Synthesis and preliminary in vivo evaluation of new 2-Aryl-6-methyl-1,2-dihydro-1H-pyridin-4-ones and 2-Aryl-6-methylpiperidin-4-ols, as potential anti-amnesiant agents

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 20, Issue 6, 2005, Pages 551-556

  Leflemme, Nicolas ^a,b   Freret, Thomas ^a,b   Boulouard, Michel ^a,b   Dallemagne, Patrick ^b   Rault, Sylvain ^a,b  

^a CENTRE D ETUDES ET DE RECHERCHE SUR LE MÉDICAMENT DE NORMANDIE   (France)

^b UNIVERSITÉ DE CAEN   (France)

Author keywords

Amino esters; nAChRs ligands; Pyridinones; Spontaneous alternation; Sulfinamides; Working memory

Indexed keywords

2 (3 CHLOROPHENYL) 6 METHYL 1,2 DIHYDRO 1H PYRIDIN 4 ONE; 2 ARYL 6 METHYL 1,2 DIHYDRO 1H PYRIDIN 4 ONE DERIVATIVE; 2 ARYL 6 METHYLPIPERIDIN 4 OL; ARECOLINE; ESTER DERIVATIVE; PIPERIDINE DERIVATIVE; PYRIDINE DERIVATIVE; SCOPOLAMINE; UNCLASSIFIED DRUG; PYRIDONE DERIVATIVE;

AMNESIA; ANIMAL EXPERIMENT; ARTICLE; CHEMICAL PROCEDURES; CONTROLLED STUDY; DRUG ACTIVITY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SYNTHESIS; WORKING MEMORY; ANIMAL; CHEMICAL STRUCTURE; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; SHORT TERM MEMORY; STEREOISOMERISM;

AMNESIA; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; MALE; MEMORY, SHORT-TERM; MICE; MOLECULAR STRUCTURE; PIPERIDINES; PYRIDONES; SCOPOLAMINE; STEREOISOMERISM;

EID: 33644977501     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.1080/14756360500212266     Document Type: Article

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