Intraclonal variability of VH genes in follicular lymphoma patients who have received anti-idiotypic immunotherapy

Journal of Immunotherapy

Volumn 29, Issue 1, 2006, Pages 61-66

  Yáñez, Rosa ^a   Barrios, Yvelise ^a   Cabrera, Rafael ^a   Díaz Espada, Fernando ^a  

^a HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

Author keywords

Idiotypes; Lymphoma; Non Hodgkin lymphoma immunotherapy; Subclones; Tumour vaccines

Indexed keywords

COMPLEMENTARY DNA; GAMMA INTERFERON; IDIOTYPIC ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN M; RNA; THYMIDINE; TRITIUM; TUMOR VACCINE; ANTIIDIOTYPIC ANTIBODY; CANCER VACCINE; IMMUNOGLOBULIN IDIOTYPE;

ADULT; ARTICLE; AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION; B CELL LYMPHOMA; CANCER IMMUNOTHERAPY; CLINICAL ARTICLE; CYTOKINE PRODUCTION; DNA SEQUENCE; ENZYME LINKED IMMUNOSORBENT ASSAY; FOLLICULAR LYMPHOMA; GENE REARRANGEMENT; HUMAN; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; MALE; NONHODGKIN LYMPHOMA; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TREATMENT OUTCOME; DRUG EFFECT; GENETICS; IMMUNOLOGY; IMMUNOTHERAPY; MIDDLE AGED; MOLECULAR GENETICS;

ADULT; ANTIBODIES, ANTI-IDIOTYPIC; BASE SEQUENCE; CANCER VACCINES; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN IDIOTYPES; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOTHERAPY; LYMPHOMA, FOLLICULAR; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION;

EID: 33644824054     PISSN: 15249557     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.cji.0000182270.66506.e1     Document Type: Article

References (19)

1. Stevenson GT, Elliot EV, Stevenson FK. Idiotypic determinants on the surface immunoglobulin of neoplastic lymphocytes: a therapeutic target. Fed Proc. 1977;36:2268-2271.
2. Bahler DW, Campbell MJ, Hart S, et al. Ig V(H) gene expression among human follicular lymphomas. Blood. 1991;78:1561-1568.
3. Noppe SM, Heirman C, Bakkus MHC, et al. The genetic variability of the VH genes in follicular lymphoma: the impact of the hypermutation mechanism. Br J Haematol. 1999;107:625-640.
4. MacLennan IC. Germinal centers. Annu Rev Immunol. 1994;12:117-139.
5. Kwak LW, Campbell MJ, Czerwinski DK, et al. Induction of immune responses in patients with B-cell lymphoma against the surface-immunoglobulin idiotype expressed by their tumors. N Engl J Med. 1992;327:1209-1215.
6. Bendandi M, Gocke CD, Kobrin CB, et al. Complete molecular remissions induced by patient-specific vaccination plus granulocyte-monocyte colony-stimulating factor against lymphoma. Nat Med. 1999;5:1171-1177.
7. Barrios Y, Cabrera R, Yáñez R, et al. Anti-idiotypic vaccination in the treatment of low-grade B-cell lymphoma. Haematologica. 2002;87:400-407.
8. Hawkins RE, Zhu D, Ovecka M, et al. Idiotypic vaccination against B-cell lymphoma. Rescue of variable region gene sequences from biopsy material for assembly as single-chain Fv personal vaccines. Blood. 1994;83:3279-3288.
9. Jacob J, Kelsoe G, Rajewsky K, et al. Intraclonal generation of antibody mutants in germinal centres. Nature. 1991;354:389-392.
10. Cook GP, Tomlinson IM. The human immunoglobulin VH repertoire. Immunol Today. 1995;16:237-242.
11. Wilson PC, de Bouteiller O, Liu YJ, et al. Somatic hypermutation introduces insertions and deletions into immunoglobulin Ig genes. J Exp Med. 1998;187:59-70.
12. Kobrin CB, Bendandi M, Kwak LW. Novel secondary Ig VH gene rearrangement and in-frame Ig heavy chain complementarity-determining region III insertion/deletion variants in de novo follicular lymphoma. J Immunol. 2001;166:2235-2243.
13. Lesk AM, Chothia C. Evolution of proteins formed by β-sheets. II. The core of the immunoglobulin domains. J Mol Biol. 1982;60:325-342.
14. Sklar J, Cleary ML, Thielemans K, et al. Biclonal B-cell lymphomas. N Engl J Med. 1984;311:20-27.
15. Barrios Y, Plaza A, Cabrera R, et al. Active idiotypic vaccination in a patient with biclonal follicular lymphoma. Cancer Immunol Immunother. 2001;50:87-92.
16. Ottensmeier CH, Thompsett AR, Zhu D, et al. Analysis of VH genes in follicular and diffuse lymphoma shows ongoing somatic mutation and multiple isotype transcripts in early disease with changes during disease progression. Blood. 1998;91:4292-4299.
17. Aarts WM, Bende RJ, Bossenbroek JG, et al. Variable heavy-chain gene analysis of follicular lymphomas: subclone selection rather than clonal evolution over time. Blood. 2001;98:238-240.
18. Trojan A, Schultze JL, Witzens M, et al. Immunoglobulin framework-derived peptides function as cytotoxic T-cell epitopes commonly expressed in B-cell malignancies. Nat Med. 2000;6:667-672.
19. Baskar S, Kobrin CB, Kwak LW. Autologous lymphoma vaccines induce human T cell responses against multiple, unique epitopes. J Clin Invest. 2004;113:1498-1510.