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Volumn 6, Issue 1, 2006, Pages 141-152

Maintenance biotherapy with interleukin-2 and interferon for metastatic renal cell cancer

Author keywords

Immunotherapy; Interferon ; Interleukin 2; Maintenance treatment; Renal cell carcinoma

Indexed keywords

ACETYLCYSTEINE; ANTINEOPLASTIC AGENT; ANTINEOPLASTIC HORMONE AGONISTS AND ANTAGONISTS; FLUOROURACIL; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOMODULATING AGENT; INTERFERON; INTERLEUKIN 2; ISOTRETINOIN; MEDROXYPROGESTERONE ACETATE; NEXAVAR; PLACEBO; RETINOIC ACID; SORAFENIB; SUNITINIB; THIOCTIC ACID; ALPHA INTERFERON;

EID: 33644840168     PISSN: 14737140     EISSN: 17448328     Source Type: Journal    
DOI: 10.1586/14737140.6.1.141     Document Type: Review
Times cited : (3)

References (89)
  • 2
    • 0027138852 scopus 로고
    • Estimates of the worldwide mortality from eighteen major cancers in 1985. Implications for prevention and projections of future burden
    • Pisani P, Parkin DM, Ferlay J. Estimates of the worldwide mortality from eighteen major cancers in 1985. Implications for prevention and projections of future burden. Int. J. Cancer 55, 891-903 (1993).
    • (1993) Int. J. Cancer , vol.55 , pp. 891-903
    • Pisani, P.1    Parkin, D.M.2    Ferlay, J.3
  • 3
    • 0033526386 scopus 로고    scopus 로고
    • Rising incidence of renal cell cancer in the United States
    • Chow WH, Devesa SS, Warren JL, Fraumeni JF Jr. Rising incidence of renal cell cancer in the United States. JAMA 281, 1628-1631 (1999).
    • (1999) JAMA , vol.281 , pp. 1628-1631
    • Chow, W.H.1    Devesa, S.S.2    Warren, J.L.3    Fraumeni Jr., J.F.4
  • 4
    • 0034796962 scopus 로고    scopus 로고
    • The changing natural history of renal cell carcinoma
    • Pantuck AJ, Zisman A, Belldegrun AS. The changing natural history of renal cell carcinoma. J. Urol. 166, 1611-1623 (2001).
    • (2001) J. Urol. , vol.166 , pp. 1611-1623
    • Pantuck, A.J.1    Zisman, A.2    Belldegrun, A.S.3
  • 6
    • 0034885288 scopus 로고    scopus 로고
    • Complex perioperative immuno-dysfunction in patients with renal cell carcinoma
    • Bohm M, Ittenson A, Philipp C, Rohl FW, Ansorge S, Allhof EP. Complex perioperative immuno-dysfunction in patients with renal cell carcinoma. J. Urol. 166, 831-836 (2001).
    • (2001) J. Urol. , vol.166 , pp. 831-836
    • Bohm, M.1    Ittenson, A.2    Philipp, C.3    Rohl, F.W.4    Ansorge, S.5    Allhof, E.P.6
  • 7
    • 0036155773 scopus 로고    scopus 로고
    • Defective death receptor signaling as a cause of tumor immune escape
    • French LE, Tschopp J. Defective death receptor signaling as a cause of tumor immune escape. Semin. Cancer Biol. 12, 51-55 (2002).
    • (2002) Semin. Cancer Biol. , vol.12 , pp. 51-55
    • French, L.E.1    Tschopp, J.2
  • 8
    • 0036623140 scopus 로고    scopus 로고
    • Immune escape of tumors: Apoptosis resistance and tumor counterattack
    • Igney FH, Krammer PH. Immune escape of tumors: apoptosis resistance and tumor counterattack. J. Leukoc. Biol. 71, 907-920 (2002).
    • (2002) J. Leukoc. Biol. , vol.71 , pp. 907-920
    • Igney, F.H.1    Krammer, P.H.2
  • 9
    • 0036852191 scopus 로고    scopus 로고
    • Natural selection of tumor variants in the generation of 'tumor escape' phenotypes
    • Khong HT, Restifo NP. Natural selection of tumor variants in the generation of 'tumor escape' phenotypes. Nature Immunol. 3, 999-1005 (2002).
    • (2002) Nature Immunol. , vol.3 , pp. 999-1005
    • Khong, H.T.1    Restifo, N.P.2
  • 10
    • 0038069515 scopus 로고    scopus 로고
    • MHC class I antigens, immune surveillance and tumor immune escape
    • Garcia-Lora A, Algarra I, Garrido F. MHC class I antigens, immune surveillance and tumor immune escape. J. Cell Physiol. 195, 346-355 (2003).
    • (2003) J. Cell Physiol. , vol.195 , pp. 346-355
    • Garcia-Lora, A.1    Algarra, I.2    Garrido, F.3
  • 11
    • 0032863781 scopus 로고    scopus 로고
    • In vivo description of dendritic cells in human renal cell carcinoma
    • Schwaab T, Schned AR, Heaney JA et al. In vivo description of dendritic cells in human renal cell carcinoma. J. Urol. 162, 291-292 (1999).
    • (1999) J. Urol. , vol.162 , pp. 291-292
    • Schwaab, T.1    Schned, A.R.2    Heaney, J.A.3
  • 12
    • 0037379733 scopus 로고    scopus 로고
    • Gangliosides expressed by the renal cell carcinoma cell line SK-RC-45 are involved in tumor-induced apoptosis of T-cells
    • Kudo D, Rayman P, Horton C et al. Gangliosides expressed by the renal cell carcinoma cell line SK-RC-45 are involved in tumor-induced apoptosis of T-cells. Cancer Res. 63, 1676-1683 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 1676-1683
    • Kudo, D.1    Rayman, P.2    Horton, C.3
  • 13
    • 0033995215 scopus 로고    scopus 로고
    • Tumor-induced dysfunction in interleukin-2 production and interleukin-2 receptor signaling: A mechanism of immune escape
    • Rayman P, Uzzo RG, Kolenko V et al. Tumor-induced dysfunction in interleukin-2 production and interleukin-2 receptor signaling: a mechanism of immune escape. Cancer J. Sci. Am. 6(Suppl.1), S81-S87 (2000).
