Early and late immunohistochemical and ultrastructural changes associated with functional impairment of the lachrymal gland following external beam radiation

International Journal of Experimental Pathology

Volumn 87, Issue 1, 2006, Pages 65-71

  Hakim, Samer G ^a   Schroder, Christina ^a   Geerling, Gerd ^a   Lauer, Isabel ^a   Wedel, Thilo ^b   Kosmehl, Hartwig ^c   Driemel, Oliver ^c   Jacobsen, Hans Christian ^a   Trenkle, Thomas ^a   Hermes, Dirk ^a   Sieg, Peter ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b UNIVERSITY OF LÜBECK   (Germany)

^c HELIOS KLINIKUM ERFURT   (Germany)

Author keywords

SMA; Dysfunction; Lachrymal gland; Radiation; Tenascin C

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; TECHNETIUM 99M; TENASCIN; ACTIN; DIAGNOSTIC AGENT; PERTECHNETIC ACID TC 99M; RADIOPHARMACEUTICAL AGENT;

ACINAR CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXTERNAL BEAM RADIOTHERAPY; EYE; EYE DISEASE; FEMALE; FUNCTIONAL DISEASE; IMMUNOHISTOCHEMISTRY; IMMUNOHISTOLOGY; LACRIMAL GLAND; MYOEPITHELIUM CELL; NONHUMAN; PRIORITY JOURNAL; RABBIT; RADIATION PROTECTION; SCHIRMER TEST; SCINTIGRAPHY; ANIMAL; DRY EYE; ELECTRON MICROSCOPY; LACRIMAL APPARATUS; METHODOLOGY; PATHOLOGY; RADIATION EXPOSURE; RADIATION INJURY; RADIATION RESPONSE; RANDOMIZATION; SCINTISCANNING; STAINING; TIME; ULTRASTRUCTURE;

ACTINS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, RADIATION; DRY EYE SYNDROMES; FEMALE; IMMUNOHISTOCHEMISTRY; LACRIMAL APPARATUS; MICROSCOPY, ELECTRON; RABBITS; RADIATION INJURIES, EXPERIMENTAL; RADIOPHARMACEUTICALS; RANDOM ALLOCATION; SODIUM PERTECHNETATE TC 99M; STAINING AND LABELING; TENASCIN; TIME FACTORS;

EID: 33644960549     PISSN: 09599673     EISSN: 13652613     Source Type: Journal    
DOI: 10.1111/j.0959-9673.2006.00456.x     Document Type: Article

References (16)

1. Bartley G.B. Gorman C.A. 2002 Perspective - Part I: the Mayo Orbital Radiotherapy for Graves Ophthalmopathy (ORGO) study: lessons learned OphthalPlastReconstrSurg 18 170 172
2. Eter N. Schuller H. 2001 External beam radiotherapy for age-related macular degeneration causes transient objective changes in tear-film function Graefes ArchClinExpOphthalmol 239 923 926
3. Garrett J.R. 1987 The proper role of nerves in salivary secretion: a review JDentRes 66 387 397
4. Gazda M.J. Schultheiss T.E. Stephens L.C. Ang K.K. Peters L.J. 1992 The relationship between apoptosis and atrophy in the irradiated lachrimal gland IntJRadiatOncolBiolPhys 24 693 697
5. Hakim S.G. Geerling G. Lauer I. Sieg P. 2002 Scintigraphic evaluation of lachrimal glands using a rabbit experimental model Ophthalmic Res 34 254 257
6. Heimann H. Coupland S.E. Gochman R. Hellmich M. Foerster M.H. 2001 Alterations in expression of mucin, tenascin-C and syndecan-1 in the conjunctiva following retinal surgery and plaque radiotherapy Graefes ArchClinExpOphthalmol 239 488 495
7. - co-transport system JClinInvest 79 1310 1313
8. Jones P.L. Boudreau N. Myers C.A. Erickson H.P. Bissell M.J. 1995 Tenascin-C inhibits extracellular matrix-dependent gene expression in mammary epithelial cells. Localization of active regions using recombinant tenascin fragments JCell Sci 108 519 527
9. Kwok S.K. Ho P.C. Leung S.F. et al. 1998 An analysis of the incidence and risk factors of developing severe keratopathy in eyes after megavoltage external beam irradiation Ophthalmology 105 2051 2055
10. Munter M.W. Karger C.P. Hoffner S.G. et al. 2004 Evaluation of salivary gland function after treatment of head-and-neck tumors with intensity-modulated radiotherapy by quantitative pertechnetate scintigraphy IntJRadiatOncolBiolPhys 58 175 184
11. Nakissa N. Rubin P. Strohl R. Keys H. 1983 Ocular and orbital complications following radiation therapy of paranasal sinus malignancies and review of literature Cancer 51 980 986
12. Satoh Y. Sano K. Habara Y. Kanno T. 1997 Effects of carbachol and catecholamines on ultrastructure and intracellular calcium-ion dynamics of acinar and MEC of lachrimal glands Cell Tissue Res 289 473 485
13. Solans R. Bosch J.A. Galofre P. et al. 2001 Salivary and lachrimal gland dysfunction (sicca syndrome) after radioiodine therapy JNuclMed 42 738 743
14. Stephens L.C. Ang K.K. Schultheiss T.E. King G.K. Brock W.A. Peters L.J. 1986 Target cell and mode of radiation injury in rhesus salivary glands RadiotherOncol 7 165 174
15. Vissink A. Jansma J. Spijkervet F.K. Burlage F.R. Coppes R.P. 2003 Oral sequelae of head and neck radiotherapy CritRevOral BiolMed 14 199 212
16. Zettinig G. Hanselmayer G. Fueger B.J. et al. 2002 Long-term impairment of the lachrimal glands after radioiodine therapy: a cross-sectional study EurJNuclMedMolImaging 29 1428 1432