Advances in the treatment of interstitial cystitis

Expert Opinion on Pharmacotherapy

Volumn 7, Issue 4, 2006, Pages 411-419

  Parsons, C Lowell ^a  

^a UCSD MEDICAL CENTER   (United States)

Author keywords

Bladder; Heparinoid therapy; Interstitial cystitis; Intravesical therapy; Pelvic pain; Pentosan polysulfate

Indexed keywords

AMITRIPTYLINE; BCG VACCINE; CAPSAICIN; CITRATE POTASSIUM; CITRATE SODIUM; CYSTISTAT; DIMETHYL SULFOXIDE; FLUOXETINE; GLYCEROPHOSPHATE; HEPARIN; HEPARINOID; HYALURONIC ACID; HYDROXYZINE; IMIPRAMINE; PENTOSAN POLYSULFATE; PLACEBO; POTASSIUM; PRELIEF; RESINIFERATOXIN; SERTRALINE;

CLINICAL FEATURE; CLINICAL TRIAL; DEPRESSION; DIAGNOSTIC PROCEDURE; DISEASE CONTROL; DISEASE COURSE; DISEASE EXACERBATION; DISEASE SEVERITY; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; GASTROINTESTINAL SYMPTOM; HUMAN; INTERSTITIAL CYSTITIS; PATHOPHYSIOLOGY; PATIENT CARE; PELVIS PAIN SYNDROME; RARE DISEASE; REVIEW; SENSITIVITY ANALYSIS; URINARY FREQUENCY; URINARY TRACT; URINARY URGENCY;

ADMINISTRATION, INTRAVESICAL; ANALGESICS, NON-NARCOTIC; ANESTHETICS, LOCAL; ANTI-INFLAMMATORY AGENTS; CLINICAL TRIALS; CYSTITIS, INTERSTITIAL; DIMETHYL SULFOXIDE; DITERPENES; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; HEPARINOIDS; HUMANS; LIDOCAINE; NEUROTOXINS; PELVIC PAIN; PENTOSAN SULFURIC POLYESTER; SODIUM BICARBONATE;

EID: 33644924062     PISSN: 14656566     EISSN: None     Source Type: Journal    
DOI: 10.1517/14656566.7.4.411     Document Type: Review

References (43)

