Pharmacokinetics and pharmacodynamics of benidipine using a slow receptor-binding model

Journal of Clinical Pharmacy and Therapeutics

Volumn 30, Issue 6, 2005, Pages 541-547

  Yun, H Y ^a   Yun, M H ^a   Kang, W ^b   Kwon, K I ^a  

^a Chungnam National University   (South Korea)

^b Catholic University of Daegu   (South Korea)

Author keywords

Benidipine; Pharmacokinetic pharmacodynamic modelling; Slow receptor binding model

Indexed keywords

BENIDIPINE; PLACEBO; RECEPTOR; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; DIHYDROPYRIDINE DERIVATIVE; VASODILATOR AGENT;

ADULT; AREA UNDER THE CURVE; ARTICLE; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DRUG BLOOD LEVEL; HEART RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MODEL; RECEPTOR BINDING; BIOLOGICAL MODEL; BLOOD; BLOOD PRESSURE; CLINICAL TRIAL; DRUG EFFECT; METABOLISM;

ADULT; BLOOD PRESSURE; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; DIHYDROPYRIDINES; HEART RATE; HUMANS; MODELS, BIOLOGICAL; VASODILATOR AGENTS;

EID: 33644987904     PISSN: 02694727     EISSN: 13652710     Source Type: Journal    
DOI: 10.1111/j.1365-2710.2005.00682.x     Document Type: Article

References (7)

1. Muto K, Kurodo T, Kawato H, Karasawa A, Kubo K, Nakamizo N (1988) Synthesis and pharmacological activity of stereoisomers of 1,4-dihydro-2,6- dimethyl-4-(3-nitrophenyl) -3,5-pyridine-decarboxylic acid methyl 1-(phenylmethyl)-3-piperidinyl ester. Arzneimittel-Forschung/Drug Research, 38 (II 1662 1665.
2. Kobayashi H, Kobayashi S (1997) Relationship between plasma concentration and antihypertensive effects of the dihydropyridine calcium antagonist, benidipine, in rats. Journal of Pharmacy and Pharmacology, 49, 1200 1204.
3. Kang W, Yun H, Liu K-H, Kwon K, Shin J-G (2004) Determination of benidipine in human plasma using liquid chromatography-tandem mass spectrometry. Journal of Chromatography B, 805, 311 314.
4. Kang WK, Yun H-Y, Kwon K-I (2005) Assessing the bioequivalence of 4 and 8 mg benidipine tablets in healthy volunteers after a single oral dose. Journal of Clinical Pharmacy and Therapeutics, 30, 85 90.
5. Shimada S, Nakazima Y, Yamamoto K, Sawada Y, Iga T (1996) Comparative pharmacodynamics of eight calcium channel blocking agents in Japanese essential hypertensive patients. Biological and Pharmaceutical Bulletin, 19, 430 437.
6. Kobayashi H, Kobayashi S, Inoue A, Oka T, Nakamizo N (1988) Pharmacokinetic study of benidipine hydrochloride in rats and dogs. Arzneimittel-Forschung/Drug Res., 38 (II 1750 1752.
7. Maier-Lenz H, Rode H, Lenau H et al. (1988) Benidipine hydrochloride - a new calcium channel blocker of the dihydropyridine type. Arzneimittel-Forschung/ Drug Research, 38 (II 1757 1763.