Pathologic examination of the axillary sentinel lymph nodes in patients with early-stage breast carcinoma: Current and resolving controversies on the basis of the European Institute of Oncology experience

Virchows Archiv

Volumn 448, Issue 3, 2006, Pages 241-247

  Viale, Giuseppe ^a,b   Mastropasqua, Mauro G ^a   Maiorano, Eugenio ^c   Mazzarol, Giovanni ^a  

^a EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF BARI   (Italy)

Author keywords

Breast carcinoma; Micrometastasis; Sentinel node biopsy

Indexed keywords

MESSENGER RNA; TUMOR MARKER;

BREAST CARCINOMA; CANCER STAGING; CANCER SURVIVAL; CLINICAL PROTOCOL; CONSENSUS; DIAGNOSTIC ACCURACY; EARLY CANCER; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MICROMETASTASIS; MOLECULAR BIOLOGY; PRIORITY JOURNAL; PROGNOSIS; REVIEW; SENTINEL LYMPH NODE BIOPSY; TISSUE SECTION;

ACADEMIES AND INSTITUTES; ADENOCARCINOMA; AXILLA; BREAST NEOPLASMS; EUROPE; FEMALE; HUMANS; LYMPHATIC METASTASIS; PREDICTIVE VALUE OF TESTS; SENTINEL LYMPH NODE BIOPSY;

EID: 33644830410     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00428-005-0103-3     Document Type: Review

References (50)

1. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF (2003) Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A 100:3983-3988
2. Bostick PJ, Chatterjee S, Chi DD, Huynh KT, Giuliano AE, Cote R, Hoon DS (1998) Limitations of specific reverse-transcriptase polymerase chain reaction markers in the detection of metastases in the lymph nodes and blood of breast cancer patients. J Clin Oncol 16:2632-2640
3. Branagan G, Hughes D, Jeffrey M, Crane-Robinson C, Perry PM (2002) Detection of micrometastases in lymph nodes from patients with breast cancer. Br J Surg 89:86-89
4. Carter BA, Jensen RA, Simpson JF, Page DL (2000) Benign transport of breast epithelium into axillary lymph nodes after biopsy. Am J Clin Pathol 113:259-265
5. Chilosi M, Lestani M, Pedron S, Montagna L, Benedetti A, Pizzolo G, Menestrina F (1994) A rapid immunostaining method for frozen sections. Biotech Histochem 69:235-239
6. Chiu A, Hoda SA, Yao DX, Rosen PP (2001) A potential source of false-positive sentinel nodes: immunostain misadventure. Arch Pathol Lab Med 125:1497-1499
7. Cote RJ, Peterson HF, Chaiwun B, Gelber RD, Goldhirsch A, Castiglione-Gertsch M, Gusterson B, Neville AM (1999) Role of immunohistochemical detection of lymph-node metastases in management of breast cancer. International Breast Cancer Study Group. Lancet 354:896-900
8. Cserni G, Amendoeira I, Apostolikas N, Bellocq JP, Bianchi S, Boecker W, Borisch B, Connolly CE, Decker T, Dervan P, Drijkoningen M, Ellis IO, Elston CW, Eusebi V, Faverly D, Heikkila P, Holland R, Kerner H, Kulka J, Jacquemier J, Lacerda M, Martinez-Penuela J, De Miguel C, Peterse JL, Rank F, Regitnig P, Reiner A, Sapino A, Sigal-Zafrani B, Tanous AM, Thorstenson S, Zozaya E, Fejes G, Wells CA (2004) Discrepancies in current practice of pathological evaluation of sentinel lymph nodes in breast cancer. Results of a questionnaire based survey by the European Working Group for Breast Screening Pathology. J Clin Pathol 57:695-701
9. de Widt-Levert L, Tjan-Heijnen V, Bult P, Ruers T, Wobbes T (2003) Stage migration in breast cancer: surgical decisions concerning isolated tumour cells and micro-metastases in the sentinel lymph node. Eur J Surg Oncol 29:216-220
10. den Bakker MA, van Weeszenberg A, de Kanter AY, Beverdam FH, Pritchard C, van der Kwast TH, Menke-Pluymers M (2002) Non-sentinel lymph node involvement in patients with breast cancer and sentinel node micrometastasis; too early to abandon axillary clearance. J Clin Pathol 55:932-935
11. Doglioni C, Dell'Orto P, Zanetti G, Iuzzolino P, Coggi G, Viale G (1990) Cytokeratin-immunoreactive cells of human lymph nodes and spleen in normal and pathological conditions. An immunocytochemical study. Virchows Arch A Pathol Anat Histopathol 416:479-490
12. Dontu G, Abdallah WM, Foley JM, Jackson KW, Clarke MF, Kawamura MJ, Wicha MS (2003) In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev 17:1253-1270
13. Fisher CJ, Hill S, Millis RR (1994) Benign lymph node inclusions mimicking metastatic carcinoma. J Clin Pathol 47:245-247
14. Franke WW, Moll R (1987) Cytoskeletal components of lymphoid organs. I. Synthesis of cytokeratins 8 and 18 and desmin in subpopulations of extrafollicular reticulum cells of human lymph nodes, tonsils, and spleen. Differentiation 36:145-163
15. Gillanders WE, Mikhitarian K, Hebert R, Mauldin PD, Palesch Y, Walters C, Urist MM, Mann GB, Doherty G, Hermann VM, Hill AD, Eremin O, El-Sheemy M, Orr RK, Valle AA, Henderson MA, Dewitty RL, Sugg SL, Frykberg E, Yeh K, Bell RM, Metcalf JS, Elliott BM, Brothers T, Robison J, Mitas M, Cole DJ (2004) Molecular detection of micrometastatic breast cancer in histopathology-negative axillary lymph nodes correlates with traditional predictors of prognosis: an interim analysis of a prospective multi-institutional cohort study. Ann Surg 239:828-840
16. Glinsky GV, Berezovska O, Glinskii AB (2005) Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer. J Clin Invest 115:1503-1521