    • (2000) Cancer J. Sci. Am. , vol.6 , Issue.SUPPL. 1
    • Rayman, P.1    Uzzo, R.G.2    Kolenko, V.3
  • 14
    • 0035289453 scopus 로고    scopus 로고
    • Tumor-induced sensitivity to apoptosis in T-cells from patients with renal cell carcinoma: Role of nuclear factor-κB
    • Finke JH, Rayman P, George R et al. Tumor-induced sensitivity to apoptosis in T-cells from patients with renal cell carcinoma: role of nuclear factor-κB. Clin. Cancer Res. 7(Suppl.3), S940-S946 (2001).
    • (2001) Clin. Cancer Res. , vol.7 , Issue.SUPPL. 3
    • Finke, J.H.1    Rayman, P.2    George, R.3
  • 15
    • 0036592081 scopus 로고    scopus 로고
    • Restoration of naive cell repertoire in the appropriate cytokine milieu: A model for preventing cancer relapses
    • Singh HP, Gupta S, Raina V. Restoration of naive cell repertoire in the appropriate cytokine milieu: a model for preventing cancer relapses. Med. Hypotheses 58, 554-557 (2002).
    • (2002) Med. Hypotheses , vol.58 , pp. 554-557
    • Singh, H.P.1    Gupta, S.2    Raina, V.3
  • 16
    • 0034873652 scopus 로고    scopus 로고
    • T-cell immunity in the induction and maintenance of a tumor dormant state
    • Schirrmacher V. T-cell immunity in the induction and maintenance of a tumor dormant state. Semin. Cancer Biol. 11, 285-295 (2001).
    • (2001) Semin. Cancer Biol. , vol.11 , pp. 285-295
    • Schirrmacher, V.1
  • 17
  • 18
    • 0032738062 scopus 로고    scopus 로고
    • Extrathymic CD4/CD8 double-positive T-cells
    • Zuckermann FA. Extrathymic CD4/CD8 double-positive T-cells. Vet. Immunol. Immunopathol 72, 55-66 (1999).
    • (1999) Vet. Immunol. Immunopathol , vol.72 , pp. 55-66
    • Zuckermann, F.A.1
  • 19
  • 20
    • 0035413380 scopus 로고    scopus 로고
    • Coexpression of CD4 and CD8 alpha on rat T-cells in whole blood: A sensitive marker for monitoring T-cell immunosuppressive drugs
    • Diaz-Romero J, Vogt G, Weckbecker G. Coexpression of CD4 and CD8 alpha on rat T-cells in whole blood: a sensitive marker for monitoring T-cell immunosuppressive drugs. J. Immunol. Methods 254, 1-12 (2001).
    • (2001) J. Immunol. Methods , vol.254 , pp. 1-12
    • Diaz-Romero, J.1    Vogt, G.2    Weckbecker, G.3
  • 21
    • 0032400862 scopus 로고    scopus 로고
    • Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo
    • Gabrilovich D, Ishida T, Oyama T et al. Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo. Blood 92, 4150-4166 (1998).
    • (1998) Blood , vol.92 , pp. 4150-4166
    • Gabrilovich, D.1    Ishida, T.2    Oyama, T.3
  • 22
    • 0032741283 scopus 로고    scopus 로고
    • Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function
    • Gabrilovich D, Ishida T, Nadaf S, Ohm JE, Carbone DP. Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function. Clin. Cancer Res. 5, 2963-2970 (1999).
    • (1999) Clin. Cancer Res. , vol.5 , pp. 2963-2970
    • Gabrilovich, D.1    Ishida, T.2    Nadaf, S.3    Ohm, J.E.4    Carbone, D.P.5
  • 23
    • 0031892785 scopus 로고    scopus 로고
    • Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-kappa B activation in hemopoietic progenitor cells
    • Oyama T, Ran S, Ishida T et al. Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-kappa B activation in hemopoietic progenitor cells. J. Immunol. 160, 1224-1232 (1998).
    • (1998) J. Immunol. , vol.160 , pp. 1224-1232
    • Oyama, T.1    Ran, S.2    Ishida, T.3
  • 24
    • 14644415949 scopus 로고    scopus 로고
    • Biology and clinical development of vascular endothelial growth factor-targeted therapy in renal cell carcinoma
    • Rini B, Small EJ. Biology and clinical development of vascular endothelial growth factor-targeted therapy in renal cell carcinoma. J. Clin. Oncol. 23, 1028-1043 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 1028-1043
    • Rini, B.1    Small, E.J.2
  • 26
    • 0033736398 scopus 로고    scopus 로고
    • Molecular analysis of mechanisms regulating drug sensitivity and the development of new chemotherapy strategies for genitourinary carcinomas
    • Naito S, Koga H, Yokomizo A et al. Molecular analysis of mechanisms regulating drug sensitivity and the development of new chemotherapy strategies for genitourinary carcinomas. World J. Surg. 24, 1183-1186 (2000).
    • (2000) World J. Surg. , vol.24 , pp. 1183-1186
    • Naito, S.1    Koga, H.2    Yokomizo, A.3
  • 27
    • 0033978220 scopus 로고    scopus 로고
    • Systemic therapy for renal cell carcinoma
    • Motzer RJ, Russo P. Systemic therapy for renal cell carcinoma. J. Urol. 163, 408-417 (2000).
    • (2000) J. Urol. , vol.163 , pp. 408-417
    • Motzer, R.J.1    Russo, P.2
  • 28
    • 0034038518 scopus 로고    scopus 로고
    • Chemotherapy for renal cell carcinoma
    • Amato RJ. Chemotherapy for renal cell carcinoma. Semin. Oncol. 27, 177-186 (2000).
