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Volumn 234, Issue 2, 2006, Pages 109-123

Gonadotropin-releasing hormone in apoptosis of prostate cancer cells

Author keywords

GnRH a; Gonadotropin; MAPK; PKB; Prostate cancer cells; Signaling cascades

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTIANDROGEN; BUSERELIN; CETRORELIX; GONADORELIN; GONADORELIN ANTAGONIST; GONADORELIN RECEPTOR; GONADORELIN[1 [N ACETYL 3 (2 NAPHTHYL) DEXTRO ALANINE] 2 (4 CHLORO DEXTRO PHENYLALANINE) 3 DEXTRO TRYPTOPHAN 6 DEXTRO CITRULLINE 10 DEXTRO ALANINE]; GONADORELIN[1 [N ACETYL 3 (2 NAPHTHYL) DEXTRO ALANINE] 2 (4 CHLORO DEXTRO PHENYLALANINE) 3 DEXTRO TRYPTOPHAN 6 DEXTRO HOMOCITRULLINE 10 DEXTRO ALANINE]; GONADORELIN[1,3 (N ACETYL DEXTRO TRYPTOPHAN) 2 (4 CHLORO DEXTRO PHENYLALANINE) 6 DEXTRO LYSINE 10 DEXTRO ALANINE]; GOSERELIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; UNCLASSIFIED DRUG;

EID: 33644992893     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2005.02.038     Document Type: Review
Times cited : (49)

References (134)
  • 1
    • 4544262511 scopus 로고    scopus 로고
    • Newly recognized GnRH receptors: Function and relative role
    • J.D. Neill, L.C. Musgrove, and L.W. Duck Newly recognized GnRH receptors: function and relative role Trends Endocrinol. Metab. 15 2004 383 392
    • (2004) Trends Endocrinol. Metab. , vol.15 , pp. 383-392
    • Neill, J.D.1    Musgrove, L.C.2    Duck, L.W.3
  • 2
    • 4444258378 scopus 로고    scopus 로고
    • Genomics view of gonadotrope signaling circuits
    • F. Ruf, and S.C. Sealfon Genomics view of gonadotrope signaling circuits Trends Endocrinol. Metab. 15 2004 331 338
    • (2004) Trends Endocrinol. Metab. , vol.15 , pp. 331-338
    • Ruf, F.1    Sealfon, S.C.2
  • 4
    • 33644991721 scopus 로고    scopus 로고
    • Molecular biology of gonadotropin-releasing hormone (GnRH)-I, GnRH-II and their receptors in humans
    • C.K. Cheng, and P.C. Leung Molecular biology of gonadotropin-releasing hormone (GnRH)-I, GnRH-II and their receptors in humans Endocr. Rev. 2004
    • (2004) Endocr. Rev.
    • Cheng, C.K.1    Leung, P.C.2
  • 5
    • 0001169908 scopus 로고
    • Gonadotropin secretion and its control
    • E. Knobil J.D. Neill Raven Press New York, NY
    • G. Fink Gonadotropin secretion and its control E. Knobil J.D. Neill The Physiology of Reproduction 1988 Raven Press New York, NY 1349 1377
    • (1988) The Physiology of Reproduction , pp. 1349-1377
    • Fink, G.1
  • 6
    • 0028306250 scopus 로고
    • Gonadotropin-releasing hormone and its analogs
    • P.M. Conn, and W.F. Crowley Jr. Gonadotropin-releasing hormone and its analogs Annu. Rev. Med. 45 1994 391 405
    • (1994) Annu. Rev. Med. , vol.45 , pp. 391-405
    • Conn, P.M.1    Crowley Jr., W.F.2
  • 7
    • 0026020369 scopus 로고
    • Clinical uses of gonadotropin-releasing hormone analogues
    • R.F. Casper Clinical uses of gonadotropin-releasing hormone analogues Can. Med. Assoc. J. 144 1991 153 158
    • (1991) Can. Med. Assoc. J. , vol.144 , pp. 153-158
    • Casper, R.F.1
  • 8
    • 0028235123 scopus 로고
    • The use of luteinizing hormone releasing hormone agonists and antagonists in gynaecological cancers
    • G. Emons, and A.V. Schally The use of luteinizing hormone releasing hormone agonists and antagonists in gynaecological cancers Hum. Reprod. 9 1994 1364 1379
    • (1994) Hum. Reprod. , vol.9 , pp. 1364-1379
    • Emons, G.1    Schally, A.V.2
  • 9
    • 0028285865 scopus 로고
    • Gonadotrophin-releasing hormone agonists. a guide to use and selection
    • M. Filicori Gonadotrophin-releasing hormone agonists. A guide to use and selection Drugs 48 1994 41 58
    • (1994) Drugs , vol.48 , pp. 41-58
    • Filicori, M.1
  • 10
    • 9644279380 scopus 로고    scopus 로고
    • Androgen deprivation therapy for prostate cancer: Current status and future prospects
    • H. Miyamoto, E.M. Messing, and C. Chang Androgen deprivation therapy for prostate cancer: current status and future prospects Prostate 61 2004 332 353
    • (2004) Prostate , vol.61 , pp. 332-353
    • Miyamoto, H.1    Messing, E.M.2    Chang, C.3
  • 11
    • 0026545546 scopus 로고
    • Direct effects of luteinizing hormone-releasing hormone agonists and antagonists on MCF-7 mammary cancer cells
    • T. Segal-Abramson, H. Kitroser, J. Levy, A.V. Schally, and Y. Sharoni Direct effects of luteinizing hormone-releasing hormone agonists and antagonists on MCF-7 mammary cancer cells Proc. Natl Acad. Sci. USA 89 1992 2336 2339
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 2336-2339
    • Segal-Abramson, T.1    Kitroser, H.2    Levy, J.3    Schally, A.V.4    Sharoni, Y.5
  • 12
    • 0030923675 scopus 로고    scopus 로고
    • The genes for gonadotropin-releasing hormone and its receptor are expressed in human breast with fibrocystic disease and cancer
    • M.L. Kottler, A. Starzec, M.C. Carre, J.P. Lagarde, A. Martin, and R. Counis The genes for gonadotropin-releasing hormone and its receptor are expressed in human breast with fibrocystic disease and cancer Int. J. Cancer 71 1997 595 599
    • (1997) Int. J. Cancer , vol.71 , pp. 595-599
    • Kottler, M.L.1    Starzec, A.2    Carre, M.C.3    Lagarde, J.P.4    Martin, A.5    Counis, R.6
  • 13
    • 0027380592 scopus 로고
    • High affinity binding and direct antiproliferative effects of LHRH analogues in human ovarian cancer cell lines
    • G. Emons, O. Ortmann, M. Becker, G. Irmer, B. Springer, and R. Laun High affinity binding and direct antiproliferative effects of LHRH analogues in human ovarian cancer cell lines Cancer Res. 53 1993 5439 5446
    • (1993) Cancer Res. , vol.53 , pp. 5439-5446
    • Emons, G.1    Ortmann, O.2    Becker, M.3    Irmer, G.4    Springer, B.5    Laun, R.6
  • 14
    • 0025317908 scopus 로고
    • Detection and partial characterization of receptors for [D-Trp6]-luteinizing hormone-releasing hormone and epidermal growth factor in human endometrial carcinoma
    • G. Srkalovic, J.L. Wittliff, and A.V. Schally Detection and partial characterization of receptors for [D-Trp6]-luteinizing hormone-releasing hormone and epidermal growth factor in human endometrial carcinoma Cancer Res. 50 1990 1841 1846
    • (1990) Cancer Res. , vol.50 , pp. 1841-1846
    • Srkalovic, G.1    Wittliff, J.L.2    Schally, A.V.3
  • 15
    • 0029920507 scopus 로고    scopus 로고
    • The expression of gonadotropin-releasing hormone and its receptor in endometrial cancer, and its relevance as an autocrine growth factor
    • E. Chatzaki, C.M. Bax, K.A. Eidne, L. Anderson, J.G. Grudzinskas, and C.J. Gallagher The expression of gonadotropin-releasing hormone and its receptor in endometrial cancer, and its relevance as an autocrine growth factor Cancer Res. 56 1996 2059 2065
    • (1996) Cancer Res. , vol.56 , pp. 2059-2065
    • Chatzaki, E.1    Bax, C.M.2    Eidne, K.A.3    Anderson, L.4    Grudzinskas, J.G.5    Gallagher, C.J.6
  • 16
    • 0031671617 scopus 로고    scopus 로고
    • Expression of gonadotropin-releasing hormone (GnRH) and GnRH receptor mRNA in prostate cancer cells and effect of GnRH on the proliferation of prostate cancer cells
    • J.Y. Bahk, J.S. Hyun, H. Lee, M.O. Kim, G.J. Cho, B.H. Lee, and W.S. Choi Expression of gonadotropin-releasing hormone (GnRH) and GnRH receptor mRNA in prostate cancer cells and effect of GnRH on the proliferation of prostate cancer cells Urol Res. 26 1998 259 264
    • (1998) Urol Res. , vol.26 , pp. 259-264
