Randomized controlled trial of three regimens of melarsoprol in the treatment of Trypanosoma brucei gambiense trypanosomiasis

Transactions of the Royal Society of Tropical Medicine and Hygiene

Volumn 100, Issue 5, 2006, Pages 437-441

  Pépin, Jacques ^a   Mpia, Bokelo ^b  

^a UNIVERSITÉ DE SHERBROOKE   (Canada)

^b Nioki Hospital   (Congo)

Author keywords

Democratic Republic of Congo; Melarsoprol; Trypanosoma brucei gambiense; Trypanosomiasis

Indexed keywords

ADRENALIN; CHLOROQUINE; CORTICOSTEROID; EFLORNITHINE; HYDROCORTISONE; MELARSOPROL; PENTAMIDINE; PHENOBARBITAL; PREDNISOLONE; TIABENDAZOLE;

ADOLESCENT; ADULT; ARTICLE; BRAIN DISEASE; CEREBROSPINAL FLUID ANALYSIS; CLINICAL TRIAL; CONSCIOUSNESS DISORDER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CONVULSION; DOSE RESPONSE; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG RESPONSE; DRUG SAFETY; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; POLYNEUROPATHY; PROBABILITY; RANDOMIZED CONTROLLED TRIAL; SKIN MANIFESTATION; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; STRONGYLOIDIASIS; TRYPANOSOMA; TRYPANOSOMIASIS;

ADOLESCENT; ADULT; ANIMALS; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; LEUKOCYTE COUNT; LYMPH NODES; MALE; MELARSOPROL; PROPORTIONAL HAZARDS MODELS; RECURRENCE; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI GAMBIENSE; TRYPANOSOMIASIS, AFRICAN;

TRYPANOSOMA; TRYPANOSOMA BRUCEI GAMBIENSE;

EID: 33644837623     PISSN: 00359203     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trstmh.2005.03.017     Document Type: Article

References (18)

1. F.I.C. Apted Treatment of human trypanosomiasis H.W. Mulligan W.H. Potts The African Trypanosomiases 1970 George Allen and Unwin London 684-710
2. J. Blum C. Burri Treatment of late-stage sleeping sickness caused by T. b. gambiense: A new approach to the use of an old drug Swiss Med. Wkly 132 2002 51-56
3. J. Burke La Trypanosomiase Humaine Africaine Fonds Médical Tropical, Bruxelles 2000 34
4. C. Burri T. Baltz C. Giroud F. Doua H.A. Welker R. Brun Pharmacokinetic properties of the trypanocidal drug melarsoprol Chemotherapy 39 1993 225-234
5. C. Burri S. Nkunku A. Merolle T. Smith J. Blum R. Brun Efficacy of a new, concise, schedule for melarsoprol in treatment of sleeping sickness caused by Trypanosoma brucei gambiense: A randomised trial Lancet 355 2000 1419-1425
6. E.A.H. Friedheim Mel B in the treatment of human trypanosomiasis Am. J. Trop. Med. Hyg. 28 1949 173-180
7. E.A.H. Friedheim Mel B in the treatment of tryparsamide resistant T. gambiense sleeping sickness: Observations on drug resistance in the trypanosomes of the French Cameroon Am. J. Trop. Med. Hyg. 31 1951 218-226
8. C.A. Hunter F.W. Jennings J.H. Adams M. Murray P.G. Kennedy Subcurative chemotherapy and fatal post-treatment reactive encephalopathies in African trypanosomiasis Lancet 339 1992 956-958
9. D. Legros S. Evans F. Maiso J.C.K. Enyaru D. Mbulamberi Risk factors for treatment failure after melarsoprol for Trypanosoma brucei gambiense trypanosomiasis in Uganda Trans. R. Soc. Trop. Med. Hyg. 93 1999 439-442
10. A. Moore M. Richer Re-emergence of epidemic sleeping sickness in southern Sudan Trop. Med. Int. Health 6 2001 342-347
11. G. Olivier D. Legros Trypanosomiase humaine africaine: Historique de la thérapeutique et de ses échecs Trop. Med. Int. Health 6 2001 855-863
12. J. Pépin H. Méda The epidemiology and control of human African trypanosomiasis Adv. Parasitol. 49 2001 71-132
13. J. Pépin F. Milord The treatment of human African trypanosomiasis Adv. Parasitol. 33 1994 1-47
14. J.F. Ruppol J. Burke Follow-up des traitements contre la trypanosomiase expérimentés à Kimpangu, République du Zaire Ann. Soc. Belge Med. Trop. 57 1977 481-494
15. A. Stanghellini T. Josenando The situation of sleeping sickness in Angola: A calamity Trop. Med. Int. Health 6 2001 330-334
16. WHO, 1986. Epidemiology and Control of African Trypanosomiasis. World Health Organization, Geneva, Technical Report Series No. 739.
17. WHO, 1998. Control and Surveillance of African Trypanosomiasis. World Health Organization, Geneva, Technical Report Series No. 881.
18. WHO, 2000. The World Health Report 2000: Health Systems: Improving Performance. World Health Organization, Geneva.