    • (2000) Semin. Oncol. , vol.27 , pp. 177-186
    • Amato, R.J.1
  • 29
    • 7144227930 scopus 로고    scopus 로고
    • Recombinant human interleukin-2, recombinant human interferon α-2a, or both in metastatic renal cell carcinoma
    • Negrier S, Escudier B, Lasser C et al. Recombinant human interleukin-2, recombinant human interferon α-2a, or both in metastatic renal cell carcinoma. N. Engl. J. Med. 338, 1272-1278 (1998).
    • (1998) N. Engl. J. Med. , vol.338 , pp. 1272-1278
    • Negrier, S.1    Escudier, B.2    Lasser, C.3
  • 30
    • 2442430437 scopus 로고    scopus 로고
    • Interleukin-2 based therapy for kidney cancer
    • Dutcher JP. Interleukin-2 based therapy for kidney cancer. Cancer Treat Res. 116, 155-172 (2003).
    • (2003) Cancer Treat Res. , vol.116 , pp. 155-172
    • Dutcher, J.P.1
  • 31
    • 0033812694 scopus 로고    scopus 로고
    • Phase II trial of interleukin-2, interferon α, and 5-fluorouracil in metastatic renal cell cancer: A Cytokine Working Group Study
    • Dutcher JP, Logan T, Gordon M et al. Phase II trial of interleukin-2, interferon α, and 5-fluorouracil in metastatic renal cell cancer: a Cytokine Working Group Study. Clin. Cancer Res. 6, 3442-3450 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , pp. 3442-3450
    • Dutcher, J.P.1    Logan, T.2    Gordon, M.3
  • 32
    • 0033846746 scopus 로고    scopus 로고
    • Interleukin-2 induces cell cycle perturbations leading to cell growth inhibition and death in malignant mesothelioma cells in vitro
    • Porta C, Danova M, Orengo AM et al. Interleukin-2 induces cell cycle perturbations leading to cell growth inhibition and death in malignant mesothelioma cells in vitro. J. Cell Physiol. 185, 126-134 (2000).
    • (2000) J. Cell Physiol. , vol.185 , pp. 126-134
    • Porta, C.1    Danova, M.2    Orengo, A.M.3
  • 33
    • 0036838028 scopus 로고    scopus 로고
    • Intrapleural interleukin-2 induces nitric oxide production in pleural effusions from malignant mesothelioma: A possible mechanism of interleukin-2-mediated cytotoxicity?
    • Porta C, Rizzo V, Zimatore M, Sartore-Bianchi Z, Danova M, Mutti L. Intrapleural interleukin-2 induces nitric oxide production in pleural effusions from malignant mesothelioma: a possible mechanism of interleukin-2-mediated cytotoxicity? Lung Cancer 38, 159-162 (2002).
    • (2002) Lung Cancer , vol.38 , pp. 159-162
    • Porta, C.1    Rizzo, V.2    Zimatore, M.3    Sartore-Bianchi, Z.4    Danova, M.5    Mutti, L.6
  • 34
    • 0031572573 scopus 로고    scopus 로고
    • Nitrate plasma level as a marker of nitric oxide production after subcutaneous interleukin-2 immunotherapy
    • Porta C, Moroni M, Bobbio-Pallavicini E, Tinelli C, Regazzi-Bonora M. Nitrate plasma level as a marker of nitric oxide production after subcutaneous interleukin-2 immunotherapy. J. Natl Cancer Inst. 89, 1545 (1997).
    • (1997) J. Natl Cancer Inst. , vol.89 , pp. 1545
    • Porta, C.1    Moroni, M.2    Bobbio-Pallavicini, E.3    Tinelli, C.4    Regazzi-Bonora, M.5
  • 35
    • 0031015454 scopus 로고    scopus 로고
    • Fluorouracil in colorectal cancer - A tale of two drugs: Implications for biochemical modulation
    • Sobrero AF, Aschele C, Bertino JR. Fluorouracil in colorectal cancer - a tale of two drugs: implications for biochemical modulation. J. Clin. Oncol. 15, 368-381 (1997).
    • (1997) J. Clin. Oncol. , vol.15 , pp. 368-381
    • Sobrero, A.F.1    Aschele, C.2    Bertino, J.R.3
  • 36
    • 16644401873 scopus 로고    scopus 로고
    • Randomized Phase III trial of high-dose interleukin-2 versus subcutaneous interleukin-2 and interferon in patients with metastatic renal cell carcinoma
    • McDermott DF, Regan MM, Clark JI et al. Randomized Phase III trial of high-dose interleukin-2 versus subcutaneous interleukin-2 and interferon in patients with metastatic renal cell carcinoma. J. Clin. Oncol. 23, 133-141 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 133-141
    • McDermott, D.F.1    Regan, M.M.2    Clark, J.I.3
  • 37
    • 33646571274 scopus 로고    scopus 로고
    • Do cytokines improve survival in patients with metastatic renal cell carcinoma (MRCC) of intermediate prognosis? Results of the prospective randomized PERCY-Quattro trial
    • (Abstract 4511)
    • Negrier S, Perol D, Ravaud A et al. Do cytokines improve survival in patients with metastatic renal cell carcinoma (MRCC) of intermediate prognosis? Results of the prospective randomized PERCY-Quattro trial. Proc. Am. Soc. Clin. Oncol. 23, 380s (2005) (Abstract 4511).
    • (2005) Proc. Am. Soc. Clin. Oncol. , vol.23
    • Negrier, S.1    Perol, D.2    Ravaud, A.3
  • 38
    • 1942455781 scopus 로고    scopus 로고
    • A systematic review of the relation between interleukin-2 schedule and outcome in patients with metastatic renal cell cancer
    • Baaten G, Voogd AC, Wagstaff J. A systematic review of the relation between interleukin-2 schedule and outcome in patients with metastatic renal cell cancer. Eur. J. Cancer 40, 1127-1144 (2004).
