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Volumn 23, Issue 36, 2005, Pages 9048-9050

The epothilone dilemma

Author keywords

[No Author keywords available]

Indexed keywords

BMS 310705; EPOTHILONE B; EPOTHILONE D; EPOTHILONE DERIVATIVE; HISTAMINE H1 RECEPTOR ANTAGONIST; HISTAMINE H2 RECEPTOR ANTAGONIST; IXABEPILONE; PACLITAXEL; RICINOMACROGOL; TAXANE DERIVATIVE; UNCLASSIFIED DRUG; ZK EPO;

EID: 33644820927     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2005.03.8844     Document Type: Editorial
Times cited : (32)

References (29)
  • 1
    • 3042701597 scopus 로고    scopus 로고
    • Epothilones: Mechanism of action and biologic activity
    • Goodin S, Kane MP, Ruben MH: Epothilones: Mechanism of action and biologic activity. J Clin Oncol 22:2015-2025, 2004
    • (2004) J Clin Oncol , vol.22 , pp. 2015-2025
    • Goodin, S.1    Kane, M.P.2    Ruben, M.H.3
  • 2
    • 3142704182 scopus 로고    scopus 로고
    • The clinical development of new mitotic inhibitors that stabilize the microtubule
    • Mani S, Macapinlac M Jr, Goel S, et al: The clinical development of new mitotic inhibitors that stabilize the microtubule. Anticancer Drugs 15:553-558, 2004
    • (2004) Anticancer Drugs , vol.15 , pp. 553-558
    • Mani, S.1    Macapinlac Jr, M.2    Goel, S.3
  • 3
    • 36048991918 scopus 로고    scopus 로고
    • Phase I/II dose escalation trial of patupilone every 3 weeks in patients with non-small cell lung cancer
    • abstr 7110, suppl
    • Østerlind K, Sánchez JM, Zatloukal P, et al: Phase I/II dose escalation trial of patupilone every 3 weeks in patients with non-small cell lung cancer. J Clin Oncol 23:647, 2005 (abstr 7110, suppl)
    • (2005) J Clin Oncol , vol.23 , pp. 647
    • Østerlind, K.1    Sánchez, J.M.2    Zatloukal, P.3
  • 4
    • 33847036638 scopus 로고    scopus 로고
    • Phase I dose optimization trial of patupilone in previously treated patients (pts) with advanced colon cancer (ACC)
    • abstr 3688, suppl
    • Melichar B, Tabernero J, Casado E, et al: Phase I dose optimization trial of patupilone in previously treated patients (pts) with advanced colon cancer (ACC). J Clin Oncol 23:292, 2005 (abstr 3688, suppl)
    • (2005) J Clin Oncol , vol.23 , pp. 292
    • Melichar, B.1    Tabernero, J.2    Casado, E.3
  • 5
    • 33745245860 scopus 로고    scopus 로고
    • Phase I/II dose-escalation trial of patupilone every 3 weeks in patients with relapsed/refractory ovarian cancer
    • abstr 5056, suppl
    • Smit WM, SufliarskyJ, Spanik S, et al: Phase I/II dose-escalation trial of patupilone every 3 weeks in patients with relapsed/refractory ovarian cancer. J Clin Oncol 23:468, 2005 (abstr 5056, suppl)
    • (2005) J Clin Oncol , vol.23 , pp. 468
    • Smit, W.M.1    Sufliarsky, J.2    Spanik, S.3
  • 6
    • 33644831567 scopus 로고    scopus 로고
    • Phase I, dose-finding study of weekly single-agent patupilone in patients with advanced solid tumors
    • Rubin EH, Rothermel J, Tesfaye F, et al: Phase I, dose-finding study of weekly single-agent patupilone in patients with advanced solid tumors. J Clin Oncol 23:9120-9129, 2005
    • (2005) J Clin Oncol , vol.23 , pp. 9120-9129
    • Rubin, E.H.1    Rothermel, J.2    Tesfaye, F.3
  • 7
    • 12144285977 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of BMS-247550, a novel derivative of epothilone B, in solid tumors
    • Mani S, McDaid H, Hamilton A, et al: Phase I clinical and pharmacokinetic study of BMS-247550, a novel derivative of epothilone B, in solid tumors. Clin Cancer Res 10:1289-1298, 2004
    • (2004) Clin Cancer Res , vol.10 , pp. 1289-1298
