A simple in vitro model for investigating epithelial/mesenchymal interactions: Keratinocyte inhibition of fibroblast proliferation and fibronectin synthesis

Wound Repair and Regeneration

Volumn 13, Issue 6, 2005, Pages 543-550

  Harrison, Caroline A ^a,b   Dalley, Andrew J ^a   Mac Neil, Sheila ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b NORTHERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; FIBRONECTIN; GROWTH INHIBITOR; MITOGENIC AGENT;

ARTICLE; BURN; CELL CULTURE MONITORING; CELL INTERACTION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; EPITHELIUM CELL; FIBROBLAST; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; KERATINOCYTE; MESENCHYME CELL; MITOGENESIS; MORBIDITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SCAR FORMATION; SPLIT THICKNESS SKIN GRAFT; WOUND CONTRACTION; BIOSYNTHESIS; CELL CULTURE; COCULTURE; COMPARATIVE STUDY; CYTOLOGY; EPITHELIUM; MESODERM; METABOLISM; PHYSIOLOGY; SENSITIVITY AND SPECIFICITY; SKIN; WOUND HEALING;

CELL PROLIFERATION; CELLS, CULTURED; COCULTURE TECHNIQUES; CULTURE MEDIA, CONDITIONED; EPITHELIUM; FIBROBLASTS; FIBRONECTINS; HUMANS; KERATINOCYTES; MESODERM; SENSITIVITY AND SPECIFICITY; SKIN; WOUND HEALING;

EID: 33644887276     PISSN: 10671927     EISSN: 1524475X     Source Type: Journal    
DOI: 10.1111/j.1524-475X.2005.00076.x     Document Type: Article

References (34)