1. HAND JR: Interstitial cystitis, a report of 223 cases. J. Urol. (1949) 61:291-310.
2. PARSONS CL: Interstitial cystitis: clinical manifestations and diagnostic criteria in over 200 cases. Neurourol. Urodyn (1990) 9:241-250.
3. KOZIOL JA, CLARK DC, GITTES RF, TAN EM: The natural history of interstitial cystitis: a survey of 374 patients. J. Urol (1993) 149:465-469.
4. PARSONS CL, ZUPKAS P, PARSONS JK: Intravesical potassium sensitivity in patients with interstitial cystitis and urethral syndrome. Urology (2001) 57:428-433.
5. KOZIOL JA: Epidemiology of interstitial cystitis. Urol. Clin. North Am. (1994) 21:7-71.
6. HELD PJ, HANNO PM, WEIN AJ et al: Epidemiology of interstitial cystitis: 2. In: Interstitial Cystitis. Hanno PM, Staskin DR, Krane RJ et at. (Eds). Springer-Verlag, London, (1990):29-48.
7. PARSONS CL: Prostatitis, interstitial cystitis, chronic pelvic pain, and urethral syndrome share a common pathophysiology- lower urinary dysfunctional epithelium and potassium recycling. Urology (2003) 62:976-982.
8. PARSONS CL, GREENBERGER M, GABAL L, BIDAIR M, BARME G: The role of urinary potassium in the pathogenesis and diagnosis of interstitial cystitis.J. Urol. (1998) 159:1862-1867.
9. PARSONS CL, DELL J, STANFORD EJ et al: Increased prevalence of interstitial cystitis: previously unrecognized urologic and gynecologic cases identified using a new symptom questionnaire and intravesical potassium sensitivity. Urology (2002) 60:573-578.
10. MINAGLIA S, OZEL B, NGUYEN JN, MISHELL DR JR. Validation of Spanish version of Pelvic Pain and Urgency/Frequency (PUF) patient symptom scale. Urology (2005) 65:664-669.
11. PARSONS CL, TATSIS V: Prevalence of interstitial cystitis in young women. Urology (2004) 64:866-870.
12. PARSONS CL, ROSENBERG MT, SASSANI P et al: Quantifying symptoms in men with interstitial cystitis/prostatitis, and its correlation with potassium-sensitivity testing. BJU Int. (2005) 95:86-90.
13. STANFORD EJ, KOZIOL J, FENG A: The prevalence of interstitial cystitis, endometriosis, adhesions, and vulvar pain in women with chronic pelvic pain.J. Minim. Invasive Gynecol. (2005) 12:43-49.
14. PARSONS CL, DELL J, STANFORD EJ, BULLEN M, KAHN BS, WILLEMS JJ: The prevalence of interstitial cystitis in gynecologic patients with pelvic pain as detected by intravesical potassium sensitivity. Am. J Obstet. Gynecol. (2002) 187:1395-1400.
15. PARSONS CL, ALBO ME: Intravesical potassium sensitivity in prostatitis patients. J Urol (2002) 168:1054-1057.
16. NICKEL JC, TEICHMAN JM, GREGOIRE M, CLARK J, AND DOWNEY J: Prevalence, diagnosis, characterization, and treatment of prostatitis, interstitial cystitis, and epididymitis in outpatient urological practice: the Canadian PIE Study, Urology (2005) 66:935-940.
17. ROSENBERG MT, HAZZARD M: Prevalence of interstitial cystitis symptoms in women: a population based study in the primary care office. J. Urol. (2005) 174:2231-2234.
18. MINAGLIA S, ÖZEL B, BIZHANG R, MISHELL DR JR: Increased prevalence of interstitial cystitis in women with detrusor overactivity refractory to anticholinergic therapy. Urology (2005) 66:702-706.
19. SANT GR: Interstitial cystitis: pathophysiology, clinical evaluation and treatment. Ann. Urol. (1989) 3:172-179.
20. SANT GR, KALARU P, UCCI AA JR: Mucosal mast cell (MMC) contribution to bladder mastocytosis in interstitial cystitis. J. Urol. (1988) 139:276A.
21. LETOURNEAU R, PANG X, SANT GR et al.: Intragranular activation of bladder mast cells and their association with nerve processes in interstitial cystitis. Br. J. Urol. (1996) 77:41-54.
22. THEOHARIDES TC: Hydroxyzine in the treatment of interstitial cystitis. Urol. Clin. N. Am. (1994) 21:113-119.
23. HANNO PM, BUEHLER J, WEIN AJ: Use of amitriptyline in the treatment of interstitial cystitis.J. Urol. (1989) 141:846-848.
24. VAN OPHOVEN A, POKUPIC S, HEINECKE A, HERTLE L: A prospective, randomized, placebo controlled, double-blind study of amitriptyline for the treatment of interstitial cystitis. J. Urol. (2004) 172:533-536.
25. VAN OPHOVEN A, HERTLE L: Long-term results of amitriptyline treatment for interstitial cystitis. J. Urol. (2005) 174:1837-1840.
26. PARSONS CL, HOUSLEY T, SCHMIDT JD et al.: Treatment of interstitial cystitis with intravesical heparin. Br. J. Urol. (1994) 73:504-507.
27. HO NJ, KOZIOL JA, PARSONS CL et al.: Natural history of interstitial cystitis in 274 patients receiving sulfated polysaccharide therapy. Urology (1999) 53:1133-1139.
28. PARSONS CL, BENSON G, CHILDS SJ et al.: A quantitatively controlled method to prospectively study interstitial cystitis and which demonstrates the efficacy of pentosanpolysulfate.J. Urol. (1993) 150:845-848.
29. MULHOLLAND SG, HANNO P, PARSONS CL et al.: Pentosan polysulfate sodium for therapy of interstitial cystitis. A double-blind placebo-controlled clinical study. Urology (1990) 35:552-558.
30. PARSONS CL, MULHOLLAND SG: Successful therapy of interstitial cystitis with pentosanpolysulfate.J. Urol. (1987) 138:513-516.
31. HOLM-BENTZEN M, JACOBSEN F, NERSTROM B et al.: A prospective double-blind clinically controlled multicenter trial of sodium pentosanpolysulfate in the treatment of interstitial cystitis and related painful bladder disease.J. Urol. (1987) 138:503-507.
32. HANNO PM: Analysis of long-term Elmiron therapy for interstitial cystitis. Urology (1997) 49(Suppl. 5A):93-99.
33. NICKEL JC, BARKIN J, FORREST J et al.: Randomized, double-blind, dose-ranging study of pentosan polysulfate sodium for interstitial cystitis. Urology (2005) 65:654-658.
34. VAN OPHOVEN A, HEINECKE A. HERTLE L: Safety and efficacy of concurrent application of oral pentosan polysulfate and subcutaneous low-dose heparin for patients with interstitial cystitis. Urology (2005) 66:707-711.
35. PARSONS CL, FORREST J, NICKEL JC et al.: Effect of pentosan polysulfate therapy on intravesical potassium sensitivity. Urology (2002) 59:329-333.
36. PARSONS CL: Epithelial coating techniques in the treatment of interstitial cystitis. Urology (1997) 49(Suppl. 5A):100-104.
37. PAYNE CK, MOSBAUGH PG, FORREST JB et al: Intravesical resiniferatoxin for the treatment of interstitial cystitis: a randomized, double-blind, placebo controlled trial. J. Urol. (2005) 173:1590-1594.
38. CHEN TYH, CORCOS J, CAMEL M et al.: Prospective, randomized, double-blind study of safety and tolerability of intravesical resiniferatoxin (RTX) in interstitial cystitis (IC). Internat. Urogyn. J. Pelvic Floor Dysfunct. (2005) 16(4):293-297.
39. MAYER R, PROPERT KJ, PETERS KM et al.: A randomized controlled trial of intravesical bacillus calmette-guerin for treatment refractory interstitial cystitis. J. Urol. (2005) 173:1186-1191.
40. PARSONS CL, GREENE RA, CHUNG M et al.: Abnormal urinary potassium metabolism in patients with interstitial cystitis. J. Urol. (2005) 173:1182-1185.
41. SANT GR, PROPERT KJ, HANNO PM et al.: A pilot clinical trial of oral pentosan polysulfate and oral hydroxyzine in patients with interstitial cystitis. J. Urol. (2003) 170:810-815.
42. PARSONS CL: Successful downregulation of bladder sensory nerves with combination of heparin and alkalinized lidocaine in patients with interstitial cystitis. Urology (2005) 65:45-48.
43. NICKEL JC, DOWNEY J, HUNTER D, CLARK J: Prevalence of prostatitis-like symptoms in a population based study using the National Institutes of Health Chronic Prostatitis Symptom Index. J. Urol. (2001) 165:842-845.