Pharmacogenetics of asthma: Where are we now?

Clinics in Chest Medicine

Volumn 27, Issue 1, 2006, Pages 109-117

  Larj, Michael J ^a   Bleecker, Eugene R ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; AMINO ACID; ARGININE; ATRELEUTON; BECLOMETASONE; BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CORTICOSTEROID; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; FORMOTEROL; GLUCOCORTICOID RECEPTOR; GLYCINE; GUANINE NUCLEOTIDE BINDING PROTEIN; IPRATROPIUM BROMIDE; LEUKOTRIENE RECEPTOR BLOCKING AGENT; LIPOXYGENASE INHIBITOR; LONG ACTING DRUG; MESSENGER RNA; MONTELUKAST; PLACEBO; RNA; SALBUTAMOL; SALMETEROL; SHORT ACTING DRUG; ZAFIRLUKAST; ZILEUTON;

AREA UNDER THE CURVE; ASTHMA; CLINICAL TRIAL; CODON; DISEASE SEVERITY; DOWN REGULATION; DRUG EFFICACY; DRUG HYPERSENSITIVITY; DRUG INHIBITION; DRUG MECHANISM; DRUG SAFETY; DRUG TOLERABILITY; EXON; FORCED EXPIRATORY VOLUME; GENE CONTROL; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HUMAN; PHARMACOGENETICS; PRIORITY JOURNAL; PROGNOSIS; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; UNSPECIFIED SIDE EFFECT;

ARACHIDONATE 5-LIPOXYGENASE; ASTHMA; GENOTYPE; HUMANS; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; RECEPTORS, GLUCOCORTICOID;

EID: 33644908762     PISSN: 02725231     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ccm.2005.12.001     Document Type: Review

References (23)

1. B.S. Shastry Pharmacogenetics and the concept of individualized medicine Pharmacogenomics J 2005 Nov 22 [Epub ahead of print]
2. E. Reihsaus, M. Innis, and N. MacIntyre Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects Am J Respir Cell Mol Biol 8 1993 334 339
3. C.M. Drysdale, D.W. McGraw, and C.B. Stack Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness Proc Natl Acad Sci U S A 97 2000 10483 10488
4. S.B. Liggett Polymorphisms of the beta2-adrenergic receptor and asthma Am J Respir Crit Care Med 156 1997 S156 S162
5. S.A. Green, J. Turki, and P. Bejarano Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells Am J Respir Cell Mol Biol 13 1995 25 33
6. S. Tan, I.P. Hall, and J. Dewar Association between beta 2-adrenoceptor polymorphism and susceptibility to bronchodilator desensitisation in moderately severe stable asthmatics Lancet 350 1997 995 999
7. E. Israel, J.M. Drazen, and S.B. Liggett The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma Am J Respir Crit Care Med 162 2000 75 80
8. D.R. Taylor, J.M. Drazen, and G.P. Herbison Asthma exacerbations during long term beta agonist use: influence of beta(2) adrenoceptor polymorphism Thorax 55 2000 762 767
9. E. Israel, V.M. Chinchilli, and J.G. Ford Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial Lancet 364 2004 1505 1512
10. S.C. Lazarus, H.A. Boushey, and J.V. Fahy Long-acting {beta}2-agonist monotherapy vs continued therapy with inhaled corticosteroids in patients with persistent asthma: a randomized controlled trial JAMA 285 2001 2583 2593
11. R.F. Lemanske Jr, C.A. Sorkness, and E.A. Mauger Inhaled corticosteroid reduction and elimination in patients with persistent asthma receiving salmeterol: a randomized controlled trial JAMA 285 2001 2594 2603
12. M.X. Klotsman, C.G. Binnie, and P.M. Dorinsky Pharmacogenetic effect of a b2adrenergic receptor (ADBR2) polymorphism on b2-agonist responsiveness to salmeterol Am J Respir Crit Care Med 169 2004 A582
13. E.K. Silverman, D.J. Kwiatkowski, and J.S. Sylvia Family-based association analysis of beta2-adrenergic receptor polymorphisms in the childhood asthma management program J Allergy Clin Immunol 112 2003 870 876
14. D.W. McGraw, K.F. Almoosa, and R.J. Paul Antithetic regulation by beta-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway beta-agonist paradox J Clin Invest 112 2003 619 626
15. E.R. Bleecker, M.J. Welch, and S.F. Weinstein Low-dose inhaled fluticasone propionate versus oral zafirlukast in the treatment of persistent asthma J Allergy Clin Immunol 105 2000 1123 1129
16. W. Busse, G.D. Raphael, and S. Galant Low-dose fluticasone propionate compared with montelukast for first-line treatment of persistent asthma: a randomized clinical trial J Allergy Clin Immunol 107 2001 461 468
17. J.D. Hasday, S.S. Meltzer, and W.C. Moore Anti-inflammatory effects of zileuton in a subpopulation of allergic asthmatics Am J Respir Crit Care Med 161 2000 1229 1236
18. J.M. Drazen, C.N. Yandava, and L. Dube Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment Nat Genet 22 1999 168 170
19. J.J. Lima, S. Zhang, and A. Grant Influence of leukotriene pathway polymorphisms on response to montelukast in asthma Am J Respir Crit Care Med 2005 Nov 17 [Epub ahead of print]
20. K. Malmstrom, G. Rodriguez-Gomez, and J. Guerra Oral montelukast, inhaled beclomethasone, and placebo for chronic asthma: a randomized, controlled trial. Montelukast/Beclomethasone Study Group Ann Intern Med 130 1999 487 495
21. G.A. Hawkins, P.J. Amelung, and R.S. Smith Identification of polymorphisms in the human glucocorticoid receptor gene (NR3C1) in a multi-racial asthma case and control screening panel DNA Seq 15 2004 167 173
22. N.A. Huizenga, J.W. Koper, and P. de Lange A polymorphism in the glucocorticoid receptor gene may be associated with and increased sensitivity to glucocorticoids in vivo J Clin Endocrinol Metab 83 1998 144 151
23. K.G. Tantisira, S. Lake, and E.S. Silverman Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids Hum Mol Genet 13 2004 1353 1359