    • (2004) Eur. J. Cancer , vol.40 , pp. 1127-1144
    • Baaten, G.1    Voogd, A.C.2    Wagstaff, J.3
  • 40
    • 23844558595 scopus 로고    scopus 로고
    • Randomized Phase III trial of the Raf kinase and VEGFR inhibitor sorafenib (BAY 43-9006) in patients with advanced renal cell carcinoma (RCC)
    • (Abstract 4510)
    • Escudier B, Szczylik C, Eisen T et al. Randomized Phase III trial of the Raf kinase and VEGFR inhibitor sorafenib (BAY 43-9006) in patients with advanced renal cell carcinoma (RCC). Proc. Am. Soc. Clin. Oncol. 23, 380s (2005) (Abstract 4510).
    • (2005) Proc. Am. Soc. Clin. Oncol. , vol.23
    • Escudier, B.1    Szczylik, C.2    Eisen, T.3
  • 41
    • 23844480013 scopus 로고    scopus 로고
    • Phase 2 trials of SU11248 show antitumor activity in second-line therapy for patients with metastatic renal cell carcinoma (RCC)
    • (Abstract 4508)
    • Motzer RJ, Rini BI, Michaelson MD et al. Phase 2 trials of SU11248 show antitumor activity in second-line therapy for patients with metastatic renal cell carcinoma (RCC). Proc. Am. Soc. Clin. Oncol. 23, 380s (2005) (Abstract 4508).
    • (2005) Proc. Am. Soc. Clin. Oncol. , vol.23
    • Motzer, R.J.1    Rini, B.I.2    Michaelson, M.D.3
  • 42
    • 0030798858 scopus 로고    scopus 로고
    • Effectiveness of very low doses of immunotherapy in advanced renal cell cancer
    • Buzio C, De Palma G, Passalacqua R et al. Effectiveness of very low doses of immunotherapy in advanced renal cell cancer. Br. J. Cancer 76, 541-544 (1997).
    • (1997) Br. J. Cancer , vol.76 , pp. 541-544
    • Buzio, C.1    De Palma, G.2    Passalacqua, R.3
  • 43
    • 0027316949 scopus 로고
    • A Phase I study of prolonged continuous infusion of low dose recombinant interleukin-2 in melanoma and renal cell cancer. Part II: Immunological aspects
    • Vlasveld LT, Hekman A, Vyth-Dreede FA et al. A Phase I study of prolonged continuous infusion of low dose recombinant interleukin-2 in melanoma and renal cell cancer. Part II: immunological aspects. Br. J. Cancer 68, 559-567 (1993).
    • (1993) Br. J. Cancer , vol.68 , pp. 559-567
    • Vlasveld, L.T.1    Hekman, A.2    Vyth-Dreede, F.A.3
  • 44
    • 0027717736 scopus 로고
    • Low-dose recombinant interleukin-2 therapy: Rationale and potential clinical applications
    • Caligiuri MA. Low-dose recombinant interleukin-2 therapy: rationale and potential clinical applications. Semin. Oncol. 20, 3-10 (1993).
    • (1993) Semin. Oncol. , vol.20 , pp. 3-10
    • Caligiuri, M.A.1
  • 45
    • 0024264288 scopus 로고
    • Acute immunologic effects of interleukin-2 therapy in cancer patients: Decreased delayed type hypersensitivity response and decreased proliferative response to soluble antigens
    • Wiebke EA, Rosenberg SA, Lotze MT. Acute immunologic effects of interleukin-2 therapy in cancer patients: decreased delayed type hypersensitivity response and decreased proliferative response to soluble antigens. J. Clin. Oncol. 6, 1440-1449 (1988).
    • (1988) J. Clin. Oncol. , vol.6 , pp. 1440-1449
    • Wiebke, E.A.1    Rosenberg, S.A.2    Lotze, M.T.3
  • 46
    • 0026017971 scopus 로고    scopus 로고
    • Interleukin-2 programs mouse αβ T-lymphocytes for apoptosis
    • Lenardo MJ. Interleukin-2 programs mouse αβ T-lymphocytes for apoptosis. Nature 353, 858-861 (1999).
    • (1999) Nature , vol.353 , pp. 858-861
    • Lenardo, M.J.1
  • 47
    • 0028793528 scopus 로고
    • Low doses of rIL-2 after autologous bone marrow transplantation induce a 'prolonged' immunostimulation of NK compartment in high-grade non-Hodgkin's lymphomas
    • Raspadori D, Lauria F, Ventura MA et al. Low doses of rIL-2 after autologous bone marrow transplantation induce a 'prolonged' immunostimulation of NK compartment in high-grade non-Hodgkin's lymphomas. Ann. Hematol. 71, 175-179 (1995).
    • (1995) Ann. Hematol. , vol.71 , pp. 175-179
    • Raspadori, D.1    Lauria, F.2    Ventura, M.A.3
  • 49
    • 0035498665 scopus 로고    scopus 로고
    • Long-term immunotherapy with low-dose interleukin-2 and Interferon-α in the treatment of patients with advanced renal cell carcinoma
    • Buzio C, Andrulli S, Santi R et al. Long-term immunotherapy with low-dose interleukin-2 and Interferon-α in the treatment of patients with advanced renal cell carcinoma. Cancer 92, 2286-2296 (2001).
    • (2001) Cancer , vol.92 , pp. 2286-2296
    • Buzio, C.1    Andrulli, S.2    Santi, R.3
  • 50
    • 19444380356 scopus 로고    scopus 로고
    • 'Late' regressions of metastases from renal cancer after a period of disease progression continuing the same intermittent low dose immunotherapy regimen
    • Giacosa R, Santi R, Vaglio A et al. 'Late' regressions of metastases from renal cancer after a period of disease progression continuing the same intermittent low dose immunotherapy regimen. Acta Biomed Ateneo Parmense 75, 126-130 (2004).