    • Bahk, J.Y.1    Hyun, J.S.2    Lee, H.3    Kim, M.O.4    Cho, G.J.5    Lee, B.H.6    Choi, W.S.7
  • 17
    • 0033303530 scopus 로고    scopus 로고
    • The luteinizing hormone-releasing hormone receptor in human prostate cancer cells: Messenger ribonucleic acid expression, molecular size, and signal transduction pathway
    • P. Limonta, R.M. Moretti, M.M. Marelli, D. Dondi, M. Parenti, and M. Motta The luteinizing hormone-releasing hormone receptor in human prostate cancer cells: messenger ribonucleic acid expression, molecular size, and signal transduction pathway Endocrinology 140 1999 5250 5256
    • (1999) Endocrinology , vol.140 , pp. 5250-5256
    • Limonta, P.1    Moretti, R.M.2    Marelli, M.M.3    Dondi, D.4    Parenti, M.5    Motta, M.6
  • 18
    • 0035371234 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone receptor expression in the human prostate
    • A. Tieva, P. Stattin, P. Wikstrom, A. Bergh, and J.E. Damber Gonadotropin-releasing hormone receptor expression in the human prostate Prostate 47 2001 276 284
    • (2001) Prostate , vol.47 , pp. 276-284
    • Tieva, A.1    Stattin, P.2    Wikstrom, P.3    Bergh, A.4    Damber, J.E.5
  • 19
    • 0033842808 scopus 로고    scopus 로고
    • Luteinizing hormone-releasing hormone agonist triptorelin and antagonist cetrorelix inhibit EGF-induced c-fos expression in human gynecological cancers
    • C. Grundker, P. Volker, K.D. Schulz, and G. Emons Luteinizing hormone-releasing hormone agonist triptorelin and antagonist cetrorelix inhibit EGF-induced c-fos expression in human gynecological cancers Gynecol. Oncol. 78 2000 194 202
    • (2000) Gynecol. Oncol. , vol.78 , pp. 194-202
    • Grundker, C.1    Volker, P.2    Schulz, K.D.3    Emons, G.4
  • 20
    • 0032922082 scopus 로고    scopus 로고
    • Luteinizing hormone-releasing hormone agonists interfere with the mitogenic activity of the insulin-like growth factor system in androgen-independent prostate cancer cells
    • M.M. Marelli, R.M. Moretti, D. Dondi, M. Motta, and P. Limonta Luteinizing hormone-releasing hormone agonists interfere with the mitogenic activity of the insulin-like growth factor system in androgen-independent prostate cancer cells Endocrinology 140 1999 329 334
    • (1999) Endocrinology , vol.140 , pp. 329-334
    • Marelli, M.M.1    Moretti, R.M.2    Dondi, D.3    Motta, M.4    Limonta, P.5
  • 21
    • 0343238179 scopus 로고    scopus 로고
    • LHRH might act as a negative autocrine regulator of proliferation of human ovarian cancer
    • G. Emons, S. Weiss, O. Ortmann, C. Grundker, and K.D. Schulz LHRH might act as a negative autocrine regulator of proliferation of human ovarian cancer Eur. J. Endocrinol. 142 2000 665 670
    • (2000) Eur. J. Endocrinol. , vol.142 , pp. 665-670
    • Emons, G.1    Weiss, S.2    Ortmann, O.3    Grundker, C.4    Schulz, K.D.5
  • 22
  • 23
    • 4143145476 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone induces apoptosis of prostate cancer cells: Role of c-Jun NH2-terminal kinase, protein kinase B, and extracellular signal-regulated kinase pathways
    • S. Kraus, G. Levy, T. Hanoch, Z. Naor, and R.M. Seger Gonadotropin-releasing hormone induces apoptosis of prostate cancer cells: role of c-Jun NH2-terminal kinase, protein kinase B, and extracellular signal-regulated kinase pathways Cancer Res. 64 2004 5736 5744
    • (2004) Cancer Res. , vol.64 , pp. 5736-5744
    • Kraus, S.1    Levy, G.2    Hanoch, T.3    Naor, Z.4    Seger, R.M.5
  • 24
    • 5644247440 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone (GnRH) antagonists promote proapoptotic signaling in peripheral reproductive tumor cells by activating a Galphai-coupling state of the type I GnRH receptor
    • S. Maudsley, L. Davidson, A.J. Pawson, R. Chan, R.L. de Maturana, and R.P. Millar Gonadotropin-releasing hormone (GnRH) antagonists promote proapoptotic signaling in peripheral reproductive tumor cells by activating a Galphai-coupling state of the type I GnRH receptor Cancer Res. 64 2004 7533 7544
    • (2004) Cancer Res. , vol.64 , pp. 7533-7544
    • Maudsley, S.1    Davidson, L.2    Pawson, A.J.3    Chan, R.4    De Maturana, R.L.5    Millar, R.P.6
  • 25
    • 0346458794 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone receptor-mediated growth suppression of immortalized LbetaT2 gonadotrope and stable HEK293 cell lines
    • L.E. Miles, A.C. Hanyaloglu, J.R. Dromey, K.D. Pfleger, and K.A. Eidne Gonadotropin-releasing hormone receptor-mediated growth suppression of immortalized LbetaT2 gonadotrope and stable HEK293 cell lines Endocrinology 145 2004 194 204
    • (2004) Endocrinology , vol.145 , pp. 194-204
    • Miles, L.E.1    Hanyaloglu, A.C.2    Dromey, J.R.3    Pfleger, K.D.4    Eidne, K.A.5
  • 26
    • 0015218538 scopus 로고
    • Gonadotropin-releasing hormone: One polypeptide regulates secretion of luteinizing and follicle-stimulating hormones
    • A.V. Schally, A. Arimura, A.J. Kastin, H. Matsuo, Y. Baba, and T.W. Redding Gonadotropin-releasing hormone: one polypeptide regulates secretion of luteinizing and follicle-stimulating hormones Science 173 1971 1036 1038
    • (1971) Science , vol.173 , pp. 1036-1038
    • Schally, A.V.1    Arimura, A.2    Kastin, A.J.3    Matsuo, H.4    Baba, Y.5    Redding, T.W.6
  • 27
    • 0037012226 scopus 로고    scopus 로고
    • Evolutionary development of three gonadotropin-releasing hormone (GnRH) systems in vertebrates
    • E.A. Dubois, M.A. Zandbergen, J. Peute, and H.J. Goos Evolutionary development of three gonadotropin-releasing hormone (GnRH) systems in vertebrates Brain Res. Bull. 57 2002 413 418
    • (2002) Brain Res. Bull. , vol.57 , pp. 413-418
    • Dubois, E.A.1    Zandbergen, M.A.2    Peute, J.3    Goos, H.J.4
  • 28
    • 0030937284 scopus 로고    scopus 로고
    • Molecular mechanisms of ligand interaction with the gonadotropin- releasing hormone receptor
    • S.C. Sealfon, H. Weinstein, and R.P. Millar Molecular mechanisms of ligand interaction with the gonadotropin-releasing hormone receptor Endocr. Rev. 18 1997 180 205
    • (1997) Endocr. Rev. , vol.18 , pp. 180-205
    • Sealfon, S.C.1    Weinstein, H.2    Millar, R.P.3
  • 30
    • 0026794339 scopus 로고
    • Molecular cloning and expression of cDNA encoding the murine gonadotropin-releasing hormone receptor
    • J. Reinhart, L.M. Mertz, and K.J. Catt Molecular cloning and expression of cDNA encoding the murine gonadotropin-releasing hormone receptor J. Biol. Chem. 267 1992 21281 21284
    • (1992) J. Biol. Chem. , vol.267 , pp. 21281-21284
    • Reinhart, J.1    Mertz, L.M.2    Catt, K.J.3
  • 32
    • 0034810482 scopus 로고    scopus 로고
    • A gonadotropin-releasing hormone (GnRH) receptor specific for GnRH II in primates
    • J.D. Neill, L.W. Duck, J.C. Sellers, and L.C. Musgrove A gonadotropin-releasing hormone (GnRH) receptor specific for GnRH II in primates Biochem. Biophys. Res. Commun. 282 2001 1012 1018
    • (2001) Biochem. Biophys. Res. Commun. , vol.282 , pp. 1012-1018
    • Neill, J.D.1    Duck, L.W.2    Sellers, J.C.3    Musgrove, L.C.4
  • 33
    • 0034756120 scopus 로고    scopus 로고
    • The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci
    • B. Faurholm, R.P. Millar, and A.A. Katz The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci Genomics 78 2001 15 18
    • (2001) Genomics , vol.78 , pp. 15-18
    • Faurholm, B.1    Millar, R.P.2    Katz, A.A.3
  • 34
    • 0038069320 scopus 로고    scopus 로고
    • GnRH II and type II GnRH receptors
    • R.P. Millar GnRH II and type II GnRH receptors Trends Endocrinol. Metab. 14 2003 35 43
