Clinical efficacy and safety of transdermal methimazole in the treatment of feline hyperthyroidism

Canadian Veterinary Journal

Volumn 47, Issue 2, 2006, Pages 131-135

  Lécuyer, Manon ^a   Prini, Sabrina ^a   Dunn, Marilyn E ^a   Doucet, Michèle Y ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

THIAMAZOLE; THYROXINE;

ARTICLE; BLOOD CELL COUNT; BLOOD SAMPLING; CAT; CLINICAL FEATURE; CONTROLLED STUDY; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG RESPONSE; DRUG SAFETY; FEMALE; HYPERTHYROIDISM; MALE; NONHUMAN; SKIN MANIFESTATION; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; THROMBOCYTOPENIA; THYROXINE BLOOD LEVEL;

FELIDAE;

EID: 33644918281     PISSN: 00085286     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Mooney CT, Thoday KL. CVT Update: Medical treatment of hyperthyroidism in cats. In: Bonagura JD, ed. Kirk's Current Veterinary Therapy XIII. Philadelphia: Saunders, 2000:333-337.
2. Peterson ME. Hyperthyroidism. In: Ettinger SJ, Feldman EC, eds. Textbook of Veterinary Internal Medicine, 5th ed. Philadelphia: Saunders, 2000:1400-1417.
3. Peterson ME, Graves TK, Cavanagh I. Serum thyroid hormone concentrations fluctuate in cats with hyperthyroidism. J Vet Intern Med 1987;1:142-146.
4. Feldman EC, Nelson RW. Canine and Feline Endocrinology and Reproduction, 3rd ed. Philadelphia: Saunders, 2004:152-215.
5. Peterson ME, Hurvitz AI, Leib MS, et al. Propylthiouracil-associated hemolytic anemia, thrombocytopenia and antinuclear antibodies in cats with hyperthyroidism. J Am Vet Med Assoc 1984;18:86.
6. Trepanier LA, Peterson ME. Pharmacokinetics of methimazole in normal cats and cats with hyperthyroidism. Res Vet Sc 1991;50: 69-74.
7. Trepanier LA, Peterson ME, Aucoin DP. Pharmacokinetics of intavenous and oral methimazole following single- and multiple dose administration in normal cats. Vet Pharmacol Ther 1991;14:367-373.
8. Peterson ME. Comparison of the disposition of carbimazole and methimazole in clinically normal cats. Res Vet Sc 1993;54: 351-355.
9. Graves TK. Complications of treatment and concurrent illness associated with hyperthyroidism in cats. In: Bonagura JD, ed. Kirk's Current Veterinary Therapy XII. Philadelphia: WB Saunders, 1995:369-372.
10. Hoffman SB, Yoder AR, Trepanier LA. Bioavailability of transdermal methimazole in a pluronic lecithin organogel (PLO) in healthy cats. J Vet Pharmacol Ther 2002;25:189-193.
11. Hoffmann G, Marks SL, Taboada J, Hosgood GL, Wolfsheimer KJ. Topical methimazole treatment of cats with hyperthyroidism [Abstract], Proc 19th Am Coll Vet Int Med, Denver, Colorado 2001:112.
12. Riviere JE, Papich MG. Potential and problems of developing transdermal patches for veterinary applications. Adv Drug Deliv Rev 2001;50:175-203.
13. Magnusson BM, Walters KA, Roberts MS. Veterinary drug delivery: potential for skin penetration enhancement. Adv Drug Deliv Rev 2001;50:205-227.
14. Hoffman G, Marks SL, Taboada J, Hosgood GL, Wolfsheimer KJ. Transdermal methimazole treatment in cats with hyperthyroidism. J Feline Med Surg 2003;5:77-82.
15. Sartor LL, Trepanier LA, Kroll MM, Rodan I, Challoner L. Efficacy and safety of transdermal methimazole in the treatment of cats with hyperthyroidism. J Vet Intern Med 2004;18:65-655.
16. Becker TJ, Graves TK, Kruger JM, Braselton WE, Nachreiner RF. Effects of methimazole on renal function in cats with hyperthyroidism. J Am Anim Hosp Assoc 2000;36:215-23.
17. Retsios E. Pharm Profile: Methimazole. Compend Contin Educ Pract Vet 2001;23:36-41.
18. Peterson ME, Kintzer PP, Hurvitz AI. Methimazole treatment of 262 cats with hyperthyroidism. J Vet Intern Med 1988;2: 150-157.