    • (2004) Acta Biomed Ateneo Parmense , vol.75 , pp. 126-130
    • Giacosa, R.1    Santi, R.2    Vaglio, A.3
  • 51
    • 0028332772 scopus 로고
    • Effect of low-dose interleukin-2 on disease relapse after T-cell-depleted allogeneic bone marrow transplantation
    • Soiffer RJ, Murray C, Gonin R, Ritz J. Effect of low-dose interleukin-2 on disease relapse after T-cell-depleted allogeneic bone marrow transplantation. Blood 84, 964-971 (1994).
    • (1994) Blood , vol.84 , pp. 964-971
    • Soiffer, R.J.1    Murray, C.2    Gonin, R.3    Ritz, J.4
  • 52
    • 0029811148 scopus 로고    scopus 로고
    • Rational for interleukin-2 therapy for HIV positive individuals: Daily low doses enhance immune function without toxicity
    • Jacobson El, Pilaro F, Smith KA. Rational for interleukin-2 therapy for HIV positive individuals: daily low doses enhance immune function without toxicity. Proc. Natl Acad. Sci USA. 93, 10405-10410 (1996).
    • (1996) Proc. Natl Acad. Sci USA. , vol.93 , pp. 10405-10410
    • Jacobson, El.1    Pilaro, F.2    Smith, K.A.3
  • 53
    • 0028840964 scopus 로고
    • Prolonged administration of low-dose interleukin-2 in human immunodeficiency virus-associated malignancy results in selective expansion of innate immune effectors without significant clinical toxicity
    • Bernstein ZP, Porter MM, Gould M et al. Prolonged administration of low-dose interleukin-2 in human immunodeficiency virus-associated malignancy results in selective expansion of innate immune effectors without significant clinical toxicity. Blood 86, 3287-3294 (1995).
    • (1995) Blood , vol.86 , pp. 3287-3294
    • Bernstein, Z.P.1    Porter, M.M.2    Gould, M.3
  • 54
    • 0032520908 scopus 로고    scopus 로고
    • Ultra low dose interleukin-2 therapy promotes a Type I cytokine profile in vivo in patients with AIDS and AIDS-associated malignancies
    • Khatri VP, Fehniger TA, Baiocchi RA et al. Ultra low dose interleukin-2 therapy promotes a Type I cytokine profile in vivo in patients with AIDS and AIDS-associated malignancies. J. Clin. Invest. 101, 1373-1378 (1998).
    • (1998) J. Clin. Invest. , vol.101 , pp. 1373-1378
    • Khatri, V.P.1    Fehniger, T.A.2    Baiocchi, R.A.3
  • 55
    • 0027487085 scopus 로고
    • Immunoendocrine therapy with interleuchin-2 (IL-2) and medroxyprogesterone acetate (MPA): A randomized study with or without MPA in metastatic renal cancer patients during IL-2 maintenance treatment after response or stable disease to IL-2 subcutaneous therapy
    • Lissoni P, Barni S, Tancini G et al. Immunoendocrine therapy with interleuchin-2 (IL-2) and medroxyprogesterone acetate (MPA): a randomized study with or without MPA in metastatic renal cancer patients during IL-2 maintenance treatment after response or stable disease to IL-2 subcutaneous therapy. Tumori 79, 246-249 (1993).
    • (1993) Tumori , vol.79 , pp. 246-249
    • Lissoni, P.1    Barni, S.2    Tancini, G.3
  • 56
    • 0029122468 scopus 로고
    • Long-term subcutaneous recombinant interleukin-2 as maintenance therapy: Biological effects and clinical implications
    • Guida M, Abbate I, Casamassima A et al. Long-term subcutaneous recombinant interleukin-2 as maintenance therapy: biological effects and clinical implications. Cancer Biother. 10, 195-203 (1995).
    • (1995) Cancer Biother. , vol.10 , pp. 195-203
    • Guida, M.1    Abbate, I.2    Casamassima, A.3
  • 57
    • 0035256418 scopus 로고    scopus 로고
    • Immunotherapy (recombinant interleukin-2), hormone therapy (medroxyprogesterone acetate) and anti-oxidant agents as combined maintenance treatment of responders to previous chemotherapy
    • Mantovani G, Macciò G, Madeddu C et al. Immunotherapy (recombinant interleukin-2), hormone therapy (medroxyprogesterone acetate) and anti-oxidant agents as combined maintenance treatment of responders to previous chemotherapy. Int. J. Cancer 18,383-391 (2001).
    • (2001) Int. J. Cancer , vol.18 , pp. 383-391
    • Mantovani, G.1    Macciò, G.2    Madeddu, C.3
  • 58
    • 0034895888 scopus 로고    scopus 로고
    • Phase Ib study of subcutaneous administered interleukin-2 in combination with 13-cis retinoic acid as maintenance therapy in advanced cancer
    • Recchia F, De Filippis S, Rosselli M et al. Phase Ib study of subcutaneous administered interleukin-2 in combination with 13-cis retinoic acid as maintenance therapy in advanced cancer. Clin. Cancer Res. 7, 1251-1257 (2001).
    • (2001) Clin. Cancer Res. , vol.7 , pp. 1251-1257
    • Recchia, F.1    De Filippis, S.2    Rosselli, M.3
  • 59
    • 0036322750 scopus 로고    scopus 로고
    • Ten-year survival results in metastatic renal cell cancer patients treated with monoimmunotherapy with subcutaneous low-dose interleukin-2
    • Lissoni P, Bordin V, Vaghi M et al. Ten-year survival results in metastatic renal cell cancer patients treated with monoimmunotherapy with subcutaneous low-dose interleukin-2. Anticancer Res. 22, 1061-1064 (2002).
