Activation of NF-κB transcription factor in the preterm ovine brain and placenta after acute LPS exposure

Journal of Neuroscience Research

Volumn 83, Issue 4, 2006, Pages 567-574

  Briscoe, T ^a   Duncan, J ^a   Cock, M ^b   Choo, J ^a   Rice, G ^c   Harding, R ^b   Scheerlinck, J P Y ^a   Rees, Sandra ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

Author keywords

Cytokines; Inflammatory cascade; Lipopolysaccharide; NF B; P50 P65 subunits

Indexed keywords

8 ISOPROSTANE; BRAIN PROTEIN; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LACTIC ACID; LIPOPOLYSACCHARIDE; 8 EPI PROSTAGLANDIN F2ALPHA; 8-EPI-PROSTAGLANDIN F2ALPHA; CYTOKINE; DRUG DERIVATIVE; INTERLEUKIN 6; PROSTAGLANDIN F2 ALPHA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASAL GANGLION; BINDING AFFINITY; BRAIN; BRAIN CORTEX; CONTROLLED STUDY; FETUS BLOOD; GEL MOBILITY SHIFT ASSAY; GESTATION PERIOD; HEMATOCRIT; HIPPOCAMPUS; HYPOXEMIA; LIPID PEROXIDATION; NONHUMAN; OXIDATIVE STRESS; PLACENTA; PREMATURITY; PRIORITY JOURNAL; PROTEIN BINDING; THALAMUS; ANIMAL; BIOSYNTHESIS; BLOOD; BODY WEIGHT; BRAIN LEVEL; DRUG EFFECT; FEMALE; METABOLISM; ORGAN SIZE; PATHOLOGY; PREGNANCY; SHEEP;

ANIMALS; BODY WEIGHT; BRAIN; BRAIN CHEMISTRY; CYTOKINES; DINOPROST; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FEMALE; INTERFERON TYPE II; INTERLEUKIN-6; LIPID PEROXIDATION; LIPOPOLYSACCHARIDES; NF-KAPPA B; ORGAN SIZE; OXIDATIVE STRESS; PLACENTA; PREGNANCY; SHEEP; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33644910150     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.20757     Document Type: Article

References (39)