    • (2003) Trends Endocrinol. Metab. , vol.14 , pp. 35-43
    • Millar, R.P.1
  • 36
    • 0025294617 scopus 로고
    • Signal transduction mechanisms of Ca2+mobilizing hormones: The case of gonadotropin-releasing hormone
    • Z. Naor Signal transduction mechanisms of Ca2+mobilizing hormones: the case of gonadotropin-releasing hormone Endocr. Rev. 11 1990 326 353
    • (1990) Endocr. Rev. , vol.11 , pp. 326-353
    • Naor, Z.1
  • 37
    • 0028306894 scopus 로고
    • Control of calcium spiking frequency in pituitary gonadotrophs by a single-pool cytoplasmic oscillator
    • S.S. Stojilkovic, M. Tomic, M. Kukuljan, and K.J. Catt Control of calcium spiking frequency in pituitary gonadotrophs by a single-pool cytoplasmic oscillator Mol. Pharmacol. 45 1994 1013 1021
    • (1994) Mol. Pharmacol. , vol.45 , pp. 1013-1021
    • Stojilkovic, S.S.1    Tomic, M.2    Kukuljan, M.3    Catt, K.J.4
  • 38
    • 0032566156 scopus 로고    scopus 로고
    • GnRH signalling pathways and GnRH-induced homologous desensitization in a gonadotrope cell line (alphaT3-1)
    • B. Poulin, N. Rich, J.L. Mas, C. Kordon, A. Enjalbert, and S.V. Drouva GnRH signalling pathways and GnRH-induced homologous desensitization in a gonadotrope cell line (alphaT3-1) Mol. Cell. Endocrinol. 142 1998 99 117
    • (1998) Mol. Cell. Endocrinol. , vol.142 , pp. 99-117
    • Poulin, B.1    Rich, N.2    Mas, J.L.3    Kordon, C.4    Enjalbert, A.5    Drouva, S.V.6
  • 39
    • 18044403459 scopus 로고    scopus 로고
    • Mechanism of GnRH receptor signaling on gonadotropin release and gene expression in pituitary gonadotrophs
    • S. Shacham, D. Harris, H. Ben-Shlomo, I. Cohen, D. Bonfil, and F. Przedecki Mechanism of GnRH receptor signaling on gonadotropin release and gene expression in pituitary gonadotrophs Vitam. Horm. 63 2001 63 90
    • (2001) Vitam. Horm. , vol.63 , pp. 63-90
    • Shacham, S.1    Harris, D.2    Ben-Shlomo, H.3    Cohen, I.4    Bonfil, D.5    Przedecki, F.6
  • 40
    • 0034119581 scopus 로고    scopus 로고
    • Activation of MAPK cascades by G-protein-coupled receptors: The case of gonadotropin-releasing hormone receptor
    • Z. Naor, O. Benard, and R. Seger Activation of MAPK cascades by G-protein-coupled receptors: the case of gonadotropin-releasing hormone receptor Trends Endocrinol. Metab. 11 2000 91 99
    • (2000) Trends Endocrinol. Metab. , vol.11 , pp. 91-99
    • Naor, Z.1    Benard, O.2    Seger, R.3
  • 41
    • 0036241442 scopus 로고    scopus 로고
    • Signalling, cycling and desensitisation of gonadotrophin-releasing hormone receptors
    • C.A. McArdle, J. Franklin, L. Green, and J.N. Hislop Signalling, cycling and desensitisation of gonadotrophin-releasing hormone receptors J. Endocrinol. 173 2002 1 11
    • (2002) J. Endocrinol. , vol.173 , pp. 1-11
    • McArdle, C.A.1    Franklin, J.2    Green, L.3    Hislop, J.N.4
  • 42
    • 0035676783 scopus 로고    scopus 로고
    • Intracellular signaling pathways mediated by the gonadotropin-releasing hormone (GnRH) receptor
    • S. Kraus, Z. Naor, and R. Seger Intracellular signaling pathways mediated by the gonadotropin-releasing hormone (GnRH) receptor Arch. Med. Res. 32 2001 499 509
    • (2001) Arch. Med. Res. , vol.32 , pp. 499-509
    • Kraus, S.1    Naor, Z.2    Seger, R.3
  • 43
    • 0037318494 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase and c-Src, but not Jun N-terminal kinase, are involved in basal and gonadotropin-releasing hormone-stimulated activity of the glycoprotein hormone alpha-subunit promoter
    • D. Harris, D. Chuderland, D. Bonfil, S. Kraus, R. Seger, and Z. Naor Extracellular signal-regulated kinase and c-Src, but not Jun N-terminal kinase, are involved in basal and gonadotropin-releasing hormone-stimulated activity of the glycoprotein hormone alpha-subunit promoter Endocrinology 144 2003 612 622
    • (2003) Endocrinology , vol.144 , pp. 612-622
    • Harris, D.1    Chuderland, D.2    Bonfil, D.3    Kraus, S.4    Seger, R.5    Naor, Z.6
  • 44
    • 0029062123 scopus 로고
    • A role for mitogen-activated protein kinase in mediating activation of the glycoprotein hormone alpha-subunit promoter by gonadotropin-releasing hormone
    • M.S. Roberson, A. Misra-Press, M.E. Laurance, P.J. Stork, and R.A. Maurer A role for mitogen-activated protein kinase in mediating activation of the glycoprotein hormone alpha-subunit promoter by gonadotropin-releasing hormone Mol. Cell. Biol. 15 1995 3531 3539
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 3531-3539
    • Roberson, M.S.1    Misra-Press, A.2    Laurance, M.E.3    Stork, P.J.4    Maurer, R.A.5
  • 45
    • 0036173664 scopus 로고    scopus 로고
    • Activation of MAPK cascades by GnRH: ERK and Jun N-terminal kinase are involved in basal and GnRH-stimulated activity of the glycoprotein hormone LHbeta-subunit promoter
    • D. Harris, D. Bonfil, D. Chuderland, S. Kraus, R. Seger, and Z. Naor Activation of MAPK cascades by GnRH: ERK and Jun N-terminal kinase are involved in basal and GnRH-stimulated activity of the glycoprotein hormone LHbeta-subunit promoter Endocrinology 143 2002 1018 1025
    • (2002) Endocrinology , vol.143 , pp. 1018-1025
    • Harris, D.1    Bonfil, D.2    Chuderland, D.3    Kraus, S.4    Seger, R.5    Naor, Z.6
  • 46
    • 2042441750 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase, Jun N-terminal kinase, p38, and c-Src are involved in gonadotropin-releasing hormone-stimulated activity of the glycoprotein hormone follicle-stimulating hormone beta-subunit promoter
    • D. Bonfil, D. Chuderland, S. Kraus, D. Shahbazian, I. Friedberg, R. Seger, and Z. Naor Extracellular signal-regulated kinase, Jun N-terminal kinase, p38, and c-Src are involved in gonadotropin-releasing hormone-stimulated activity of the glycoprotein hormone follicle-stimulating hormone beta-subunit promoter Endocrinology 145 2004 2228 2244
    • (2004) Endocrinology , vol.145 , pp. 2228-2244
    • Bonfil, D.1    Chuderland, D.2    Kraus, S.3    Shahbazian, D.4    Friedberg, I.5    Seger, R.6    Naor, Z.7
  • 47
    • 0032922608 scopus 로고    scopus 로고
    • Transcriptional activation of gonadotropin-releasing hormone (GnRH) receptor gene by GnRH: Involvement of multiple signal transduction pathways
    • X. Lin, and P.M. Conn Transcriptional activation of gonadotropin- releasing hormone (GnRH) receptor gene by GnRH: involvement of multiple signal transduction pathways Endocrinology 140 1999 358 364
    • (1999) Endocrinology , vol.140 , pp. 358-364
    • Lin, X.1    Conn, P.M.2
  • 48
    • 4344637399 scopus 로고    scopus 로고
    • Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer
    • C. Grundker, and G. Emons Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer Reprod. Biol. Endocrinol. 1 2003 65
    • (2003) Reprod. Biol. Endocrinol. , vol.1 , pp. 65
    • Grundker, C.1    Emons, G.2
  • 49
    • 1342287025 scopus 로고    scopus 로고
    • Matrix metalloproteinases in reproductive endocrinology
    • B.H. Shah, and K.J. Catt Matrix metalloproteinases in reproductive endocrinology Trends Endocrinol. Metab. 15 2004 47 49
    • (2004) Trends Endocrinol. Metab. , vol.15 , pp. 47-49
    • Shah, B.H.1    Catt, K.J.2
  • 50
    • 0035895872 scopus 로고    scopus 로고
    • Role of dynamin, Src, and Ras in the protein kinase C-mediated activation of ERK by gonadotropin-releasing hormone
    • O. Benard, Z. Naor, and R. Seger Role of dynamin, Src, and Ras in the protein kinase C-mediated activation of ERK by gonadotropin-releasing hormone J. Biol. Chem. 276 2001 4554 4563
