Age-related changes in unstimulated salivary function and composition and its relations to medications and oral sensorial complaints

Aging Clinical and Experimental Research

Volumn 17, Issue 5, 2005, Pages 358-366

  Nagler, Rafael M ^a,b   Hershkovich, Oded ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b RAMBAM MEDICAL CENTER   (Israel)

Author keywords

Age; Burning mouth syndrome; Flow rate; Saliva; Taste; Xerostomia

Indexed keywords

ALBUMIN; AMYLASE; CALCIUM; CHLORIDE; IMMUNOGLOBULIN; LACTATE DEHYDROGENASE; LYSOZYME; MAGNESIUM; PHOSPHATE; POTASSIUM; PROTEIN; SODIUM; URIC ACID; ZINC;

ADULT; AGED; AGING; ARTICLE; BURNING MOUTH SYNDROME; CHEMICAL COMPOSITION; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFECT; DRUG USE; FEMALE; GROUPS BY AGE; HUMAN; MAJOR CLINICAL STUDY; MALE; RADIATION RESPONSE; SALIVA ANALYSIS; SALIVATION; SJOEGREN SYNDROME; TASTE DISORDER; XEROSTOMIA; ADOLESCENT; CHEMISTRY; COMPARATIVE STUDY; LONGITUDINAL STUDY; MIDDLE AGED; ORAL DRUG ADMINISTRATION; PATHOPHYSIOLOGY; PHYSIOLOGY; SALIVA; SALIVARY GLAND;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AGING; BURNING MOUTH SYNDROME; FEMALE; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; SALIVA; SALIVARY GLANDS; SALIVATION; TASTE DISORDERS; XEROSTOMIA;

EID: 33644842464     PISSN: 15940667     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03324623     Document Type: Article

References (47)

