In vivo and in vitro antifungal activity of the polyene derivative SPA-S-753 against encapsulated form of Cryptococcus neoformans

Infection

Volumn 25, Issue 1, 1997, Pages 27-31

  Strippoli, V ^a   D'Auria, F D ^b   Simonetti, N ^b   Basti, D ^a   Bruzzese, T ^c  

^a Maxillofacial Surgery Departement   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c Societa Prodotti Antibiotici S p A   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; ANTIFUNGAL AGENT; ELECTROLYTE; N DIMETHYLAMINOACETYLPARTRICIN A 2 DIMETHYLAMINOETHYLAMIDE DIASPARTATE; POLYENE; POTASSIUM ION; SPA S 753; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIFUNGAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYPTOCOCCOSIS; CRYPTOCOCCUS NEOFORMANS; ENCAPSULATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MORPHOLOGY; MOUSE; NONHUMAN; PH; STRAIN DIFFERENCE;

AMPHOTERICIN B; ANIMALS; ANTIBIOTICS, ANTIFUNGAL; CAPSULES; CRYPTOCOCCOSIS; CRYPTOCOCCUS NEOFORMANS; MALE; MICE; POLYENES;

EID: 33644965094     PISSN: 03008126     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02113503     Document Type: Article

References (10)

1. Lin, H. S., Medoff, G., Kobayashi, G. S.: Effects of amphotericin B on macrophages and their precursor cells. Antimicrob. Agents Chemother. 11 (1977) 154-160.
2. Medoff, G., Kobayashi, G. S.: Mode of action of antifungal drug. In: Howard, D. H. (ed.): Fungi pathogenic for humans and animals, part B. Marcel Dekker Inc., New York 1983, pp. 325-355.
3. Adler-Moore, J. P., Profitt, R. T.: Development, characterization, efficacy and mode of action of ambisome, a unilamellar liposomal formulation of amphotericin B. J. Liposome Res. 3 (1993) 429-450.
4. Strippoli, V., Simonetti, N., Villa, A., Bruzzese, T.: Antimicrobial activity of SPA-S-753 a new derivative of partricin A. Eur. Bull. Drug. Res. 1 (1992) 113-118.
5. Strippoli, V., Simonetti, N., D'Auria, F. D., Bruzzese, T.: In vivo activity of SPA-S-753, a water-soluble polyene antibiotic effective against C, albicans. Eur. Bull. Drug. Res. 3 (1994) 71-76.
6. Barnett, J. A., Payne, R. W., Yarrow, D.: YEAST characteristics and identification. Cambridge University Press, Cambridge (1983) 362-363.
7. Strippoli, V., Piacentini, A.: Large capsule production in C. neoformans cells. 2. National Congress FIMUA (Federazione Italiana Micopatologia Umana ed Animale) Turin, November 10-12, 1994, p. 14.
8. Gale, E. F.: The release of potassium ions from Candida albicans in the presence of polyene antibiotics. J. Gen. Microbiol. 80 (1974) 451-465.
9. Strippoli, V., D'Auria, F. D., Simonetti, N.: Investigation of the activity by contact of miconazole sulfosalicylate. J. Chemother. 2 (1990) 371-376.
10. Shmeeda, H. R., Golden, B., Barenholz, Y., Shinitzky, M.: Membrane lipids and ageing. In: Biomembranes-structural and functional aspects. Balaban Publishers, VCH, Weinheim, Germany, 1994 p. 5.