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Volumn 66, Issue 2, 2005, Pages 160-171

17β- and 17α-estradiol are non-competitive inhibitors of dopamine uptake: Implications for Parkinson's disease models and therapeutics

Author keywords

Cytoprotection; Dopamine transport; Estradiol; Mitochondria; MPTP; Parkinson's disease

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 17ALPHA ESTRADIOL; APOMORPHINE; DOPAMINE; DOPAMINE TRANSPORTER; ESTRADIOL; OXIDOPAMINE; TRITIUM;

EID: 33644846211     PISSN: 02724391     EISSN: 10982299     Source Type: Journal    
DOI: 10.1002/ddr.20055     Document Type: Article
Times cited : (3)

References (50)
  • 1
    • 0034199379 scopus 로고    scopus 로고
    • Anti-oxidative neuroprotection by estrogens in mouse cortical cultures
    • Bae Y-H, Hwang JY, Kim YH, Koh JY. 2000. Anti-oxidative neuroprotection by estrogens in mouse cortical cultures. J Korean Med Sci 15:327-336.
    • (2000) J Korean Med Sci , vol.15 , pp. 327-336
    • Bae, Y.-H.1    Hwang, J.Y.2    Kim, Y.H.3    Koh, J.Y.4
  • 2
    • 10244246626 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative damage in Alzheimer's and Parkinson's diseases and coenzyme Q10 as a potential treatment
    • Beal MF. 2004. Mitochondrial dysfunction and oxidative damage in Alzheimer's and Parkinson's diseases and coenzyme Q10 as a potential treatment. J Bioenerg Biomem 36:381-386.
    • (2004) J Bioenerg Biomem , vol.36 , pp. 381-386
    • Beal, M.F.1
  • 4
    • 0034885726 scopus 로고    scopus 로고
    • Differential neuroprotective effects of equine estrogens against oxidized low density lipoprotein-induced neuronal cell death
    • Berco M, Bhavnani BR. 2001. Differential neuroprotective effects of equine estrogens against oxidized low density lipoprotein-induced neuronal cell death. J Soc Gynecol Invest 8:245-254.
    • (2001) J Soc Gynecol Invest , vol.8 , pp. 245-254
    • Berco, M.1    Bhavnani, B.R.2
  • 5
    • 0030922625 scopus 로고    scopus 로고
    • Ovariectomy and estradiol treatment affect the dopamine transporter and its gene expression in the rat brain
    • Bosse R, Rivest R, Di Paolo T. 1997. Ovariectomy and estradiol treatment affect the dopamine transporter and its gene expression in the rat brain. Mol Brain Res 46:343-346.
    • (1997) Mol Brain Res , vol.46 , pp. 343-346
    • Bosse, R.1    Rivest, R.2    Di Paolo, T.3
  • 6
    • 0034664249 scopus 로고    scopus 로고
    • Stereospecific prevention by 17beta-estradiol of MPTP-induced dopamine depletion in mice
    • Callier S, Morissette M, Grandbois M, Di Paolo T. 2000. Stereospecific prevention by 17beta-estradiol of MPTP-induced dopamine depletion in mice. Synapse 37:245-251.
    • (2000) Synapse , vol.37 , pp. 245-251
    • Callier, S.1    Morissette, M.2    Grandbois, M.3    Di Paolo, T.4
  • 7
    • 0036327927 scopus 로고    scopus 로고
    • Evaluation of the protective effect of oestradiol against toxicity induced by 6-hydroxydopamine and 1-methyl-4-phenylpyridinium ion (MPP+) towards dopaminergic mesencephalic neurones in primary culture
    • Callier S, Le Saux M, Lhiaubet A-M, Di Paolo T, Rostene W, Pelaprat D. 2002. Evaluation of the protective effect of oestradiol against toxicity induced by 6-hydroxydopamine and 1-methyl-4-phenylpyridinium ion (MPP+) towards dopaminergic mesencephalic neurones in primary culture. J Neurochem 80:307-316.
