Vitamin C supplementation could reverse diabetes-induced endothelial cell dysfunction in mesenteric microcirculation in STZ-rats

Clinical Hemorheology and Microcirculation

Volumn 34, Issue 1-2, 2006, Pages 315-321

  Sridulyakul, Pattrin ^a   Chakraphan, Daroonwan ^a   Patumraj, Suthiluk ^a  

^a CHULALONGKORN UNIVERSITY   (Thailand)

Author keywords

Diabetes; Endothelial dysfunction; Leukocyte adhesion; Vasodilation; Vitamin C

Indexed keywords

ASCORBIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; GLUCOSE BLOOD LEVEL; GLYCOSYLATION; LEUKOCYTE ADHERENCE; MALE; MICROCIRCULATION; NONHUMAN; RAT; STREPTOZOCIN DIABETES;

ANIMALS; ASCORBIC ACID; CELL ADHESION; DIABETES MELLITUS, EXPERIMENTAL; DIETARY SUPPLEMENTS; ENDOTHELIAL CELLS; LEUKOCYTES; MALE; MICROCIRCULATION; MICROSCOPY, VIDEO; RATS; RATS, SPRAGUE-DAWLEY; SPLANCHNIC CIRCULATION; STREPTOZOCIN; VASODILATION;

EID: 33644814979     PISSN: 13860291     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (11)

1. T. Nishikawa, D. Edelstein, X.L. Du, S. Yamagishi, T. Matsumura, Y. Kaneda, M.A. Yorek, D. Beebe, P.J. Oates, H.P. Hammes, I. Giardino and M. Brownlee, Normalizing mitochondrial superoxide production blocks three pathways of hyperglycemic damage, Nature 404 (2000), 787-790.
2. M. Brownlee, Biochemistry and molecular cell biology of diabetic complications, Nature 414 (2001), 813-820.
3. X.L. Du, D. Edelstein, L. Rossetti, I.G. Fantus, H. Goldberg, F. Ziyadeh, J. Wu and M. Brownlee, Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp 1 glycosylation, PNAS 97 (2000), 12222-12226.
4. A. Jariyapongskul, S. Patumraj, Yamaguchi and H. Niimi, The effect of long-term supplementation of vitamin C on leukocyte adhesion to the cerebral endothelium in STZ-induced diabetic rats. Clin. Hemorheol. Microcirc. 27 (2002), 67-76.
5. A.S. De Vriese, T.J. Verbeuren, J. Van de Voorde, N.H. Lameire and P.M. Vanhoutte, Endothelial dysfunction in diabetes, Br. J. Pharmacol. 130 (2000), 963-974.
6. M. Fukao, Y. Hattaori, M. Kanno, I. Sakuma and A. Kitabatake, Alterations in endothelium-dependent hyperpolarization and relaxation in mesenteric arteries from streptozotocin-induced diabetic rats, Br. J. Pharmacol. 121 (1997), 1383-1391.
7. A. Jariyapongskul, S. Patumraj, Yamaguchi and H. Niimi, Cerebral endothelial dysfunction in diabetes: intravital microscopic analysis using streptozotocin-induced diabetic rats, Clin. Hemorheol. Microcirc. 29 (2003), 331-335.
8. C.K. Sen and L. Packer, Antioxidant and redox regulation of gene transcripton, FASEB J. 10 (1996), 709-720.
9. A. Kashiwagi, Complications of diabetes mellitus and oxidative stress, JAMA 44 (2001). 521-528.
10. D. Benz, P. Cadet, K. Mantione, W. Zhu and G. Stefano, Total nitric oxide and health: a free radical and scavenger of free radicals, Med. Sci. Monit. 8 (2002), RA1-RA4.
11. C.J. Meininger, R.S. Marinos, K. Hatakeyama, R. Martinez-Zaguilan, J.D. Rojas, K.A. Kelly and G. Wu, Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiency, Biochem. J. 349 (2000), 353-356.