Identification of potent anticancer activity in Ximenia americana aqueous extracts used by African traditional medicine

Toxicology and Applied Pharmacology

Volumn 211, Issue 3, 2006, Pages 177-187

  Voss, Cristina ^a   Eyol, Ergül ^a   Berger, Martin R ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

CC531 isogenic rat model; New antineoplastic agent; Plant origin; Selective cytotoxicity

Indexed keywords

CISPLATIN; GALACTOSE; GEMCITABINE; MILTEFOSINE; PLANT EXTRACT; RIBULOSEBISPHOSPHATE CARBOXYLASE; SOLVENT; UNCLASSIFIED DRUG; XEMINIA AMERICANA EXTRACT;

AFRICAN MEDICINE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CHRONIC MYELOID LEUKEMIA; COLORECTAL CANCER; CONTROLLED STUDY; CYTOTOXICITY; DRUG IDENTIFICATION; GENE SEQUENCE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; INTESTINE ABSORPTION; MALE; MITOCHONDRIAL GENETICS; NONHUMAN; OLACACEAE; RAT; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LIVER NEOPLASMS, EXPERIMENTAL; MEDICINE, AFRICAN TRADITIONAL; NEOPLASM TRANSPLANTATION; OLACACEAE; PLANT EXTRACTS; RATS; RATS, INBRED STRAINS; WATER; XENOGRAFT MODEL ANTITUMOR ASSAYS;

ANIMALIA; OLACACEAE; XIMENIA AMERICANA;

EID: 33644971594     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2005.05.016     Document Type: Article

References (20)

1. K.P. Adam, and H. Becker Peptide-proteine K.P. Adam H. Becker Analytik Biogener Arzneistoffe 2000 Wissenschaftliche Verlagsgesellschaft Stuttgart 470 474
2. L. Barbieri, M.G. Battelli, and F. Stirpe Ribosome-inactivating proteins from plants Biochim. Biophys. Acta 1154 1993 237 282
3. M.G. Battelli Cytotoxicity and toxicity to animals and humans of ribosome-inactivating proteins Min. Rev. Med. Chem. 4 2004 513 521
4. A. De Naeyer, V. Pocock, S. Milligan, and D. De Keukeleire Estrogenic activity of a polyphenolic extract of the leaves of Epimedium brevicornum Fitoterapia 76 2005 35 40
5. P.A. De Smet The role of plant-derived drugs and herbal medicines in healthcare Drugs 54 1997 801 840
6. H.M. Kantarjian, M. Talpaz, V. Santini, A. Murgo, B. Cheson, and S.M. O'Brien Homoharringtonine: history, current research, and future direction Cancer 92 2001 1591 1605
7. M. Kinter, and N.E. Sherman An in-gel digestion protocol D.M. Desiderio M.M. Nibbering Protein Sequencing and Identification Using Tandem Mass Spectrometry 2000 Wiley-Interscience New York 152 160
8. S.M. Konstantinov, M. Topashka-Ancheva, A. Benner, and M.R. Berger Alkylphosphocholines: effects on human leukemic cell lines and normal bone marrow cells Int. J. Cancer 77 1998 778 786
9. D.T. Okpako Traditional African medicine: theory and pharmacology explored Trends Pharmacol. Sci. 20 1999 482 485
10. R.W. Owen, R. Haubner, W.E. Hull, G. Erben, B. Spiegelhalder, H. Bartsch, and B. Haber Isolation and structure elucidation of the major individual polyphenols in carob fibre Food Chem. Toxicol. 41 2003 1727 1738
11. D.N. Perkins, D.J. Pappin, D.M. Creasy, and J.S. Cottrell Probability-based protein identification by searching sequence databases using mass spectrometry data Electrophoresis 20 1999 3551 3567
12. J. Saenger, M. Leible, M.H. Seelig, and M.R. Berger Chemoembolization of rat liver metastasis with irinotecan and quantification of tumor cell reduction J. Cancer Res. Clin. Oncol. 130 2004 203 210
13. R.W. Spjut, and R.E. Perdue Jr. Plant folklore: a tool for predicting sources of antitumor activity? Cancer Treat. Rep. 60 1976 979 985
14. W. Tang, I. Hemm, and B. Bertram Recent development of antitumor agents from chinese herbal medicines: Part I. Low molecular compounds Planta Med. 69 2003 97 108
15. W. Tang, I. Hemm, and B. Bertram Recent development of antitumor agents from Chinese herbal medicines: Part II. High molecular compounds Planta Med. 69 2003 193 201
16. J. Treutlein, and M. Wink Molecular phylogeny of cycads inferred from rbcL sequences Naturwissenschaften 89 2002 221 225
17. H. Wada, S. Mizutani, J. Nishimura, Y. Usuki, M. Kohsaki, M. Komai, H. Kaneko, S. Sakamoto, D. Delia, and A. Kanamaru Establishment and molecular characterization of a novel leukemic cell line with Philadelphia chromosome expressing p230 BCR/ABL fusion protein Cancer Res. 55 1995 3192 3196
18. A. Wittmer, K. Khazaie, and M.R. Berger Quantitative detection of lac-Z-transfected CC531 colon carcinoma cells in an orthotopic rat liver metastasis model Clin. Exp. Metastasis 17 1999 369 376
19. Z. Xiao, Y. Hao, B. Liu, and L. Qian Indirubin and meisoindigo in the treatment of chronic myelogenous leukemia in China Leuk. Lymphoma 43 2002 1763 1768
20. R.M. Zacharius, T.E. Zell, J.H. Morrison, and J.J. Woodlock Glycoprotein staining following electrophoresis on acrylamide gels Anal. Biochem. 30 1969 148 152