Synthesis and biological properties of new α-methylene-γ- butyrolactones and α,β-unsaturated δ-lactones

European Journal of Medicinal Chemistry

Volumn 41, Issue 2, 2006, Pages 192-200

  Cateni, Francesca ^a   Zilic, Jelena ^a   Zacchigna, Marina ^a   Bonivento, Paolo ^a   Frausin, Fabiana ^a   Scarcia, Vito ^a  

^a UNIVERSITY OF TRIESTE   (Italy)

Author keywords

, Unsaturated lactones; Methylene butyrolactones; Antiproliferative activity; Cytotoxic activity

Indexed keywords

(4,4 DIMETHYL 2 OXODIHYDROFURAN 3 YLIDENE)ACETIC ACID; (4,4 DIMETHYL 2 OXODIHYDROFURAN 3 YLIDENE)ACETIC ACID 4' PHENYLBUTYL ESTER; (4,4 DIMETHYL 2 OXODIHYDROFURAN 3 YLIDENE)ACETIC ACID NON 3' ENYL ESTER; (4,4 DIMETHYL 2 OXODIHYDROFURAN 3 YLIDENE)ACETIC ACID NON 3' YNL ESTER; 2 (4,4 DIMETHYL 2 OXODIHYDROFURAN 3 YLIDENE) 3 OXO 3 PHENYLPROPIONIC ACID ETHYL ESTER; 2 (4,4 DIMETHYL 2 OXODIHYDROFURAN 3 YLIDENE)PROPIONIC ACID; 2 (4,4 DIMETHYL 2 OXODIHYDROFURAN 3 YLIDENE)PROPIONIC ACID 4' PHENYLBUTYL ESTER; 2 (4,4 DIMETHYL 2 OXODIHYDROFURAN 3 YLIDENE)PROPIONIC ACID NON 3' ENYL ESTER; 2 (4,4 DIMETHYL 2 OXODIHYDROFURAN 3 YLIDENE)PROPIONIC ACID NON 3' YNL ESTER; 3,5,5 TRIMETHYL 4 NON 1 ENYL 5,6 DIHYDRO 2H PYRAN 2 ONE; 3,5,5 TRIMETHYL 4 OCT 1 ENYL 5,6 DIHYDRO 2H PYRAN 2 ONE; 4,4 DIMETHYLDIHYDROFURAN 2,3 DIONE; 5,5 DIMETHYL 2 OXO 5,6 DIHYDRO 2H PYRAN 3,4 DICARBOXYLIC ACID 4 (4' METHOXYCARBONYLBUTYL)ESTER; 5,5 DIMETHYL 2 OXO 5,6 DIHYDRO 2H PYRAN 3,4 DICARBOXYLIC ACID BIS (4' PHENYLBUTYL)ESTER; 5,5 DIMETHYL 2 OXO 5,6 DIHYDRO 2H PYRAN 3,4 DICARBOXYLIC ACID BIS ALLYLAMIDE; 5,5 DIMETHYL 2 OXO 5,6 DIHYDRO 2H PYRAN 3,4 DICARBOXYLIC ACID DINON 3' ENYL ESTER; 5,5 DIMETHYL 2 OXO 5,6 DIHYDRO 2H PYRAN 3,4 DICARBOXYLIC ACID DINON 3' YNYL ESTER; BUTYROLACTONE; CISPLATIN; CYANOACETIC ACID(4,4 DIMETHYL 2 OXODIHYDROFURAN 3 YLIDENE)HYDRAZIDE; FURAN DERIVATIVE; LACTONE DERIVATIVE; N BENZYL 2 (4,4 DIMETHYL 2 OXODIHYDROFURAN 3 YLIDENE)ACETAMIDE; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CELL PROLIFERATION; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSICAL CHEMISTRY; TUMOR CELL LINE;

4-BUTYROLACTONE; ANIMALS; ANTINEOPLASTIC AGENTS; HUMANS; INHIBITORY CONCENTRATION 50; LACTONES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 33644961939     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2005.10.009     Document Type: Article

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