    • (2002) J Neurochem , vol.80 , pp. 307-316
    • Callier, S.1    Le Saux, M.2    Lhiaubet, A.-M.3    Di Paolo, T.4    Rostene, W.5    Pelaprat, D.6
  • 8
    • 14744288140 scopus 로고    scopus 로고
    • Estrogen and cytokines production: The possible cause of gender differences in neurological diseases
    • Czlonkowska A, Ciesielska A, Gromadzka G, Kurkowska-Jastrzebska I. 2005. Estrogen and cytokines production: the possible cause of gender differences in neurological diseases. Curr Pharm Des 11:1017-1030.
    • (2005) Curr Pharm Des , vol.11 , pp. 1017-1030
    • Czlonkowska, A.1    Ciesielska, A.2    Gromadzka, G.3    Kurkowska-Jastrzebska, I.4
  • 9
    • 0037455047 scopus 로고    scopus 로고
    • Differences in dopaminergic neuroprotective effects of estrogen during estrous cycle
    • Datla KP, Murray HE, Pillai AV, Gillies GE, Dexter DT. 2003. Differences in dopaminergic neuroprotective effects of estrogen during estrous cycle. Neuroreport 14:47-50.
    • (2003) Neuroreport , vol.14 , pp. 47-50
    • Datla, K.P.1    Murray, H.E.2    Pillai, A.V.3    Gillies, G.E.4    Dexter, D.T.5
  • 10
    • 0034787713 scopus 로고    scopus 로고
    • Tamoxifen eliminates estrogen's neuroprotective effect upon MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system
    • Dluzen DE, McDermott JL, Anderson LI. 2001. Tamoxifen eliminates estrogen's neuroprotective effect upon MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system. Neurotox Res 3:291-300.
    • (2001) Neurotox Res , vol.3 , pp. 291-300
    • Dluzen, D.E.1    McDermott, J.L.2    Anderson, L.I.3
  • 11
    • 1842843369 scopus 로고    scopus 로고
    • Modulation of olfactory bulb tyrosine hydroxylase and catecholamine transporter mRNA by estrogen
    • Dluzen DE, Park JH, Kim K. 2002. Modulation of olfactory bulb tyrosine hydroxylase and catecholamine transporter mRNA by estrogen. Mol Brain Res 108:121-128.
    • (2002) Mol Brain Res , vol.108 , pp. 121-128
    • Dluzen, D.E.1    Park, J.H.2    Kim, K.3
  • 12
    • 0027933701 scopus 로고
    • +: Implications for neurodegeneration
    • +: Implications for neurodegeneration. J Neurochem, 63:584-591.
    • (1994) J Neurochem , vol.63 , pp. 584-591
    • Dykens, J.A.1
  • 13
    • 0002884280 scopus 로고
    • Mitochondrial radical production and mechanisms of oxidative excitotoxicity
    • Davies KJA, Ursini F, editors. Padova: Cleup Press (U. of Padova)
    • Dykens JA. 1995. Mitochondrial radical production and mechanisms of oxidative excitotoxicity. In:Davies KJA, Ursini F, editors. The oxygen paradox. Padova: Cleup Press (U. of Padova). p 453-467.
    • (1995) The Oxygen Paradox , pp. 453-467
    • Dykens, J.A.1
  • 14
    • 0002552667 scopus 로고    scopus 로고
    • Mitochondrial free radical production and the etiology of neurodegenerative disease
    • Beal MF, Bodis-Wollner I, Howell N, editors. New York: John Wiley & Sons
    • Dykens JA. 1997. Mitochondrial free radical production and the etiology of neurodegenerative disease. In: Beal MF, Bodis-Wollner I, Howell N, editors. Neurodegenerative diseases: mitochondria and free radicals in pathogenesis. New York: John Wiley & Sons, p 29-55.
    • (1997) Neurodegenerative Diseases: Mitochondria and Free Radicals in Pathogenesis , pp. 29-55
    • Dykens, J.A.1
  • 16
    • 12244282418 scopus 로고    scopus 로고
    • Polyphenolic steroids and neuroprotection: A proposed mitochondrial mechanism
    • Dykens JA, Simpkins JW, Wang J, Gordon K. 2003. Polyphenolic steroids and neuroprotection: a proposed mitochondrial mechanism. Exp Gerontol 38:101-107.
