Studies on the stability of the chloramphenicol in the microemulsion free of alcohols

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 62, Issue 3, 2006, Pages 288-294

  Lv, Feng Feng ^a,b   Li, Na ^a   Zheng, Li Qiang ^a   Tung, Chen Ho ^b  

^a SHANDONG UNIVERSITY   (China)

^b TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY   (China)

Author keywords

1H NMR; Chloramphenicol eye drops; DLS; HPLC; Microemulsion; Non ionic surfactants; Phase behavior; Stability

Indexed keywords

ALCOHOL; CHLORAMPHENICOL; EYE DROPS; POLYSORBATE 20; SORBITAN LAURATE;

ARTICLE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG STABILITY; DRUG STRUCTURE; ELECTRIC CONDUCTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILICITY; LIGHT SCATTERING; MICROEMULSION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHASE TRANSITION;

ALCOHOLS; CHEMISTRY, PHARMACEUTICAL; CHLORAMPHENICOL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; ELECTRIC CONDUCTIVITY; EMULSIONS; EXCIPIENTS; LIGHT; MAGNETIC RESONANCE SPECTROSCOPY; OPHTHALMIC SOLUTIONS; SCATTERING, RADIATION;

EID: 33644825932     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2005.09.006     Document Type: Article

References (21)

1. K. Jarvinen, T. Jarvinen, and A. Urtti Ocular absorption following topical delivery Adv. Drug Deliv. Rev. 16 1 1995 3 19
2. The Pharmacopoeia Committee of State, Pharmacopoeia of People's Republic of China, Chemical Industry Press, Beijing, 2000, pp. 931.
3. H.F. Eicke, W. Meier, and H. Hammerich On electric conductivity of infinite clusters in water-in-oil microemulsions Langmuir 10 7 1994 2223 2227
4. M. Gradzielski, and H. Hoffmann Influence of charges on structure and dynamics of an O/W microemulsion. Effect of admixing ionic surfactants J. Phys. Chem. 98 10 1994 2613 2623
5. Th.F. Vandamme Microemulsions as ocular drug delivery systems: recent developments and future challenges Prog. Retin. Eye Res. 21 1 2002 15 24
6. E. Peira, P. Scolari, and M.R. Gasco Transdermal permeation of apomorphine through hairless mouse skin from microemulsions Int. J. Pharm. 226 1/2 2001 47 51
7. M. Trotta, E. Ughzio, E. Peira, and C. Pulitano Influence of ion pairing on topical delivery of retinoic acid from microemulsions J. Controlled Release 86 2/3 2003 315 321
8. M. Kreilgaard, E.J. Pedersen, and J.W. Jaroszewski NMR characterization and transdermal drug delivery potential of microemulsion systems J. Controlled Release 69 3 2000 421 433
9. O. Soderman, and M. Nyden NMR in microemulsions. NMR translational diffusion studies of a model microemulsion Colloids Surf. A Physicochem. Eng. Asp. 158 1/2 1999 273 280
10. B. Baroli, M.A. López-Quintela, M.B. Delgado-Charro, A.M. Fadda, and J. Blanco-Mendez Microemulsiona for topical delivery of 8-methosalen J. Controlled Release 69 2000 209 218
11. J.M. Sarciaux, L. Acar, and P.A. Sado Using microemulsion formulations for oral drug delivery of therapeutic peptides Int. J. Pharm. 120 2 1995 127 136
12. S.K. Mehta, and K. Bala Tween-based microemulsions: a percolation view Fluid Phase Equilib. 172 2 2000 197 209
13. L.Q. Zheng, H. Minamikawa, K. Harada, and T. Inoue Effect of inorganic salts on the phase behavior of an aqueous mixture of heptaethylene glycol dodecyl ether Langmuir 19 25 2003 10487 10494
14. G.S. Grest, I. Webman, and S.A. Safran Dynamic percolation in microemulsions Phys. Rev. A 33 4 1986 2842 2845
15. Q.Y. Xing, and R.Q. Xu Basic Organic Chemistry 1993 Higher Education Press Beijing p. 346
16. L. Qi, J. Ma, H. Cheng, and Z. Zhao Preparation of BaSO4 nanoparticles in non-ionic w/o microemulsions Colloids Surf., A 108 1996 117 126
17. S.L. Nolan, R.J. Philips, P.M. Cotts, and S.R. Dungan Light scattering study on the effect of polymer composition on the structural properties of PEO-PPO-PEO micelles J. Colloid Interf. Sci. 191 1997 291 302
18. S. Benita, and M.Y. Levy Submicron emulsions as colloidal drug carriers for intravenous administration: comprehensive physicochemical characterization J. Pharm. Sci. 82 1993 1069
19. S.H. Klang, J. Frucht-Prey, A. Hoffman, and S. Benita Physicochemical characterization and acute toxicity evaluation of a positively charged submicron emulsion vehicle J. Pharm. Pharmacol. 46 1994 986 993
20. I. Siebenbrodt, and S. Keipert Poloxamer-systems as potential ophthalmic microemulsions Eur. J. Pharm. Biopharm. 39 1993 25 30
21. A. Hasse, and S. Keipert Development and characterization of microemulsions for ocular application Eur. J. Pharm. Biopharm. 43 1997 179 183