    • (2001) J. Biol. Chem. , vol.276 , pp. 4554-4563
    • Benard, O.1    Naor, Z.2    Seger, R.3
  • 51
    • 0032230247 scopus 로고    scopus 로고
    • Stimulation of Jun N-terminal kinase (JNK) by gonadotropin-releasing hormone in pituitary alpha T3-1 cell line is mediated by protein kinase C, c-Src, and CDC42
    • N.L. Levi, T. Hanoch, O. Benard, M. Rozenblat, D. Harris, and N. Reiss Stimulation of Jun N-terminal kinase (JNK) by gonadotropin-releasing hormone in pituitary alpha T3-1 cell line is mediated by protein kinase C, c-Src, and CDC42 Mol. Endocrinol. 12 1998 815 824
    • (1998) Mol. Endocrinol. , vol.12 , pp. 815-824
    • Levi, N.L.1    Hanoch, T.2    Benard, O.3    Rozenblat, M.4    Harris, D.5    Reiss, N.6
  • 52
    • 0032963917 scopus 로고    scopus 로고
    • Activation of the p38 mitogen-activated protein kinase pathway by gonadotropin-releasing hormone
    • M.S. Roberson, T. Zhang, H.L. Li, and J.M. Mulvaney Activation of the p38 mitogen-activated protein kinase pathway by gonadotropin-releasing hormone Endocrinology 140 1999 1310 1318
    • (1999) Endocrinology , vol.140 , pp. 1310-1318
    • Roberson, M.S.1    Zhang, T.2    Li, H.L.3    Mulvaney, J.M.4
  • 53
    • 0035952645 scopus 로고    scopus 로고
    • New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades
    • K.L. Pierce, L.M. Luttrell, and R.J. Lefkowitz New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades Oncogene 20 2001 1532 1539
    • (2001) Oncogene , vol.20 , pp. 1532-1539
    • Pierce, K.L.1    Luttrell, L.M.2    Lefkowitz, R.J.3
  • 54
    • 0041355688 scopus 로고    scopus 로고
    • C-Src is activated by the epidermal growth factor receptor in a pathway that mediates JNK and ERK activation by gonadotropin-releasing hormone in COS7 cells
    • S. Kraus, O. Benard, Z. Naor, and R. Seger c-Src is activated by the epidermal growth factor receptor in a pathway that mediates JNK and ERK activation by gonadotropin-releasing hormone in COS7 cells J. Biol. Chem. 278 2003 32618 32630
    • (2003) J. Biol. Chem. , vol.278 , pp. 32618-32630
    • Kraus, S.1    Benard, O.2    Naor, Z.3    Seger, R.4
  • 55
    • 0346422464 scopus 로고    scopus 로고
    • Neuropeptide-induced transactivation of a neuronal epidermal growth factor receptor is mediated by metalloprotease-dependent formation of heparin-binding epidermal growth factor
    • B.H. Shah, M.P. Farshori, and K.J. Catt Neuropeptide-induced transactivation of a neuronal epidermal growth factor receptor is mediated by metalloprotease-dependent formation of heparin-binding epidermal growth factor J. Biol. Chem. 279 2004 414 420
    • (2004) J. Biol. Chem. , vol.279 , pp. 414-420
    • Shah, B.H.1    Farshori, M.P.2    Catt, K.J.3
  • 56
    • 0031877855 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone receptor couples to multiple G proteins in rat gonadotrophs and in GGH3 cells: Evidence from palmitoylation and overexpression of G proteins
    • D. Stanislaus, S. Ponder, T.H. Ji, and P.M. Conn Gonadotropin-releasing hormone receptor couples to multiple G proteins in rat gonadotrophs and in GGH3 cells: evidence from palmitoylation and overexpression of G proteins Biol. Reprod. 59 1998 579 586
    • (1998) Biol. Reprod. , vol.59 , pp. 579-586
    • Stanislaus, D.1    Ponder, S.2    Ji, T.H.3    Conn, P.M.4
  • 57
    • 0027164286 scopus 로고
    • Cholera toxin and pertussis toxin provoke differential effects on luteinizing hormone release, inositol phosphate production, and gonadotropin-releasing hormone (GnRH) receptor binding in the gonadotrope: Evidence for multiple guanyl nucleotide binding proteins in GnRH action
    • B.E. Hawes, S. Barnes, and P.M. Conn Cholera toxin and pertussis toxin provoke differential effects on luteinizing hormone release, inositol phosphate production, and gonadotropin-releasing hormone (GnRH) receptor binding in the gonadotrope: evidence for multiple guanyl nucleotide binding proteins in GnRH action Endocrinology 132 1993 2124 2130
    • (1993) Endocrinology , vol.132 , pp. 2124-2130
    • Hawes, B.E.1    Barnes, S.2    Conn, P.M.3
  • 58
    • 0035020249 scopus 로고    scopus 로고
    • Antiproliferative signaling of luteinizing hormone-releasing hormone in human endometrial and ovarian cancer cells through G protein alpha(I)-mediated activation of phosphotyrosine phosphatase
    • C. Grundker, P. Volker, and G. Emons Antiproliferative signaling of luteinizing hormone-releasing hormone in human endometrial and ovarian cancer cells through G protein alpha(I)-mediated activation of phosphotyrosine phosphatase Endocrinology 142 2001 2369 2380
    • (2001) Endocrinology , vol.142 , pp. 2369-2380
    • Grundker, C.1    Volker, P.2    Emons, G.3
  • 59
    • 0029816592 scopus 로고    scopus 로고
    • Coupling of gonadotropin-releasing hormone receptor to Gi protein in human reproductive tract tumors
    • A. Imai, H. Takagi, S. Horibe, T. Fuseya, and T. Tamaya Coupling of gonadotropin-releasing hormone receptor to Gi protein in human reproductive tract tumors J. Clin. Endocrinol. Metab. 81 1996 3249 3253
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , pp. 3249-3253
    • Imai, A.1    Takagi, H.2    Horibe, S.3    Fuseya, T.4    Tamaya, T.5
  • 60
    • 0030614823 scopus 로고    scopus 로고
    • Gi protein activation of gonadotropin-releasing hormone-mediated protein dephosphorylation in human endometrial carcinoma
    • A. Imai, S. Horibe, A. Takagi, and T. Tamaya Gi protein activation of gonadotropin-releasing hormone-mediated protein dephosphorylation in human endometrial carcinoma Am. J. Obstet. Gynecol. 176 1997 371 376
    • (1997) Am. J. Obstet. Gynecol. , vol.176 , pp. 371-376
    • Imai, A.1    Horibe, S.2    Takagi, A.3    Tamaya, T.4
  • 61
    • 0034748094 scopus 로고    scopus 로고
    • Signaling and antiproliferative effects mediated by GnRH receptors after expression in breast cancer cells using recombinant adenovirus
    • H.M. Everest, J.N. Hislop, T. Harding, J.B. Uney, A. Flynn, R.P. Millar, and C.A. McArdle Signaling and antiproliferative effects mediated by GnRH receptors after expression in breast cancer cells using recombinant adenovirus Endocrinology 142 2001 4663 4672
    • (2001) Endocrinology , vol.142 , pp. 4663-4672
    • Everest, H.M.1    Hislop, J.N.2    Harding, T.3    Uney, J.B.4    Flynn, A.5    Millar, R.P.6    McArdle, C.A.7
  • 63
    • 0037418302 scopus 로고    scopus 로고
    • An agonist-induced switch in G protein coupling of the gonadotropin-releasing hormone receptor regulates pulsatile neuropeptide secretion
    • L.Z. Krsmanovic, N. Mores, C.E. Navarro, K.K. Arora, and K.J. Catt An agonist-induced switch in G protein coupling of the gonadotropin-releasing hormone receptor regulates pulsatile neuropeptide secretion Proc. Natl Acad. Sci. USA 100 2003 2969 2974
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 2969-2974
    • Krsmanovic, L.Z.1    Mores, N.2    Navarro, C.E.3    Arora, K.K.4    Catt, K.J.5
  • 64
    • 0037199927 scopus 로고    scopus 로고
    • Involvement of both G(q/11) and G(s) proteins in gonadotropin-releasing hormone receptor-mediated signaling in L beta T2 cells
    • F. Liu, I. Usui, L.G. Evans, D.A. Austin, P.L. Mellon, J.M. Olefsky, and N.J. Webster Involvement of both G(q/11) and G(s) proteins in gonadotropin-releasing hormone receptor-mediated signaling in L beta T2 cells J. Biol. Chem. 277 2002 32099 32108