    • (2003) Exp Gerontol , vol.38 , pp. 101-107
    • Dykens, J.A.1    Simpkins, J.W.2    Wang, J.3    Gordon, K.4
  • 17
    • 5144234438 scopus 로고    scopus 로고
    • Moderation of photoreceptor apoptosis in the S334ter transgenic rat model of retinitis pigmentosa by a novel estradiol analog
    • Dykens JA, Carroll AK, Wiley SE, Zhao L, Wen R. 2004. Moderation of photoreceptor apoptosis in the S334ter transgenic rat model of retinitis pigmentosa by a novel estradiol analog. Biochem Pharmacol 68:1971-1984.
    • (2004) Biochem Pharmacol , vol.68 , pp. 1971-1984
    • Dykens, J.A.1    Carroll, A.K.2    Wiley, S.E.3    Zhao, L.4    Wen, R.5
  • 18
    • 0038620413 scopus 로고    scopus 로고
    • Effects of estradiol, phytoestrogens, and Ginkgo biloba extracts against 1-methyl-4-phenyl-pyridine-induced oxidative stress
    • Gagne B, Gelinas S, Bureau G, Lagace B, Ramassamy C, Chiasson K, Valastro B, Martinoli MG. 2003. Effects of estradiol, phytoestrogens, and Ginkgo biloba extracts against 1-methyl-4-phenyl-pyridine-induced oxidative stress. Endocrine 21: 89-95.
    • (2003) Endocrine , vol.21 , pp. 89-95
    • Gagne, B.1    Gelinas, S.2    Bureau, G.3    Lagace, B.4    Ramassamy, C.5    Chiasson, K.6    Valastro, B.7    Martinoli, M.G.8
  • 19
    • 0036786068 scopus 로고    scopus 로고
    • Neuroprotective effect of estradiol and phytoestrogens on MPP+-induced cytotoxicity in neuronal PC12 cells
    • Gelinas S, Martinoli M-G. 2002. Neuroprotective effect of estradiol and phytoestrogens on MPP+-induced cytotoxicity in neuronal PC12 cells. J Neurosci Res 70:90-96.
    • (2002) J Neurosci Res , vol.70 , pp. 90-96
    • Gelinas, S.1    Martinoli, M.-G.2
  • 20
    • 0031021372 scopus 로고    scopus 로고
    • 17α-estradiol exerts neuroprotective effects in SK-N-SH cells
    • Green PS, Bishop J, Simpkins JW. 1997a. 17α-estradiol exerts neuroprotective effects in SK-N-SH cells. J Neurosci 17:511-515.
    • (1997) J Neurosci , vol.17 , pp. 511-515
    • Green, P.S.1    Bishop, J.2    Simpkins, J.W.3
  • 21
    • 0031404546 scopus 로고    scopus 로고
    • Phenolic A ring requirement for the neuroprotective effects of steroids
    • Green PS, Gordon K, Simpkins JW. 1997b. Phenolic A ring requirement for the neuroprotective effects of steroids. J Steroid Biochem Mol Biol 63:229-235.
    • (1997) J Steroid Biochem Mol Biol , vol.63 , pp. 229-235
    • Green, P.S.1    Gordon, K.2    Simpkins, J.W.3
  • 22
    • 0031940591 scopus 로고    scopus 로고
    • Nuclear estrogen receptor independent neuroprotection by estratrienes: A novel interaction with glutathionine
    • Green PS, Gridley KE, Simpkins JW. 1997c. Nuclear estrogen receptor independent neuroprotection by estratrienes: a novel interaction with glutathionine. Neuroscience 84:7-10.
    • (1997) Neuroscience , vol.84 , pp. 7-10
    • Green, P.S.1    Gridley, K.E.2    Simpkins, J.W.3
  • 23
    • 0031724393 scopus 로고    scopus 로고
    • A novel, synergistic interaction between 17 beta-estradiol and glutathione in the protection of neurons against beta-amyloid 25-35-induced toxicity in vitro
    • Gridley KE, Green PS, Simpkins JW. 1998. A novel, synergistic interaction between 17 beta-estradiol and glutathione in the protection of neurons against beta-amyloid 25-35-induced toxicity in vitro. Mol Pharmacol 54:874-880.
