Metastatic colorectal cancer: Is there one standard approach?

ONCOLOGY

Volumn 19, Issue 9, 2005, Pages 1147-1154

  Saltz, Leonard B ^a,b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BEVACIZUMAB; CETUXIMAB; CYCLOOXYGENASE 2 INHIBITOR; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; OXALIPLATIN; PLACEBO; TRASTUZUMAB; VASCULOTROPIN; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; DRUG DERIVATIVE; EPIDERMAL GROWTH FACTOR RECEPTOR; FOLFOX PROTOCOL; MONOCLONAL ANTIBODY; PLATINUM COMPLEX; TUMOR MARKER;

ALOPECIA; ANTINEOPLASTIC ACTIVITY; ARTERY THROMBOSIS; BREAST CANCER; CANCER SURVIVAL; CLINICAL PRACTICE; CLINICAL TRIAL; COLORECTAL CANCER; COMBINATION CHEMOTHERAPY; CONTROLLED CLINICAL TRIAL; DIGESTIVE SYSTEM PERFORATION; DRUG APPROVAL; DRUG BINDING; DRUG EFFECT; DRUG EFFICACY; DRUG HALF LIFE; DRUG MECHANISM; DRUG MEGADOSE; DRUG SAFETY; FOOD AND DRUG ADMINISTRATION; GASTROINTESTINAL TOXICITY; HEART INFARCTION; HUMAN; HYPERTENSION; IMMUNOHISTOCHEMISTRY; METASTASIS; MONOTHERAPY; NEUROPATHY; NEUROTOXICITY; PERIPHERAL NEUROPATHY; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; RASH; REVIEW; STROKE; TREATMENT FAILURE; TREATMENT RESPONSE; TUMOR GROWTH; COLORECTAL TUMOR; METABOLISM; PATHOLOGY; STANDARD;

ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CAMPTOTHECIN; CLINICAL TRIALS; COLORECTAL NEOPLASMS; FLUOROURACIL; HUMANS; IMMUNOHISTOCHEMISTRY; LEUCOVORIN; ORGANOPLATINUM COMPOUNDS; RECEPTOR, EPIDERMAL GROWTH FACTOR; TUMOR MARKERS, BIOLOGICAL;

EID: 33644807050     PISSN: 08909091     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (25)

