Long-term management of patients with symptoms of gastro-oesophageal reflux disease - A Norwegian randomised prospective study comparing the effects of esomeprazole and ranitidine treatment strategies on health-related quality of life in a general practitioners setting

International Journal of Clinical Practice

Volumn 60, Issue 1, 2006, Pages 15-22

  Hansen, Åage Norman ^a   Bergheim, R ^a   Fagertun, H ^a   Lund, H ^a   Wiklund, I ^b   Moum, B ^c  

^a ASTRAZENECA   (United Kingdom)

^b ASTRAZENECA R AND D   (Sweden)

^c Østfold Central Hospital   (Norway)

Author keywords

Acid suppression; Gastro oesophageal reflux disease; Health related quality of life; Proton pump inhibitor; Symptoms

Indexed keywords

ESOMEPRAZOLE; RANITIDINE; ANTIULCER AGENT; OMEPRAZOLE; PROTON PUMP;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; DRUG DOSE REGIMEN; DRUG EFFICACY; EMOTIONALITY; FEMALE; FOOD INTAKE; GASTROESOPHAGEAL REFLUX; GENERAL PRACTITIONER; HUMAN; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; NORWAY; PATIENT SATISFACTION; PHYSICAL ACTIVITY; PRIORITY JOURNAL; QUALITY OF LIFE; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; SLEEP; SYMPTOM; TREATMENT OUTCOME; ADOLESCENT; AGED; COMPARATIVE STUDY; DRUG ANTAGONISM; GENERAL PRACTICE; MIDDLE AGED; MULTICENTER STUDY; PROSPECTIVE STUDY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTI-ULCER AGENTS; FAMILY PRACTICE; FEMALE; GASTROESOPHAGEAL REFLUX; HUMANS; MALE; MIDDLE AGED; OMEPRAZOLE; PATIENT SATISFACTION; PROSPECTIVE STUDIES; PROTON PUMPS; QUALITY OF LIFE; RANITIDINE; TREATMENT OUTCOME;

EID: 33644833377     PISSN: 13685031     EISSN: 17421241     Source Type: Journal    
DOI: 10.1111/j.1368-5031.2006.00768.x     Document Type: Article

References (25)

1. Spechler SJ. Epidemiology and natural history of gastro- oesophageal reflux disease. Digestion 1992; 51 (Suppl. 1): 24-9.
2. Dent J, Brun J, Fendrick AM et al. on behalf of the Genval Workshop Group. An evidence-based appraisal of reflux disease management - the Genval Workshop Report. Gut 1999; 44 (Suppl. 2): S1-S16.
3. Orlando RC. The pathogenesis of gastroesophageal reflux disease: The relationship between epithelial defense, dysmotility, and acid exposure. Am J Gastroenterol 1997; 92 (Suppl. 4): 3S-5S (Discussion 5S-7S).
4. Lagergren J, Bergstrom R, Lindgren A et al. Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N Engl J Med 1999; 340: 825-31.
5. Revicki DA, Wood M, Maton PN et al. The impact of gastroesophageal reflux disease on health-related quality of life. Am J Med 1998; 104: 252-8.
6. Havelund T, Lind T, Wiklund I et al. Quality of life in patients with heartburn but without esophagitis: Effects of treatment with omeprazole. Am J Gastroenterol 1999; 94: 1782-9.
7. Kulig M, Leodolter A, Vieth M et al. Quality if life in patients with gastroesophageal reflux disease. Qual Life Res 2002; 11: 649, A111.
8. Talley NJ, Fullerton S, Junghard O et al. Quality of life in patients with endoscopy-negative heartburn: Reliability and sensitivity of disease-specific instruments. Am J Gastroenterol 2001; 96: 1998-2004.
9. Lind T, Havelund T, Carlsson R et al. Heartburn without oesophagitis: efficacy of omeprazole therapy and features determining therapeutic response. Scand J Gastroenterol 1997; 32: 974-9.
10. Carlsson R, Dent J, Watts R et al. Gastro-oesophageal reflux disease in primary care: An international study of different treatment strategies with omeprazole. Eur J Gastroenterol Hepatol 1997; 10: 119-24.
11. Smout APJM. Endoscopy-negative acid reflux disease. Aliment Pharmacol Ther 1997; 11 (Suppl. 1): 81-5.
12. Wiklund I, Bardhan KD, Muller-Lissner S et al. Quality of life during acute and intermittent treatment of gastroesophageal reflux disease with omeprazole compared with ranitidine. Results from a multi-center clinical trial. Ital J Gastroenterol Hepatol 1998; 30: 19-27.
13. Tew S, Jamieson GG, Pilowsky I et al. The illness behavior of patients with gastroesophageal reflux disease with and without endoscopic esophagitis. Dis Esophagus 1997; 10: 9-15.
14. Vakil N, Ryden-Bergsten N, Bergenheim K. Systematic review: patient-centred endpoints in economic evaluations of gastro-oesophageal reflux disease. Aliment Pharmacol Ther 2002; 16: 1469-80.
15. Richter JE, Kahrilas PJ, Johanson J et al. Efficacy and safety of esomeprazole compared with omeprazole in GERD patients with erosive esophagitis: A randomized controlled trial. Am J Gastroenterol 2001; 96: 656-65.
16. Kahrilas PJ, Falk GW. Johnson DA et al. Esomeprazole improves healing and symptom resolution as compared with omeprazole in reflux oesophagitis patients: A randomised controlled trial. Aliment Pharmacol Ther 2000; 14: 1249-58.
17. Castell DO, Kahrilas PJ, Richter JE et al. Esomeprazole (40 mg) compared with lansoprazole (30 mg) in the treatment of erosive esophagitis. Am J Gastroenterol 2002; 97: 575-83.
18. Miner PB, Katz PO, Chen Y et al. Esomeprazole 40 mg provides more effective intragastric acid suppression at steady rate than standard doses of other proton pump inhibitors. Gastroenterology 2003; 124 (4 Suppl. 1): A-229.
19. Nexium Prescribing Information.
20. Moum B, Meineche-Schmidt V, Junghard O et al. Esomeprazole 40 mg once daily provides high symptom relief in uninvestigated GERD patients after 4 weeks' treatment. Scand J Gastroenterol 2003; 38 (Suppl. 238): A-P1.
21. Norman Hansen A, Wahlqvist P, Jørgensen E. et al. Six-month management of patients following treatment of gastroesophageal reflux disease symptoms - a Norwegian randomised prospective study comparing the cost and effectiveness of esomeprazole and ranitidine treatment strategies in a general practitioners setting. Int J Clin Pract 2005; 59: 655-64.
22. Wiklund IK, Junghard O, Grace E et al. Quality of life in reflux and dyspepsia patients. Psychometric documentation of a new disease-specific questionnaire (QOLRAD). Eur J Surg Suppl 1998; 583: 41-9.
23. Juniper EF, Guyatt GH, Willan A et al. Determining a minimal important change in a disease-specific quality of life questionnaire. J Clin Epidemiol 1994; 47: 81-7.
24. Talley NJ, Fullerton S, Junghard O et al. Quality of life in patients with endoscopy negative heartburn: Reliability and sensitivity of disease-specific instruments. Am J Gastroenterol 2001; 96: 1998-2004.
25. Talley NJ, Junghard O, Wiklund I. Why do patients with gastroesophageal reflux disease have a poor health-related quality of life (HRQL)? Gastroenterology 2001; 120 (Suppl. 1): A423 (abstract 2158).