Spatiotemporal distribution of Connexin45 in the olivocerebellar system

Journal of Comparative Neurology

Volumn 495, Issue 2, 2006, Pages 173-184

  Van Der Giessen, Ruben S ^a   Maxeiner, Stephan ^b   French, Pim J ^a   Willecke, Klaus ^b   De Zeeuw, Chris I ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

Cerebellar cortex; Cerebellar nuclei; Connexin36; Development; Gap junctions; Inferior olive; Stellate cells

Indexed keywords

ALKALINE PHOSPHATASE; BETA GALACTOSIDASE; CONNEXIN 36; CONNEXIN 45;

ADOLESCENT; ADULTHOOD; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; CELL ULTRASTRUCTURE; CEREBELLUM CORTEX; CEREBELLUM NUCLEUS; CONTROLLED STUDY; ELECTRON MICROSCOPY; GAP JUNCTION; IN SITU HYBRIDIZATION; INFERIOR OLIVE; MOTOR COORDINATION; MOUSE; NEWBORN; NONHUMAN; OLIVARY NUCLEUS; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PURKINJE CELL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSORIMOTOR FUNCTION; STELLATE CELL; TRANSGENIC MOUSE;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; BLOTTING, NORTHERN; CELL COUNT; CEREBELLUM; CONNEXINS; EYE PROTEINS; GAP JUNCTIONS; GENE EXPRESSION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MICE; MICE, INBRED C57BL; MICROSCOPY, IMMUNOELECTRON; NEURAL PATHWAYS; OLIVARY NUCLEUS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 33644856342     PISSN: 00219967     EISSN: 10969861     Source Type: Journal    
DOI: 10.1002/cne.20873     Document Type: Article

References (36)

