Providing guidelines and education is not enough: An audit of gentamicin use at The Royal Melbourne Hospital

Internal Medicine Journal

Volumn 36, Issue 1, 2006, Pages 37-42

  Leong, C L ^a,b   Buising, Kirsty ^b   Richards, M ^b   Robertson, M ^b   Street, A ^b  

^a HOSPITAL KUALA LUMPUR   (Malaysia)

^b ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

Dosing; Gentamicin; Monitoring

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIBIOTIC AGENT; CREATININE; GENTAMICIN;

ABDOMINAL INFECTION; ADULT; AGED; AGING; ANTIBIOTIC PROPHYLAXIS; ANTIBIOTIC THERAPY; ARTICLE; AUSTRALIA; CLINICAL PRACTICE; CREATININE BLOOD LEVEL; DEVICE INFECTION; DRUG BLOOD LEVEL; DRUG MONITORING; EDUCATION PROGRAM; HOSPITAL PATIENT; HUMAN; INFECTION; MAJOR CLINICAL STUDY; MEDICAL AUDIT; NEPHROTOXICITY; PNEUMONIA; POSTOPERATIVE INFECTION; PRACTICE GUIDELINE; PRIORITY JOURNAL; SEPTICEMIA; SKIN INFECTION; SOFT TISSUE INFECTION; URINARY TRACT INFECTION; WOUND INFECTION;

AGED; ANTI-BACTERIAL AGENTS; ANTIBIOTIC PROPHYLAXIS; DRUG UTILIZATION REVIEW; GENTAMICINS; GUIDELINE ADHERENCE; HOSPITALS, URBAN; HUMANS; MEDICAL AUDIT; MIDDLE AGED; PHYSICIAN'S PRACTICE PATTERNS; PRACTICE GUIDELINES; SKIN DISEASES, INFECTIOUS; URINARY TRACT INFECTIONS; VICTORIA;

EID: 33644840334     PISSN: 14440903     EISSN: 14455994     Source Type: Journal    
DOI: 10.1111/j.1445-5994.2006.01002.x     Document Type: Article

References (20)

1. Kahlmeter G, Dahlager J. Aminoglycoside toxicity-a review of clinical studies published between 1975 and 1982. J Antimicrob Chemother 1984; 13 Suppl A: 9-22.
2. Lloyd B, Minor M. Gentamicin-induced bilateral vestibular hypofunction. JAMA 1998; 279: 541-4.
3. Ali M, Goetz M. A meta-analysis of the relative efficacy and toxicity of single daily dosing versus multiple daily dosing of aminoglycosides. Clin Infect Dis 1997; 24: 796-809.
4. Bailey T, Little J, Littenberg B, Reichley R, Dunagan W. A meta-analysis of extended-interval dosing versus multiple daily dosing of aminoglycosides. Clin Infect Dis 1997; 24: 786-95.
5. Munckhof W, Grayson ML, Turnidge JD. A meta-analysis of studies on the safety and efficacy of aminoglycosides given either once daily or as divided doses. J Antimicrob Chemother 1996; 37: 645-63.
6. Freeman C, Nicolau D, Belliveau P, Nightingale C. Once-daily dosing of aminoglycosides: review and recommendations for clinical practice. J Antimicrob Chemother 1997; 39: 677-86.
7. Contapoulos-Ioannidis DG, Giotis ND, Baliatsa DV, Ionnidis JP. Extended interval aminoglycoside administration for children: a metaanalysis, Paediatrics 2004; 114: e111-18.
8. Barclay M, Begg E, Hickling K. What is the evidence for once-daily aminoglycoside therapy? Clin Pharmacokinet 1994; 27: 32-48.
9. Paterson D, Robson J, Wagener M. Risk factors for toxicity in elderly patients given aminoglycosides once daily. J Gen Intern Med 1998; 13: 735-9.
10. Raveh D, Kopyt M, Hite Y, Rudensky B, Sonnenblick M, Yinnon A. Risk factors for nephrotoxicity in elderly patients receiving once-daily aminoglycosides. QJM 2002; 95: 291-7.
11. Bartal C, Danon A, Schlaeffer F, Reisenberg K, Alkan M, Smoliakov R et al. Pharmacokinetic dosing of aminoglycosides: a controlled trial. Am J Med 2003; 114: 194-8.
12. Streetman D, Nafziger A, Destache C, Bertino AJ. Individualized pharmacokinetic monitoring results in less aminoglycoside-associated nephrotoxicity and fewer associated costs. Pharmacotherapy 2001; 21: 443-51.
13. Ismail R, Haq A, Azman M, Rahman A. Therapeutic drug monitoring of gentamicin: a 6-year follow-up audit. J Clin Pharm Ther 1997; 22: 21-5.
14. Bartal C, Danon A, Schlaeffer F, Reisenberg K, Alkan M, Smoliakov R et al. Pharmacokinetic dosing of aminoglycosides: a controlled trial. Am J Med 2003; 114: 194-8.
15. Writing Group for Therapeutic Guidelines: Antibiotic Version 12. Therapeutic Guidelines: Antibiotic. Version 12. Melbourne, Australia: Therapeutic Guidelines Limited; 2003.
16. Li S, Ioannides-Demos L, Spicer W, Berbatis C, Spelman D, Tong N et al. Prospective audit of aminoglycoside usage in a general hospital with assessments of clinical processes and adverse clinical outcomes. Med J Aust 1989; 151: 224-32.
17. Saint S, Lipsky B. Preventing catheter-related bacteriuria: should we? Can we? How? Arch Intern Med 1999; 159: 800-808.
18. Shrimpton S, Milmoe M, Wilson A, Felmingham D, Drayan S, Barrass C et al. Audit of prescription and assay of aminoglycosides in a UK teaching hospital. J Antimicrob Chemother 1993; 31: 599-606.
19. Li SC, Ioannides-Demos LL, Spicer WJ, Spelman DW, Tong N, McLean AJ. Prospective audit of an aminoglycoside consultative service in a general hospital. Med J Aust 1992; 157: 308-11.
20. Evans R, Pestotnik S, Classen D, Clemmer T, Weaver L, Orme JF Jr et al. A computer-assisted management program for antibiotics and other antiinfective agents. N Engl J Med 1998; 338: 232-8.