    • Mani, S.1    McDaid, H.2    Hamilton, A.3
  • 8
    • 23244452107 scopus 로고    scopus 로고
    • Continuous weekly administration of the epothilone-B derivative, BMS247550 (NSC710428): A phase I and pharmacokinetic (PK) study
    • abstr 411
    • Hao D, Hammond LA, deBono JS, et al: Continuous weekly administration of the epothilone-B derivative, BMS247550 (NSC710428): A phase I and pharmacokinetic (PK) study. Proc Am Soc Clin Oncol 21:103a, 2002 (abstr 411)
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Hao, D.1    Hammond, L.A.2    deBono, J.S.3
  • 9
    • 3442898528 scopus 로고    scopus 로고
    • A phase II trial of the epothilone B analog, BMS-247550, in patients with previously treated advanced colorectal cancer
    • Eng C, Kindler HL, Nattam S, et al: A phase II trial of the epothilone B analog, BMS-247550, in patients with previously treated advanced colorectal cancer. Ann Oncol 15:928-932, 2004
    • (2004) Ann Oncol , vol.15 , pp. 928-932
    • Eng, C.1    Kindler, H.L.2    Nattam, S.3
  • 10
    • 20144377696 scopus 로고    scopus 로고
    • Multi-institutional randomized phase II trial of the epothilone B analog ixabepilone (BMS-247550) with or without estramustine phosphate in patients with progressive castrate metastatic prostate cancer
    • Galsky MD, Small EJ, Oh WK, et al: Multi-institutional randomized phase II trial of the epothilone B analog ixabepilone (BMS-247550) with or without estramustine phosphate in patients with progressive castrate metastatic prostate cancer. J Clin Oncol 23:1439-1446, 2005
    • (2005) J Clin Oncol , vol.23 , pp. 1439-1446
    • Galsky, M.D.1    Small, E.J.2    Oh, W.K.3
  • 11
    • 21144441199 scopus 로고    scopus 로고
    • Evaluation of epothilone B analog in advanced soft tissue sarcoma: A phase II study of the phase II consortium
    • Okuno S, Maples WJ, Mahoney MR, et al: Evaluation of epothilone B analog in advanced soft tissue sarcoma: A phase II study of the phase II consortium. J Clin Oncol 23:3069-3073, 2005
    • (2005) J Clin Oncol , vol.23 , pp. 3069-3073
    • Okuno, S.1    Maples, W.J.2    Mahoney, M.R.3
  • 12
    • 0041703019 scopus 로고    scopus 로고
    • Pharmacological effects of formulation vehicles: Implications for cancer chemotherapy
    • ten Tije AJ, Verweij J, Loos W, et al: Pharmacological effects of formulation vehicles: Implications for cancer chemotherapy. Clin Pharmacokinet 42:665-685, 2003
    • (2003) Clin Pharmacokinet , vol.42 , pp. 665-685
    • ten Tije, A.J.1    Verweij, J.2    Loos, W.3
  • 13
    • 0038811741 scopus 로고    scopus 로고
    • Phase I trial and pharmacokinetic study of BMS-247550, an epothilone B analog, administered intravenously on a daily schedule for five days
    • Abraham J, Agrawal M, Bakke S, et al: Phase I trial and pharmacokinetic study of BMS-247550, an epothilone B analog, administered intravenously on a daily schedule for five days. J Clin Oncol 21:1866-1873, 2003
    • (2003) J Clin Oncol , vol.21 , pp. 1866-1873
    • Abraham, J.1    Agrawal, M.2    Bakke, S.3
  • 14
    • 20244376916 scopus 로고    scopus 로고
    • A phase I clinical trial of ixabepilone (BMS-247550), an epothilone B analog, administered intravenously on a daily schedule for 3 days
    • Zhuang SH, Agrawal M, Edgerly M, et al: A phase I clinical trial of ixabepilone (BMS-247550), an epothilone B analog, administered intravenously on a daily schedule for 3 days. Cancer 103:1932-1938, 2005
    • (2005) Cancer , vol.103 , pp. 1932-1938
    • Zhuang, S.H.1    Agrawal, M.2    Edgerly, M.3
  • 15
    • 31344455354 scopus 로고    scopus 로고