1. Ferrara N, Hillan KJ, Gerber HP, et al: Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov 3:391-400, 2004.
2. Jain RK: Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy. Nat Med 7:987-989, 2001.
3. Willett CG, Boucher Y, di Tomaso E, et al: Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med 10:145-147, 2004.
4. Hurwitz H, Fehrenbacher L, Novotny W, et al: Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350:2335-2342, 2004.
5. Saltz LB, Cox JV, Blanke C, et al: Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. N Engl J Med 343:905-914, 2000.
6. Giantonio BJ, Catalano PJ, Meropol NJ, et al: High-dose bevacizumab in combination with FOLFOX4 improves survival in pateints with previously treated advanced colorectal cancer: Results from the Eastern Cooperative Oncology Group (ECOG) study 3200 (abstract 169a). Proc Gastrointestinal Cancers Symposium, Jan 2005, p 168.
7. Kabbinavar F, Hurwitz H, Fehrenbacher L, et al: Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J Clin Oncol 21:60-65, 2003.
8. Kabbinavar FF, Schulz J, McCleod M, et al: Bevacizumab (a monoclonal antibody to vascular endothelial growth factor) to prolong progression-free survival in first-line colorectal cancer (CRC) in subjects who are not suitable candidates for first-line CPT-11 (abstract 3516). Proc Am Soc Clin Oncol 22(14S):249, 2004.
9. Saltz LB, Lenz HJ, Kindler H, et al: Interim report of randomized phase II trial of cetuximab/bevacizumab/irinotecan (CBI) versus cetuximab/bevacizumab (CB) in irinotecan-refractory colorectal cancer (abstract 169b). Proc Gastrointestinal Cancers Symposium, Jan 2005, p 169.
10. Goldberg RM, Sargent DJ, Morton RF, et al: A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J Clin Oncol 22:23-30, 2004.
11. Rothenberg ML, Oza AM, Bigelow RH, et al: Superiority of oxaliplatin and fluorouracil-leucovorin compared with either therapy alone in patients with progressive colorectal cancer after irinotecan and fluorouracil-leucovorin: Interim results of a phase III trial. J Clin Oncol 11:2059-2069, 2003.
12. Brentjens R, Saltz L: Epidermal growth factor receptor blocakde and the treatment of solid tumor malignancies, in Devita VT, Hellman S, Rosenberg SA (eds): Progress in Oncology 2002. Sudbury, Mass, Jones and Bartlett, 2003.
13. Saltz LB, Meropol NJ, Loehrer PJ Sr, et al: Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol 22:1201-1208, 2004.
14. Cunningham D, Humblet Y, Siena S, et al: Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 351:337-345, 2004.
15. Lenz HJ, Mayer RJ, Gold PJ, et al: Activity of cetuximab in patients with colorectal cancer refractory to both irinotecan and oxaliplatin (abstract 3510). Proc Am Soc Clin Oncol 23:248, 2004.
16. Saltz LB, Rubin M, Hochster H, et al: Cetuximab (IMC-C225) plus irinotecan (CPT-11) is active in CPT-11-refractory colorectal cancer that express epidermal growth factor receptor (abstract 7). Proc Am Soc Clin Oncol 20:2a, 2001.
17. Rosenberg AH, Loehrer PJ, et al: Erbitux (IMC-C225) plus weekly irinotecan (CPT-11), fluorouracil (5FU) and leucovorin (LV) in colorectal cancer (CRC) that expresses the epidermal growth factor receptor (EGFr) (abstract 536). Proc Am Soc Clin Oncol 21:135a, 2002.
18. Rougier P, Raoul JL, Van Laethem JL, et al: Cetuximab+FOLFIRI as first-line treatment for metastatic colorectal CA (abstract 3513). Proc Am Soc Clin Oncol 23:248, 2004.
19. Tabernero JM, Van Cutsem E, Sastre J, et al: An international phase II study of cetuximab in combination with oxaliplatin/5-fluorouracil (5-FU)/folinic acid (FA) (FOLFOX-4) in the first-line treatment of patients with metastatic colorectal cancer (CRC) expressing epidermal growth factor receptor (EGFR). Preliminary results (abstract 3512). Proc Am Soc Clin Oncol 23:248, 2004.
20. Chung KY, Shia J, Kemeny NE, et al: Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry. J Clin Oncol 23:1803-1810, 2005.
21. Atkins D, Reiffen KA, Tegtmeier CL, et al: Immunohistochemical detection of EGFR in paraffin-embedded tumor tissues: Variation in staining intensity due to choice of fixative and storage time of tissue sections. J Histochem Cytochem 52:893-901, 2004.
22. de Gramont A, Bosset JF, Milan C, et al: Randomized trial comparing monthly low-dose leucovorin and fluorouracil bolus with bimonthly high-dose leucovorin and fluorouracil bolus plus continuous infusion for advanced colorectal cancer: A French intergroup study. J Clin Oncol 15:808-815, 1997.
23. Tournigand C, Andre T, Achille E, et al: FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: A randomized GERCOR study. J Clin Oncol 22:229-237, 2004.
24. Colucci G, Maiello E, Gebbia V, et al: Preliminary results of a randomized multicenter trial of the Grupo Oncologico Italia Meridionale (GOIM) comparing FOLFIRI vs FOLFOX in advanced colorectal cancer (ACC) patients (abstract 1021). Proc Am Soc Clin Oncol 22:225, 2003.
25. Maughan T, on behalf of the NCRI Colorectal Group: Fluorouracil, oxaliplatin, CPT-11 use and sequencing in advanced colorectal cancer: The UK MRC FOCUS (CR08) trial (abstract 165). Proc Gastrointestinal Cancers Symposium, Jan 2005, p 166.