Myeloperoxidase activity imaging using 67Ga labeled substrate

Molecular Imaging and Biology

Volumn 7, Issue 6, 2005, Pages 403-410

  Sans, Manel Querol ^a   Chen, John W ^b   Weissleder, Ralph ^b   Bogdanov Jr , Alexei A ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Desferrioxamine; Gallium; Myeloperoxidase; SPECT CT

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; DEFEROXAMINE MESYLATE; DICYCLOHEXYLCARBODIIMIDE; GALLIUM CITRATE GA 67; LEUKOCYTE ENZYME; MATRIGEL; MYELOPEROXIDASE; DIAGNOSTIC AGENT; GALLIUM; PEROXIDASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPLEX FORMATION; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG TISSUE LEVEL; DRUG UPTAKE; ENZYME ACTIVITY; ENZYME SUBSTRATE; FEASIBILITY STUDY; HIGH RESOLUTION COMPUTER TOMOGRAPHY; IMAGE ANALYSIS; IMAGE PROCESSING; IMPLANT; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOUSE; MOUSE STRAIN; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; RADIOACTIVITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TISSUE DISTRIBUTION; ULTRAVIOLET RADIATION; ANIMAL; C57BL MOUSE; CHEMICAL STRUCTURE; ENZYME SPECIFICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KINETICS; METABOLISM; SPECTROSCOPY;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GALLIUM RADIOISOTOPES; KINETICS; MALE; MICE; MICE, INBRED C57BL; MOLECULAR STRUCTURE; PEROXIDASE; SPECTRUM ANALYSIS; SUBSTRATE SPECIFICITY; TOMOGRAPHY, X-RAY COMPUTED;

EID: 33644861038     PISSN: 15361632     EISSN: 18602002     Source Type: Journal    
DOI: 10.1007/s11307-005-0020-5     Document Type: Article

References (24)

1. Blasberg RG, Gelovani J (2002) Molecular-genetic imaging: A nuclear medicine-based perspective. Mol Imaging 1:280-300
2. Massoud TF, Gambhir SS (2003) Molecular imaging in living subjects: Seeing fundamental biological processes in a new light. Genes Dev 17:545-580
3. Bogdanov A Jr, Weissleder R (2002) In vivo imaging of gene delivery and expression. Trends Biotechnol 20:11S-18S
4. Rausch PG, Pryzwansky KB, Spitznagel JK (1978) Immunocytochemical identification of azurophilic and specific granule markers in the giant granules of Chediak-Higashi neutrophils. N Engl J Med 298:693-698
5. Nicholls S, Hazen S (2005) Myeloperoxidase and cardiovascular disease. Arterioscler Thromb Vasc Biol 25:1102-1111
6. Daugherty A, Dunn JL, Rateri DL, Heinecke JW (1994) Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions. J Clin Invest 94:437-444
7. Nagra RM, Becher B, Tourtellotte WW, et al. (1997) Immunohistochemical and genetic evidence of myeloperoxidase involvement in multiple sclerosis. J Neuroimmunol 78:97-107
8. 2. J Neural Transm Suppl 32:249-257
9. Heinecke JW, Li W, Francis GA, Goldstein JA (1993) Tyrosyl radical generated by myeloperoxidase catalyzes the oxidative cross-linking of proteins. J Clin Invest 91:2866-2872
10. Chen JW, Pham W, Weissleder R, Bogdanov A (2004) Human myeloperoxidase: A potential target for molecular MR imaging in atherosclerosis. J Magn Reson Med 52:1021-1028
11. Zhang C, Yang J, Jacobs JD, Jennings LK (2003) Interaction of myeloperoxidase with vascular NAD(P)H oxidase-derived reactive oxygen species in vasculature: Implications for vascular diseases. Am J Physiol, Heart Circ Physiol 285:H2563-H2572
12. Bergt C, Pennathur S, Fu X, et al. (2004) The myeloperoxidase product hypochlorous acid oxidizes HDL in the human artery wall and impairs ABCA1-dependent cholesterol transport. Proc Natl Acad Sci USA 101:13032-13037
13. Hershko CM, Link GM, Konijn AM, Cabantchik ZI (2005) Iron chelation therapy. Curr Hematol Rep 4:110-116
14. 67 Ga-desferrioxamine-folate, a potential radiopharmaceutical for tumor imaging. Bioconjug Chem 7:56-62
15. Mathias CJ, Lewis MR, Reichert DE, Laforest R, Sharp TL, Lewis JS, Yang, Z-F, Waters DJ, Snyder PW, Low PS, Welch MJ, Green MA (2003) Preparation of 66Ga- and 68Ga-labelled Ga(III)-desferrio-xamine-folate as potential folate-receptor-targeted PET radiopharmaceuticals. Nucl Med Biol 30:725-731
16. Reichert DE, Lewis JS, Anderson CJ (1999) Metal complexes as diagnostic tools. Coord Chem Rev 184:3-66
17. Anderson CJ, Welch M (1999) Radiometal-labeled agents (non-technetium) for diagnostic imaging. Chem Rev 99:2219-2234
18. Weiner R, Hoffer PB, Thakur ML (1981) Lactoferrin: Its role as a Ga-67-binding protein in polymorphonuclear leukocytes. J Nucl Med 22:32-37
19. Tsan MF (1985) Mechanism of gallium-67 accumulation in inflammatory lesions. J Nucl Med 26:88-92
20. 67Ga localization in malignant disease. Nucl Med Biol 23:745-751
21. Tien M (1999) Myeloperoxidase-catalyzed oxidation of tyrosine. Arch Biochem Biophys 367:61-66
22. McCormick ML, Gaut JP, Lin TS, Britigan BE, Buettner GR, Heinecke JW (1998) Electron paramagnetic resonance detection of free tyrosyl radical generated by myeloperoxidase, lactoperoxidase, and horseradish peroxidase. J Biol Chem 273:32030-32037
23. Jantschko W, Furtmuller PG, Allegra M, Livrea MA, Jakopitsch C, Regelsberger G, Obinger C (2002) Redox intermediates of plant and mammalian peroxidases: A comparative transient-kinetic study of their reactivity toward indole derivatives. Arch Biochem Biophys 398:12-22
24. Querol M, Chen J, Weissleder R, Bogdanov A (2005) DTPA-bisamide-based MR sensor agents for peroxidase imaging. Org Lett 7:1719-1722