    • A phase II study of KOS-862 (epothilone D) as second-line therapy in non-small cell lung cancer
    • abstr 7127, suppl
    • Yee L, Lynch T, Villalona-Calero M, et al: A phase II study of KOS-862 (epothilone D) as second-line therapy in non-small cell lung cancer. J Clin Oncol 23:652, 2005 (abstr 7127, suppl)
    • (2005) J Clin Oncol , vol.23 , pp. 652
    • Yee, L.1    Lynch, T.2    Villalona-Calero, M.3
  • 16
    • 2442505920 scopus 로고    scopus 로고
    • KOS-862 (epothilone D): A comparison of two schedules in patients with advanced malignancies
    • abstr 539
    • Piro LD, Rosen LS, Parson M, et al: KOS-862 (epothilone D): A comparison of two schedules in patients with advanced malignancies. Proc Am Soc Clin Oncol 22:135, 2003 (abstr 539)
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 135
    • Piro, L.D.1    Rosen, L.S.2    Parson, M.3
  • 17
    • 0347325036 scopus 로고    scopus 로고
    • Phase I trial of novel epothilone B analog BMS-310705 IV q 21 days
    • abstr 515
    • Mekhail T, Chung C, Holden S, et al: Phase I trial of novel epothilone B analog BMS-310705 IV q 21 days. Proc Am Soc Clin Oncol 22:129, 2003 (abstr 515)
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 129
    • Mekhail, T.1    Chung, C.2    Holden, S.3
  • 18
    • 21244499905 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic (PK) study of the novel epothilone BMS-310705 in patients (pts) with advanced solid cancer
    • abstr 519
    • Sessa C, Perotti A, Malossi A, et al: Phase I and pharmacokinetic (PK) study of the novel epothilone BMS-310705 in patients (pts) with advanced solid cancer. Proc Am Soc Clin Oncol 22:130, 2003 (abstr 519)
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 130
    • Sessa, C.1    Perotti, A.2    Malossi, A.3
  • 19
    • 33646547391 scopus 로고    scopus 로고
    • A phase I study of the novel, third generation epothilone ZK-EPO in patients with advanced solid tumors
    • abstr 2051, suppl
    • Schmid P, Kiewe P, Kuehnhardt D, et al: A phase I study of the novel, third generation epothilone ZK-EPO in patients with advanced solid tumors. J Clin Oncol 23:147, 2005 (abstr 2051, suppl)
    • (2005) J Clin Oncol , vol.23 , pp. 147
    • Schmid, P.1    Kiewe, P.2    Kuehnhardt, D.3
  • 20
    • 0037132703 scopus 로고    scopus 로고
    • Role of body surface area in dosing of investigational anticancer agents in adults, 1991-2001
    • Baker SD, Verweij J, Rowinsky EK, et al: Role of body surface area in dosing of investigational anticancer agents in adults, 1991-2001. J Natl Cancer Inst 94:1883-1888, 2002
    • (2002) J Natl Cancer Inst , vol.94 , pp. 1883-1888
    • Baker, S.D.1    Verweij, J.2    Rowinsky, E.K.3
  • 21
    • 54349088260 scopus 로고    scopus 로고
    • A phase IIa trial of weekly EP0906 in patients with hormone-refractory prostate cancer (HPRC)
    • abstr 4563, suppl, 397s
    • Hussain A, Dipaola RS, Baron AD, et al: A phase IIa trial of weekly EP0906 in patients with hormone-refractory prostate cancer (HPRC). J Clin Oncol 22:397s, 2004 (abstr 4563, suppl)
    • (2004) J Clin Oncol , vol.22
    • Hussain, A.1    Dipaola, R.S.2    Baron, A.D.3
  • 22
    • 21044441003 scopus 로고    scopus 로고
    • Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in metastatic and locally advanced breast cancer
    • Low JA, Wedam SB, Lee JJ, et al: Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in metastatic and locally advanced breast cancer. J Clin Oncol 23:2726-2734, 2005
    • (2005) J Clin Oncol , vol.23 , pp. 2726-2734
    • Low, J.A.1    Wedam, S.B.2    Lee, J.J.3
  • 23
    • 0003339029 scopus 로고    scopus 로고