    • (1998) Mol Pharmacol , vol.54 , pp. 874-880
    • Gridley, K.E.1    Green, P.S.2    Simpkins, J.W.3
  • 24
    • 24944439152 scopus 로고    scopus 로고
    • Nonclassical, distinct endocytic signals dictate constitutive and PKC-regulated neurotransmitter transporter internalization
    • Holton KL, Loder MK, Melikian HE. 2005. Nonclassical, distinct endocytic signals dictate constitutive and PKC-regulated neurotransmitter transporter internalization. Nat Neurosci 8:881-888.
    • (2005) Nat Neurosci , vol.8 , pp. 881-888
    • Holton, K.L.1    Loder, M.K.2    Melikian, H.E.3
  • 25
    • 0035069370 scopus 로고    scopus 로고
    • Mechanisms of estrogenic protection against gp120-induced neurotoxicity
    • Howard SA, Brooke SM, Sapolsky RM. 2000. Mechanisms of estrogenic protection against gp120-induced neurotoxicity. Exp Neurol 168:385-391.
    • (2000) Exp Neurol , vol.168 , pp. 385-391
    • Howard, S.A.1    Brooke, S.M.2    Sapolsky, R.M.3
  • 27
    • 0035040148 scopus 로고    scopus 로고
    • Neurotrophic and neuroprotective actions of estrogens and their therapeutic implications
    • Lee SJ, McEwen BS. 2001. Neurotrophic and neuroprotective actions of estrogens and their therapeutic implications. Annu Rev Pharmacol Toxicol 41:569-591.
    • (2001) Annu Rev Pharmacol Toxicol , vol.41 , pp. 569-591
    • Lee, S.J.1    McEwen, B.S.2
  • 28
    • 0025605629 scopus 로고
    • A simple and sensitive mirotiter plate estrogen bioassay based on stimulation of alkaline phosphatase in Ishikawa cells: Estrogenic action of δ5 adrenal steroids
    • Littlefield B A, Gurpide E, Markiewicz L, McKinley B, Hochberg RP. 1990. A simple and sensitive mirotiter plate estrogen bioassay based on stimulation of alkaline phosphatase in Ishikawa cells: estrogenic action of δ5 adrenal steroids. Endocrinology 127: 2757-2762.
    • (1990) Endocrinology , vol.127 , pp. 2757-2762
    • Littlefield, B.A.1    Gurpide, E.2    Markiewicz, L.3    McKinley, B.4    Hochberg, R.P.5
  • 29
    • 0020478933 scopus 로고
    • Status of the mitochondrial pool of glutathione in the isolated hepatocyte
    • Meredith MJ, Reed DJ. 1982. Status of the mitochondrial pool of glutathione in the isolated hepatocyte. J Biol Chem 257:3747-3753.
    • (1982) J Biol Chem , vol.257 , pp. 3747-3753
    • Meredith, M.J.1    Reed, D.J.2
  • 30
    • 0023200904 scopus 로고
    • Inhibition of synaptosomal high-affinity uptake of dopamine and serotonin by estrogen agonists and antagonists
    • Michel MC, Rother A, Hiemke C, Ghraf R. 1987. Inhibition of synaptosomal high-affinity uptake of dopamine and serotonin by estrogen agonists and antagonists. Biochem Pharmacol 36:3175-3180.
    • (1987) Biochem Pharmacol , vol.36 , pp. 3175-3180
    • Michel, M.C.1    Rother, A.2    Hiemke, C.3    Ghraf, R.4
  • 31
    • 0024999709 scopus 로고
    • Effect of estradiol and progesterone on rat striatal dopamine uptake sites
    • Morissette M, Biron D, Di Paolo T. 1990. Effect of estradiol and progesterone on rat striatal dopamine uptake sites. Brain Res Bull 25:419-422.
    • (1990) Brain Res Bull , vol.25 , pp. 419-422
    • Morissette, M.1    Biron, D.2    Di Paolo, T.3
  • 32
    • 0026764489 scopus 로고
    • Changes of rat striatal neuronal membrane morphology and steroid content during the estrous cycle
    • Morissette M, Garcia-Segura LM, Belanger A, Di Paolo T. 1992. Changes of rat striatal neuronal membrane morphology and steroid content during the estrous cycle. Neuroscience 49:893-902.