17. Guenther JM, Hansen NM, DiFronzo LA, Giuliano AE, Collins JC, Grube BL, O'Connell TX (2003) Axillary dissection is not required for all patients with breast cancer and positive sentinel nodes. Arch Surg 138:52-56
18. Hermanek P, Hutter RV, Sobin LH, Wittekind C (1999) International Union Against Cancer. Classification of isolated tumor cells and micrometastasis. Cancer 86:2668-2673
19. Holdsworth PJ, Hopkinson JM, Leveson SH (1988) Benign axillary epithelial lymph node inclusions - a histological pitfall. Histopathology 13:226-228
20. Inokuchi M, Ninomiya I, Tsugawa K, Terada I, Miwa K (2003) Quantitative evaluation of metastases in axillary lymph nodes of breast cancer. Br J Cancer 89:1750-1756
21. Karsten U, Stosiek P (2002) Fast and sensitive immunodetection of carcinoma cells in sentinel nodes. Virchows Arch 440:325-329
22. Kuehn T, Bembenek A, Decker T, Munz DL, Sautter-Bihl ML, Untch M, Wallwiener D, Consensus Committee of the German Society of Senology (2005) A concept for the clinical implementation of sentinel lymph node biopsy in patients with breast carcinoma with special regard to quality assurance. Cancer 103:451-461
23. Lawrence WD, Association of Directors of Anatomic and Surgical Pathology (2001) ADASP recommendations for processing and reporting of lymph node specimens submitted for evaluation of metastatic disease. Virchows Arch 439:601-603
24. Lee AH, Ellis IO, Pinder SE, Elston CW (2000) Pathological assessment of sentinel lymph-node biopsies in patients with breast cancer. Virchows Arch 436:97-101
25. Liang WC, Sickle-Santanello BJ, Nims TA (2001) Is a completion axillary dissection indicated for micrometastases in the sentinel lymph node? Am J Surg 182:365-368
26. Maiorano E, Mazzarol GM, Pruneri G, Mastropasqua MG, Zurrida S, Orvieto E, Viale G (2003) Ectopic breast tissue as a possible cause of false-positive axillary sentinel lymph node biopsies. Am J Surg Pathol 27:513-518
27. Mamounas EP, Brown A, Anderson S, Smith R, Julian T, Miller B, Bear HD, Caldwell CB, Walker AP, Mikkelson WM, Stauffer JS, Robidoux A, Theoret H, Soran A, Fisher B, Wickerham DL, Wolmark N (2005) Sentinel node biopsy after neoadjuvant chemotherapy in breast cancer: results from National Surgical Adjuvant Breast and Bowel Project Protocol B-27. J Clin Oncol 23:2694-2702
28. Manzotti M, Dell'Orto P, Maisonneuve P, Zurrida S, Mazzarol G, Viale G (2001) Reverse transcription-polymerase chain reaction assay for multiple mRNA markers in the detection of breast cancer metastases in sentinel lymph nodes. Int J Cancer 95:307-312
29. Mitas M, Mikhitarian K, Walters C, Baron PL, Elliott BM, Brothers TE, Robison JG, Metcalf JS, Palesch YY, Zhang Z, Gillanders WE, Cole DJ (2001) Quantitative real-time RT-PCR detection of breast cancer micrometastasis using a multigene marker panel. Int J Cancer 93:162-171
30. Nos C, Harding-MacKean C, Freneaux P, Trie A, Falcou MC, Sastre-Garau X, Clough KB (2003) Prediction of tumour involvement in remaining axillary lymph nodes when the sentinel node in a woman with breast cancer contains metastases. Br J Surg 90:1354-1360
31. Ouellette RJ, Richard D, Maicas E (2004) RT-PCR for mammaglobin genes, MGB1 and MGB2, identifies breast cancer micrometastases in sentinel lymph nodes. Am J Clin Pathol 121:637-643
32. Rahusen FD, Torrenga H, van Diest PJ, Pijpers R, van der Wall E, Licht J, Meijer S (2001) Predictive factors for metastatic involvement of nonsentinel nodes in patients with breast cancer. Arch Surg 136:1059-1063
33. Reynolds C, Mick R, Donohue JH, Grant CS, Farley DR, Callans LS, Orel SG, Keeney GL, Lawton TJ, Czerniecki BJ (1999) Sentinel lymph node biopsy with metastasis: can axillary dissection be avoided in some patients with breast cancer? J Clin Oncol 17:1720-1726
34. Ridolfi RL, Rosen PP, Thaler H (1977) Nevus cell aggregates associated with lymph nodes: estimated frequency and clinical significance. Cancer 39:164-171
