The influence of granulation on super disintegrant performance

Pharmaceutical Development and Technology

Volumn 11, Issue 1, 2006, Pages 47-53

  Zhao, Na ^a   Augsburger, Larry L ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

Author keywords

Disintegration test; Granulation; Super disintegrants; Water uptake

Indexed keywords

CROSCARMELLOSE SODIUM; CROSPOVIDONE; DISINTEGRATING AGENT; NAPROXEN; PREDNISONE; STARCH GLYCOLATE SODIUM;

ARTICLE; CRUSHING STRENGTH; DRUG FORMULATION; DRUG GRANULATION; DRUG GRANULE; DRUG SOLUBILITY; PARTICLE SIZE; PRIORITY JOURNAL; SIMULATION; TABLET DISINTEGRATION; TABLET DISINTEGRATION TIME; TABLET MATRIX; WATER TRANSPORT;

CHEMISTRY, PHARMACEUTICAL; DRUG COMPOUNDING; EXCIPIENTS; KINETICS; PARTICLE SIZE; POLYMETHYL METHACRYLATE; POVIDONE; POWDERS; SOLUBILITY; STARCH; TABLETS; WATER;

EID: 33644982986     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.1080/10837450500463828     Document Type: Article

References (10)

1. Van Kamp, H.V.; Bolhuis, G.K.; Lerk, C.F. Improvement by super disintegrants of the properties of tablets containing lactose prepared by wet granulation. Pharm. Weekbl ad. 1983, 5 (4), 165-171.
2. Gordon, M.S.; Chatterjee, B.; Chowhan, Z.T. Effect of the mode of croscarmellose sodium incorporation on tablet dissolution and friability. J. Pharm. Sci. 1990, 79 (1), 43-47.
3. Gordon, M.S.; Rudraraju, V.S.; Dani, K.; Chowhan, Z.T. Effect of the mode of super disintegrant incorporation on dissolution in wet granulated tablets. J. Pharm. Sci. 1993, 82 (2), 220-226.
4. Khattab, I.; Menon, A.; Sakr, A. Effect of mode of incorporation of disintegrants on the characteristics of fluid-bed wet-granulated tablets. J. Pharm. Pharmacol. 1993, 45 (Aug), 687-691.
5. Gould, P.L.; Tan, S.B. Effect of recompression on disintegrant efficiency in tablets prepared by wet granulation. Drug Dev. Ind. Pharm. 1985, 11 (Feb-Mar), 441-460.
6. Gould, P.L.; Tan, S.B. Effect of recompression on the swelling kinetics of wet massed tablets containing super disintegrants. Drug Dev. Ind. Pharm. 1985, 11 (Sep-Oct), 1819-1836.
7. Rowe, R.C.; Sheskey, P.J.; Weller, P.J. Pharmaceutical Excipients 2001; American Pharmaceutical Association: Washington, D.C., 2001.
8. Zhao, N.; Augsburger, L.L. The influence of swelling capacity of super disintegrants in different pH media on the dissolution of hydrochlorothiazide from directly compressed tablet. AAPS Pharmscitech. 2005, 6(1), E120-E126.
9. Zhao, N.; Augsburger, L.L. On the development of a disintegrating functionality test for super disintegrants. AAPS Pharmsci. 2003, 5 (4), M1256.
10. Zhao, N.; Augsburger, L.L. Functional comparison of three classes of super disintegrants in promoting aspirin tablet disintegration and dissolution. AAPS Pharmscitech. 2005, 6 (4), E634-E640.