    • (2002) Anticancer Res. , vol.22 , pp. 1061-1064
    • Lissoni, P.1    Bordin, V.2    Vaghi, M.3
  • 60
    • 0036719062 scopus 로고    scopus 로고
    • Maintenance biotherapy for metastatic melanoma with interleukin-2 and granulocyte macrophage-colony stimulating factor improves survival for patients responding to induction concurrent biochemotherapy
    • O'Day SJ, Boasberg PD, Piro L et al. Maintenance biotherapy for metastatic melanoma with interleukin-2 and granulocyte macrophage-colony stimulating factor improves survival for patients responding to induction concurrent biochemotherapy. Clin. Cancer Res. 8, 2775-2781 (2002).
    • (2002) Clin. Cancer Res. , vol.8 , pp. 2775-2781
    • O'Day, S.J.1    Boasberg, P.D.2    Piro, L.3
  • 61
    • 0036635945 scopus 로고    scopus 로고
    • Phase II study of subcutaneously administered interleukin-2 in combination with medroxyprogesterone acetate and antioxidant agents as maintenance treatment in advanced cancer responders to previous chemotherapy
    • Mantovani G, Macciò A, Madeddu C et al. Phase II study of subcutaneously administered interleukin-2 in combination with medroxyprogesterone acetate and antioxidant agents as maintenance treatment in advanced cancer responders to previous chemotherapy. Oncol Rep. 9, 887-896 (2002).
    • (2002) Oncol Rep. , vol.9 , pp. 887-896
    • Mantovani, G.1    Macciò, A.2    Madeddu, C.3
  • 62
    • 0036618008 scopus 로고    scopus 로고
    • Interleukin-2 and 13-cis retinoic acid in the treatment of minimal residual disease: A Phase II study
    • Recchia F, De Filippis S, Rosselli M, Saggio G, Fumagalli L, Rea S. Interleukin-2 and 13-cis retinoic acid in the treatment of minimal residual disease: a Phase II study. Int. J. Oncol. 20, 1275-1282 (2002).
    • (2002) Int. J. Oncol. , vol.20 , pp. 1275-1282
    • Recchia, F.1    De Filippis, S.2    Rosselli, M.3    Saggio, G.4    Fumagalli, L.5    Rea, S.6
  • 63
    • 0642281441 scopus 로고    scopus 로고
    • Subcutaneous interleukin-2 and interferon α administration in patients with metastatic renal cell carcinoma: Final results of SCAPP III, a large, multicenter, Phase II, nonrandomized study with sequential analysis design - The Subcutaneous Administration Propeukin Program Co-operative Group
    • Tourani JM, Pfister C, Tubiana N et al. Subcutaneous interleukin-2 and interferon α administration in patients with metastatic renal cell carcinoma: final results of SCAPP III, a large, multicenter, Phase II, nonrandomized study with sequential analysis design - The Subcutaneous Administration Propeukin Program Co-operative Group. J. Clin. Oncol. 21, 3987-3994 (2003).
    • (2003) J. Clin. Oncol. , vol.21 , pp. 3987-3994
    • Tourani, J.M.1    Pfister, C.2    Tubiana, N.3
  • 64
    • 22944485657 scopus 로고    scopus 로고
    • Phase II randomized study of interleukin-2 with or without 13-cis retinoic acid as maintenance therapy in patients with advanced cancer responsive to chemotherapy
    • Recchia F, Saggio G, Cesta A et al. Phase II randomized study of interleukin-2 with or without 13-cis retinoic acid as maintenance therapy in patients with advanced cancer responsive to chemotherapy. AntiCancer Res. 25, 3149-3157 (2005).
    • (2005) AntiCancer Res. , vol.25 , pp. 3149-3157
    • Recchia, F.1    Saggio, G.2    Cesta, A.3
  • 65
    • 33644820746 scopus 로고    scopus 로고
    • Interleukin-2 and 13-cis retinoic acid as maintenance therapy in advanced ovarian cancer
    • Recchia F, Saggio G, Cesta A et al. Interleukin-2 and 13-cis retinoic acid as maintenance therapy in advanced ovarian cancer. Int. J. Oncol. 27, 1039-1046 (2005).
    • (2005) Int. J. Oncol. , vol.27 , pp. 1039-1046
    • Recchia, F.1    Saggio, G.2    Cesta, A.3
  • 66
    • 0035023268 scopus 로고    scopus 로고
    • Long-term treatment with low doses of interleukin-2 and interferon-α: Immunological effects in advanced renal cell cancer
    • Pavone L, Andrulli S, Santi R, Majori M, Buzio C. Long-term treatment with low doses of interleukin-2 and interferon-α: immunological effects in advanced renal cell cancer. Cancer Immunol. Immunother. 50, 82-86 (2001).
    • (2001) Cancer Immunol. Immunother. , vol.50 , pp. 82-86
    • Pavone, L.1    Andrulli, S.2    Santi, R.3    Majori, M.4    Buzio, C.5
  • 67
    • 15844364381 scopus 로고    scopus 로고
    • Daily subcutaneous injection of low-dose interleukin-2 expands natural killer cells in vivo without significant toxicity
    • Meropol NJ, Porter M, Blumenson LE et al. Daily subcutaneous injection of low-dose interleukin-2 expands natural killer cells in vivo without significant toxicity. Clin. Cancer Res. 2,669-677 (1996).
    • (1996) Clin. Cancer Res. , vol.2 , pp. 669-677
    • Meropol, N.J.1    Porter, M.2    Blumenson, L.E.3
  • 68
    • 0025824067 scopus 로고
    • + cells: Examination of morphology, function, T-cell receptor rearrangement, and pore-forming protein expression
    • + cells: examination of morphology, function, T-cell receptor rearrangement, and pore-forming protein expression. Cell Immunol. 136, 495-496 (1991).