    • (1992) Neuroscience , vol.49 , pp. 893-902
    • Morissette, M.1    Garcia-Segura, L.M.2    Belanger, A.3    Di Paolo, T.4
  • 33
    • 2442534084 scopus 로고    scopus 로고
    • Differential cytotoxicity of human wild type and mutant alpha-synuclein in human neuroblastoma SH-SY5Y cells in the presence of dopamine
    • Moussa C, Wersinger C, Tomita Y, Sidhu A. 2004. Differential cytotoxicity of human wild type and mutant alpha-synuclein in human neuroblastoma SH-SY5Y cells in the presence of dopamine. Biochemistry 43:5539-5550.
    • (2004) Biochemistry , vol.43 , pp. 5539-5550
    • Moussa, C.1    Wersinger, C.2    Tomita, Y.3    Sidhu, A.4
  • 35
    • 14744293013 scopus 로고    scopus 로고
    • Neuroprotective effects of an estratriene analog are estrogen receptor independent in vitro and in vivo
    • Perez E, Liu R, Yang SH, Cai ZY, Covey DF, Simpkins JW. 2005. Neuroprotective effects of an estratriene analog are estrogen receptor independent in vitro and in vivo. Brain Res 1038:216-222.
    • (2005) Brain Res , vol.1038 , pp. 216-222
    • Perez, E.1    Liu, R.2    Yang, S.H.3    Cai, Z.Y.4    Covey, D.F.5    Simpkins, J.W.6
  • 36
    • 0031855610 scopus 로고    scopus 로고
    • Protein kinase-mediated bidirectional trafficking and functional regulation of the human dopamine transporter
    • Pristupa ZB, McConkey F, Liu F, Man HY, Lee FJ, Wang YT, Niznik HB. 1998. Protein kinase-mediated bidirectional trafficking and functional regulation of the human dopamine transporter. Synapse 30:79-87.
    • (1998) Synapse , vol.30 , pp. 79-87
    • Pristupa, Z.B.1    McConkey, F.2    Liu, F.3    Man, H.Y.4    Lee, F.J.5    Wang, Y.T.6    Niznik, H.B.7
  • 38
    • 0037531382 scopus 로고    scopus 로고
    • Repeated estradiol treatment prevents MPTP-induced dopamine depletion in male mice
    • Ramirez AD, Liu X, Menniti FS. 2003. Repeated estradiol treatment prevents MPTP-induced dopamine depletion in male mice. Neuroendocrinology 77:223-231.
    • (2003) Neuroendocrinology , vol.77 , pp. 223-231
    • Ramirez, A.D.1    Liu, X.2    Menniti, F.S.3
  • 39
    • 16444377893 scopus 로고    scopus 로고
    • Estradiol modulates the synapsins phosphorylation by various protein kinases in the rat brain under in vitro and in vivo conditions
    • Rebas E, Lachowicz L, Lachowicz A. 2005. Estradiol modulates the synapsins phosphorylation by various protein kinases in the rat brain under in vitro and in vivo conditions. J Physiol Pharmacol 56:39-48.
    • (2005) J Physiol Pharmacol , vol.56 , pp. 39-48
    • Rebas, E.1    Lachowicz, L.2    Lachowicz, A.3
  • 40
    • 0037606099 scopus 로고    scopus 로고
    • Estrogens and Parkinson disease: Novel approach for neuroprotection
    • Sawada H, Shimohama S. 2003. Estrogens and Parkinson disease: novel approach for neuroprotection. Endocrine 21:77-79.
    • (2003) Endocrine , vol.21 , pp. 77-79
    • Sawada, H.1    Shimohama, S.2
  • 41
    • 0032401010 scopus 로고    scopus 로고
    • Estradiol protects mesencephalic dopaminergic neurons from oxidative stress-induced neuronal death
    • Sawada H, Ibi M, Kihara T, Urushitani M, Akaike A, Shimohama S. 1998. Estradiol protects mesencephalic dopaminergic neurons from oxidative stress-induced neuronal death. J Neurosci Res 54: 707-719.