    • (2002) J. Biol. Chem. , vol.277 , pp. 32099-32108
    • Liu, F.1    Usui, I.2    Evans, L.G.3    Austin, D.A.4    Mellon, P.L.5    Olefsky, J.M.6    Webster, N.J.7
  • 65
    • 0031790855 scopus 로고    scopus 로고
    • A conserved tyrosine residue (Y601) in transmembrane domain 5 of the human thyrotropin receptor serves as a molecular switch to determine G-protein coupling
    • H. Biebermann, T. Schoneberg, A. Schulz, G. Krause, A. Gruters, G. Schultz, and T. Gudermann A conserved tyrosine residue (Y601) in transmembrane domain 5 of the human thyrotropin receptor serves as a molecular switch to determine G-protein coupling Fed. Am. Soc. Exp. Biol. J. 12 1998 1461 1471
    • (1998) Fed. Am. Soc. Exp. Biol. J. , vol.12 , pp. 1461-1471
    • Biebermann, H.1    Schoneberg, T.2    Schulz, A.3    Krause, G.4    Gruters, A.5    Schultz, G.6    Gudermann, T.7
  • 66
    • 0031808508 scopus 로고    scopus 로고
    • Coupling of the PTH/PTHrP receptor to multiple G-proteins. Direct demonstration of receptor activation of Gs, Gq/11, and Gi(1) by [alpha-32P]GTP-gamma-azidoanilide photoaffinity labeling
    • W.F. Schwindinger, J. Fredericks, L. Watkins, H. Robinson, J.M. Bathon, and M. Pines Coupling of the PTH/PTHrP receptor to multiple G-proteins. Direct demonstration of receptor activation of Gs, Gq/11, and Gi(1) by [alpha-32P]GTP-gamma-azidoanilide photoaffinity labeling Endocrine 8 1998 201 209
    • (1998) Endocrine , vol.8 , pp. 201-209
    • Schwindinger, W.F.1    Fredericks, J.2    Watkins, L.3    Robinson, H.4    Bathon, J.M.5    Pines, M.6
  • 67
    • 0034697039 scopus 로고    scopus 로고
    • Epidermal growth factor receptor tyrosine kinase mediates Ras activation by gonadotropin-releasing hormone
    • R. Grosse, S. Roelle, A. Herrlich, J. Hohn, and T. Gudermann Epidermal growth factor receptor tyrosine kinase mediates Ras activation by gonadotropin-releasing hormone J. Biol. Chem. 275 2000 12251 12260
    • (2000) J. Biol. Chem. , vol.275 , pp. 12251-12260
    • Grosse, R.1    Roelle, S.2    Herrlich, A.3    Hohn, J.4    Gudermann, T.5
  • 69
    • 0842306321 scopus 로고    scopus 로고
    • Development of prostate cancer treatment: The good news
    • S.R. Denmeade, and J.T. Isaacs Development of prostate cancer treatment: the good news Prostate 58 2004 211 224
    • (2004) Prostate , vol.58 , pp. 211-224
    • Denmeade, S.R.1    Isaacs, J.T.2
  • 72
    • 0035656527 scopus 로고    scopus 로고
    • Detection of mRNA expression of gonadotropin-releasing hormone and its receptor in normal and neoplastic rat prostates
    • H.L. Lau, X.M. Zhu, P.C. Leung, L.W. Chan, G.F. Chen, and P.S. Chan Detection of mRNA expression of gonadotropin-releasing hormone and its receptor in normal and neoplastic rat prostates Int. J. Oncol. 19 2001 1193 1201
    • (2001) Int. J. Oncol. , vol.19 , pp. 1193-1201
    • Lau, H.L.1    Zhu, X.M.2    Leung, P.C.3    Chan, L.W.4    Chen, G.F.5    Chan, P.S.6
  • 73
    • 0028205260 scopus 로고
    • Rat gonadotropin-releasing hormone (GnRH) receptor: Tissue expression and hormonal regulation of its mRNA
    • S.S. Kakar, K. Grantham, L.C. Musgrove, D. Devor, J.C. Sellers, and J.D. Neill Rat gonadotropin-releasing hormone (GnRH) receptor: tissue expression and hormonal regulation of its mRNA Mol. Cell. Endocrinol. 101 1994 151 157
    • (1994) Mol. Cell. Endocrinol. , vol.101 , pp. 151-157
    • Kakar, S.S.1    Grantham, K.2    Musgrove, L.C.3    Devor, D.4    Sellers, J.C.5    Neill, J.D.6
  • 74
    • 0033918911 scopus 로고    scopus 로고
    • Effects of triptorelin, a gonadotropin-releasing hormone agonist, on the human prostatic cell lines PC3 and LNCaP
    • L. Ravenna, L. Salvatori, S. Morrone, C. Lubrano, M.R. Cardillo, and F. Sciarra Effects of triptorelin, a gonadotropin-releasing hormone agonist, on the human prostatic cell lines PC3 and LNCaP J. Androl. 21 2000 549 557
    • (2000) J. Androl. , vol.21 , pp. 549-557
    • Ravenna, L.1    Salvatori, L.2    Morrone, S.3    Lubrano, C.4    Cardillo, M.R.5    Sciarra, F.6
  • 75
    • 0026716297 scopus 로고
    • Antiproliferative effects of luteinizing hormone-releasing hormone agonists on the human prostatic cancer cell line LNCaP
    • P. Limonta, D. Dondi, R.M. Moretti, R. Maggi, and M. Motta Antiproliferative effects of luteinizing hormone-releasing hormone agonists on the human prostatic cancer cell line LNCaP J. Clin. Endocrinol. Metab. 75 1992 207 212
    • (1992) J. Clin. Endocrinol. Metab. , vol.75 , pp. 207-212
    • Limonta, P.1    Dondi, D.2    Moretti, R.M.3    Maggi, R.4    Motta, M.5
  • 76
    • 0028071856 scopus 로고
    • Inhibitory effects of analogs of luteinizing hormone-releasing hormone on the growth of the androgen-independent Dunning R-3327-AT-1 rat prostate cancer
    • J. Pinski, H. Reile, G. Halmos, K. Groot, and A.V. Schally Inhibitory effects of analogs of luteinizing hormone-releasing hormone on the growth of the androgen-independent Dunning R-3327-AT-1 rat prostate cancer Int. J. Cancer 59 1994 51 55
    • (1994) Int. J. Cancer , vol.59 , pp. 51-55
    • Pinski, J.1    Reile, H.2    Halmos, G.3    Groot, K.4    Schally, A.V.5
  • 77
    • 0025373247 scopus 로고
    • Regression of nitrosamine-induced pancreatic cancers in hamsters treated with luteinizing hormone-releasing hormone antagonists or agonists
    • B. Szende, G. Srkalovic, K. Groot, K. Lapis, and A.V. Schally Regression of nitrosamine-induced pancreatic cancers in hamsters treated with luteinizing hormone-releasing hormone antagonists or agonists Cancer Res. 50 1990 3716 3721
    • (1990) Cancer Res. , vol.50 , pp. 3716-3721
    • Szende, B.1    Srkalovic, G.2    Groot, K.3    Lapis, K.4    Schally, A.V.5
  • 78
  • 80
    • 0031960297 scopus 로고    scopus 로고
    • Growth-inhibitory effects of luteinizing hormone-releasing hormone (LHRH) agonists on xenografts of the du 145 human androgen-independent prostate cancer cell line in nude mice
    • D. Dondi, R.M. Moretti, M. Montagnani Marelli, G. Pratesi, D. Polizzi, and M. Milani Growth-inhibitory effects of luteinizing hormone-releasing hormone (LHRH) agonists on xenografts of the DU 145 human androgen-independent prostate cancer cell line in nude mice Int. J. Cancer 76 1998 506 511
    • (1998) Int. J. Cancer , vol.76 , pp. 506-511
    • Dondi, D.1    Moretti, R.M.2    Montagnani Marelli, M.3    Pratesi, G.4    Polizzi, D.5    Milani, M.6
  • 81
    • 0033593572 scopus 로고    scopus 로고
    • Cell death in development
    • D.L. Vaux, and S.J. Korsmeyer Cell death in development Cell 96 1999 245 254
    • (1999) Cell , vol.96 , pp. 245-254
    • Vaux, D.L.1    Korsmeyer, S.J.2
  • 82
    • 8444220527 scopus 로고    scopus 로고
    • Molecular mechanisms of caspase regulation during apoptosis
    • S.J. Riedl, and Y. Shi Molecular mechanisms of caspase regulation during apoptosis Nat. Rev. Mol. Cell. Biol. 5 2004 897 907
    • (2004) Nat. Rev. Mol. Cell. Biol. , vol.5 , pp. 897-907
    • Riedl, S.J.1    Shi, Y.2
  • 83
    • 0242656497 scopus 로고    scopus 로고
    • Death receptor-induced cell killing
    • A. Thorburn Death receptor-induced cell killing Cell Signal 16 2004 139 144
    • (2004) Cell Signal , vol.16 , pp. 139-144
    • Thorburn, A.1
  • 84
    • 3943071150 scopus 로고    scopus 로고
    • Cytochrome C-mediated apoptosis
    • X. Jiang, and X. Wang Cytochrome C-mediated apoptosis Annu. Rev. Biochem. 73 2004 87 106
    • (2004) Annu. Rev. Biochem. , vol.73 , pp. 87-106
    • Jiang, X.1    Wang, X.2
  • 85
    • 15644381250 scopus 로고    scopus 로고
    • Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress- activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1
    • K. Maundrell, B. Antonsson, E. Magnenat, M. Camps, M. Muda, and C. Chabert Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress- activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1 J. Biol. Chem. 272 1997 25238 25242
    • (1997) J. Biol. Chem. , vol.272 , pp. 25238-25242
    • Maundrell, K.1    Antonsson, B.2    Magnenat, E.3    Camps, M.4    Muda, M.5    Chabert, C.6
  • 86
    • 0033499801 scopus 로고    scopus 로고
    • BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M
    • K. Yamamoto, H. Ichijo, and S.J. Korsmeyer BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M Mol. Cell. Biol. 19 1999 8469 8478
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 8469-8478
    • Yamamoto, K.1    Ichijo, H.2    Korsmeyer, S.J.3
  • 87
    • 0141953270 scopus 로고    scopus 로고
    • A JNK-dependent pathway is required for TNFalpha-induced apoptosis
    • Y. Deng, X. Ren, L. Yang, Y. Lin, and X. Wu A JNK-dependent pathway is required for TNFalpha-induced apoptosis Cell 115 2003 61 70
    • (2003) Cell , vol.115 , pp. 61-70
    • Deng, Y.1    Ren, X.2    Yang, L.3    Lin, Y.4    Wu, X.5
  • 88
    • 0037230304 scopus 로고    scopus 로고
    • Activation of the JNK signaling pathway: Breaking the brake on apoptosis
    • A. Lin Activation of the JNK signaling pathway: breaking the brake on apoptosis Bioessays 25 2003 17 24
    • (2003) Bioessays , vol.25 , pp. 17-24
    • Lin, A.1
  • 89
    • 0034014706 scopus 로고    scopus 로고
    • The expression profile for the tumour suppressor gene PTEN and associated polymorphic markers
    • J.A. Hamilton, L.M. Stewart, L. Ajayi, I.C. Gray, N.E. Gray, and K.G. Roberts The expression profile for the tumour suppressor gene PTEN and associated polymorphic markers Br. J. Cancer 82 2000 1671 1676
    • (2000) Br. J. Cancer , vol.82 , pp. 1671-1676
    • Hamilton, J.A.1    Stewart, L.M.2    Ajayi, L.3    Gray, I.C.4    Gray, N.E.5    Roberts, K.G.6
  • 91
    • 0035848705 scopus 로고    scopus 로고
    • Reverse phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion front
    • C.P. Paweletz, L. Charboneau, V.E. Bichsel, N.L. Simone, T. Chen, and J.W. Gillespie Reverse phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion front Oncogene 20 2001 1981 1989
    • (2001) Oncogene , vol.20 , pp. 1981-1989
    • Paweletz, C.P.1    Charboneau, L.2    Bichsel, V.E.3    Simone, N.L.4    Chen, T.5    Gillespie, J.W.6
  • 94
    • 0033564514 scopus 로고    scopus 로고
    • The phosphatidylinositol 3′-kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells
    • J. Lin, R.M. Adam, E. Santiestevan, and M.R. Freeman The phosphatidylinositol 3′-kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells Cancer Res. 59 1999 2891 2897
    • (1999) Cancer Res. , vol.59 , pp. 2891-2897
    • Lin, J.1    Adam, R.M.2    Santiestevan, E.3    Freeman, M.R.4
  • 95
    • 0034637524 scopus 로고    scopus 로고
    • Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression
    • J.R. Graff, B.W. Konicek, A.M. McNulty, Z. Wang, K. Houck, and S. Allen Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression J. Biol. Chem. 275 2000 24500 24505
    • (2000) J. Biol. Chem. , vol.275 , pp. 24500-24505
    • Graff, J.R.1    Konicek, B.W.2    McNulty, A.M.3    Wang, Z.4    Houck, K.5    Allen, S.6
  • 96
    • 0035990924 scopus 로고    scopus 로고
    • Inhibition of protein kinase B/Akt. implications for cancer therapy
    • M.M. Hill, and B.A. Hemmings Inhibition of protein kinase B/Akt. implications for cancer therapy Pharmacol. Ther. 93 2002 243 251
    • (2002) Pharmacol. Ther. , vol.93 , pp. 243-251
    • Hill, M.M.1    Hemmings, B.A.2
  • 97
    • 0033119571 scopus 로고    scopus 로고
    • Antiapoptotic signaling in LNCaP prostate cancer cells: A survival signaling pathway independent of phosphatidylinositol 3′-kinase and Akt/protein kinase B
    • J.P. Carson, G. Kulik, and M.J. Weber Antiapoptotic signaling in LNCaP prostate cancer cells: a survival signaling pathway independent of phosphatidylinositol 3′-kinase and Akt/protein kinase B Cancer Res. 59 1999 1449 1453
    • (1999) Cancer Res. , vol.59 , pp. 1449-1453
    • Carson, J.P.1    Kulik, G.2    Weber, M.J.3
  • 98
    • 0141594871 scopus 로고    scopus 로고
    • Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway
    • Y. Tanaka, M.V. Gavrielides, Y. Mitsuuchi, T. Fujii, and M.G. Kazanietz Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway J. Biol. Chem. 278 2003 33753 33762
    • (2003) J. Biol. Chem. , vol.278 , pp. 33753-33762
    • Tanaka, Y.1    Gavrielides, M.V.2    Mitsuuchi, Y.3    Fujii, T.4    Kazanietz, M.G.5
  • 100
    • 0035921762 scopus 로고    scopus 로고
    • Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer
    • X. Chen, H. Thakkar, F. Tyan, S. Gim, H. Robinson, and C. Lee Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer Oncogene 20 2001 6073 6083
    • (2001) Oncogene , vol.20 , pp. 6073-6083
    • Chen, X.1    Thakkar, H.2    Tyan, F.3    Gim, S.4    Robinson, H.5    Lee, C.6
  • 102
    • 0032723879 scopus 로고    scopus 로고
    • Role of mitogen-activated protein kinase/extracellular signal-regulated kinase cascade in gonadotropin-releasing hormone-induced growth inhibition of a human ovarian cancer cell line
    • A. Kimura, M. Ohmichi, H. Kurachi, H. Ikegami, J. Hayakawa, and K. Tasaka Role of mitogen-activated protein kinase/extracellular signal-regulated kinase cascade in gonadotropin-releasing hormone-induced growth inhibition of a human ovarian cancer cell line Cancer Res. 59 1999 5133 5142
    • (1999) Cancer Res. , vol.59 , pp. 5133-5142
    • Kimura, A.1    Ohmichi, M.2    Kurachi, H.3    Ikegami, H.4    Hayakawa, J.5    Tasaka, K.6
  • 104
    • 0036296651 scopus 로고    scopus 로고
    • Luteinizing hormone-releasing hormone induces JunD-DNA binding and extends cell cycle in human ovarian cancer cells
    • A.R. Gunthert, C. Grundker, K. Hollmann, and G. Emons Luteinizing hormone-releasing hormone induces JunD-DNA binding and extends cell cycle in human ovarian cancer cells Biochem. Biophys. Res. Commun. 294 2002 11 15
    • (2002) Biochem. Biophys. Res. Commun. , vol.294 , pp. 11-15
    • Gunthert, A.R.1    Grundker, C.2    Hollmann, K.3    Emons, G.4
  • 105
    • 0028325891 scopus 로고
    • Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras
    • C.M. Pfarr, F. Mechta, G. Spyrou, D. Lallemand, S. Carillo, and M. Yaniv Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras Cell 76 1994 747 760
    • (1994) Cell , vol.76 , pp. 747-760
    • Pfarr, C.M.1    Mechta, F.2    Spyrou, G.3    Lallemand, D.4    Carillo, S.5    Yaniv, M.6
  • 106
    • 0031804790 scopus 로고    scopus 로고
    • Fas and Fas ligand system may mediate antiproliferative activity of gonadotropin-releasing hormone receptor in endometrial cancer cells
    • A. Imai, A. Takagi, S. Horibe, H. Takagi, and T. Tamaya Fas and Fas ligand system may mediate antiproliferative activity of gonadotropin-releasing hormone receptor in endometrial cancer cells Int. J. Oncol. 13 1998 97 100
    • (1998) Int. J. Oncol. , vol.13 , pp. 97-100
    • Imai, A.1    Takagi, A.2    Horibe, S.3    Takagi, H.4    Tamaya, T.5
  • 107
    • 3242697972 scopus 로고    scopus 로고
    • Luteinizing hormone-releasing hormone (LHRH) inhibits apoptosis induced by cytotoxic agent and UV-light but not apoptosis mediated through CD95 in human ovarian and endometrial cancer cells
