhancer. J Biol Chem 273:14998-15006.
8. Chansky H, Robbins JR, Cha S, Raskind WH, Conrad EU, Sandell LJ. 1998. Expression of cartilage extracellular matrix and potential regulatory genes in a new human chondrosarcoma cell line. J Orthop Res 16:521-530.
9. Davies SR, Sakano S, Zhu Y, Sandell LJ. 2002. Distribution of the transcription factors Sox9, AP-2, and deltaEF1 in adult murine articular and meniscal cartilage and growth plate. J Histochem Cytochem 50:1059-1065.
10. Davies S, Chang L, Yu H, Stormo G, Sandell LJ. 2004a. Computational identification of a chondrocyte regulatory module. Trans Orthopedic Res Soc 50:61.
11. Davies SR, Li J, Okazaki K, Sandell LJ. 2004b. Tissue-restricted expression of the Cdrap/Mia gene within a conserved multigenic housekeeping locus. Genomics 83:667-678.
12. Dietz UH, Sandell LJ. 1996. Cloning of a retinoic acid-sensitive mRNA expressed in cartilage and during chondrogenesis. J Biol Chem 271:3311-3316.
13. Greenwel P, Tanaka S, Penkov D, Zhang W, Olive M, Moll J, Vinson C, Di Liberto M, Ramirez F. 2000. Tumor necrosis factor alpha inhibits type I collagen synthesis through repressive CCAAT/enhancer-binding proteins. Mol Cell Biol 20:912-918.
14. Gutierrez S, Javed A, Tennant DK, van Rees M, Montecino M, Stein GS, Stein JL, Lian JB. 2002. CCAAT/enhancer-binding proteins (C/EBP) beta and delta activate osteocalcin gene transcription and synergize with Runx2 at the C/EBP element to regulate bone-specific expression. J Biol Chem 277:1316-1323.
15. Huang Z, Xu H, Sandell L. 2004. Negative regulation of chondrocyte differentiation by transcription factor AP-2alpha. J Bone Miner Res 19:245-255.
16. Imamura T, Imamura C, Iwamoto Y, Sandell LJ. 2005. Transcriptional co-activators CREB-binding protein/p300 increase chondrocyte Cd-rap gene expression by multiple mechanisms including sequestration of the repressor CCAAT/enhancer-binding protein. J Biol Chem 280:16625-16634.
17. Jones PL, Ping D, Boss JM. 1997. Tumor necrosis factor alpha and interleukin-1beta regulate the murine manganese superoxide dismutase gene through a complex intronic enhancer involving C/EBP-beta and NF-kappaB. Mol Cell Biol 17:6970-6981.
18. Kirfel J, Kelter M, Cancela LM, Price PA, Schule R. 1997. Identification of a novel negative retinoic acid responsive element in the promoter of the human matrix G1a protein gene. Proc Natl Acad Sci USA 94:2227-2232.
19. Lefebvre V, Zhou G, Mukhopadhyay K, Smith CN, Zhang Z, Eberspaecher H, Zhou X, Sinha S, Maity SN, de Crombrugghe B. 1996. An 18-base-pair sequence in the mouse proalphal(II) collagen gene is sufficient for expression in cartilage and binds nuclear proteins that are selectively expressed in chondrocytes. Mol Cell Biol 16:4512-4523.
20. Lefebvre V, Huang W, Harley VR, Goodfellow PN, de Crombrugghe B. 1997. SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alphal(II) collagen gene. Mol Cell Biol 17:2336-2346.
21. Lefebvre V, Li P, de Crombrugghe B. 1998. A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene. EMBO J 17:5718-5733.
22. th Annual Meeting:11.
23. Liu Y, Li H, Tanaka K, Tsumaki N, Yamada Y. 2000. Identification of an enhancer sequence within the first intron required for cartilage-specific transcription of the alpha2(XI) collagen gene. J Biol Chem 275:12712-12718.
24. Massaad C, Paradon M, Jacques C, Salvat C, Bereziat G, Berenbaum F, Olivier JL. 2000. Induction of secreted type IIA phospholipase A2 gene transcription by interleukin-1beta. Role of C/EBP factors. J Biol Chem 275:22686-22694.