1. Rheinwald JG Green H. Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. Cell 1975 6 : 331 43.
2. Clark RA. Fibronectin matrix deposition and fibronectin receptor expression in healing and normal skin. J Invest Dermatol 1990 94 : 128S 134S.
3. Deitch EA Wheelahan TM Rose MP Clothier J Cotter J. Hypertrophic burn scars: analysis of variables. J Trauma 1983 23 : 895 8.
4. Muir IF Barclay TL Settle JAD. Burns and their treatment. 3rd ed. London : Butterworths, 1987.
5. Gillman T Penn J Bronks D Roux M. A re-examination of certain aspects of the histogenesis of the healing of cutaneous wounds. Br J Surg 1955 43 : 141 53.
6. Catty RH. Healing and contracture of experimental full thickness wounds in the human. Br J Surg 1965 52 : 542 8.
7. McDonald WS Deitch EA. Hypertrophic skin grafts in burned patients: a prospective analysis of variables. J Trauma 1987 27 : 147 50.
8. Jackson DM. The evolution of burn treatment in the last 50 years. Burns 1991 17 : 329 34.
9. Rudolph R Klein L. Healing processes in skin grafts. Surg Gynecol Obstet 1973 136 : 641 54.
10. Walden JL Garcia H Hawkins H Crouchet JR Traber L Gore DC. Both dermal matrix and epidermis contribute to an inhibition of wound contraction. Ann Plast Surg 2000 45 : 162 6.
11. Olutoye OO Yager DR Cohen IK Diegelmann RF. Lower cytokine release by fetal porcine platelets: a possible explanation for reduced inflammation after fetal wounding. J Pediatr Surg 1996 31 : 91 5.
12. Cross SE Naylor IL Coleman RA Teo TC. An experimental model to investigate the dynamics of wound contraction. Br J Plast Surg 1995 48 : 189 97.
13. De Vries H Mekkes J Middlekoop E Hinrichs WLJ Wildevuur CRH Westerhof W. Dermal substitutes for full-thickness wounds in a one-stage grafting model. Wound Rep Reg 1993 1 : 244 52.
14. Rudolph R. Inhibition of myofibroblasts by skin grafts. Plast Reconstr Surg 1979 63 : 473 80.
15. Garbin S Pittet B Montandon D Gabbiani G Desmoulière A. Covering by a flap induces apoptosis of granulation tissue myofibroblasts and vascular cells. Wound Rep Reg 1996 4 : 244 51.
16. Wood FM Stoner M. Implication of basement membrane development on the underlying scar in partial-thickness burn injury. Burns 1996 22 : 459 62.
17. Chakrabarty KH Heaton M Dalley AJ Dawson RA Freedlander E Khaw PT Mac Neil S. Keratinocyte-driven contraction of reconstructed human skin. Wound Rep Reg 2001 9 : 95 106.
18. Ralston DR Layton C Dalley AJ Boyce SG Freedlander E Mac Neil S. Keratinocytes contract human dermal extracellular matrix and reduce soluble fibronectin production by fibroblasts in a skin composite model. Br J Plast Surg 1997 50 : 408 15.
19. Aeschlimann D Thomazy V. Protein crosslinking in assembly and remodelling of extracellular matrices: the role of transglutaminases. Connect Tissue Res 1999 41 : 1 27.
20. Lim IJ Phan TT Song C Tan WT Longaker MT. Investigation of the influence of keloid-derived keratinocytes on fibroblast growth and proliferation in vitro. Plast Reconstr Surg 2001 107 : 797 808.
21. Lim IJ Phan TT Bay BH Qi R Huynh H Tan WT Lee ST Longaker MT. Fibroblasts cocultured with keloid keratinocytes: normal fibroblasts secrete collagen in a keloidlike manner. Am J Physiol Cell Physiol 2002 283 : C212 22.
22. Xia W Phan TT Lim IJ Longaker MT Yang GP. Complex epithelial-mesenchymal interactions modulate transforming growth factor-beta expression in keloid-derived cells. Wound Rep Reg 2004 12 : 546 56.
23. Garner WL. Epidermal regulation of dermal fibroblast activity. Plast Reconstr Surg 1998 102 : 135 9.
24. Maas-Szabowski N Shimotoyodome A Fusenig NE. Keratinocyte growth regulation in fibroblast cocultures via a double paracrine mechanism. J Cell Sci 1999 112 : 1843 53.
25. Grone A. Keratinocytes and cytokines. Vet Immunol Immunopathol 2002 88 : 1 12.
26. Luger TA Schwarz T. Evidence for an epidermal cytokine network. J Invest Dermatol 1990 95 : 100S 4S.
27. Brauchle M Angermeyer K Hubner G Werner S. Large induction of keratinocyte growth factor expression by serum growth factors and pro-inflammatory cytokines in cultured fibroblasts. Oncogene 1994 9 : 3199 204.
28. Boxman IL Ruwhof C Boerman OC Lowik CW Ponec M. Role of fibroblasts in the regulation of proinflammatory interleukin IL-1, IL-6 and IL-8 levels induced by keratinocyte-derived IL-1. Arch Dermatol Res 1996 288 : 391 8.
29. Rubin JS Bottaro DP Chedid M Miki T Ron D Cheon G Taylor WG Fortney E Sakata H Finch PW. Keratinocyte growth factor. Cell Biol Int 1995 19 : 399 411.
30. Tavakkol A Elder JT Griffiths CE Cooper KD Talwar H Fisher GJ Keane KM Foltin SK Voorhees JJ. Expression of growth hormone receptor, insulin-like growth factor 1 (IGF-1) and IGF-1 receptor mRNA and proteins in human skin. J Invest Dermatol 1992 99 : 343 9.
31. Ando Y Jensen PJ. Epidermal growth factor and insulin-like growth factor I enhance keratinocyte migration. J Invest Dermatol 1993 100 : 633 9.
32. Katz AB Taichman LB. Epidermis as a secretory tissue: an in vitro tissue model to study keratinocyte secretion. J Invest Dermatol 1994 102 : 55 60.
33. Ghosh MM Boyce S Layton C Freedlander E Mac Neil S. A comparison of methodologies for the preparation of human epidermal-dermal composites. Ann Plast Surg 1997 39 : 390 404.
34. Sun T Higham M Layton C Haycock J Short R Mac Neil S. Developments in xenobiotic-free culture of human keratinocytes for clinical use. Wound Rep Reg 2004 12 : 626 34.