Evolution of a new drug formulation: The rationale for high-dose, short-course therapy with azithromycin

International Journal of Antimicrobial Agents

Volumn 26, Issue SUPPL. 3, 2005, Pages

  Blumer, Jeffrey L ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Azithromycin microspheres; Pharmacodynamics; Pharmacokinetics; Short course therapy

Indexed keywords

AZITHROMYCIN; BETA LACTAM; CIPROFLOXACIN; DRUG VEHICLE; LEVOFLOXACIN; MICROSPHERE; MOXIFLOXACIN; PENICILLIN G; TELITHROMYCIN;

ANTIBACTERIAL ACTIVITY; AREA UNDER THE CURVE; DIARRHEA; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; DRUG HALF LIFE; DRUG INHIBITION; DRUG MEGADOSE; DRUG POTENCY; DRUG RELEASE; DRUG TARGETING; DRUG TISSUE LEVEL; DRUG TOLERABILITY; DRUG TRANSPORT; DRUG UPTAKE; FOOD DRUG INTERACTION; GASTROINTESTINAL SYMPTOM; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INFECTION; MACROPHAGE; MAXIMUM ALLOWABLE CONCENTRATION; NEUTROPHIL; NONHUMAN; OTITIS MEDIA; PERITONITIS; PHAGOCYTE; PNEUMONIA; PRIORITY JOURNAL; REVIEW; SHORT COURSE THERAPY;

EID: 33644929543     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-8579(05)80320-6     Document Type: Article

References (18)

1. Abdel-Rahman S.M., and Kearns G.L. The pharmacokinetic-pharmacodynamic interface: determinants of anti-effective drug action and efficacy in pediatrics Feigin R.D. Cherry J.D. Demmler G.J. Kaplan S.C. Textbook of pediatric infectious diseases 5th ed. 2004 Saunders Philadelphia, PA 2965 2987
2. Ferguson J. The use of chemical potentials as indices of toxicity Proc R Soc London B Biol Sci 127 1939 387 404
3. Eagle H., Fleischmim R., and Musselman A. The effective concentrations of penicillin in vitro and in vivo for streptococci, pneumococci, and Treponema pallidum J Bacteriol 59 1950 625 643
4. Hunstad D.A., and St Jeme J.W. III Molecular determinants of microbial pathogenesis Feigin R.D. Cherry J.D. Demmler G.J. Kaplan S.C. Textbook ofpediatric infectious diseases 5th ed. 2004 Saunders Philadelphia, PA 2 20
5. Liu P., Allaudeen H., Chandra R., Phillips K.F., and Sharma A. Serum and white blood cell (WBC) pharmacokinetics (PK) of a novel, single-dose azithromycin (AZ) microsphere formulation Abstract accepted for ICAAC 2005 New Orleans, September 21-24 2005
6. Girard D, Bergeron J.M., Milisen W.B., and Retsema J.A. Comparison of azithromycin, roxithromycin, and cephalexin penetration kinetics in early and mature abscesses J Antimicrob Chemother 31 Suppl E 1993 17 28
7. Retsema J.A., Bergeron J.M., Girard D., Milisen W.B., and Girard A.E. Preferential concentration of azithromycin in an infected mouse thigh model J Antimicrob Chemother 31 Suppl E 1993 5 16
8. Mandell G.L., and Coleman E. Uptake, transport, and delivery of antimicrobial agents by human polymorphonuclear neutrophils Antimicrob Agents Chemother 45 2001 1794 1798
9. Gladue R.P., Bright G.M., Isaacson R.E., and Newborg M.E. In vitro and in vivo uptake of azithromycin CCP-62,993 by phagocytic cells: possible mechanism of delivery and release at sites of infection Antimicrob Agents Chemother 33 1989 277 282
10. Hand W.L., and Hand D.L. Characteristics and mechanisms of azithromycin accumulation and efflux in human polymorphonuclear leukocytes Int J Antimicrob Agents 18 2001 419 425
11. Hakansson A., Carlstedt I., Davies J., Mossberg A.K., Sabharwal H., and Svanborg C. Aspects on the interaction of Streptococcus pneumoniae and Haemophilus infuence with human respiratory tract mucosa Am J Respir Crit Care Med 154 1996 5187 5191
12. Jecker P., McWilliam A., and Napoli S. Acute laryngitis in the rat induced by Moraxella catarrhalis and Bordetella pertussis: number of neutrophils, dendritic cells, and T and B lymphocytes accumulating during infection in the laryngeal mucosa strongly differs in adjacent locations Pediatr Res 46 1999 760 766
13. Ichimiya I., Suzuki M., Hirano T., and Mogi G. The influence of pneumococcal otitis media on the cochlear lateral wall Hear Res 131 1999 128 134
14. Tong H.H., Blue L.E., James M.A., Chen Y.P., and DeMaria T.F. Evaluation of phase variation of nontypeable Haemophilus influenzae lipooligosaccharide during nasopharyngeal colonization and development of otitis media in the chinchilla model Infect Immun 68 2000 4593 4597
15. Melhus A., and Ryan A.E. Expression of cytokine genes during pneumococcal and nontypeable Haemophilus infuenzae acute otitis media in the rat Infect Immun 68 2000 4024 4031
16. Rynnel-Dagoo B., and Agren K. The nasopharynx and the middle ear: inflammatory reactions in middle ear disease Vaccine 19 2001 526 531
17. Babl F.E., Pelton S.I., and Li Z. Experimental acute otitis media due to nontypeable Haemophilus infuenzae: comparison of high and low azithromycin doses with placebo Antimicrob Agents Chemother 46 2002 2194 2199
18. Girard D., Finegan S.M., Cimochowski C.R., Dunne M.W., and Giovanis A. Accelerated dosing of azithromycin in preclinical infection models Poster presented at the 102nd American Society for Microbiology General Meeting Salt Lake City, UT, May 19-23 2002