1. Barger SW, Moerman AM, Mao X. 2005. Molecular mechanisms of cytokine-induced neuroprotection: NFκB and neuroplasticity. Curr Pharm Des 11:985-998.
2. Beg AA, Baltimore D. 1996. An essential role for NF-κB in preventing TNF-alpha-induced cell death. Science 274:782-784.
3. Bell MJ, Hallenbeck JM. 2002. Effects of intrauterine inflammation on developing rat brain. J Neurosci Res 70:570-579.
4. Billiau A, Heremans H, Vermeire K, Matthys P. 1998. Immunomodulatory properties of interferon-gamma. An update. Ann N Y Acad Sci 856:22-32.
5. Blackwell TS, Christman JW. 1997. The role of nuclear factor-kappa B in cytokine gene regulation. Am J Respir Cell Mol Biol 17:3-9.
6. Cai Z, Pan ZL, Pang Y, Evans OB, Rhodes PG. 2000. Cytokine induction in fetal rat brains and brain injury in neonatal rats after maternal lipopolysaccharide administration. Pediatr Res 47:64-72.
7. Cock ML, Harding R. 1997. Renal and amniotic fluid responses to umbilicoplacental embolization for 20 days in fetal sheep. Am J Physiol 273:R1094-1102.
8. Dalitz P, Harding R, Rees SM, Cock ML. 2003. Prolonged reductions in placental blood flow and cerebral oxygen delivery in preterm fetal sheep exposed to endotoxin: possible factors in white matter injury after acute infection. J Soc Gynecol Investig 10:283-290.
9. Dammann O, Leviton A. 1997. Maternal intrauterine infection, cytokines, and brain damage in the preterm newborn. Pediatr Res 42:1-8.
10. Darnell JE Jr, Kerr IM, Stark GR. 1994. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415-1421.
11. Deguchi K, Mizuguchi M, Takashima S. 1996. Immunohistochemical expression of tumor necrosis factor alpha in neonatal leukomalacia. Pediatr Neurol 14:13-16.
12. Deryckere F, Gannon F. 1994. A one-hour mini preparation technique for extraction of DNA-binding proteins from animal tissues. Biotechni-ques 16:405.
13. Duncan JR, Cock ML, Rees S, Harding R. 2003. The effects of repeated endotoxin exposure on placental structure in sheep. Placenta 24:786-789.
14. Duncan JR, Cock ML, Scheerlinck JP, Westcott KT, McLean C, Harding R, Rees SM. 2002. White matter injury after repeated endotoxin exposure in the preterm ovine fetus. Pediatr Res 52:941-949.
15. Egan PJ, Rothel JS, Andrews AE, Seow HF, Wood PR, Nash AD. 1994. Characterization of monoclonal antibodies to ovine tumor necrosis factor-alpha and development of a sensitive immunoassay. Vet Immunol Immunopathol 41:259-274.
16. Gadjeva M, Tomczak MF, Zhang M, Wang YY, Dull K, Rogers AB, Erdman SE, Fox JG, Carroll M, Horwitz BH. 2004. A role for NF-kappa B subunits p50 and p65 in the inhibition of lipopolysaccharide-induced shock. J Immunol 173:5786-5793.
17. Gilles FH, Leviton A, Kerr CS. 1976. Endotoxin leukoencephalopathy in the telencephalon of the newborn kitten. J Neurol Sci 27:183-191.
18. Grether JK, Nelson KB. 1997. Maternal infection and cerebral palsy in infants of normal birth weight. JAMA 278:207-211.
19. Kadhim H, Tabarki B, Verellen G, De Prez C, Rona AM, Sebire G. 2001. Inflammatory cytokines in the pathogenesis of periventricular leukomalacia. Neurology 56:1278-1284.
20. Lappas M, Permezel M, Rice GE. 2003. N-acetyl-cysteine inhibits phospholipid metabolism, proinflammatory cytokine release, protease activity, and nuclear factor-kappaB deoxyribonucleic acid-binding activity in human fetal membranes in vitro. J Clin Endocrinol Metab 88:1723-1729.
21. Mallard C, Welin AK, Peebles D, Hagberg H, Kjellmer I. 2003. White matter injury following systemic endotoxemia or asphyxia in the fetal sheep. Neurochem Res 28:215-223.
22. Mattson MP, Camandola S. 2001. NF-kappaB in neuronal plasticity and neurodegenerative disorders. J Clin Invest 107:247-254.
23. McWaters P, Hurst L, Chaplin PJ, Collins RA, Wood PR, Scheerlinck JP. 2000. Characterization of monoclonal antibodies to ovine interleukin-6 and the development of a sensitive capture ELISA. Vet Immunol Immunopathol 73:155-165.
24. Meffert MK, Baltimore D. 2005. Physiological functions for brain NF-κB. Trends Neurosci 28:37-43.
25. Morrow JD, Roberts LJ 2nd. 1996. The isoprostanes. Current knowledge and directions for future research. Biochem Pharmacol 51:1-9.
26. Nelson KB. 2003. Can we prevent cerebral palsy? N Engl J Med 349:1765-1769.
27. Ornoy A, Altshuler G. 1976. Maternal endotoxemia, fetal anomalies, and central nervous system damage: a rat model of a human problem. Am J Obstet Gynecol 124:196-204.
28. Pahl HL. 1999. Activators and target genes of Rel/NF-kappaB transcrip-tion factors. Oncogene 18:6853-6866.
29. Panek RB, Benveniste EN. 1995. Class II MHC gene expression in microglia. Regulation by the cytokines IFN-gamma, TNF-alpha, and TGF-beta. J Immunol 154:2846-2854.
30. Pizzi M, Goffi F, Boroni F, Benarese M, Perkins SE, Liou HC, Spano P. 2002. Opposing roles for NF-kappa B/Rel factors p65 and c-Rel in the modulation of neuron survival elicited by glutamate and interleukin-1beta. J Biol Chem 277:20717-20723.
31. Qiu J, Grafe MR, Schmura SM, Glasgow JN, Kent TA, Rassin DK, Perez-Polo JR. 2001. Differential NF-kappa B regulation of bcl-x gene expression in hippocampus and basal forebrain in response to hypoxia. J Neurosci Res 64:223-234.
32. Sanz O, Acarin L, Gonzalez B, Castellano B. 2002. NF-κB and IκBα expression following traumatic brain injury to the immature rat brain. J Neurosci Res 67:772-780.
33. Schreck R, Rieber P, Baeuerle PA. 1991. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. EMBO J 10:2247-2258.
34. Shrikant P, Chung IY, Ballestas ME, Benveniste EN. 1994. Regulation of intercellular adhesion molecule-1 gene expression by tumor necrosis factor-alpha, interleukin-1 beta, and interferon-gamma in astrocytes. J Neuroimmunol 51:209-220.
35. van den Tweel ER, Kavelaars A, Lombardi MS, May M, Groenendaal F, Heijnen CJ, van Bel F. 2005. Inhibition of nuclear factor kB activation by NBD peptide following hypoxia-ischemia in neonatal rats is not neuroprotective. Abstract 1767. Pediatric Academic Societies Meeting, Washington, DC.
36. Volpe JJ. 2001. Neurology of the newborn. In: Hund R, editor. Philadelphia: W.B. Saunders Company. 912 p.
37. Yoon BH, Romero R, Kim CJ, Jun JK, Gomez R, Choi JH, Syn HC. 1995. Amniotic fluid interleukin-6: a sensitive test for antenatal diagnosis of acute inflammatory lesions of preterm placenta and prediction of perinatal morbidity. Am J Obstet Gynecol 172:960-970.
38. Yoon BH, Romero R, Yang SH, Jun JK, Kim IO, Choi JH, Syn HC. 1996. Interleukin-6 concentrations in umbilical cord plasma are elevated in neonates with white matter lesions associated with periventricular leukomalacia. Am J Obstet Gynecol 174:1433-1440.
39. Yu Z, Zhou D, Bruce-Keller AJ, Kindy MS, Mattson MP. 1999. Lack of the p50 subunit of nuclear fàctor-ê increases the vulnerability of hippocampal neurons to excitotoxic injury. J Neurosci 19:8856-8865.