Immunohistochemical analysis of the antiapoptotic Mcl-1 and Bcl-2 proteins in follicular lymphoma

British Journal of Haematology

Volumn 132, Issue 6, 2006, Pages 743-746

  Michels, Jorg ^a,b   Foria, Vipul ^c   Mead, Ben ^a   Jackson, Gill ^a   Mullee, Mark ^d   Johnson, Peter W M ^a   Packham, Graham ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b BRITISH COLUMBIA CANCER AGENCY   (Canada)

^c SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

^d UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

Bcl 2; Follicular lymphoma; Grading; Mcl 1

Indexed keywords

PROTEIN BCL 2; PROTEIN MCL 1;

ADULT; AGED; ARTICLE; CANCER SURVIVAL; CELL; CELL COUNT; CELL LABELING; CELL LEVEL; CENTROBLAST; CENTROCYTE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; FOLLICULAR LYMPHOMA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; STAINING; TISSUE SECTION;

ADULT; AGED; AGED, 80 AND OVER; APOPTOSIS; CYTOPLASM; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHOMA, FOLLICULAR; MALE; MIDDLE AGED; NEOPLASM PROTEINS; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 33644911471     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2005.05954.x     Document Type: Article

References (12)

1. Agarwal B. Naresh K.N. 2002 Bcl-2 family of proteins in indolent B-cell non-Hodgkin's lymphoma: study of 116 cases American Journal of Hematology 70 278 282
2. Bastion Y. Sebban C. Berger F. Felman P. Salles G. Dumontet C. Bryon P.A. Coiffier B. 1997 Incidence, predictive factors, and outcome of lymphoma transformation in follicular lymphoma patients Journal of Clinical Oncology 15 1587 1594
3. Chau I. Jones R. Cunningham D. Wotherspoon A. Maisey N. Norman A.R. Jain P. Bishop L. Horwich A. Catovsky D. 2003 Outcome of follicular lymphoma grade 3: is anthracycline necessary as front-line therapy British Journal of Cancer 89 36 42
4. Cho-Vega J.H. Rassidakis G.Z. Admirand J.H. Oyarzo M. Ramalingam P. Paraguya A. McDonnell T.J. Amin H.M. Medeiros L.J. 2004 MCL-1 expression in B-cell non-Hodgkin's lymphomas Human Pathology 35 1095 1100
5. Dardick I. Caldwell D.R. 1986 Follicular center cell lymphoma. Morphologic data relating to observer reproducibility Cancer 58 2477 2484
6. Gascoyne R.D. Adomat S.A. Krajewski S. Krajewska M. Horsman D.E. Tolcher A.W. O'Reilly S.E. Hoskins P. Coldman A.J. Reed J.C. Connors J.M. 1997 Prognostic significance of Bcl-2 protein expression and Bcl-2 gene rearrangement in diffuse aggressive non-Hodgkin's lymphoma Blood 90 244 251
7. Khoury J.D. Medeiros L.J. Rassidakis G.Z. McDonnell T.J. Abruzzo L.V. Lai R. 2003 Expression of Mcl-1 in mantle cell lymphoma is associated with high-grade morphology, a high proliferative state, and p53 overexpression Journal of Pathology 199 90 97
8. McDonnell T.J. Korsmeyer S.J. 1991 Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18) Nature 349 254 256
9. Michels J. O'Neill J.W. Dallman C.L. Mouzakiti A. Habens F. Brimmell M. Zhang K.Y. Craig R.W. Marcusson E.G. Johnson P.W. Packham G. 2004 Mcl-1 is required for Akata6 B-lymphoma cell survival and is converted to a cell death molecule by efficient caspase-mediated cleavage Oncogene 23 4818 4827
10. Nathwani B.N. Harris N.L. Weisenburger D. Isaacson P.G. Piris M.A. Berger F. Muller-Hermelink H.K. Swerdlow S.H. 2001 Pathology and genetics of tumors of haematopoietic and lymphoid tissues In: World Health Organization Classification of Tumors. Follicular Lymphoma ed. by Jaffe E.S. Harris N.L. Stein H. Vardiman J.W. pp 162 167 IARC Press Lyon q2
11. Zhang C.L. Kamarashev J. Qin J.Z. Burg G. Dummer R. Dobbeling U. 2003 Expression of apoptosis regulators in cutaneous T-cell lymphoma (CTCL) cells Journal of Pathology 200 249 254
12. Zhou P. Levy N.B. Xie H. Qian L. Lee C.Y. Gascoyne R.D. Craig R.W. 2001 MCL1 transgenic mice exhibit a high incidence of B-cell lymphoma manifested as a spectrum of histologic subtypes Blood 97 3902 3909