1. Vissink A, Spijkervet FK, Van Nieuw Amerongen A. Aging and saliva: a review of the literature. Spec Care Dentist 1996; 16: 95-103.
2. Ship JA, Pillemer SR, Baum BJ. Xerostomia and the geriatric patient. J Am Geriatr Soc 2002; 50: 535-43.
3. Ben-Aryeh H, Miron D, Berdicevsky I, et al. Xerostomia in the elderly: prevalence, diagnosis, complications and treatment. Gerodontology 1985; 4: 77-82.
4. Parvinen T, Larmas M. Age dependency of stimulated salivary flow rate, pH, and Lactobacillus and yeast concentrations. J Dent Res 1982; 61: 1052-5.
5. Baum B. Evaluation of stimulated parotid saliva flow rate in different age groups. J Dent Res 1981; 60: 1292-6.
6. Ben-Aryeh H, Miron D, Szargel R, Gutman D. Whole-saliva secretion rates in old and young healthy subjects. J Dent Res 1984; 63: 1147-8.
7. Nagler RM, Hershkovich O. Sialochemical and gustatory analyses in patients with oral sensorial complaints. J Pain 2004; 5: 56-3.
8. Bertram U. Xerostomia. Clinical aspects, pathology and pathogenesis. Acta Odontol Scand 1967; 25 (Suppl 49): 1-126.
9. Gutman D, Ben-Aryeh H. The influence of age on salivary content and rate of flow. Int J Oral Surg 1974; 3: 314-7.
10. Tanida T, Ueta E, Tobiume A, et al. Influence of aging on candidal growth and adhesion regulatory agents in saliva. J Oral Pathol Med 2001; 30: 328-35.
11. Streckfus C, Bigler L, O'Bryan T. Aging and salivary cytokine concentrations as predictors of whole saliva flow rates among women: a preliminary study. Gerontology 2002; 48: 282-8.
12. Percival RS, Challacombe SJ, Marsh PD. How rates of resting whole and stimulated parotid saliva in relation to age and gender. J Dent Res 1994; 73: 1416-20.
13. Navazesh M, Mulligan RA, Kipnis V, et al. Comparison of whole saliva flow rates and mucin concentrations in healthy Caucasian young and aged adults. J Dent Res 1992; 71: 1275-8.
14. Scott J. Degenerative changes in the histology of the human submandibular salivary gland occurring with age. J Biol Buccale 1977; 5: 311-9.
15. Scott J, Flower EA, Burns J. A quantitative study of histological changes in the human parotid gland occurring with adult age. J Oral Pathol 1987; 16: 505-10.
16. Chrischillles EA, Foley DJ, Wallace RB, et al. Use of medications by persons 65 and over: data from the established populations for epidemiologic studies of the elderly. J Gerontol 1992; 47: M137-44.
17. Van Nieuw Amerongen A. Salivary secretion and taste alteration in elderly subjects. Ned Tijdschr Tandheelkd 1989; 96: 193-5 (in Dutch).
18. Nagler R, Marmary Y, Krausz Y, et al. Major salivary gland dysfunction in human acute and chronic graft-versus-host disease (GVHD). Bone Marrow Transplant 1996; 17: 219-24.
19. Nagler RM, Salamer F, Reznick AZ, Nahir M. Salivary glands involvement in rheumatoid arthritis and its relation to the induced oxidative stress. Rheumatology 2003; 42: 1-8.
20. Nager RM, Hershkovich O, Lischinsky S, et al. Saliva analysis in the clinical setting: revisiting an underused diagnostic tool. J Invest Med 2002; 50: 214-25.
21. Nagler RM, Klein I, Zerzhevsky N, et al. Characterization of the differentiated antioxidant profile of human saliva. Free Radic Biol Med 2002; 32: 268-77.
22. Nagler RM, Lischinsky S, Diamond E, et al. New insights into salivary lactate dehydrogenase of human subjects. J Lab Clin Med 2001; 137: 363-9.
23. Mancini G, Carbonara AO, Heremans JF. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry 1965; 2: 235-54.
24. Vissink A, Panders AK, Gravenmade EJ, Vermey A. The causes and consequences of hyposalivation. Ear Nose Throat J 1988; 67: 166-8, 173-6.
25. Lee SK, Lee SW, Chung SC, et al. Analysis of residual saliva and minor salivary gland secretions in patients with dry mouth. Arch Oral Biol 2002; 47: 637-41.
26. Heintze U, Birkhed D, Bjorn H. Secretion rate and buffer effect of resting and stimulated whole saliva as a function of age and sex. Swed Dent J 1983; 7: 227-38.
27. Ben-Aryeh H, Shalev A, Szargel R, et al. The salivary flow rate and composition of whole and parotid resting and stimulated saliva in young and old healthy subjects. Biochem Med Metab Biol 1986; 36: 260-5.
28. Meurman JH, Rantonen P, Pajukoski H, Sulkava R. Salivary albumin and other constituents and their relation to oral and general health in the elderly. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002; 94: 432-8.
29. Shugars DC, Watkins CA, Cowen HJ. Salivary concentration of secretory leukocyte protease inhibitor, an antimicrobial protein, is decreased with advanced age. Gerontology 2001; 47: 246-53.
30. Vissink A, Spijkervet FK, Van Nieuw Amerongen A. Changes in secretion and composition of saliva with aging. Ned Tijdschr Tandheelkd 1997; 104: 186-9 (in Dutch).
31. Ben-Aryeh H, Fisher M, Szargel R, Laufer D. Composition of whole unstimulated saliva of healthy children: changes with age. Arch Oral Biol 1990; 35: 929-31.
32. Shem RJ, Fox PC, Li SH. Influence of age on the secretory rates of the human minor salivary glands and whole saliva. Arch Oral Biol 1993; 38: 755-61.
33. Zhou JN, Liu RY, van Heerikhuize J, et al. Alterations in the circadian rhythm of salivary melatonin during middle age. J Pineal Res 2003; 34: 11-6 (Review).
34. Ship JA, Fischer DJ. The relationship between dehydration and parotid salivary gland functioning in young and older healthy adults. J Gerontol 1997; 52: M310-9.
35. Yeh CK, Johnson DA, Dodds MW, et al. Association of salivary flow rates with maximal bite force. J Dent Res 2000; 79: 1560-5.
36. Chauncey HH, Feller RP, Kapur KK. Longitudinal age-related changes in human parotid saliva composition. J Dent Res 1987; 66: 599-602.
37. Wu AJ, Atkinson JC, Fox PC, et al. Cross-sectional and longitudinal analyses of stimulated parotid salivary constituents in healthy, different-aged subjects. J Gerontol 1993; 48: M219-24.
38. Baum BJ, Costa PT Jr, Izutsu KT. Sodium handling by aging human parotid glands is inconsistent with a two-stage secretion model. Am J Physiol 1984; 246 (1 Pt 2): R35-9.
39. Baum BJ, Kousvelari EE, Oppenheim FG. Exocrine protein secretion from human parotid glands during aging: stable release of the acidic proline-rich proteins. J Gerontol 1982; 37: 392-5.
40. Streckfus CF, Wu AJ, Ship JA, Brown LJ. Comparison of stimulated parotid salivary gland flow rates in normotensive and hypertensive persons. Oral Surg Oral Med Oral Pathol 1994; 77: 615-9.
41. Tylenda CA, Ship JA, Fox PC, Baum BJ. Evaluation of submandibular salivary flow rate in different age groups. J Dent Res 1988; 67: 1225-8.
42. Pedersen W, Schubert M, Izutsu K, et al. Age-dependent decreases in human submandibular gland flow rates as measured under resting and post-stimulation conditions. J Dent Res 1985; 64: 822-5.
43. Wu AJ, Baum BJ, Ship JA. Extended stimulated parotid and submandibular secretion in a healthy young and old population. J Gerontol 1995; 50A: M45-8.
44. Nagler RM, Nagler A. Pilocarpine hydrochloride relieves xerostomia in chronic graft-versus-host-disease: a sialometrical study. Bone Marrow Transplant 1999; 23: 1007-11.
45. Nagler R, Marmary Y, Fox PC, et al. Irradiation-induced damage to the salivary glands: the role of redox-active iron and copper. Radiat Res 1997; 147: 468-76.
46. Johnson JT, Ferretti GA, Methery WJ, et al. Oral pilocarpine for post-irradiation xerostomia in patients with head and neck cancer. N Engl J Med 1993; 329: 390-5.
47. Yeh CK, Johnson DA, Dodds MW. Impact of aging on human salivary gland function: a community-based study. Aging Clin Exp Res 1998; 10: 421-8.