    • (1991) Cell Immunol. , vol.136 , pp. 495-496
    • Ortaldo, J.R.1    Winkler-Pickett, R.T.2    Yagita, H.3    Young, H.A.4
  • 70
    • 0141483735 scopus 로고    scopus 로고
    • Lymphocyte counts independently predict overall survival in advanced cancer patients: A biomarker for IL-2 immunotherapy
    • Fumagalli LA, Vinke J, Hoff W, Ypma E, Brivio F, Nespoli A. Lymphocyte counts independently predict overall survival in advanced cancer patients: a biomarker for IL-2 immunotherapy. J. Immunother. 26, 394-402 (2003).
    • (2003) J. Immunother. , vol.26 , pp. 394-402
    • Fumagalli, L.A.1    Vinke, J.2    Hoff, W.3    Ypma, E.4    Brivio, F.5    Nespoli, A.6
  • 71
    • 0034085042 scopus 로고    scopus 로고
    • Eosinophils and C4 predict clinical failure of combination immunotherapy with very low doses subcutaneous interleukin-2 and interferon in renal cell carcinoma patients
    • Moroni M, Porta C, De Amici M, Quaglini S, Cattabiani MA, Buzio C. Eosinophils and C4 predict clinical failure of combination immunotherapy with very low doses subcutaneous interleukin-2 and interferon in renal cell carcinoma patients. Haematologica 85, 298-303 (2000).
    • (2000) Haematologica , vol.85 , pp. 298-303
    • Moroni, M.1    Porta, C.2    De Amici, M.3    Quaglini, S.4    Cattabiani, M.A.5    Buzio, C.6
  • 72
    • 0020349687 scopus 로고
    • Influence of macrophage activation on the synthesis of complement components C2, C3, C4
    • Hartung HP, Zanker B, Bitter-Suermann D. Influence of macrophage activation on the synthesis of complement components C2, C3, C4. Ad. Exp. Med. Biol. 155, 525-529 (1982).
    • (1982) Ad. Exp. Med. Biol. , vol.155 , pp. 525-529
    • Hartung, H.P.1    Zanker, B.2    Bitter-Suermann, D.3
  • 73
    • 0342594637 scopus 로고    scopus 로고
    • The immunosurveillance of cancer: Specific and non-specific mechanisms
    • Dalgleish AG, Browning M (Eds.). Cambridge University Press, Cambridge, UK
    • Vile RG, Chong H, Dorudi S. The immunosurveillance of cancer: specific and non-specific mechanisms. Tumor Immunology, Immunotherapy and Cancer vaccines. Dalgleish AG, Browning M (Eds.). Cambridge University Press, Cambridge, UK, 7-38 (1996).
    • (1996) Tumor Immunology, Immunotherapy and Cancer Vaccines , pp. 7-38
    • Vile, R.G.1    Chong, H.2    Dorudi, S.3
  • 74
    • 0025916290 scopus 로고
    • Increase in soluble interleukin-2 receptor and neopterin serum levels during immunotherapy of cancer with interleukin-2
    • Lissoni P, Tisi E, Brivio F et al. Increase in soluble interleukin-2 receptor and neopterin serum levels during immunotherapy of cancer with interleukin-2. Eur. J. Cancer 27, 1014-1016 (1991).
    • (1991) Eur. J. Cancer , vol.27 , pp. 1014-1016
    • Lissoni, P.1    Tisi, E.2    Brivio, F.3
  • 75
    • 0026754550 scopus 로고
    • Tumor-associated tissue inflammatory reaction and eosinophilia in primary superficial bladder cancer
    • Flamm J. Tumor-associated tissue inflammatory reaction and eosinophilia in primary superficial bladder cancer. Urology 40, 180-185 (1992).
    • (1992) Urology , vol.40 , pp. 180-185
    • Flamm, J.1
  • 76
    • 0027970322 scopus 로고
    • Tumor-associated tissue eosinophdia and long-term prognosis for carcinoma of the larynx
    • Thompson AC, Bradley PJ, Griffin NR. Tumor-associated tissue eosinophdia and long-term prognosis for carcinoma of the larynx. Am. J. Surg. 168, 469-471 (1994).
    • (1994) Am. J. Surg. , vol.168 , pp. 469-471
    • Thompson, A.C.1    Bradley, P.J.2    Griffin, N.R.3
  • 77
    • 0030837554 scopus 로고    scopus 로고
    • Eosinophils and human cancer
    • Samoszuk M. Eosinophils and human cancer. Histol. Histopathol. 12, 807-812 (1997).
    • (1997) Histol. Histopathol. , vol.12 , pp. 807-812
    • Samoszuk, M.1
  • 78
    • 0026663801 scopus 로고
    • Tumor-associated eosinophilia in interleukin-2-treated patients: Evidence of toxic eosinophil degranulation on bladder cancer cells
    • Huland E, Huland H. Tumor-associated eosinophilia in interleukin-2-treated patients: evidence of toxic eosinophil degranulation on bladder cancer cells. J Cancer Res. Clin. Oncol. 118, 463-467 (1992).
    • (1992) J Cancer Res. Clin. Oncol. , vol.118 , pp. 463-467
    • Huland, E.1    Huland, H.2
  • 79
    • 0027298415 scopus 로고
    • In vitro antitumor activity of eosinophils from cancer patients treated with subcutaneous administration of interleukin-2. Role of interleukin-5
    • Rivoltini L, Viggiano V, Spinazzè S et al. In vitro antitumor activity of eosinophils from cancer patients treated with subcutaneous administration of interleukin-2. Role of interleukin-5. Int. J. Cancer 54, 8-15 (1993).
    • (1993) Int. J. Cancer , vol.54 , pp. 8-15
    • Rivoltini, L.1    Viggiano, V.2    Spinazzè, S.3
  • 80
    • 0030765161 scopus 로고    scopus 로고
    • The eosinophil granule proteins in serum, but not the oxidative metabolism of the blood eosinophils, are increased in cancer
    • Trulson A, Nilsson S, Venge P. The eosinophil granule proteins in serum, but not the oxidative metabolism of the blood eosinophils, are increased in cancer. Br. J. Haematol. 98, 312-314 (1997).