25. Murakami S, Lefebvre V, de Crombrugghe B. 2000. Potent inhibition of the master chondrogenic factor Sox9 gene by interleukin-1 and tumor necrosis factor-alpha. J Biol Chem 275:3687-3692.
26. Murray D, Precht P, Balakir R, Horton WE Jr. 2000. The transcription factor deltaEF1 is inversely expressed with type II collagen mRNA and can repress Col2a1 promoter activity in transfected chondrocytes. J Biol Chem 275:3610-3618.
27. Ogasawara A. 2001. Fluid shear stress-induced cyclooxygenase-2 expression is mediated by C/EBP beta, cAMP-response element-binding protein, and AP-1 in osteoblastic MC3T3-E1 cells. J Biol Chem 276:7048-7054.
28. Okazaki K, Li J, Yu H, Fukui N, Sandell LJ. 2002. CCAAT/enhancer binding protein beta and delta mediate the repression of gene transcription of cartilage-derived retinoic acid-sensitive protein induced by interleukin-1b. J Biol Chem 277:31526-31533.
29. Sandell LJ, Adler P. 1999. Developmental patterns of cartilage. Front Biosci 4:D731-D742.
30. Sock E, Pagon RA, Keymolen K, Lissens W, Wegner M, Scherer G. 2003. Loss of DNA-dependent dimerization of the transcription factor SOX9 as a cause for campomelic dysplasia. Hum Mol Genet 12:1439-1447.
31. Stoll R, Renner C, Zweckstetter M, Bruggert M, Ambrosius D, Palme S, Engh RA, Golob M, Breibach I, Buettner R, Voelter W, Holak TA, Bosserhoff AK. 2001. The extracellular human melanoma inhibitory activity (MIA) protein adopts an SH3 domain-like fold. EMBO J 20:340-349.
32. Tanaka K, Matsumoto Y, Nakatani F, Iwamoto Y, Yamada Y. 2000. A zinc finger transcription factor, alphaA-crystallin binding protein 1, is a negative regulator of the chondrocyte-specific enhancer of the alpha1(II) collagen gene. Mol Cell Biol 20:4428-4435.
33. Thomas B, Berenbaum F, Humbert L, Bian H, Bereziat G, Crofford L, Olivier JL. 2000. Critical role of C/EBPdelta and C/EBPbeta factors in the stimulation of the cyclooxygenase-2 gene transcription by interleukin-1beta in articular chondrocytes. Eur J Biochem 267:6798-6809.
34. Tsuda M, Takahashi S, Takahashi Y, Asahara H. 2003. Transcriptional co-activators CREB-binding protein and p300 regulate chondrocyte-specific gene expression via association with Sox9. J Biol Chem 278:27224-27229.
35. Tsumaki N, Kimura T, Tanaka K, Kimura JH, Ochi T, Yamada Y. 1998. Modular arrangement of cartilage- and neural tissue-specific cis-elements in the mouse alpha2(XI) collagen promoter. J Biol Chem 273:22861-22864.
36. Xie WF, Kondo S, Sandell LJ. 1998. Regulation of the mouse cartilage-derived retinoic acid-sensitive protein gene by the transcription factor AP-2. J Biol Chem 273:5026-5032.
37. Xie W-F, Zhang X, Sandell LJ. 2000. The 2.2 kb promoter of cartilage-derived retinoic acid-sensitive protein controls gene expression in cartilage and embryonic mammary buds of transgenic mice. Matrix Biol 19:501-509.
38. Zhang D-E, Hetherington CJ, Meyers S, Rhoades KL, Larson CJ, Chen H-M, Hiebert SW, Tenen DG. 1996. CCAAT enhancer-binding protein (C/EBP) and AML1 (CBFα2) synergistically activate the macrophage colony-stimulating factor receptor promoter. Mol Cell Biol 16:1231-1240.
39. Zhou G, Lefebvre V, Zhang Z, Eberspaecher H, de Crombrugghe B. 1998. Three high mobility group-like sequences within a 48-base pair enhancer of the Col2a1 gene are required for cartilage-specific expression in vivo. J Biol Chem 273:14989-14997.