35. Sachdev U, Murphy K, Derzie A, Jaffer S, Bleiweiss IJ, Brower S (2002) Predictors of nonsentinel lymph node metastasis in breast cancer patients. Am J Surg 183:213-217
36. Schroder CP, Ruiters MH, de Jong S, Tiebosch AT, Wesseling J, Veenstra R, de Vries J, Hoekstra HJ, de Leij LF, de Vries EG (2003) Detection of micrometastatic breast cancer by means of real time quantitative RT-PCR and immunostaining in perioperative blood samples and sentinel nodes. Int J Cancer 106:611-618
37. Schwartz GF, Giuliano AE, Veronesi U, Consensus Conference Committee (2002) Proceedings of the consensus conference on the role of sentinel lymph node biopsy in carcinoma of the breast, April 19-22, 2001, Philadelphia, Pennsylvania. Cancer 94:2542-2551
38. Singletary SE, Greene FL, Sobin LH (2003) Classification of isolated tumour cells: clarification of the 6th edn of the American Joint Committee on Cancer Staging Manual. Cancer 98:2740-2741
39. Tousimis E, Van Zee KJ, Fey JV, Hoque LW, Tan LK, Cody HS 3rd, Borgen PI, Montgomery LL (2003) The accuracy of sentinel lymph node biopsy in mulricentric and multifocal invasive breast cancers. J Am Coll Surg 197:529-535
40. Turner RR, Chu KU, Qi K, Botnick LE, Hansen NM, Glass EC, Giuliano AE (2000) Pathologic features associated with non-sentinel lymph node metastases in patients with metastatic breast carcinoma in a sentinel lymph node. Cancer 89:574-581
41. Veronesi U, Paganelli G, Galimberti V, Viale G, Zurrida S, Bedoni M, Costa A, de Cicco C, Geraghty JG, Luini A, Sacchini V, Veronesi P (1997) Sentinel-node biopsy to avoid axillary dissection in breast cancer with clinically negative lymph-nodes. Lancet 349:1864-1867
42. Veronesi U, Paganelli G, Viale G, Galimberti V, Luini A, Zurrida S, Robertson C, Sacchini V, Veronesi P, Orvieto E, De Cicco C, Intra M, Tosi G, Scarpa D (1999) Sentinel lymph node biopsy and axillary dissection in breast cancer: results in a large series. J Natl Cancer Inst 91:368-373
43. Veronesi U, Paganelli G, Viale G, Luini A, Zurrida S, Galimberti V, Intra M, Veronesi P, Robertson C, Maisonneuve P, Renne G, De Cicco C, De Lucia F, Gennari R (2003) A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancer. N Engl J Med 349:546-553
44. Veronesi U, Galimberti V, Mariani L, Gatti G, Paganelli G, Viale G, Zurrida S, Veronesi P, Intra M, Gennari R, Rita Vento A, Luini A, Tullii M, Bassani G, Rotmensz N (2005) Sentinel node biopsy in breast cancer: early results in 953 patients with negative sentinel node biopsy and no axillary dissection. Eur J Cancer 41:231-237
45. Viale G, Bosari S, Mazzarol G, Galimberti V, Luini A, Veronesi P, Paganelli G, Bedoni M, Orvieto E (1999) Intraoperative examination of axillary sentinel lymph nodes in breast carcinoma patients. Cancer 85:2433-2438
46. Viale G, Maiorano E, Mazzarol G, Zurrida S, Galimberti V, Luini A, Renne G, Pruneri G, Maisonneuve P, Veronesi U (2001) Histologic detection and clinical implications of micrometastases in axillary sentinel lymph nodes for patients with breast carcinoma. Cancer 92:1378-1384
47. Viale G, Maiorano E, Pruneri G, Mastropasqua MG, Valentini S, Galimberti V, Zurrida S, Maisonneuve P, Paganelli G, Mazzarol G (2005) Predicting the risk for additional axillary metastases in patients with breast carcinoma and positive sentinel lymph node biopsy. Ann Surg 241:319-325
48. Weigelt B, Verduijn P, Bosma AJ, Rutgers EJ, Peterse HL, van't Veer LJ (2004) Detection of metastases in sentinel lymph nodes of breast cancer patients by multiple mRNA markers. Br J Cancer 90:1531-1537
49. Wong SL, Edwards MJ, Chao C, Tuttle TM, Noyes RD, Woo C, Cerrito PB, McMasters KM, University of Louisville Breast Cancer Sentinel Lymph Node Study Group (2001) Predicting the status of the nonsentinel axillary nodes: a multicenter study. Arch Surg 136:563-568
50. Zurrida S, Orecchia R, Galimberti V, Luini A, Giannetti I, Ballardini B, Amadori A, Veronesi G, Veronesi U (2002) Axillary radiotherapy instead of axillary dissection: a randomized trial. Italian Oncological Senology Group. Ann Surg Oncol 9:156-160