1. Bastianelli E. 2003. Distribution of calcium-binding proteins in the cerebellum. Cerebellum 2:242-262.
2. Belluardo N, Mudo G, Trovato-Salinaro A, Le Gurun S, Charollais A, Serre-Beinier V, Amato G, Haefliger JA, Meda P, Condorelli DF. 2000. Expression of connexin36 in the adult and developing rat brain. Brain Res 865:121-138.
3. Bevans CG, Kordel M, Rhee SK, Harris AL. 1998. Isoform composition of connexin channels determines selectivity among second messengers and uncharged molecules. J Biol Chem 273:2808-2816.
4. Bourrat F, Sotelo C. 1983. Postnatal development of the inferior olivary complex in the rat. I. An electron microscopic study of the medial accessory olive. Brain Res 284:291-310.
5. Bukauskas FF, Angele AB, Verselis VK, Bennett MV. 2002. Coupling asymmetry of heterotypic connexin 45/connexin 43-EGFP gap junctions: properties of fast and slow gating mechanisms. Proc Natl Acad Sci U S A 99:7113-7118.
6. Condorelli DF, Parenti R, Spinella F, Trovato Salinaro A, Belluardo N, Cardile V, Cicirata F. 1998. Cloning of a new gap junction gene (Cx36) highly expressed in mammalian brain neurons. Eur J Neurosci 10: 1202-1208.
7. Condorelli DF, Trovato-Salinaro A, Mudo G, Mirone MB, Belluardo N. 2003. Cellular expression of connexins in the rat brain: neuronal localization, effects of kainate-induced seizures and expression in apoptotic neuronal cells. Eur J Neurosci 18:1807-1827.
8. De Zeeuw CI, Berrebi AS. 1995. Postsynaptic targets of Purkinje cell terminals in the cerebellar and vestibular nuclei of the rat. Eur J Neurosci 7:2322-2333.
9. De Zeeuw CI, Holstege JC, Ruigrok TJ, Voogd J. 1989. Ultrastructural study of the GABAergic, cerebellar, and mesodiencephalic innervation of the cat medial accessory olive: anterograde tracing combined with immunocytochemistry. J Comp Neurol 284:12-35.
10. De Zeeuw CI, Hertzberg EL, Mugnaini E. 1995. The dendritic lamellar body: a new neuronal organelle putatively associated with dendrodendritic gap junctions. J Neurosci 15:1587-1604.
11. De Zeeuw CI, Simpson JI, Hoogenraad CC, Galjart N, Koekkoek SK, Ruigrok TJ. 1998. Microcircuitry and function of the inferior olive. Trends Neurosci 21:391-400.
12. De Zeeuw CI, Chorev E, Devor A, Manor Y, Van Der Giessen RS, De Jeu MT, Hoogenraad CC, Bijman J, Ruigrok TJ, French P, Jaarsma D, Kistler WM, Meier C, Petrasch-Parwez E, Dermietzel R, Söhl G, Gueldenagel M, Willecke K, Yarom Y. 2003. Deformation of network connectivity in the inferior olive of connexin 36-deficient mice is compensated by morphological and electrophysiological changes at the single neuron level. J Neurosci 23:4700-4711.
13. Degen J, Meier C, Van Der Giessen RS, Söhl G, Petrasch-Parwez E, Urschel S, Dermietzel R, Schilling K, De Zeeuw CI, Willecke K. 2004. Expression pattern of lacZ reporter gene representing connexin36 in transgenic mice. J Comp Neurol 473:511-525.
14. Duan L, Yuan H, Su CJ, Liu YY, Rao ZR. 2004. Ultrastructure of junction areas between neurons and astrocytes in rat supraoptic nuclei. World J Gastroenterol 10:117-121.
15. French PJ, O'Connor V, Voss K, Stean T, Hunt SP, Bliss TV. 2001. Seizure-induced gene expression in area CA1 of the mouse hippocampus. Eur J Neurosci 14:2037-2041.
16. Hertlein B, Butterweck A, Haubrich S, Willecke K, Traub O. 1998. Phosphorylated carboxy terminal serine residues stabilize the mouse gap junction protein connexin45 against degradation. J Membr Biol 162: 247-257.
17. Hombach S, Janssen-Bienhold U, Söhl G, Schubert T, Bussow H, Ott T, Weiler R, Willecke K. 2004. Functional expression of connexin57 in horizontal cells of the mouse retina. Eur J Neurosci 19:2633-2640.
18. Korn H, Sotelo C, Crepel F. 1973. Electronic coupling between neurons in the rat lateral vestibular nucleus. Exp Brain Res 16:255-275.
19. Krüger O, Plum A, Kim JS, Winterhager E, Maxeiner S, Hallas G, Kirchhoff S, Traub O, Lamers WH, Willecke K. 2000. Defective vascular development in connexin 45-deficient mice. Development 127:4179-4193.
20. Kumar NM, Gilula NB. 1996. The gap junction communication channel. Cell 84:381-388.
21. Mann-Metzer P, Yarom Y. 1999. Electrotonic coupling interacts with intrinsic properties to generate synchronized activity in cerebellar networks of inhibitory interneurons. J Neurosci 19:3298-3306.
22. Mann-Metzer P, Yarom Y. 2000. Electrotonic coupling synchronizes interneuron activity in the cerebellar cortex. Prog Brain Res 124:115-122.
23. Maxeiner S, Krüger O, Schilling K, Traub O, Urschel S, Willecke K. 2003. Spatiotemporal transcription of connexin45 during brain development results in neuronal expression in adult mice. Neuroscience 119:689-700.
24. Maxeiner S, Dedek K, Janssen-Bienhold U, Ammermuller J, Brune H, Kirsch T, Pieper M, Degen J, Krüger O, Willecke K, Weiler R. 2005. Deletion of connexin45 in mouse retinal neurons disrupts the rod/cone signaling pathway between AII amacrine and ON cone bipolar cells and leads to impaired visual transmission. J Neurosci 25:566-576.
25. Nelles E, Butzler C, Jung D, Temme A, Gabriel HD, Dahl U, Traub O, Stumpel F, Jungermann K, Zielasek J, Toyka KV, Dermietzel R, Willecke K. 1996. Defective propagation of signals generated by sympathetic nerve stimulation in the liver of connexin32-deficient mice. Proc Natl Acad Sci U S A 93:9565-9570.
26. Ruigrok TJ, Voogd J. 2000. Organization of projections from the inferior olive to the cerebellar nuclei in the rat. J Comp Neurol 426:209-228.
27. Söhl G, Degen J, Teubner B, Willecke K. 1998. The murine gap junction gene connexin36 is highly expressed in mouse retina and regulated during brain development. FEBS Lett 428:27-31.
28. Söhl G, Odermatt B, Maxeiner S, Degen J, Willecke K. 2004. New insights into the expression and function of neural connexins with transgenic mouse mutants. Brain Res Brain Res Rev 47:245-259.
29. Sotelo C, Llinas R, Baker R. 1974. Structural study of inferior olivary nucleus of the cat: morphological correlates of electrotonic coupling. J Neurophysiol 37:541-559.
30. Theis M, Söhl G, Speidel D, Kuhn R, Willecke K. 2003. Connexin43 is not expressed in principal cells of mouse cortex and hippocampus. Eur J Neurosci 18:267-274.
31. Theis M, Söhl G, Eiberger J, Willecke K. 2005. Emerging complexities in identity and function of glial connexins. Trends Neurosci 28:188-195.
32. Valiunas V. 2002. Biophysical properties of connexin-45 gap junction hemichannels studied in vertebrate cells. J Gen Physiol 119:147-164.
33. Van der Want JJ, Wiklund L, Guegan M, Ruigrok T, Voogd J. 1989. Anterograde tracing of the rat olivocerebellar system with Phaseolus vulgaris leucoagglutinin (PHA-L). Demonstration of climbing fiber collateral innervation of the cerebellar nuclei. J Comp Neurol 288:1-18.
34. van Veen TA, van Rijen HV, Jongsma HJ. 2000. Electrical conductance of mouse connexin45 gap junction channels is modulated by phosphorylation. Cardiovasc Res 46:496-510.
35. Weber PA, Chang HC, Spaeth KE, Nitsche JM, Nicholson BJ. 2004. The permeability of gap junction channels to probes of different size is dependent on connexin composition and permeant-pore affinities. Biophys J 87:958-973.
36. Willecke K, Eiberger J, Degen J, Eckardt D, Romualdi A, Guldenagel M, Deutsch U, Söhl G. 2002. Structural and functional diversity of connexin genes in the mouse and human genome. Biol Chem 383:725-737.