Computational simulation of a non-Newtonian model of the blood separation process

Artificial Organs

Volumn 29, Issue 12, 2005, Pages 949-959

  De Gruttola, Sandro ^a   Boomsma, Kevin ^a   Poulikakos, Dimos ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

Apheresis; Blood separation; Centrifugation; Computational fluid dynamics; Particle flow; Variable viscosity

Indexed keywords

BLOOD; CELLS; LAGRANGE MULTIPLIERS; NON NEWTONIAN FLOW; SEPARATORS; SUSPENSIONS (FLUIDS); VISCOSITY;

APHERESIS; BLOOD SEPARATION; COMPUTATIONAL FLUID DYNAMICS MODELING; COMPUTATIONAL SIMULATION; NON-NEWTONIAN; NON-NEWTONIAN MODELS; PARTICLE FLOW; RED BLOOD CELL; SEPARATION PROCESS; VARIABLE VISCOSITY;

COMPUTATIONAL FLUID DYNAMICS;

APHERESIS; ARTICLE; BLOOD; BLOOD VISCOSITY; COMPUTER SIMULATION; ERYTHROCYTE; GEOMETRY; HEMATOCRIT; HUMAN; HYDRODYNAMICS; LEUKOCYTE; MATHEMATICAL MODEL; PLASMA; PRIORITY JOURNAL; TEMPERATURE; THROMBOCYTE; VELOCITY; BIOLOGICAL MODEL; BIOPHYSICS; BLOOD RHEOLOGY; CELL SEPARATION; CENTRIFUGATION; METHODOLOGY;

BIOPHYSICS; BLOOD COMPONENT REMOVAL; CELL SEPARATION; CENTRIFUGATION; COMPUTER SIMULATION; ERYTHROCYTES; HEMORHEOLOGY; HUMANS; MODELS, BIOLOGICAL;

EID: 33644875795     PISSN: 0160564X     EISSN: 15251594     Source Type: Journal    
DOI: 10.1111/j.1525-1594.2005.00164.x     Document Type: Article

References (29)

1. A.A.o.B.B.H. Committee (ed.). Guidelines for Therapeutic Hemapheresis. Bethesda : American Association of Blood Banks, 1995.
2. Ohene-Frempong K Weiner SJ Sleeper LA, et al. Cerebrovascular accidents in sickle cell disease: rates and risk factors. Blood 1998 91 : 288 94.
3. Pepkowitz S. Red cell exchange and other therapeutic alteration of red cell mass. In: McLeod B Price TH Drew MJ, eds. Apheresis Principles and Practice. Bethesda, MD : American Association of Blood Banks, 1997 355 74.
4. Brown RI. The physics of continuous-flow centrifugal cell-separation. Artif Organs 1989 13 : 4 20.
5. Burgstaler EA. Current instrumentation of apheresis. In: McLeod BC Price TH Drew MJ, eds. Apheresis: Principles and Practice. Bethesda, MD : American Association of Blood Banks, 1997; 85 112.
6. th Edition. Stuttgart : Georg Thieme Verlag, 1991.
7. Hochmuth RM. Properties of red blood cells. In: Skalak R Chien S, eds. Handbook of Bioengineering. New York : McGraw-Hill Co, 1986 ; 12.1 12.17.
8. Schmid-Schoenbein GW. Rheology of leukocytes. In: Skalak R Chien S, eds. Handbook of Bioengineering. New York : McGraw-Hill, 1986; 13.1 13.25.
9. Hawksley PGW. The effect of concentration on the settling of suspensions and flow through porous media. In: Some Aspects of Fluid Flow - Conference at Leamington Spa, 1950. London : Edward Arnold, 1951; 114 8.
10. Vand V. Viscosity of solutions and suspensions. 1. Theory. J Phys Colloid Chem 1948 52 : 277 99.
11. Chien S Usami H Taylor M Lundberg JL Gregersen MI. Effects of hematocrit and plasma proteins on human blood rheology at low shear rates. J Appl Physiol 1966 21 : 81 7
12. Charm S Kurland GS. Blood viscocity. In: JW Sons, ed. Blood Flow and Microcirculation. New York : Wiley Biomedical Health Publication, 1974; 32 6.
13. Rand PW Lacombe E Hunt HE Austin WH. Viscosity of normal blood under normothermic and hypothermic conditions. J Appl Physiol 1964 19 : 117 22.
14. Brooks DE Goodwin JW Seaman GVF. Interactions among erythrocytes under shear. J Appl Phys 1970 2 : 172 7.
15. Huang CR Whelan JA Wang HH Copley AL. A mathematical model of sedimentation analysis applied to human blood. Biorheology 1971 7 : 205.
16. Chien S. Shear dependence of effective cell volume as a determinant of blood viscosity. Science 1970 168 : 977 9
17. Chien S King RG Skalak R. Viscoelastic properties of human blood and red cell suspensions. Biorheology 1975 12 : 90.
18. De Gruttola S Boomsma K Poulikakos D Ventikos Y. Computational simulation blood separation process. Artif Organs 2005 28 : 665 74.
19. Longest PW Kleinstreuer C Buchanan JR. Efficient computation of micro-particle dynamics including wall effects. Comput Fluids 2004 33 : 577 601.
20. Boussinesq VJ. Sur la Resistance qu'Oppose un Liquide Indefini en Repos. Acad Sci 1885 100 : 935 7.
21. Basset AB. On motion of sphere in a viscous liquid. Philos Trans R Soc Lond 1888 179 : 43 63.
22. Vojir DJ Michaelides EE. Effect of the history term on the motion of rigid spheres in a viscous fluid. Int J Multiphas Flow 1994 20 : 547 56.
23. th Edition. New York : McGraw-Hill, 1968.
24. Sartory WK. Prediction of concentration profiles during erythrocytes sedimentation by a hindered settling model. Biorheology 1974 11 : 253 64.
25. Svedberg T Pederson KO. The Ultracentrifuge. New York : Oxford University Press, 1940.
26. Vandoormaal JP Raithby GD. Enhancements of the simple method for predicting incompressible fluid flows. Numer Heat Transfer 1984 7 : 147 63.
27. Sartory WK. Modes of operation in continuous flow sedimentation of erythrocytes. Ann Biomed Engineering 1975 3 : 13 33.
28. De Zilwa SRN Khezzar L Whitelaw JH. Flows through plane sudden-expansion. Int J Num Meth Fluids 1998 32 : 313 29.
29. Leverett LB Hellums JD Alfrey CP Lynch EC. Red blood-cell damage by shear-stress. Biophys J 1972 12 : 257 73.