CDKN2B methylation is an independent poor prognostic factor in newly diagnosed acute promyelocytic leukemia [8]

Leukemia

Volumn 20, Issue 1, 2006, Pages 149-151

  Chim, C S ^a   Lau, J S ^b   Wong, K F ^b   Kwong, Y L ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b QUEEN ELIZABETH HOSPITAL   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ARSENIC TRIOXIDE; CYTARABINE; DAUNORUBICIN; ETOPOSIDE; PROMYELOCYTIC LEUKEMIA PROTEIN; PROTEIN P15; RETINOIC ACID; TIOGUANINE;

ADOLESCENT; ADULT; AGE; AGED; CANCER SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; DEATH; DNA METHYLATION; DRUG RESPONSE; FEMALE; HUMAN; KAPLAN MEIER METHOD; LETTER; LEUKEMIA RELAPSE; LEUKEMIA REMISSION; LEUKOCYTE COUNT; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; PROMYELOCYTIC LEUKEMIA; PROPORTIONAL HAZARDS MODEL; SEX DIFFERENCE; STATISTICAL SIGNIFICANCE; SURVIVAL TIME;

EID: 33644970781     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2404052     Document Type: Letter

References (8)

1. Tallman MS, Nabhan C, Feusner JH, Rowe JM. Acute promyelocytic leukemia: evolving therapeutic strategies. Blood 2002; 99: 759-767.
2. Sanz MA, Martin G, Gonzalez M, Leon A, Rayon C, Rivas C et al. Programa de Estudio y Traitmiento de las Hemopatias Malignas. Risk-adapted treatment of acute promyelocytic leukemia with all-trans-retinoic acid and anthracycline monochemotherapy: A multicenter study by the PETHEMA group. Blood 2004; 103: 1237-1243.
3. Chim CS, Liang R, Tam C, Kwong YL. p15 and P16 promoter methylation in acute promyelocytic leukemia. J Clin Oncol 2001; 19: 2033-2040.
4. Teofili L, Martini M, Luongo M, Diverio D, Capelli G, Breccia M et al. Hypermethylation of GpG islands in the promoter region of p15(INK4b) in acute promyelocytic leukemia represses p15(INK4b) expression and correlates with poor prognosis. Leukemia 2003; 17: 919-924.
5. Au WY, Kumana CR, Kou M, Mak R, Chan GC, Lam CW et al. Oral arsenic trioxide in the treatment of relapsed acute promyelocytic leukemia. Blood 2003; 102: 407-408.
6. Kiyoi H, Naoe T, Yokota S, Nakao M, Minami S, Kuriyama K et al. Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia. Leukemia Study Group of the Ministry of Health and Welfare (Kohseisho). Leukemia 1997; 11: 1447-1452.
7. Callens C, Chevret S, Cayuela JM, Cassinat B, Raffoux E, de Botton S, et al., European APL Group. Prognostic implication of FLT3 and Ras gene mutations in patients with acute promyelocytic leukemia (APL): A retrospective study from the European APL Group. Leukemia 2005; 19: 1153-1160.
8. Au WY, Fung AT, Ma ES, Chan CH, Wong KF, Chim CS et al. Serial studies of methylation of CDKN2B and CDKN2A in relapsed acute promyelocytic leukaemia treated with arsenic trioxide. Br J Haematol 2005, (in press).