    • A.R. Gunthert, C. Grundker, B. Bottcher, and G. Emons Luteinizing hormone-releasing hormone (LHRH) inhibits apoptosis induced by cytotoxic agent and UV-light but not apoptosis mediated through CD95 in human ovarian and endometrial cancer cells Anticancer Res. 24 2004 1727 1732
    • (2004) Anticancer Res. , vol.24 , pp. 1727-1732
    • Gunthert, A.R.1    Grundker, C.2    Bottcher, B.3    Emons, G.4
  • 108
    • 7044234874 scopus 로고    scopus 로고
    • Internalization of cytotoxic analog AN-152 of luteinizing hormone-releasing hormone induces apoptosis in human endometrial and ovarian cancer cell lines independent of multidrug resistance-1 (MDR-1) system
    • A.R. Gunthert, C. Grundker, T. Bongertz, T. Schlott, A. Nagy, A.V. Schally, and G. Emons Internalization of cytotoxic analog AN-152 of luteinizing hormone-releasing hormone induces apoptosis in human endometrial and ovarian cancer cell lines independent of multidrug resistance-1 (MDR-1) system Am. J. Obstet. Gynecol. 191 2004 1164 1172
    • (2004) Am. J. Obstet. Gynecol. , vol.191 , pp. 1164-1172
    • Gunthert, A.R.1    Grundker, C.2    Bongertz, T.3    Schlott, T.4    Nagy, A.5    Schally, A.V.6    Emons, G.7
  • 109
    • 0036965115 scopus 로고    scopus 로고
    • Expression of gonadotropin-releasing hormone II (GnRH-II) receptor in human endometrial and ovarian cancer cells and effects of GnRH-II on tumor cell proliferation
    • C. Grundker, A.R. Gunthert, R.P. Millar, and G. Emons Expression of gonadotropin-releasing hormone II (GnRH-II) receptor in human endometrial and ovarian cancer cells and effects of GnRH-II on tumor cell proliferation J. Clin. Endocrinol. Metab. 87 2002 1427 1430
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 1427-1430
    • Grundker, C.1    Gunthert, A.R.2    Millar, R.P.3    Emons, G.4
  • 110
    • 0034740086 scopus 로고    scopus 로고
    • Expression and antiproliferative effect of a second form of gonadotropin-releasing hormone in normal and neoplastic ovarian surface epithelial cells
    • K.C. Choi, N. Auersperg, and P.C. Leung Expression and antiproliferative effect of a second form of gonadotropin-releasing hormone in normal and neoplastic ovarian surface epithelial cells J. Clin. Endocrinol. Metab. 86 2001 5075 5078
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 5075-5078
    • Choi, K.C.1    Auersperg, N.2    Leung, P.C.3
  • 111
    • 2942685557 scopus 로고    scopus 로고
    • Type II gonadotropin-releasing hormone stimulates p38 mitogen-activated protein kinase and apoptosis in ovarian cancer cells
    • K.Y. Kim, K.C. Choi, S.H. Park, C.S. Chou, N. Auersperg, and P.C. Leung Type II gonadotropin-releasing hormone stimulates p38 mitogen-activated protein kinase and apoptosis in ovarian cancer cells J. Clin. Endocrinol. Metab. 89 2004 3020 3026
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 3020-3026
    • Kim, K.Y.1    Choi, K.C.2    Park, S.H.3    Chou, C.S.4    Auersperg, N.5    Leung, P.C.6
  • 112
    • 0027273447 scopus 로고
    • A prospective, randomized trial of gonadotropin-releasing hormone agonist plus estrogen-progestin or progestin 'add-back' regimens for women with leiomyomata uteri
    • A.J. Friedman, M. Daly, M. Juneau-Norcross, M.S. Rein, C. Fine, R. Gleason, and M. Leboff A prospective, randomized trial of gonadotropin-releasing hormone agonist plus estrogen-progestin or progestin 'add-back' regimens for women with leiomyomata uteri J. Clin. Endocrinol. Metab. 76 1993 1439 1445
    • (1993) J. Clin. Endocrinol. Metab. , vol.76 , pp. 1439-1445
    • Friedman, A.J.1    Daly, M.2    Juneau-Norcross, M.3    Rein, M.S.4    Fine, C.5    Gleason, R.6    Leboff, M.7
  • 113
    • 0036204393 scopus 로고    scopus 로고
    • Down-regulation of proliferation and up-regulation of apoptosis by gonadotropin-releasing hormone agonist in cultured uterine leiomyoma cells
    • Y. Wang, H. Matsuo, O. Kurachi, and T. Maruo Down-regulation of proliferation and up-regulation of apoptosis by gonadotropin-releasing hormone agonist in cultured uterine leiomyoma cells Eur. J. Endocrinol. 146 2002 447 456
    • (2002) Eur. J. Endocrinol. , vol.146 , pp. 447-456
    • Wang, Y.1    Matsuo, H.2    Kurachi, O.3    Maruo, T.4
  • 114
    • 0031762899 scopus 로고    scopus 로고
    • Suppression of cell proliferation and induction of apoptosis in uterine leiomyoma by gonadotropin-releasing hormone agonist (leuprolide acetate)
    • T. Mizutani, A. Sugihara, K. Nakamuro, and N. Terada Suppression of cell proliferation and induction of apoptosis in uterine leiomyoma by gonadotropin-releasing hormone agonist (leuprolide acetate) J. Clin. Endocrinol. Metab. 83 1998 1253 1255
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , pp. 1253-1255
    • Mizutani, T.1    Sugihara, A.2    Nakamuro, K.3    Terada, N.4
  • 115
    • 0036775167 scopus 로고    scopus 로고
    • Fas and its ligand, caspases, and bcl-2 expression in gonadotropin-releasing hormone agonist-treated uterine leiomyoma
    • S.C. Huang, M.J. Tang, K.F. Hsu, Y.M. Cheng, and C.Y. Chou Fas and its ligand, caspases, and bcl-2 expression in gonadotropin-releasing hormone agonist-treated uterine leiomyoma J. Clin. Endocrinol. Metab. 87 2002 4580 4586
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 4580-4586
    • Huang, S.C.1    Tang, M.J.2    Hsu, K.F.3    Cheng, Y.M.4    Chou, C.Y.5
  • 117
    • 0028809209 scopus 로고
    • Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death
    • E. Yang, J. Zha, J. Jockel, L.H. Boise, C.B. Thompson, and S.J. Korsmeyer Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death Cell 80 1995 285 291
    • (1995) Cell , vol.80 , pp. 285-291
    • Yang, E.1    Zha, J.2    Jockel, J.3    Boise, L.H.4    Thompson, C.B.5    Korsmeyer, S.J.6
  • 118
    • 0008937269 scopus 로고
    • Inhibition of growth of human mammary tumor cells by potent antagonists of luteinizing hormone-releasing hormone
    • Y. Sharoni, E. Bosin, A. Miinster, J. Levy, and A.V. Schally Inhibition of growth of human mammary tumor cells by potent antagonists of luteinizing hormone-releasing hormone Proc. Natl Acad. Sci. USA 86 1989 1648 1651
    • (1989) Proc. Natl Acad. Sci. USA , vol.86 , pp. 1648-1651
    • Sharoni, Y.1    Bosin, E.2    Miinster, A.3    Levy, J.4    Schally, A.V.5
  • 119
    • 0026081289 scopus 로고
    • Influence of luteinizing hormone-releasing hormone agonists on human mammary carcinoma cell lines and their xenografts
    • B. Vincze, I. Palyi, D. Daubner, T. Kremmer, I. Szamel, and I. Bodrogi Influence of luteinizing hormone-releasing hormone agonists on human mammary carcinoma cell lines and their xenografts J. Steroid Biochem. Mol. Biol. 38 1991 119 126
    • (1991) J. Steroid Biochem. Mol. Biol. , vol.38 , pp. 119-126
    • Vincze, B.1    Palyi, I.2    Daubner, D.3    Kremmer, T.4    Szamel, I.5    Bodrogi, I.6
  • 120
    • 0026643867 scopus 로고
    • Inhibition of growth of MCF-7 MIII human breast carcinoma in nude mice by treatment with agonists or antagonists of LH-RH
    • T. Yano, E. Korkut, J. Pinski, K. Szepeshazi, S. Milovanovic, and K. Groot Inhibition of growth of MCF-7 MIII human breast carcinoma in nude mice by treatment with agonists or antagonists of LH-RH Breast. Cancer Res. Treat. 21 1992 35 45
    • (1992) Breast. Cancer Res. Treat. , vol.21 , pp. 35-45
    • Yano, T.1    Korkut, E.2    Pinski, J.3    Szepeshazi, K.4    Milovanovic, S.5    Groot, K.6
  • 121
    • 0027955040 scopus 로고