    • Phase II study of the novel epothilone BMS-247550 in patients (pts) with metastatic gastric adenocarcinoma previously treated with a taxane
    • abstr 619
    • Ajani JA, Shah MA, Bokemeyer C, et al: Phase II study of the novel epothilone BMS-247550 in patients (pts) with metastatic gastric adenocarcinoma previously treated with a taxane. Proc Am Soc Clin Oncol 21:155a, 2002 (abstr 619)
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Ajani, J.A.1    Shah, M.A.2    Bokemeyer, C.3
  • 24
    • 0043005788 scopus 로고    scopus 로고
    • A randomized phase II study of epothilone analog BMS-247550 in patients (pts) with non-small cell lung cancer (NSCLC) who have failed first-line platinum-based chemotherapy
    • abstr 2519
    • Vansteenkiste JF, Breton JL, Sandler A, et al: A randomized phase II study of epothilone analog BMS-247550 in patients (pts) with non-small cell lung cancer (NSCLC) who have failed first-line platinum-based chemotherapy. Proc Am Soc Clin Oncol 22:626, 2003 (abstr 2519)
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 626
    • Vansteenkiste, J.F.1    Breton, J.L.2    Sandler, A.3
  • 25
    • 0041503044 scopus 로고    scopus 로고
    • A phase II study of epothilone analog BMS-247550 in patients (pts) with metastatic breast cancer (MBC) previously treated with an anthracycline
    • abstr 69
    • Roche HH, Cure H, Bunnell C, et al: A phase II study of epothilone analog BMS-247550 in patients (pts) with metastatic breast cancer (MBC) previously treated with an anthracycline. Proc Am Soc Clin Oncol 22:18, 2003 (abstr 69)
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 18
    • Roche, H.H.1    Cure, H.2    Bunnell, C.3
  • 26
    • 0347325038 scopus 로고    scopus 로고
    • Safety and efficacy of EPO906 in patients with advanced colorectal cancer: A review of 2 phase II trials
    • abstr 1135
    • Poplin E, Moore M, O'Dwyer P, et al: Safety and efficacy of EPO906 in patients with advanced colorectal cancer: A review of 2 phase II trials. Proc Am Soc Clin Oncol 22:283, 2003 (abstr 1135)
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 283
    • Poplin, E.1    Moore, M.2    O'Dwyer, P.3
  • 27
    • 0347336851 scopus 로고    scopus 로고
    • Phase II trial evaluating the safety and efficacy of EPO906 in patients with advanced renal cancer
    • abstr 1628
    • Thompson JA, Swerdloff J, Escudier B, et al: Phase II trial evaluating the safety and efficacy of EPO906 in patients with advanced renal cancer. Proc Am Soc Clin Oncol 22:405, 2003 (abstr 1628)
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 405
    • Thompson, J.A.1    Swerdloff, J.2    Escudier, B.3
  • 28
    • 13844302107 scopus 로고    scopus 로고
    • A phase II clinical trial of BMS-247550 (ixabepilone), a microtubule-stabilizing agent in renal cell cancer
    • abstr 4550, suppl
    • Zhuang SH, Menefee M, Kotz H, et al: A phase II clinical trial of BMS-247550 (ixabepilone), a microtubule-stabilizing agent in renal cell cancer. J Clin Oncol 22:394a, 2004 (abstr 4550, suppl)
    • (2004) J Clin Oncol , vol.22
    • Zhuang, S.H.1    Menefee, M.2    Kotz, H.3
  • 29
    • 33644975420 scopus 로고    scopus 로고
    • A phase II study of epothilone B analog (EpoB)-BMS 2477550 (NSC#710428) in stage IV malignant melanoma (MM)
    • abstr 7542, suppl, 720s
    • Pavlick AC, Millward M, Farrel K, et al: A phase II study of epothilone B analog (EpoB)-BMS 2477550 (NSC#710428) in stage IV malignant melanoma (MM). J Clin Oncol 22:720s, 2004 (abstr 7542, suppl)
    • (2004) J Clin Oncol , vol.22
    • Pavlick, A.C.1    Millward, M.2    Farrel, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.