    • (1998) J Neurosci Res , vol.54 , pp. 707-719
    • Sawada, H.1    Ibi, M.2    Kihara, T.3    Urushitani, M.4    Akaike, A.5    Shimohama, S.6
  • 44
    • 0037450414 scopus 로고    scopus 로고
    • Estrogen prevents the loss of CAl hippocampal neurons in gerbils after ischemic injury
    • Shughrue PJ, Merchenthaler I. 2003. Estrogen prevents the loss of CAl hippocampal neurons in gerbils after ischemic injury. Neuroscience 116:851-861.
    • (2003) Neuroscience , vol.116 , pp. 851-861
    • Shughrue, P.J.1    Merchenthaler, I.2
  • 45
    • 0030818062 scopus 로고    scopus 로고
    • Role of estrogen replacement therapy in memory enhancement and the prevention of neuronal loss associated with Alzheimers disease
    • Simpkins JW, Green PS, Gridley KE, Singh M, de Fiebre NC, Rajakumar G. 1997. Role of estrogen replacement therapy in memory enhancement and the prevention of neuronal loss associated with Alzheimers disease. Am J Med 103:19S-25S.
    • (1997) Am J Med , vol.103
    • Simpkins, J.W.1    Green, P.S.2    Gridley, K.E.3    Singh, M.4    De Fiebre, N.C.5    Rajakumar, G.6
  • 46
    • 0342803689 scopus 로고    scopus 로고
    • Estrogen-induced activation of the mitogen-activated protein kinase cascade in the cerebral cortex of estrogen receptor-.alpha. knock-out mice
    • Singh M, Setalo G, Guan X, Frail DE, Toran-Allerand CD. 2000. Estrogen-induced activation of the mitogen-activated protein kinase cascade in the cerebral cortex of estrogen receptor-.alpha. knock-out mice. J Neurosci 20:1694-1700.
    • (2000) J Neurosci , vol.20 , pp. 1694-1700
    • Singh, M.1    Setalo, G.2    Guan, X.3    Frail, D.E.4    Toran-Allerand, C.D.5
  • 47
    • 1442323686 scopus 로고    scopus 로고
    • Minireview: A plethora of estrogen receptors in the brain: Where will it end?
    • Toran-Allerand C D. 2004. Minireview: A plethora of estrogen receptors in the brain: where will it end? Endocrinology 145:1069-1074.
    • (2004) Endocrinology , vol.145 , pp. 1069-1074
    • Toran-Allerand, C.D.1
  • 48
    • 0642364992 scopus 로고    scopus 로고
    • Modulation of dopamine transporter function by alpha-synuclein is altered by impairment of cell adhesion and by induction of oxidative stress
    • Wersinger C, Prou D, Vernier P, Sidhu A. 2003. Modulation of dopamine transporter function by alpha-synuclein is altered by impairment of cell adhesion and by induction of oxidative stress. FASEB J 17:2151-2153.
    • (2003) FASEB J , vol.17 , pp. 2151-2153
    • Wersinger, C.1    Prou, D.2    Vernier, P.3    Sidhu, A.4
  • 49
    • 0036239624 scopus 로고    scopus 로고
    • The estrogen receptor is not essential for all estrogen neuroprotection: New evidence from a new analog
    • Xia S, Cai ZY, Thio LL, Kim-Han JS, Dugan LL, Covey DF, Rothman SM. 2002. The estrogen receptor is not essential for all estrogen neuroprotection: new evidence from a new analog. Neurobiol Dis 9:282-293.
    • (2002) Neurobiol Dis , vol.9 , pp. 282-293
    • Xia, S.1    Cai, Z.Y.2    Thio, L.L.3    Kim-Han, J.S.4    Dugan, L.L.5    Covey, D.F.6    Rothman, S.M.7
  • 50
    • 1342309220 scopus 로고    scopus 로고
    • The use of estrogens and related compounds in the treatment of damage from cerebral ischemia
    • Yang S-H, Liu R, Wu SS, Simpkins JW. 2003. The use of estrogens and related compounds in the treatment of damage from cerebral ischemia. Ann NY Acad Sci 1007:101-107.
    • (2003) Ann NY Acad Sci , vol.1007 , pp. 101-107
    • Yang, S.-H.1    Liu, R.2    Wu, S.S.3    Simpkins, J.W.4


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