    • Inhibitory effect of bombesin/gastrin-releasing peptide antagonist RC-3095 and luteinizing hormone-releasing hormone antagonist SB-75 on the growth of MCF-7 MIII human breast cancer xenografts in athymic nude mice
    • T. Yano, J. Pinski, K. Szepeshazi, G. Halmos, S. Radulovic, K. Groot, and A.V. Schally Inhibitory effect of bombesin/gastrin-releasing peptide antagonist RC-3095 and luteinizing hormone-releasing hormone antagonist SB-75 on the growth of MCF-7 MIII human breast cancer xenografts in athymic nude mice Cancer 73 1994 1229 1238
    • (1994) Cancer , vol.73 , pp. 1229-1238
    • Yano, T.1    Pinski, J.2    Szepeshazi, K.3    Halmos, G.4    Radulovic, S.5    Groot, K.6    Schally, A.V.7
  • 122
    • 0025865928 scopus 로고
    • Gonadotropin-releasing hormone analogues inhibit cell proliferation and activate signal transduction pathways in MDA-MB-231 human breast cancer cell line
    • G. Keri, A. Balogh, B. Szoke, I. Teplan, and O. Csuka Gonadotropin-releasing hormone analogues inhibit cell proliferation and activate signal transduction pathways in MDA-MB-231 human breast cancer cell line Tumour Biol. 12 1991 61 67
    • (1991) Tumour Biol. , vol.12 , pp. 61-67
    • Keri, G.1    Balogh, A.2    Szoke, B.3    Teplan, I.4    Csuka, O.5
  • 123
    • 9444256957 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone (GnRH) agonist triptorelin inhibits estradiol-induced serum response element (SRE) activation and c-fos expression in human endometrial, ovarian and breast cancer cells
    • C. Grundker, A.R. Gunthert, M. Hellriegel, and G. Emons Gonadotropin-releasing hormone (GnRH) agonist triptorelin inhibits estradiol-induced serum response element (SRE) activation and c-fos expression in human endometrial, ovarian and breast cancer cells Eur. J. Endocrinol. 151 2004 619 628
    • (2004) Eur. J. Endocrinol. , vol.151 , pp. 619-628
    • Grundker, C.1    Gunthert, A.R.2    Hellriegel, M.3    Emons, G.4
  • 124
    • 0026705613 scopus 로고
    • Effect of luteinizing hormone-releasing hormone analogs containing cytotoxic radicals on growth of estrogen-independent MXT mouse mammary carcinoma in vivo
    • K. Szepeshazi, A.V. Schally, A. Juhasz, A. Nagy, and T. Janaky Effect of luteinizing hormone-releasing hormone analogs containing cytotoxic radicals on growth of estrogen-independent MXT mouse mammary carcinoma in vivo Anticancer Drugs 3 1992 109 116
    • (1992) Anticancer Drugs , vol.3 , pp. 109-116
    • Szepeshazi, K.1    Schally, A.V.2    Juhasz, A.3    Nagy, A.4    Janaky, T.5
  • 125
    • 0036173838 scopus 로고    scopus 로고
    • Two forms of GnRH are expressed in human breast tissue and overexpressed in breast cancer: A putative mechanism for the antiproliferative effect of GnRH by down-regulation of acidic ribosomal phosphoproteins P1 and P2
    • A. Chen, E. Kaganovsky, S. Rahimipour, N. Ben-Aroya, E. Okon, and Y. Koch Two forms of GnRH are expressed in human breast tissue and overexpressed in breast cancer: a putative mechanism for the antiproliferative effect of GnRH by down-regulation of acidic ribosomal phosphoproteins P1 and P2 Cancer Res. 62 2002 1036 1044
    • (2002) Cancer Res. , vol.62 , pp. 1036-1044
    • Chen, A.1    Kaganovsky, E.2    Rahimipour, S.3    Ben-Aroya, N.4    Okon, E.5    Koch, Y.6
  • 127
    • 4444274816 scopus 로고    scopus 로고
    • Chemotherapy targeted to cancers through tumoral hormone receptors
    • A.V. Schally, and A. Nagy Chemotherapy targeted to cancers through tumoral hormone receptors Trends Endocrinol. Metab. 15 2004 300 310
    • (2004) Trends Endocrinol. Metab. , vol.15 , pp. 300-310
    • Schally, A.V.1    Nagy, A.2
  • 128
    • 0032797051 scopus 로고    scopus 로고
    • Cancer chemotherapy based on targeting of cytotoxic peptide conjugates to their receptors on tumors
    • A.V. Schally, and A. Nagy Cancer chemotherapy based on targeting of cytotoxic peptide conjugates to their receptors on tumors Eur. J. Endocrinol. 141 1999 1 14
    • (1999) Eur. J. Endocrinol. , vol.141 , pp. 1-14
    • Schally, A.V.1    Nagy, A.2
  • 129
    • 0035129338 scopus 로고    scopus 로고
    • In vitro targeting of a cytotoxic analog of luteinizing hormone-releasing hormone AN-207 to ES-2 human ovarian cancer cells as demonstrated by microsatellite analyses
    • J.M. Arencibia, A.V. Schally, G. Halmos, A. Nagy, and H. Kiaris In vitro targeting of a cytotoxic analog of luteinizing hormone-releasing hormone AN-207 to ES-2 human ovarian cancer cells as demonstrated by microsatellite analyses Anticancer Drugs 12 2001 71 78
    • (2001) Anticancer Drugs , vol.12 , pp. 71-78
    • Arencibia, J.M.1    Schally, A.V.2    Halmos, G.3    Nagy, A.4    Kiaris, H.5
  • 130
    • 0033765579 scopus 로고    scopus 로고
    • Effective treatment of metastatic MDA-MB-435 human estrogen-independent breast carcinomas with a targeted cytotoxic analogue of luteinizing hormone-releasing hormone AN-207
    • L. Chatzistamou, A.V. Schally, A. Nagy, P. Armatis, K. Szepeshazi, and G. Halmos Effective treatment of metastatic MDA-MB-435 human estrogen-independent breast carcinomas with a targeted cytotoxic analogue of luteinizing hormone-releasing hormone AN-207 Clin. Cancer Res. 6 2000 4158 4165
    • (2000) Clin. Cancer Res. , vol.6 , pp. 4158-4165
    • Chatzistamou, L.1    Schally, A.V.2    Nagy, A.3    Armatis, P.4    Szepeshazi, K.5    Halmos, G.6
  • 131
    • 13044272900 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone analogue conjugates with strong selective antitumor activity
    • I. Palyi, B. Vincze, S. Lovas, I. Mezo, J. Pato, and A. Kalnay Gonadotropin-releasing hormone analogue conjugates with strong selective antitumor activity Proc. Natl Acad. Sci. USA 96 1999 2361 2366
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 2361-2366
    • Palyi, I.1    Vincze, B.2    Lovas, S.3    Mezo, I.4    Pato, J.5    Kalnay, A.6
  • 132
    • 1542615080 scopus 로고    scopus 로고
    • Binding and cytotoxicity of conjugated and recombinant fusion proteins targeted to the gonadotropin-releasing hormone receptor
    • L. Qi, T.M. Nett, M.C. Allen, X. Sha, G.S. Harrison, and B.A. Frederick Binding and cytotoxicity of conjugated and recombinant fusion proteins targeted to the gonadotropin-releasing hormone receptor Cancer Res. 64 2004 2090 2095
    • (2004) Cancer Res. , vol.64 , pp. 2090-2095
    • Qi, L.1    Nett, T.M.2    Allen, M.C.3    Sha, X.4    Harrison, G.S.5    Frederick, B.A.6
  • 133
    • 0035861586 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone receptor-coupled gene network organization
    • E. Wurmbach, T. Yuen, B.J. Ebersole, and S.C. Sealfon Gonadotropin-releasing hormone receptor-coupled gene network organization J. Biol. Chem. 276 2001 47195 47201
    • (2001) J. Biol. Chem. , vol.276 , pp. 47195-47201
    • Wurmbach, E.1    Yuen, T.2    Ebersole, B.J.3    Sealfon, S.C.4
  • 134
    • 0038243537 scopus 로고    scopus 로고
    • Identification of distinct gene expression profiles associated with treatment of LbetaT2 cells with gonadotropin-releasing hormone agonist using microarray analysis
    • S.S. Kakar, S.J. Winters, W. Zacharias, D.M. Miller, and S. Flynn Identification of distinct gene expression profiles associated with treatment of LbetaT2 cells with gonadotropin-releasing hormone agonist using microarray analysis Gene 308 2003 67 77
    • (2003) Gene , vol.308 , pp. 67-77
    • Kakar, S.S.1    Winters, S.J.2    Zacharias, W.3    Miller, D.M.4    Flynn, S.5


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