    • (1997) Br. J. Haematol. , vol.98 , pp. 312-314
    • Trulson, A.1    Nilsson, S.2    Venge, P.3
  • 81
    • 0031574104 scopus 로고    scopus 로고
    • Cationic protein-rich supernatants of cultured eosinophils from IL-2-treated patients have no cytotoxic activity on human renal cell carcinoma and melanoma cells: A preliminary report
    • Moroni M, Porta C, Gritti D et al. Cationic protein-rich supernatants of cultured eosinophils from IL-2-treated patients have no cytotoxic activity on human renal cell carcinoma and melanoma cells: a preliminary report. Ann. NY Acad. Sci. 832, 295-303 (1997).
    • (1997) Ann. NY Acad. Sci. , vol.832 , pp. 295-303
    • Moroni, M.1    Porta, C.2    Gritti, D.3
  • 82
    • 0031864807 scopus 로고    scopus 로고
    • Eosinophils and serum eosinophilic cationic proteins in interleukin-2-based immunotherapy
    • Porta C, Moroni M, De Amici M. Eosinophils and serum eosinophilic cationic proteins in interleukin-2-based immunotherapy. Br. J. Haematol. 100, 607-609 (1998).
    • (1998) Br. J. Haematol. , vol.100 , pp. 607-609
    • Porta, C.1    Moroni, M.2    De Amici, M.3
  • 83
    • 0032836685 scopus 로고    scopus 로고
    • Daily subcutaneous ultra-low-dose interleukin-2 with daily low-dose interferon-alpha in patients with advanced renal cell carcinoma
    • Clark JI, Gaynor ER, Martone B et al. Daily subcutaneous ultra-low-dose interleukin-2 with daily low-dose interferon-alpha in patients with advanced renal cell carcinoma. Clin. Cancer Res. 5, 2374-2380 (1999).
    • (1999) Clin. Cancer Res. , vol.5 , pp. 2374-2380
    • Clark, J.I.1    Gaynor, E.R.2    Martone, B.3
  • 84
    • 0028929682 scopus 로고
    • Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy
    • Fyfe G, Fisher RI, Rosenberg SA, Sznol M, Parkinson DR, Louise AC. Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy. J. Clin. Oncol. 13, 688-696 (1995).
    • (1995) J. Clin. Oncol. , vol.13 , pp. 688-696
    • Fyfe, G.1    Fisher, R.I.2    Rosenberg, S.A.3    Sznol, M.4    Parkinson, D.R.5    Louise, A.C.6
  • 85
    • 0031415591 scopus 로고    scopus 로고
    • An ongoing prospective randomized comparison of interleukin-2 regimens for the treatment of metastatic renal cell carcinoma
    • Yang JC, Rosenberg SA. An ongoing prospective randomized comparison of interleukin-2 regimens for the treatment of metastatic renal cell carcinoma. Cancer J. Sci. Am. 3(Suppl. 1), S79-S84 (1997).
    • (1997) Cancer J. Sci. Am. , vol.3 , Issue.SUPPL. 1
    • Yang, J.C.1    Rosenberg, S.A.2
  • 86
    • 7144227930 scopus 로고    scopus 로고
    • Recombinant human interleukin-2, recombinant human interferon α-2a, or both, in metastatic renal cell carcinoma
    • Negrier S, Escudier B, Lasser C et al. Recombinant human interleukin-2, recombinant human interferon α-2a, or both, in metastatic renal cell carcinoma. N. Engl. J. Med. 338, 1272-1278 (1998).
    • (1998) N. Engl. J. Med. , vol.338 , pp. 1272-1278
    • Negrier, S.1    Escudier, B.2    Lasser, C.3
  • 87
    • 0028266553 scopus 로고
    • Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose bolus interleukin-2
    • Rosenberg SA, Yang JC, Topalian SL et al. Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose bolus interleukin-2. JAMA 271, 907-913 (1994).
    • (1994) JAMA , vol.271 , pp. 907-913
    • Rosenberg, S.A.1    Yang, J.C.2    Topalian, S.L.3
  • 88
    • 33645652266 scopus 로고    scopus 로고
    • Chronic low-dose sc interleukin-2 (IL-2) and α-Interferon (α-IFN) in advanced renal cell carcinoma (ARCC): Preliminary efficacy results of an Italian Oncology Group for Clinical Research (GOIRC) trial
    • IL, USA, October
    • Porta C, Passalacqua R, Caminiti C et al. Chronic low-dose sc. interleukin-2 (IL-2) and α-Interferon (α-IFN) in advanced renal cell carcinoma (ARCC): preliminary efficacy results of an Italian Oncology Group for Clinical Research (GOIRC) trial. 2nd International Kidney Cancer Symposium, IL, USA, October (2001).
    • (2001) 2nd International Kidney Cancer Symposium
    • Porta, C.1    Passalacqua, R.2    Caminiti, C.3
  • 89
    • 33645633457 scopus 로고    scopus 로고
    • Phase III, randomized, multicentre trial of maintenance biotherapy with interleukin-2 (IL-2) and interferon-α (IFN) for metastatic renal cell cancer (RCC)
    • (Abstract 4605)
    • Passalacqua R, Buzio C, Dalla Chiesa M et al. Phase III, randomized, multicentre trial of maintenance biotherapy with interleukin-2 (IL-2) and interferon-α (IFN) for metastatic renal cell cancer (RCC). Proc. Am. Soc. Clin. Oncol. 23, 404s (2005) (Abstract 4605).
    • (2005) Proc. Am. Soc. Clin. Oncol. , vol.23
    • Passalacqua, R.1    Buzio, C.2    Dalla Chiesa, M.3


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